Is There an Association Between GNβ3-C825T Genotype and Lower Functional Gastrointestinal Disorders?

Gastroenterology

Volumn 130, Issue 7, 2006, Pages 1985-1994

  Andresen, Viola ^a   Camilleri, Michael ^a,b   Kim, H Jae ^a   Stephens, Debra A ^a   Carlson, Paula J ^a   Talley, Nicholas J ^a   Saito, Yuri A ^a   Urrutia, Raul ^b   Zinsmeister, Alan R ^c  

^a Clinical Enteric Neuroscience Translational and Epidemiological Research Mayo Clinic   (United States)

^b MAYO CLINIC   (United States)

^c Mayo Clinic   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; THYMIDINE; G PROTEIN BETA3 SUBUNIT; G-PROTEIN BETA3 SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DIGESTIVE SYSTEM FUNCTION DISORDER; DNA DETERMINATION; DNA POLYMORPHISM; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GNBETA3 GENE; HUMAN; INTESTINE FUNCTION; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; QUESTIONNAIRE; REGRESSION ANALYSIS; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; ADOLESCENT; AGE DISTRIBUTION; CASE CONTROL STUDY; COHORT ANALYSIS; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HOSPITALIZATION; MIDDLE AGED; PATHOPHYSIOLOGY; PREVALENCE; PROBABILITY; REFERENCE VALUE; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEX RATIO; STATISTICAL MODEL;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; IRRITABLE BOWEL SYNDROME; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PREVALENCE; PROBABILITY; REFERENCE VALUES; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; SEX DISTRIBUTION;

EID: 33744543509     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2006.03.017     Document Type: Article

References (52)

