Antiphospholipid antibody-mediated reproductive failure in antiphospholipid syndrome

Clinical Reviews in Allergy and Immunology

Volumn 38, Issue 2-3, 2010, Pages 141-147

  Blank, Miri ^a   Shoenfeld, Yehuda ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Antiphospholipid; Antiphospholipid syndrome; Autoantibodies; Autoimmunity

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; DNA VACCINE; FATTY ACID BINDING PROTEIN; LIPOCORTIN 5; MITOCHONDRION ANTIBODY; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID ANTIBODY; THROMBOPLASTIN;

ANTIBODY TITER; ANTIPHOSPHOLIPID SYNDROME; ARTERY THROMBOSIS; AUTOIMMUNITY; DNA IMMUNIZATION; FETUS RESORPTION; FETUS WASTAGE; FIRST TRIMESTER PREGNANCY; HUMAN; INFERTILITY; INTRAUTERINE GROWTH RETARDATION; NIDATION; NONHUMAN; PLACENTA INSUFFICIENCY; PREECLAMPSIA; PREGNANCY DISORDER; RECURRENT ABORTION; REVIEW; SECOND TRIMESTER PREGNANCY; SPONTANEOUS ABORTION; THIRD TRIMESTER PREGNANCY; VEIN THROMBOSIS;

ANIMALS; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME;

EID: 77953326773     PISSN: 10800549     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12016-009-8146-x     Document Type: Review

References (73)

