Gastroesophageal reflux disease is associated with the C825T polymorphism in the G-protein β3 subunit gene (GNB3)

American Journal of Gastroenterology

Volumn 104, Issue 2, 2009, Pages 281-285

  De Vries, D R ^a   Ter Linde, J J M ^a   Van Herwaarden, M A ^b   Smout, A J P M ^a   Samsom, M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b DEVENTER HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GENOMIC DNA; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT;

ADULT; ALLELE; ARTICLE; COMORBIDITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DYSPEPSIA; ESOPHAGUS PH; FEMALE; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL SYMPTOM; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUESTIONNAIRE; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADULT; AGED; BODY MASS INDEX; CASE-CONTROL STUDIES; DYSPEPSIA; ESOPHAGEAL PH MONITORING; FEMALE; GASTROESOPHAGEAL REFLUX; GENETIC PREDISPOSITION TO DISEASE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 59749088457     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2008.139     Document Type: Article

References (35)

1. Dent J, El Serag HB, Wallander MA et al. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 2005;54:710-7.
2. Locke GR, Zinsmeister AR, Fett SL et al. Overlap of gastrointestinal symptom complexes in a US community. Neurogastroenterol Motil 2005;17:29-34.
3. Louis E, DeLooze D, Deprez P et al. Heartburn in Belgium: prevalence, impact on daily life, and utilization of medical resources. Eur J Gastroenterol Hepatol 2002;14:279-84.
4. Bredenoord AJ, Weusten BLAM, Curvers WL et al. Determinants of perception of heartburn and regurgitation. Gut 2006;55:313-8.
5. Cicala M, Emerenziani S, Caviglia R et al. Intra-oesophageal distribution and perception of acid reflux in patients with non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2003;18:605-13.
6. Weusten B, Akkermans L, vanBerge-Henegouwen G et al. Symptom perception in gastroesophageal reflux disease is dependent on spatiotemporal reflux characteristics. Gastroenterology 1995;108:1739-44.
7. Trimble KC, Pryde A, Heading RC. Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut 1995;37:7-12.
8. Mehta AJ, De Caestecker JS, Camm AJ et al. Sensitization to painful distention and abnormal sensory perception in the esophagus. Gastroenterology 1995;108:311-9.
9. Sarkar S, Aziz Q, Woolf CJ et al. Contribution of central sensitisation to the development of non-cardiac chest pain. Lancet 2000;356:1154-9.
10. Fass R, Naliboff B, Higa L et al. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998;115:1363-73.
11. Mayer EA, Gebhart GF. Basic and clinical aspects of visceral hyperalgesia. Gastroenterology 1994;107:271-93.
12. de Vries DR, van Herwaarden MA, Baron A et al. Concomitant functional dyspepsia and irritable bowel syndrome decrease health-related quality of life in gastroesophageal reflux disease. Scand J Gastroenterol 2007;42:951-6.
13. Romero Y, Cameron AJ, Locke GR III et al. Familial aggregation of gastroesophageal reflux in patients with Barrett's esophagus and esophageal adenocarcinoma. Gastroenterology 1997;113:1449-56.
14. Trudgill NJ, Kapur KC, Riley SA. Familial clustering of reflux symptoms. Am J Gastroenterol 1999;94:1172-8.
15. Cameron AJ, Lagergren J, Henriksson C et al. Gastroesophageal reflux disease in monozygotic and dizygotic twins. Gastroenterology 2002;122:55-9.
16. Mohammed I, Cherkas LF, Riley SA et al. Genetic influences in gastro-oesophageal reflux disease: a twin study. Gut 2003;52:1085-9.
17. Siffert W, Rosskopf D, Siffert G et al. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998;18:45-8.
18. Camilleri CE, Carlson PJ, Camilleri M et al. A study of candidate genotypes associated with dyspepsia in a U.S. community. Am J Gastroenterol 2006;101:581-92.
19. Holtmann G, Siffert W, Haag S et al. G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functioncal) dyspepsia. Gastroenterology 2004;126:971-9.
20. Lelyveld Nv, Ter Linde JJM, Schipper M et al. Candidate genes in functional dyspepsia. Neurogastroenterol Motil 2008;20:767-73.
21. van Herwaarden M, Samsom M, Smout A. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations. Gastroenterology 2000;119:1439-46.
22. Wiener GJ, Richter JE, Copper JB et al. The symptom index - a clinically important parameter of ambulatory 24-hour esophageal Ph monitoring. Am J Gastroenterol 1988;83:358-61.
23. Weusten BL, Roelofs JM, Akkermans LM et al. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data . Gastroenterology 1994;107:1741-5.
24. Drossman DA. The functional gastrointestinal disorders and the Rome II process. Gut 1999;45:1-5.
25. Siffert W, Forster P, Jockel KH et al. Worldwide ethnic distribution of the G protein beta 3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 1999;10:1921-30.
26. Zar JH. Biostatistical Analysis, 4th edn, Prentice Hall International: New Jersey, 1999.
27. Andresen V, Camilleri M, Kim HJ et al. Is there an association between GN beta 3-C825T genotype and lower functional gastrointestinal disorders? Gastroenterology 2006;130:1985-94.
28. Zhang H, Cang CL, Kawasaki Y et al. Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. J Neurosci 2007;27:12067-77.
29. Yoshida N, Uchiyama K, Kuroda M et al. Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux disease . Scand J Gastroenterol 2004;39:816-22.
30. Adwanikar H, Ji G, Li W et al. Spinal CGRP1 receptors contribute to supraspinally organized pain behavior and pain-related sensitization of amygdala neurons. Pain 2007;132:53-66.
31. Greco R, Tassorelli C, Sandrini G et al. Role of calcitonin gene-related peptide and substance P in different models of pain. Cephalalgia 2008;28:114-26.
32. Ji G, Neugebauer V. Pro- and anti-nociceptive effects of corticotropin-releasing factor (CRF) in central amygdala neurons are mediated through different receptors. J Neurophysiol 2008;99:1201-12.
33. Kovelowski CJ, Ossipov MH, Sun H et al. Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. Pain 2000;87:265-73.
34. Neubert MJ, Kincaid W, Heinricher MM. Nociceptive facilitating neurons in the rostral ventromedial medulla. Pain 2004;110:158-65.
35. Siffert W. G protein polymorphisms inhypertension, atherosclerosis, and diabetes. Annu Rev Med 2005;56:17-28.