Defensins in viral infections

Journal of Innate Immunity

Volumn 1, Issue 5, 2009, Pages 413-420

  Ding, Jian ^a   Chou, Yi Ying ^a   Chang, Theresa L ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

Antimicrobial peptides; Defensins; Infectious diseases; Virus host cell interactions; Viruses

Indexed keywords

ALPHA DEFENSIN; ALPHA DEFENSIN 5; ALPHA DEFENSIN 6; BETA DEFENSIN 2; BETA DEFENSIN 3; BETA DEFENSIN 4; DEFENSIN; UNCLASSIFIED DRUG;

HERPES SIMPLEX VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS; INNATE IMMUNITY; NONHUMAN; PARAMYXOVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; VACCINIA VIRUS; VIRUS ENVELOPE; VIRUS INFECTION; VIRUS TRANSMISSION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; DEFENSINS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; MICE; VIRUS DISEASES; VIRUSES;

EID: 77953381818     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000226256     Document Type: Review

References (69)

1. Daher KA, Selsted ME, Lehrer RI: Direct inactivation of viruses by human granulocyte defensins. J Virol 1986;60:1068-1074. (Pubitemid 17179284)
2. Ouellette AJ: Paneth cell alpha-defensin synthesis and function. Curr Top Microbiol Immunol 2006;306:1-25.
3. Ganz T: Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003;3:710-720. (Pubitemid 41070812)
4. Rehaume LM, Hancock RE: Neutrophil-derived defensins as modulators of innate immune function. Crit Rev Immunol 2008;28:185-200.
5. Selsted ME, Ouellette AJ: Mammalian defensins in the antimicrobial immune response. Nat Immunol 2005;6:551-557.
6. Yang D, Biragyn A, Hoover DM, Lubkowski J, Oppenheim JJ: Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol 2004;22:181-215. (Pubitemid 38680422)
7. Ganz T: Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect Immun 1987;55:568-571. (Pubitemid 17021942)
8. Mackewicz CE, Yuan J, Tran P, Diaz L, Mack E, Selsted ME, Levy JA: Alpha-defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors. Aids 2003;17:F23-F32. (Pubitemid 37297148)
9. Zaharatos GJ, He T, Lopez P, Yu W, Yu J, Zhang L: Alpha-defensins released into stimulated CD8+ T-cell supernatants are likely derived from residual granulocytes within the irradiated allogeneic peripheral blood mononuclear cells used as feeders. J Acquir Immune Defic Syndr 2004;36:993-1005. (Pubitemid 38989364)
10. Salzman NH, Underwood MA, Bevins CL: Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol 2007;19:70-83.
11. Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME: A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science 1999;286:498-502.
12. Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME: Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem 2002;277:3079-3084. (Pubitemid 34953167)
13. Nguyen TX, Cole AM, Lehrer RI: Evolution of primate theta-defensins: a serpentine path to a sweet tooth. Peptides 2003;24:1647-1654.
14. Cole AM, Hong T, Boo LM, Nguyen T, Zhao C, Bristol G, Zack JA, Waring AJ, Yang OO, Lehrer RI: Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1. Proc Natl Acad Sci USA 2002;99:1813-1818. (Pubitemid 34168972)
15. Tecle T, White MR, Gantz D, Crouch EC, Hartshorn KL: Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses. J Immunol 2007;178:8046-8052. (Pubitemid 46898076)
16. Shi J, Aono S, Lu W, Ouellette AJ, Hu X, Ji Y, Wang L, Lenz S, van Ginkel FW, Liles M, Dykstra C, Morrison EE, Elson CO: A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol 2007;179:1245-1253.
17. Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW: Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 2002;298:1025-1029. (Pubitemid 35247310)
18. Funderburg N, Lederman MM, Feng Z, Drage MG, Jadlowsky J, Harding CV, Weinberg A, Sieg SF: Human-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. Proc Natl Acad Sci USA 2007;104:18631-18635. (Pubitemid 350210748)
19. Chong KT, Thangavel RR, Tang X: Enhanced expression of murine beta-defensins (MBD-1, -2,- 3, and -4) in upper and lower airway mucosa of influenza virus infected mice. Virology 2008;380:136-143.
20. Quinones-Mateu ME, Lederman MM, Feng Z, Chakraborty B, Weber J, Rangel HR, Marotta ML, Mirza M, Jiang B, Kiser P, Medvik K, Sieg SF, Weinberg A: Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication. Aids 2003;17:F39-F48. (Pubitemid 38147012)
21. Duits LA, Nibbering PH, van Strijen E, Vos JB, Mannesse-Lazeroms SP, van Sterkenburg MA, Hiemstra PS: Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells. FEMS Immunol Med Microbiol 2003;38:59-64. (Pubitemid 37297444)
22. Proud D, Sanders SP, Wiehler S: Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivo. J Immunol 2004;172:4637-4645. (Pubitemid 38375283)
23. Kota S, Sabbah A, Chang TH, Harnack R, Xiang Y, Meng X, Bose S: Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappaB-mediated innate antiviral response against human respiratory syncytial virus. J Biol Chem 2008;283:22417-22429.
24. Chang TL, Vargas J Jr, DelPortillo A, Klotman ME: Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity. J Clin Invest 2005;115:765-773. (Pubitemid 40322253)
25. Furci L, Sironi F, Tolazzi M, Vassena L, Lusso P: Alpha-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4. Blood 2007;109:2928-2935. (Pubitemid 46482090)
26. Zhang L, Yu W, He T, Yu J, Caffrey RE, Dalmasso EA, Fu S, Pham T, Mei J, Ho JJ, Zhang W, Lopez P, Ho DD: Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor. Science 2002;298:995-1000.
27. Chang TL, Francois F, Mosoian A, Klotman ME: CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition. J Virol 2003;77:6777-6784. (Pubitemid 36666872)
28. Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI: Activity of alpha- and theta-defensins against primary isolates of HIV-1. J Immunol 2004;173:515-520. (Pubitemid 38797379)
29. Guo CJ, Tan N, Song L, Douglas SD, Ho WZ: Alpha-defensins inhibit HIV infection of macrophages through upregulation of CC-chemokines. Aids 2004;18:1217-1218. (Pubitemid 38738526)
30. Wu Z, Cocchi F, Gentles D, Ericksen B, Lubkowski J, Devico A, Lehrer RI, Lu W: Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro. FEBS Lett 2005;579:162-166. (Pubitemid 40023390)
31. Tanabe H, Ouellette AJ, Cocco MJ, Robinson WE, Jr: Differential effects on human immunodeficiency virus type 1 replication by alpha- defensins with comparable bactericidal activities. J Virol 2004;78:11622-11631. (Pubitemid 39390748)
32. Klotman ME, Rapista A, Teleshova N, Micsenyi A, Jarvis GA, Lu W, Porter E, Chang TL: Neisseria gonorrhoeae -induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission. J Immunol 2008;180:6176-6185.
33. Nakashima H, Yamamoto N, Masuda M, Fujii N: Defensins inhibit HIV replication in vitro. Aids 1993;7:1129. (Pubitemid 23246462)
34. Sun L, Finnegan CM, Kish-Catalone T, Blumenthal R, Garzino-Demo P, La Terra Maggiore GM, Berrone S, Kleinman C, Wu Z, Abdelwahab S, Lu W, Garzino-Demo A: Human beta-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. J Virol 2005;79:14318-14329. (Pubitemid 41552729)