1. Carp HJ (2004) Antiphospholipid syndrome in pregnancy. Curr Opin Obstet Gynecol 16:129-135
2. Khamashta MA (1998) Management of thrombosis and pregnancy loss in the antiphospholipid syndrome. Lupus 7(Suppl 2):S162-S165
3. Carp HJ, Shoenfeld Y (2007) Anti-phospholipid antibodies and infertility. Clin Rev Allergy Immunol 32:159-161
4. Tincani A, Nuzzo M, Filippini M, Rovetto B, Gatti G, Barbolini E, Zatti S, Ramazzotto F, Lojacono A (2009) Obstetric manifestations of the antiphospholipid syndrome. In: Handbook of systemic autoimmune diseases. "Antiphospholipid syndrome in systemic autoimmune diseases". Edt, Cervera R, Reverter JC, and Khamashta M. Elsevier B.V. 10, 117-124
5. Hughes GRV, Harris EN, Gharavi AE (1986) The anti-cardiolipin syndrome. J Rheumatol 13:486-489
6. McNeil HP, Chesterman CN, Krilis SA (1991) Immunological and clinical importance of anti-phospholipid antibodies. Adv Immunol 49:193-280
7. Lee RM, Emlen W, Scott JR, Branch DW, Silver RM (1999) Anti-beta2-glycoprotein-I antibodies in women with recurrent spontaneous abortion, unexplained fetal death, and antiphospholipid syndrome. Am J Obstet Gynecol 181:642-648
8. Shimada K, Koike T, Ichikawa K, Tsutsumi A, Takabayashi K, Tomioka H, Yoshida S (1989) IgC class anti-cardiolipin antibody as a possible marker for evaluating fetal risk in patients with systemic lupus erythematosus. J Autoimmun 2:843-849
9. Out HJ, Kooijman CD, Bruins HW, Derksen RHWM (1991) Histopathological findings from patients with intrauterine fetal death and antiphospholipid antibodies. Eur J Obstet Gynecol 41:179-186
10. D'Anna R, Scilipoti A, Leonardi J, Scuderi M, Jasonni VM, Leonardi R (1997) Anticardiolipin antibodies in pre-eclampsia and intrauterine growth retardation. Clin Exp Obstet Gynecol 24:135-137
11. Shurtz-Swirsky R, Inbar O, Blank M, Cohen J, Bakimer R, Barnea ER, Shoenfeld Y (1993) In vitro effect of anticardiolipin autoantibodies upon total and pulsatile placental hCG secretion during early pregnancy. Amer J Reprod Immunol 29:206-210
12. diSimone N, Moroni PL, del Papa N, Raschi E, Caliandro D, De Carolas CS, Khamashta MA, Atsumi T, Hughes GR, Balestrieri G, Tincani A, Casali P, Caruso A (2000) Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein-I. Arthritis Rheum 43:140-150
13. Sebire NJ, Fox H, Backos M, Rai R, Paterson C, Regan L (2002) Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure. Hum Reprod 17:1067-1071
14. Blank M, Anafi L, Zandman-Goddard G, Krause I, Goldman S, Shalev E, Cervera R, Font J, Fridkin M, Thiesen HJ, Shoenfeld Y (2007) The efficacy of specific IVIG anti-idiotypic antibodies in antiphospholipid syndrome (APS): trophoblast invasiveness and APS animal model. Int Immunol 19:857-865
15. Galli M, Comfurious P, Massen C, Hemker MH, Be-Bates PJ, van-Breda P, Vriesman J (1990) Anti-cardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor Lancet 335:1544-1547
16. Pierangeli SS, Chen PP, Raschi E, Scurati S, Grossi C, Borghi MO, Palomo I, Harris EN, Meroni PL (2008) Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms. Semin Thromb Hemost 34:236-250
17. Bouma B, deGroot PG, Jean MH, van den Elsen JML, Ravelli RBG, Schouten A, Simmelink MJA, Derksen RWM, Kroon J, Gros P (1999) Adhesion mechanism of human beta2-glycoprotein I to phospholipids based on its crystal structure. EMBO J 18:5166-5174
18. Branch DW, Dudley DJ, Mitchell MD, Creighton KA, Abbott TM, Hammond EH, Daynes RA (1990) Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss. Am J Obstet Gynecol 163:210-216
19. Blank M, Cohen J, Toder V, Shoenfeld Y (1991) Induction of antiphospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc Natl Acad Sci USA 88:3069-3073
20. Suzuki T, Takabayashi K, Ichikawa K, Ishiguro IN, Yoshiki T, Koike T (1996) Effect of monoclonal anticardiolipin antibody on pregnant mice. J Rheumatol 23:83-86
