Interleukin 10 genotypes in irritable bowel syndrome: Evidence for an inflammatory component?

Gut

Volumn 52, Issue 1, 2003, Pages 91-93

  Gonsalkorale, W M ^a   Perrey, C ^b   Pravica, V ^b   Whorwell, P J ^a   Hutchinson, I V ^b  

^a MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA;

ALLELISM; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA EXTRACTION; GENE FREQUENCY; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOPATHOLOGY; IRRITABLE COLON; LEUKOCYTE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ALLELES; CASE-CONTROL STUDIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-10; TRANSFORMING GROWTH FACTOR BETA;

EID: 0037215492     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.52.1.91     Document Type: Article

References (24)

1. Quigley EMM. Disturbances in small bowel motility. In: Houghton LA, Whorwell PJ, eds. Clinical Gastroenterology: Irritable Bowel Syndrome. Baillière's Best Practice and Research, Vol 13. London: Baillière Tindall, 1999:385-96.
2. Spiller RC. Disturbances in large bowel motility. In: Houghton LA, Whorwell PJ, eds. Clinical Gastroenterology: Irritable Bowel Syndrome. Baillière's Best Practice and Research, Vol 13. London: Baillière Tindall, 1999:397-414.
3. Houghton LA. Sensory dysfunction and the irritable bowel syndrome. In: Houghton LA, Whorwell PJ, eds. Clinical Gastroenterology: Irritable Bowel Syndrome. Baillière's Best Practice and Research, Vol 13. London: Baillière Tindall, 1999:415-28.
4. King TS, Elia M, Hunter JO. Abnormal colonic fermentation in irritable bowel syndrome. Lancet 1998;352:1187-9.
5. Drossman DA, Creed FH, Fava GA, et al. Psychosocial aspects of the functional gastrointestinal disorders. Gastroenterol Int 1995;8:47-90.
6. Collins SM, Piche T, Rampal P. The putative role of inflammation in the irritable bowel syndrome. Gut 2001;49:743-5.
7. Weston AP, Biddle WL, Bhatia PS, et al. Terminal ileal mucosal mast cells in irritable bowel syndrome. Dig Dis Sci 1993;38:1590-5.
8. O'Sullivan M, Breslin NP, Harman I, et al. Increased mucosal mast cells-Evidence of an inflammatory response in IBS. Gut 1999;44(suppl 1):A132.
9. Isgar B, Harman M, Kaye MD, et al. Symptoms of irritable bowel syndrome in ulcerative colitis in remission. Gut 1983;24:190-2.
10. Bergin AJ, Donnelly TC, McKendrick MW, et al. Changes in ano-rectal function in persistent bowel disturbance following salmonella gastroenteritis. Eur J Gastroenterol Hepatol 1993;5:617-20.
11. Gwee KA, Graham JC, McKendrick MW, et al. Psychometric scores and persistence of irritable bowel syndrome after infectious diarrhoea. Lancet 1996;346:150-3.
12. Neal KR, Hebden J, Spiller R. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: Postal survey of patients. BMJ 1997;314:779-82.
13. Spiller RC, Jenkins D, Thornley JP, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000;47:804-11.
14. Wilson GA, Symons JA, McDowell TL, et al. Effects of a polymorphism in the human tumor necrosis factor promoter on transcriptional activation. Proc Natl Acad Sci USA 1997;94:3195-9.
15. Turner DM, Williams DM, Sankaran D, et al. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenetics 1997;24:1-8.
16. 1 production, fibrotic lung disease and graft fibrosis after lung transplantation. Transplantation 1998;66:1014-20.
17. Pravica V, Asderakis A, Perrey C, et al. In vitro production of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene. Eur J Immunogenet 1999;26:1-3.
18. McGuire W, Hill AV, Allsopp CE, et al. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature 1994;371:508-10.
19. Kuhn R, Lohler J, Rennick D, et al. Interleukin-10 deficient mice develop chronic enterocolitis. Cell 1993;75:263-74.
20. Tagore A, Gonsalkorale WM, Pravica V, et al. Interleukin-10 (IL-10) genotypes in inflammatory bowel disease. Tissue Antigens 1999;54:386-90.
21. Thomspon WG, Creed F, Drossman DA, et al. Functional bowel disorders and functional abdominal pain. Gastroenterol Int 1992;5:75-91.
22. 1 gene polymorphisms. Transplant Immunol 1999;7:127-8.
23. 1 and tumour necrosis factor-α genes: A technical report. Transpl Immunol 1998;6:193-7.
24. Crawley E, Kay R, Sillibourne J, et al. Polymorphic haplotypes of the IL-10 5′ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 1999;42:1101-8.