1. Drossman D.A., Li Z., Andruzzi E., Temple R.D., Talley N.J., Thompson W.G., Whitehead W.E., Janssens J., Funch-Jensen P., Corazziari E., et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci 38 (1993) 1569-1580
2. Drossman D.A., Camilleri M., Mayer E.A., and Whitehead W.E. AGA technical review on irritable bowel syndrome. Gastroenterology 123 (2002) 2108-2131
3. Sondek J., Bohm A., Lambright D.G., Hamm H.E., and Sigler P.B. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature 379 (1996) 369-374
4. Baumgart D., Naber C., Haude M., Oldenburg O., Erbel R., Heusch G., and Siffert W. G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation. Circ Res 85 (1999) 965-969
5. Rosskopf D., Manthey I., Habich C., Kielbik M., Eisenhardt A., Nikula C., Urban M., Kohnen S., Graf E., Ravens U., and Siffert W. Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit. Biochem J 371 (2003) 223-232
6. Siffert W., Rosskopf D., Siffert G., Busch S., Moritz A., Erbel R., Sharma A.M., Ritz E., Wichmann H.E., Jakobs K.H., and Horsthemke B. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 18 (1998) 45-48
7. Rosskopf D., Koch K., Habich C., Geerdes J., Ludwig A., Wilhelms S., Jakobs K.H., and Siffert W. Interaction of Gbeta3s, a splice variant of the G-protein Gbeta3, with Ggamma- and Galpha-proteins. Cell Signal 15 (2003) 479-488
8. Ruiz-Velasco V., and Ikeda S.R. A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channels. Physiol Genomics 13 (2003) 85-95
9. Avissar S., and Schreiber G. Ziskind-Somerfeld Research Award. The involvement of guanine nucleotide binding proteins in the pathogenesis and treatment of affective disorders. Biol Psychiatry 31 (1992) 435-459
10. Siffert W. Cardiovascular pharmacogenetics. on the way toward individually tailored drug therapy. Kidney Int Suppl 84 (2003) S168-S171
11. Holtmann G., Siffert W., Haag S., Mueller N., Langkafel M., Senf W., Zotz R., and Talley N.J. G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia. Gastroenterology 126 (2004) 971-979
12. Camilleri C.E., Carlson P.J., Camilleri M., Castillo E.J., Locke III C.R., Geno D.M., Stephens D., Zinsmeister A.R., and Urrutia R. A study of candidate genotypes associated with dyspepsia in a U.S. community. Am J Gastroenterol 101 (2006) 581-592
13. Holtmann G., Liebregts T., and Siffert W. Molecular basis of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 18 (2004) 633-640
14. Kim H.J., Camilleri M., Carlson P.J., Cremonini F., Ferber I., Stephens D., McKinzie S., Zinsmeister A.R., and Urrutia R. Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 53 (2004) 829-837
15. Lee H.J., Cha J.H., Ham B.J., Han C.S., Kim Y.K., Lee S.H., Ryu S.H., Kang R.H., Choi M.J., and Lee M.S. Association between a G-protein beta 3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. Pharmacogenomics J 4 (2004) 29-33
16. Thompson W.G., Longstreth G.F., Drossman D.A., Heaton K.W., Irvine E.J., and Muller-Lissner S.A. Functional bowel disorders and functional abdominal pain. Gut 45 Suppl 2 (1999) II43-II47
17. Talley N.J., Phillips S.F., Wiltgen C.M., Zinsmeister A.R., and Melton III L.J. Assessment of functional gastrointestinal disease. the bowel disease questionnaire. Mayo Clin Proc 65 (1990) 1456-1479
18. Castillo E.J., Camilleri M., Locke G.R., Burton D.D., Stephens D.A., Geno D.M., and Zinsmeister A.R. A community-based, controlled study of the epidemiology and pathophysiology of dyspepsia. Clin Gastroenterol Hepatol 2 (2004) 985-996
19. Kalantar J.S., Locke III G.R., Zinsmeister A.R., Beighley C.M., and Talley N.J. Familial aggregation of irritable bowel syndrome. a prospective study. Gut 52 (2003) 1703-1707
20. Locke G.R.I., Fett S.L., and Zinsmeister A.R. Transition probabilities between functional gastrointestinal disorders in the community. Gastroenterology 120 (2001) A52
21. Hedrick P.H. Genetics of populations (2005), Jones and Bartlett Publishers, Boston
22. Siffert W. G protein polymorphisms in hypertension, atherosclerosis, and diabetes. Annu Rev Med 56 (2005) 17-28
23. Locke III G.R., Zinsmeister A.R., Talley N.J., Fett S.L., and Melton III L.J. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc 75 (2000) 907-912
24. Levy R.L., Jones K.R., Whitehead W.E., Feld S.I., Talley N.J., and Corey L.A. Irritable bowel syndrome in twins. heredity and social learning both contribute to etiology. Gastroenterology 121 (2001) 799-804
25. Gonsalkorale W.M., Perrey C., Pravica V., Whorwell P.J., and Hutchinson I.V. Interleukin 10 genotypes in irritable bowel syndrome. evidence for an inflammatory component?. Gut 52 (2003) 91-93
26. van der Veek P., de Kroon Y., van den Berg M., Verspaget H., and Masclee A. Tumor necrosis factor alpha and interleukin 10 gene polymorphism in irritable bowel syndrome. Gastroenterology 126 (2004) A-52
27. Yeo A., Boyd P., Lumsden S., Saunders T., Handley A., Stubbins M., Knaggs A., Asquith S., Taylor I., Bahari B., Crocker N., Rallan R., Varsani S., Montgomery D., Alpers D.H., Dukes G.E., Purvis I., and Hicks G.A. Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut 53 (2004) 1452-1458
28. Lee D.Y., Park H., Kim W.H., Lee S.I., Seo Y.J., and Choi Y.C. Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome. Korean J Gastroenterol 43 (2004) 18-22