21. Piona A, La Rosa L, Tincani A, Faden D, Magro G, Grasso S, Nicoletti F, Balestrieri G, Meroni PL (1995) Placental thrombosis and fetal loss after passive transfer of mouse lupus monoclonal or human polyclonal anti-cardiolipin antibodies in pregnant naive BALB/c mice. Scand J Immunol 41:427-432
22. George J, Blank M, Levy Y, Meroni P (1998) Differential effects of anti-beta2-glycoprotein I antibodies on endothelial cells and on the manifestations of experimental antiphospholipid syndrome. Circulation 97:900-906
23. Blank M, Shoenfeld Y, Cabilly S, Heldman Y, Fridkin M, Katchalski-Katzir E (1999) Prevention of experimental antiphospholipid syndrome and endothelial cell activation by synthetic peptides. Proc Natl Acad Sci USA 96:5164-5168
24. Blank M, Waisman A, Mozes E, Koike T, Shoenfeld Y (1999) Characteristics and pathogenic role of anti-beta2-glycoprotein I single-chain Fv domains: induction of experimental antiphospholipid syndrome. Int Immunol 11:1917-1926
25. Blank M, Faden D, Tincani A, Kopolovic J, Goldberg I, Gilburd B, Allegri F, Balestrieri G, Valesini G, Shoenfeld Y (1994) Immunization with anticardiolipin cofactor (beta-2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice. J Autoimmun 7:441-455 (Pubitemid 24268384)
26. Gharavi AE, Vega-Ostertag M, Espinola RG, Liu X, Cole L, Cox NT, Romagnoli P, Labat K, Pierangeli SS (2004) Intrauterine fetal death in mice caused by cytomegalovirus-derived peptide induced aPL antibodies. Lupus 13:17-23
27. Aron AL, Cuellar ML, Brey RL, Mckeown S, Espinoza LR, Shoenfeld Y, Gharavi AE (1995) Early onset of autoimmunity in MRL/++ mice following immunization with beta 2 glycoprotein I. Clin Exp Immunol 101:78-81
28. Blank M, George J, Barak V, Tincani A, Koike T, Shoenfeld Y (1998) Oral Tolerance to low dose β2-glycoprotein-I: immunomodulation of experimental antiphospholipid syndrome. J Immunology 161:5303-1512
29. Sthoeger ZM, Mozes E, Tartakovsky B (1993) Anti-cardiolipin antibodies induce pregnancy failure by impairing embryonic implantation. Proc Natl Acad Sci USA 90:6464-6467
30. Robertson SA, Roberts CT, van Beijering E, Pensa K, Sheng Y, Shi T, Krilis SA (2004) Effect of beta2-glycoprotein I null mutation on reproductive outcome and antiphospholipid antibody-mediated pregnancy pathology in mice. Mol Hum Reprod 10:409-416
31. Salmon JE, Girardi G (2008) Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation. J Reprod Immunol 77:51-56
32. Holers VM, Girardi G, Mo L, Guthridge JM, Molina H, Pierangeli SS, Espinola R, Xiaowei LE, Mao D, Vialpando CG, Salmon JE (2002) Complement C3 activation is required for antiphospholipid antibody induced fetal loss. J Exp Med 195:211-220 (Pubitemid 34461265)
33. Salmon JE, deGroot PG (2008) Pathogenic role of antiphospholipid antibodies. Lupus 17:405-411
34. Blank M, Krause I, Wildbaum G, Karin N, Shoenfeld Y (2003) TNFalpha DNA vaccination prevents clinical manifestations of experimental antiphospholipid syndrome. Lupus 12:546-549
35. Pierangeli SS, Liu XW, Anderson G, Barker GH, Harris EN (1996) Thrombogenic properties of murine anti-cardiolipin antibodies induced by beta2 glycoprotein I and human immunoglobulin G antiphospholipid antibodies. Circulation 94:1746-1751
36. Kornberg A, Blank M, Kaufman S, Shoenfeld Y (1994) Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J Immunol 153:1328-1332
37. Gliecher N, Barad D, Weghofer A (2007) Placental thrombosis and fetal loss after passive transfer of mouse lupus monoclonal or human polyclonal anti-cardiolipin antibodies in pregnant naive BALB/c mice. Autoimmun Rev 7:42-45
38. De Wolf F, Carreras LO, Moerman P, Vermylen J, Van Assche A, Renaer M (1982) Desidual vasculopathy and extensive placental infarction in a patient with repeated thromboembolic accidents, recurrent fetal loss, and a lupus anticoagulant. Am J Obstet Gynecol 142:829-834
39. Rand JH, Wu XX, Andree HAM, Lockwood CJ, Guller S, Scher J, Harpel PC (1997) Pregnancy loss in the antiphospholipidantibody syndrome - a possible thrombogenic mechanism. NEJM 337:154-160
