Human neutrophil α-defensin 4 inhibits HIV-1 infection in vitro

FEBS Letters

Volumn 579, Issue 1, 2005, Pages 162-166

  Wu, Zhibin ^a   Cocchi, Fiorenza ^a   Gentles, David ^a   Ericksen, Bryan ^a   Lubkowski, Jacek ^b   DeVico, Anthony ^a   Lehrer, Robert I ^c   Lu, Wuyuan ^a  

^a INSTITUTE OF HUMAN VIROLOGY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CD4; Defensin; gp120; HIV 1; Peptide synthesis; Surface plasmon resonance

Indexed keywords

ALPHA DEFENSIN; ALPHA DEFENSIN 4; ANTIVIRUS AGENT; CD4 ANTIGEN; GLYCOPROTEIN GP 120; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; NEUTROPHIL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE;

ALPHA-DEFENSINS; ANTI-HIV AGENTS; ANTIGENS, CD4; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; LIGANDS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 11144325117     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.11.062     Document Type: Article

References (35)

1. M. Zasloff Antimicrobial peptides of multicellular organisms Nature 415 2002 389 395
2. T. Ganz Defensins: antimicrobial peptides of innate immunity Nat. Immunol. 3 2003 710 720
3. R.I. Lehrer, and T. Ganz Defensins of vertebrate animals Curr. Opin. Immunol. 14 2002 96 102
4. D.M. Hoover, O. Chertov, and J. Lubkowski The structure of human beta-defensin-1: new insights into structural properties of beta-defensins J. Biol. Chem. 276 2001 39021 39026
5. D.M. Hoover, K.R. Rajashankar, R. Blumenthal, A. Puri, J.J. Oppenheim, O. Chertov, and J. Lubkowski The structure of human beta-defensin-2 shows evidence of higher order oligomerization J. Biol. Chem. 275 2000 32911 32918
6. C.P. Hill, J. Yee, M.E. Selsted, and D. Eisenberg Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization Science 251 1991 1481 1485
7. A. Biragyn, P.A. Ruffini, C.A. Leifer, E. Klyushnenkova, A. Shakhov, O. Chertov, A.K. Shirakawa, J.M. Farber, D.M. Segal, J.J. Oppenheim, and L.W. Kwak Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2 Science 298 2002 1025 1029
8. M.C. Territo, T. Ganz, M.E. Selsted, and R. Lehrer Monocyte-chemotactic activity of defensins from human neutrophils J. Clin. Invest. 84 1989 2017 2020
9. D. Yang, O. Chertov, S.N. Bykovskaia, Q. Chen, M.J. Buffo, J. Shogan, M. Anderson, J.M. Schroder, J.M. Wang, O.M. Howard, and J.J. Oppenheim Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6 Science 286 1999 525 528
10. D. Yang, Q. Chen, O. Chertov, and J.J. Oppenheim Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells J. Leukoc. Biol. 68 2000 9 14
11. J.E. Gabay, R.W. Scott, D. Campanelli, J. Griffith, C. Wilde, M.N. Marra, M. Seeger, and C.F. Nathan Antibiotic proteins of human polymorphonuclear leukocytes Proc. Natl. Acad. Sci. USA 86 1989 5610 5614
12. T. Ganz, M.E. Selsted, D. Szklarek, S.S. Harwig, K. Daher, D.F. Bainton, and R.I. Lehrer Defensins. Natural peptide antibiotics of human neutrophils J. Clin. Invest. 76 1985 1427 1435
13. C.G. Wilde, J.E. Griffith, M.N. Marra, J.L. Snable, and R.W. Scott Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family J. Biol. Chem. 264 1989 11200 11203
14. K.A. Daher, M.E. Selsted, and R.I. Lehrer Direct inactivation of viruses by human granulocyte defensins J. Virol. 60 1986 1068 1074
15. H. Nakashima, N. Yamamoto, M. Masuda, and N. Fujii Defensins inhibit HIV replication in vitro Aids 7 1993 1129
16. L. Zhang, W. Yu, T. He, J. Yu, R.E. Caffrey, E.A. Dalmasso, S. Fu, T. Pham, J. Mei, J.J. Ho, W. Zhang, P. Lopez, and D.D. Ho Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor Science 298 2002 995 1000