29. Cann P.A., Read N.W., Brown C., Hobson N., and Holdsworth C.D. Irritable bowel syndrome. relationship of disorders in the transit of a single solid meal to symptom patterns. Gut 24 (1983) 405-411
30. Sartori M., Semplicini A., Siffert W., Mormino P., Mazzer A., Pegoraro F., Mos L., Winnicki M., and Palatini P. G-protein beta3-subunit gene 825T allele and hypertension. a longitudinal study in young grade I hypertensives. Hypertension 42 (2003) 909-914
31. Exton M.S., Artz M., Siffert W., and Schedlowski M. G protein beta3 subunit 825T allele is associated with depression in young, healthy subjects. Neuroreport 14 (2003) 531-533
32. Thibaudin L., Berthoux P., Thibaudin D., Mariat C., and Berthoux F. G protein beta3 subunit C825T polymorphism in primary IgA nephropathy. Kidney Int 66 (2004) 322-328
33. von Beckerath N., Schusterschitz Y., Koch W., Griesser K., Mehilli J., Gorchakova O., Schomig A., and Kastrati A. G protein beta 3 subunit 825T allele carriage and risk of coronary artery disease. Atherosclerosis 167 (2003) 135-139
34. Wascher T.C., Paulweber B., Malaimare L., Stadlmayr A., Iglseder B., Schmoelzer I., and Renner W. Associations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis. Stroke 34 (2003) 605-609
35. Attia J., Thakkinstian A., and D'Este C. Meta-analyses of molecular association studies. methodologic lessons for genetic epidemiology. J Clin Epidemiol 56 (2003) 297-303
36. Lule G.N., and Amayo E.O. Irritable bowel syndrome in Kenyans. East Afr Med J 79 (2002) 360-363
37. Gwee K.A., Wee S., Wong M.L., and Png D.J. The prevalence, symptom characteristics, and impact of irritable bowel syndrome in an Asian urban community. Am J Gastroenterol 99 (2004) 924-931
38. Sperling H., Eisenhardt A., Virchow S., Hauck E., Lenk S., Porst H., Stief C., Wetterauer U., Rubben H., Muller N., and Siffert W. Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism. a pilot study. J Urol 169 (2003) 1048-1051
39. Holtmann G., Siffert W., Grote E., Haag S., Braun-Lang U., Langkafel M., and Talley N. G-protein mediated receptor-cell-coupling as a predictor for the long term response to treatment in patients with functional dyspepsia. Gastroenterology 124 (2003) A-80
40. Rosskopf D., Manthey I., and Siffert W. Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. Pharmacogenetics 12 (2002) 209-220
41. Dzida G., Golon-Siekierska P., Puzniak A., Sobstyl J., Bilan A., Mosiewicz J., and Hanzlik J. G-protein beta3 subunit gene C825T polymorphism is associated with arterial hypertension in Polish patients with type 2 diabetes mellitus. Med Sci Monit 8 (2002) CR597-CR602
42. Krippl P., Langsenlehner U., Renner W., Yazdani-Biuki B., Wolf G., Wascher T.C., Paulweber B., and Samonigg H. The 825C>T polymorphism of the G-protein beta-3 subunit gene (GNB3) and breast cancer. Cancer Lett 206 (2004) 59-62
43. Meirhaeghe A., Cottel D., Amouyel P., and Dallongeville J. Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. Mol Genet Metab 86 (2005) 293-299
44. Siffert W., Forster P., Jockel K.H., Mvere D.A., Brinkmann B., Naber C., Crookes R., Du P.H.A., Epplen J.T., Fridey J., Freedman B.I., Muller N., Stolke D., Sharma A.M., Al Moutaery K., Grosse-Wilde H., Buerbaum B., Ehrlich T., Ahmad H.R., Horsthemke B., Du Toit E.D., Tiilikainen A., Ge J., Wang Y., Rosskopf D., et al. Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 10 (1999) 1921-1930
45. Rankinen T., Rice T., Leon A.S., Skinner J.S., Wilmore J.H., Rao D.C., and Bouchard C. G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study. Physiol Genomics 8 (2002) 151-157
46. Hengstenberg C., Schunkert H., Mayer B., Doring A., Lowel H., Hense H.W., Fischer M., Riegger G.A., and Holmer S.R. Association between a polymorphism in the G protein beta3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction. Cardiovasc Res 49 (2001) 820-827
47. Sarrazin C., Berg T., Weich V., Mueller T., Frey U.H., Zeuzem S., Gerken G., Roggendorf M., and Siffert W. GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection. J Hepatol 43 (2005) 388-393
48. Zagradisnik B., Bracic K., Varda N.M., Kokalj Vokac N., and Gregoric A. G-protein beta3 subunit gene C825T polymorphism in patients with vesico-ureteric reflux. Ann Genet 47 (2004) 209-216
49. Martin D.N., Andreu E.P., Ramirez Lorca R., Garcia-Junco P.S., Vallejo Maroto I., Santos R.A., Miranda Guisado M.L., Grijalvo O.M., Ortiz J.V., and Carneado de la Fuente J. G-protein beta-3 subunit gene C825 T polymorphism. influence on plasma sodium and potassium concentrations in essential hypertensive patients. Life Sci 77 (2005) 2879-2886
50. Hanon O., Luong V., Mourad J.J., Bortolotto L.A., Safar M., and Girerd X. Association between the G protein beta3 subunit 825t allele and radial artery hypertrophy. J Vasc Res 39 (2002) 497-503
51. Pollex R.L., Hanley A.J., Zinman B., Harris S.B., Khan H.M., and Hegele R.A. Metabolic syndrome in aboriginal Canadians. prevalence and genetic associations. Atherosclerosis 184 (2006) 121-129
52. Mahmood M.S., Mian Z.S., Afzal A., and Frossard P.M. G-protein beta-3 subunit gene 825C>T dimorphism is associated with left ventricular hypertrophy but not essential hypertension. Med Sci Monit 11 (2005) CR6-CR9