35. Munk C, Wei G, Yang OO, Waring AJ, Wang W, Hong T, Lehrer RI, Landau NR, Cole AM: The theta-defensin, retrocyclin, inhibits HIV-1 entry. AIDS Res Hum Retroviruses 2003;19:875-881. (Pubitemid 37338913)
36. Wang W, Cole AM, Hong T, Waring AJ, Lehrer RI: Retrocyclin, an antiretroviral thetadefensin, is a lectin. J Immunol 2003;170:4708-4716.
37. Gallo SA, Wang W, Rawat SS, Jung G, Waring AJ, Cole AM, Lu H, Yan X, Daly NL, Craik DJ, Jiang S, Lehrer RI, Blumenthal R: Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation. J Biol Chem 2006;281:18787-18792. (Pubitemid 44035539)
38. Trabattoni D, Caputo SL, Maffeis G, Vichi F, Biasin M, Pierotti P, Fasano F, Saresella M, Franchini M, Ferrante P, Mazzotta F, Clerici M: Human alpha defensin in HIV-exposed but uninfected individuals. J Acquir Immune Defic Syndr 2004;35:455-463. (Pubitemid 38420654)
39. Kuhn L, Trabattoni D, Kankasa C, Semrau K, Kasonde P, Lissoni F, Sinkala M, Ghosh M, Vwalika C, Aldrovandi GM, Thea DM, Clerici M: Alpha-defensins in the prevention of HIV transmission among breastfed infants. J Acquir Immune Defic Syndr 2005;39:138-142. (Pubitemid 40741110)
40. Bosire R, John-Stewart GC, Mabuka JM, Wariua G, Gichuhi C, Wamalwa D, Ruzinski J, Goodman R, Lohman B, Mbori-Ngacha DA, Overbaugh J, Farquhar C: Breast milk alpha-defensins are associated with HIV type 1 RNA and CC chemokines in breast milk but not vertical HIV type 1 transmission. AIDS Res Hum Retroviruses 2007;23:198-203. (Pubitemid 46418333)
41. Venkataraman N, Cole AL, Svoboda P, Pohl J, Cole AM: Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid. J Immunol 2005;175:7560-7567. (Pubitemid 41713455)
42. Galvin SR, Cohen MS: The role of sexually transmitted diseases in HIV transmission. Nat Rev Microbiol 2004;2:33-42. (Pubitemid 39490046)
43. Simhan HN, Anderson BL, Krohn MA, Heine RP, Martinez de Tejada B, Landers DV, Hillier SL: Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy. Am J Obstet Gynecol 2007;196:59 e51-e55.
44. Valore EV, Wiley DJ, Ganz T: Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun 2006;74:5693-5702.
45. Porter E, Yang H, Yavagal S, Preza GC, Murillo O, Lima H, Greene S, Mahoozi L, Klein- Patel M, Diamond G, Gulati S, Ganz T, Rice PA, Quayle AJ: Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun 2005;73:4823-4833.
46. Wiesenfeld HC, Heine RP, Krohn MA, Hillier SL, Amortegui AA, Nicolazzo M, Sweet RL: Association between elevated neutrophil defensin levels and endometritis. J Infect Dis 2002;186:792-797. (Pubitemid 35013431)
47. Fan SR, Liu XP, Liao QP: Human defensins and cytokines in vaginal lavage fluid of women with bacterial vaginosis. Int J Gynaecol Obstet 2008;103:50-54.
48. Levinson P, Kaul R, Kimani J, Ngugi E, Moses S, Macdonald KS, Broliden K, Hirbod T: Levels of innate immune factors in genital fluids: association of alpha defensins and LL-37 with genital infections and increased HIV acquisition. Aids 2009:23:309-317.
49. Braida L, Boniotto M, Pontillo A, Tovo PA, Amoroso A, Crovella S: A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children. Aids 2004;18:1598-1600. (Pubitemid 39037486)
50. Milanese M, Segat L, Pontillo A, Arraes LC, de Lima Filho JL, Crovella S: DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children. Aids 2006;20:1673-1675. (Pubitemid 44162413)
51. Baroncelli S, Ricci E, Andreotti M, Guidotti G, Germano P, Marazzi MC, Vella S, Palombi L, De Rossi A, Giuliano M: Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters. Aids 2008;22:1515-1517.