17. T.L. Chang, F. Francois, A. Mosoian, and M.E. Klotman CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition J. Virol. 77 2003 6777 6784
18. C.E. Mackewicz, J. Yuan, P. Tran, L. Diaz, E. Mack, M.E. Selsted, and J.A. Levy alpha-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors Aids 17 2003 F23 F32
19. Y.Q. Tang, J. Yuan, G. Osapay, K. Osapay, D. Tran, C.J. Miller, A.J. Ouellette, and M.E. Selsted A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins Science 286 1999 498 502
20. D. Tran, P.A. Tran, Y.Q. Tang, J. Yuan, T. Cole, and M.E. Selsted Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides J. Biol. Chem. 277 2002 3079 3084
21. W. Wang, A.M. Cole, T. Hong, A.J. Waring, and R.I. Lehrer Retrocyclin, an Antiretroviral theta-Defensin, Is a Lectin J. Immunol. 170 2003 4708 4716
22. C. Munk, G. Wei, O.O. Yang, A.J. Waring, W. Wang, T. Hong, R.I. Lehrer, N.R. Landau, and A.M. Cole The theta-defensin, retrocyclin, inhibits HIV-1 entry AIDS Res. Hum. Retroviruses 19 2003 875 881
23. A.M. Cole, T. Hong, L.M. Boo, T. Nguyen, C. Zhao, G. Bristol, J.A. Zack, A.J. Waring, O.O. Yang, and R.I. Lehrer Retrocyclin: a primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1 Proc. Natl. Acad. Sci. USA 99 2002 1813 1818
24. M.E. Selsted, S.S. Harwig, T. Ganz, J.W. Schilling, and R.I. Lehrer Primary structures of three human neutrophil defensins J. Clin. Invest. 76 1985 1436 1439
25. Z. Wu, A. Prahl, R. Powell, B. Ericksen, J. Lubkowski, and W. Lu From pro defensins to defensins: synthesis and characterization of human neutrophil pro α-defensin-1 and its mature domain J. Pept. Res. 62 2003 53 62
26. Z. Wu, R. Powell, and W. Lu Productive folding of human neutrophil α-defensins in vitro without the pro-peptide J. Am. Chem. Soc. 125 2003 2402 2403
27. Z. Wu, B. Ericksen, K. Tucker, J. Lubkowski, and W. Lu Synthesis and characterization of human alpha-defensins 4-6 J. Pept. Res. 64 2004 118 125
28. C.N. Pace, F. Vajdos, L. Fee, G. Grimsley, and T. Gray How to measure and predict the molar absorption coefficient of a protein Protein Science: a Publication of the Protein Society 4 1995 2411 2423
29. A.G. Dalgleish, P.C. Beverley, P.R. Clapham, D.H. Crawford, M.F. Greaves, and R.A. Weiss The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus Nature 312 1984 763 767
30. A. Trkola, T. Dragic, J. Arthos, J.M. Binley, W.C. Olson, G.P. Allaway, C. Cheng-Mayer, J. Robinson, P.J. Maddon, and J.P. Moore CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5 Nature 384 1996 184 187
31. L. Wu, N.P. Gerard, R. Wyatt, H. Choe, C. Parolin, N. Ruffing, A. Borsetti, A.A. Cardoso, E. Desjardin, W. Newman, C. Gerard, and J. Sodroski CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5 Nature 384 1996 179 183
32. Y. Feng, C.C. Broder, P.E. Kennedy, and E.A. Berger HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor Science 272 1996 872 877
33. D.M. Eckert, and P.S. Kim Mechanisms of viral membrane fusion and its inhibition Annu. Rev. Biochem. 70 2001 777 810
34. E.A. Berger, P.M. Murphy, and J.M. Farber Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease Annu. Rev. Immunol. 17 1999 657 700
35. W. Wang, S.M. Owen, D.L. Rudolph, A.M. Cole, T. Hong, A.J. Waring, R.B. Lal, and R.I. Lehrer Activity of alpha- and theta-defensins against primary isolates of HIV-1 J. Immunol. 173 2004 515 520