G protein β3 subunit, interleukin-10, and tumor necrosis factor-α gene polymorphisms in Koreans with irritable bowel syndrome

Neurogastroenterology and Motility

Volumn 22, Issue 7, 2010, Pages 758-763

  Lee, H J ^a   Lee, S Y ^b   Choi, J E ^a   Kim, J H ^b   Sung, I K ^b   Park, H S ^b   Jin, C J ^b  

^a Korea University College of Medicine   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

Author keywords

G protein; Irritable bowel syndrome; Poly morphism; Rome III criteria

Indexed keywords

G PROTEIN BETA3 SUBUNIT; INTERLEUKIN 10; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DNA; G-PROTEIN BETA3 SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; ALLELE; ARTICLE; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; IRRITABLE COLON; KOREA; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED; QUESTIONNAIRE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; ALLELES; DNA; FEMALE; GENE FREQUENCY; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; INTERLEUKIN-10; IRRITABLE BOWEL SYNDROME; KOREA; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; QUESTIONNAIRES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77953347058     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2010.01496.x     Document Type: Article

References (35)

1. Bengtson MB, Rønning T, Vatn MH, Harris JR. Irritable bowel syndrome in twins: genes and environment. Gut 2006 55 : 1754 1759.
2. Adam B, Liebregts T, Holtmann G. Mechanisms of disease: genetics of functional gastrointestinal disorders-searching the genes that matter. Nat Clin Pract Gastroenterol Hepatol 2007 4 : 102 110.
3. Liebregts T, Adam B, Bredack C et al. Immune activation in patients with irritable bowel syndrome. Gastroenterology 2007 132 : 913 920.
4. Dinan TG, Quigley EM, Ahmed SM et al. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology 2006 130 : 304 311.
5. Rad R, Dossumbekova A, Neu B et al. Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut 2004 53 : 1082 1089.
6. Wilson AG, di Giovine FS, Blakemore AI, Duff GW. Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product. Hum Mol Genet 1992 1 : 353.
7. Kroeger KM, Carville KS, Abraham LJ. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol 1997 34 : 391 399.
8. Uglialoro AM, Turbay D, Pesavento PA et al. Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-gene promoter. Tissue Antigens 1998 52 : 359 367.
9. Hamm HE. The many faces of G protein signaling. J Biol Chem 1998 273 : 669 672.
10. Ford CE, Skiba NP, Bae H et al. Molecular basis for interactions of G protein betagamma subunits with effectors. Science 1998 280 : 1271 1274.
11. Siffert W, Rosskopf D, Siffert G et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998 18 : 45 8.
12. Rosskopf D, Manthey I, Habich C et al. Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit. Biochem J 2003 371 : 223 232. (Pubitemid 36458097)
13. Lee HJ, Cha JH, Ham BJ et al. Association between a G-protein β3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. Pharmacogenomics J 2004 4 : 29 33.
14. Siffert W, Forster P, Jöckel KH et al. Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 1999 10 : 1921 1930.
15. Hauner H, Meier M, Jöckel KH et al. Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism. Pharmacogenetics 2003 13 : 453 459.
16. Park YM, Chung YC, Lee SH et al. G-protein β3 subunit gene 825C/T polymorphism is not associated with olanzapine-induced weight gain in Korean schizophrenic patients. Psychiatry Investig 2009 6 : 39 43.
17. Saito Y, Locke G III., Zimmerman J et al. A genetic association study of 5-HTT LPR and GNβ3-C825T polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil 2007 19 : 465 470.
18. Andersen V, Camilleri M, Kim H et al. Is there an association between GNβ3-C825T genotype and lower functional gastrointestinal disorders? Gastroenterology 2006 130 : 1985 1994.
19. Wang BM, Jiang XZ, Yang YL, Liu WT, Cao XC, Zhao XZ. A study of interleukin-10 gene polymorphism in irritable bowel syndrome. Zhonghua Nei Ke Za Zhi 2006 45 : 289 292.
20. van der Veek PP, van den Berg M, de Kroon YE, Verspaget HW, Masclee AA. Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome. Am J Gastroenterol 2005 100 : 2510 2516.
21. Drossman DA, Corazziari E, Delvaux M, eds. Rome III: The Functional Gastrointestinal Disorders, 3rd edn.
22. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961 4 : 53 63.
23. Rhee MK, Lee YH, Park SH et al. A standardization study of Beck Depression Inventory (I): Korean version (K-BDI): reliability and factor analysis. Korean J Psychopharmacol 1995 4 : 77 95.
24. Edwards-Smith CJ, Jonsson JR, Purdie DM et al. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa. Hepatology 1999 30 : 526 530.
25. Vinasco J, Beraun Y, Nieto A et al. Polymorphism at the TNF loci in rheumatoid arthritis. Tissue Antigens 1997 49 : 74 8.
26. Ritchie MD, Hahn LW, Moore JH. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 2003 24 : 150 157.
27. Moore JH. Computational analysis of gene-gene interactions using multifactor dimensionality reduction. Expert Rev Mol Diagn 2004 4 : 795 803.
28. Rosskopf D, Manthey I, Siffert W. Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. Pharmacogenetics 2002 12 : 209 220.
29. Tahara T, Arisawa T, Shibata T et al. Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia. Dig Dis Sci 2008 53 : 642 646.
30. Holtmann G, Siffert W, Haag S et al. G-protein β3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. Gastroenterology 2004 126 : 971 979.
31. de Vries DR, ter Linde JJ, van Herwaarden MA, Smout AJ, Samsom M. Gastroesophageal reflux disease is associated with the C825T polymorphism in the G-protein beta3 subunit gene (GNB3). Am J Gastroenterol 2009 104 : 281 285.
32. Gonsalkorale WM, Perrey C, Pravica V, Whorwell PJ, Hutchinson IV. Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component? Gut 2003 52 : 91 3.
33. Meenagh A, Williams F, Ross OA et al. Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America. Hum Immunol 2002 63 : 1055 1061.
34. Han GR, Lee YW, Lee HL et al. A Korean population study of the nine STR loci FGA, VWA, D3S1358, D18S51, D21S11, D8S1179, D7S820, D13S317 and D5S818. Int J Legal Med 2000 114 : 41 4.
35. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990 1 : 43 6.