52. Ricci E, Malacrida S, Zanchetta M, Montagna M, Giaquinto C, Rossi AD: Role of betadefensin- 1 polymorphisms in mother-tochild transmission of human immunodeficiency virus type 1. J Acquir Immune Defic Syndr 2009;51:13-19.
53. Zapata W, Rodriguez B, Weber J, Estrada H, Quinones-Mateu ME, Zimermman PA, Lederman MM, Rugeles MT: Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals. Curr HIV Res 2008;6:531-538.
54. Sinha S, Cheshenko N, Lehrer RI, Herold BC: NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2. Antimicrob Agents Chemother 2003;47:494-500. (Pubitemid 36158072)
55. Yasin B, Wang W, Pang M, Cheshenko N, Hong T, Waring AJ, Herold BC, Wagar EA, Lehrer RI: Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J Virol 2004;78:5147-5156. (Pubitemid 38581467)
56. Hazrati E, Galen B, Lu W, Wang W, Ouyang Y, Keller MJ, Lehrer RI, Herold BC: Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection. J Immunol 2006;177:8658-8666. (Pubitemid 44893830)
57. Salvatore M, Garcia-Sastre A, Ruchala P, Lehrer RI, Chang T, Klotman ME: Alpha-defensin inhibits influenza virus replication by cell-mediated mechanism(s). J Infect Dis 2007;196:835-843. (Pubitemid 47378932)
58. Hartshorn KL, White MR, Tecle T, Holmskov U, Crouch EC: Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D. J Immunol 2006;176:6962-6972. (Pubitemid 43791972)
59. Leikina E, Delanoe-Ayari H, Melikov K, Cho MS, Chen A, Waring AJ, Wang W, Xie Y, Loo JA, Lehrer RI, Chernomordik LV: Carbohydrate- binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins. Nat Immunol 2005;6:995-1001. (Pubitemid 41486184)
60. Grubor B, Gallup JM, Meyerholz DK, Crouch EC, Evans RB, Brogden KA, Lehmkuhl HD, Ackermann MR: Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs. Clin Diagn Lab Immunol 2004;11:599-607. (Pubitemid 38661429)
61. Meyerholz DK, Grubor B, Gallup JM, Lehmkuhl HD, Anderson RD, Lazic T, Ackermann MR: Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs. J Clin Microbiol 2004;42:4780-4787. (Pubitemid 39362403)
62. Howell MD, Streib JE, Leung DY: Antiviral activity of human beta-defensin 3 against vaccinia virus. J Allergy Clin Immunol 2007;119:1022-1025. (Pubitemid 46527837)
63. Howell MD, Jones JF, Kisich KO, Streib JE, Gallo RL, Leung DY: Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum. J Immunol 2004;172:1763-1767.
64. Dugan AS, Maginnis MS, Jordan JA, Gasparovic ML, Manley K, Page R, Williams G, Porter E, O'Hara BA, Atwood WJ: Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells. J Biol Chem 2008;283:31125-31132.
65. Bastian A, Schafer H: Human alpha-defensin 1 (HNP-1) inhibits adenoviral infection in vitro. Regul Pept 2001;101:157-161. (Pubitemid 32728382)
66. Harvey SA, Romanowski EG, Yates KA, Gordon YJ: Adenovirus-directed ocular innate immunity: the role of conjunctival defensinlike chemokines (IP-10, I-TAC) and phagocytic human defensin-alpha. Invest Ophthalmol Vis Sci 2005;46:3657-3665.
67. Gropp R, Frye M, Wagner TO, Bargon J: Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy. Hum Gene Ther 1999;10:957-964. (Pubitemid 29195425)
68. Smith JG, Nemerow GR: Mechanism of adenovirus neutralization by Human alphadefensins. Cell Host Microbe 2008;3:11-19.
69. Buck CB, Day PM, Thompson CD, Lubkowski J, Lu W, Lowy DR, Schiller JT: Human alpha-defensins block papillomavirus infection. Proc Natl Acad Sci USA 2006;103:1516-1521. (Pubitemid 43191197)