40. Redecha P, Tilley R, Tencati M, Salmon JE, Kirchhofer D, Mackman N, Girardi G (2007) Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 110:2423-2431
41. Kirchhofer D, Moran P, Bullens S, Peale F, Bunting S (2005) A monoclonal antibody that inhibits mouse tissue factor function. J Thromb Haemost 3:1098-1099
42. Girardi G, Mackman N (2008) Tissue factor in antiphospholipid antibody-induced pregnancy loss: a pro-inflammatory molecule. Lupus 17:931-936
43. Moestrup SK, Schousboe I, Jacobsen C, Leheste JR, Christensen EI, Willnow TE (1998) Beta2-glycoprotein-I and beta2-glycoprotein-I complex harbor a recognition site for the endocytic receptor megalin. J Clin Invest 102:902-909
44. Ulcova-Gallova Z, Krauz V, Novakova P, Milichovska L, Micanova Z, Bibkova K, Sucha R, Turek J, Balvin M, Rokyta Z (2005) Anti-phospholipid antibodies against phosphatidylinositol, and phosphatidylserine are more significant in reproductive failure than antibodies against cardiolipin only. Am J Reprod Immunol 54:112-117
45. Matsubayashi H, Sugi T, Arai T et al (2001) Different anti-phospholipid antibody specificities are found in association with early repeated pregnancy loss versus recurrent IVF-failure patients. Am J Reprod Immunol 46:323-329
46. Sher G, Fisch JD, Maassarani G, Matzner W, Ching W, Chong P (2000) Antibodies to phosphatidylethanolamine and phosphatidylserine are associated with increased natural killer cell activity in non-male factor infertility patients. Hum Reprod 15:1932-1936
47. Katsuragawa H, Rote NS, Inoue T, Narukawa S, Kanzaki H, Mori T (1995) Monoclonal antiphosphatidylserine antibody reactivity against human first-trimester placental trophoblasts. Am J Obstet Gynecol 172:1592-1597
48. Vogt E, Lyden T, Rote NS (1992) Monoclonal antiphosphatidylserine antibody induces intrauterine growth retardation in BALB/c mice. Clin Exp Rheum 10:641-645
49. Blank M, Tincani A, Shoenfeld Y (1994) Induction of antiphospholipid syndrome in naive mice with purified IgG antiphosphatidylserine antibodies. J Rheumatol 21:100-104
50. Yodfat O, Blank M, Krause I, Shoenfeld Y (1996) The pathogenic role of antiphosphatidylserine antibodies: active immunization with the antibodies leads to the induction of antiphospholipid syndrome. 78:14-20
51. Matalon ST, Shoenfeld Y, Blank M, Yacobi S, von Landenberg P, Ornoy A (2004) Antiphosphatidylserine antibodies affect rat yolk sacs in culture: a mechanism for fetal loss in antiphospholipid syndrome. Am J Reprod Immunol 51:144-1451
52. McIntyre JA (2003) Antiphospholipid antibodies in implantation failures. Am J Reprod Immunol 49:221-229
53. Berard M, Chantome R, Marcelli A, Boffa MC (1996) Anti- phosphatidylethanolamine antibodies as the only antiphospholipid antibodies. I. Association with thrombosis and vascular coetaneous diseases. J Rheumatol 23:1369-1374
54. Sugi T, Katsunuma J, Izumi S, McIntyre JA, Makino T (1999) Prevalence and heterogeneity of antiphosphatidylethanolamine antibodies in patients with recurrent early pregnancy losses. Fertil Steril 71:1060-1065
55. Gris JC, Quere I, Sanmarco M, Boutiere B, Mercier E, Amiral J, Hubert AM, Ripart-Neveu S, Hoffet M, Tailland ML, Rousseau O, Monpeyroux F, Dauzat M, Sampol J, Daures JP, Berlan J, Mares P (2000) Antiphospholipid and antiprotein syndromes in non-thrombotic, non-autoimmune women with unexplained recurrent primary early foetal loss. The Nimes Obstetricians and Haematologists Study-NOHA. Thromb Haemost 84:228-236
56. Sugi T, McIntyre JA (2001) Anti-phosphatidylethanolamine antibodies in systemic lupus erythematosus. J Autoimmun 17:207-214
57. Hayashi Y, Aoki K, Kunimatsu M, Sasaki M, Yagami YA (1990) Sensitive assay for anti-phosphatidylethanol-amine antibody in patients with recurrent fetal loss. Nippon Sanka Fujinka Gakkai Zasshi 42:1565-1570
58. McIntyre JA, Wagenknecht DR (2000) Anti-phosphatidylethanolamine (aPE) antibodies: a survey. J Autoimmun 15:185-193
59. McIntyre JA, Wagenknecht DR, Sugi T (1997) Phospholipid binding plasma proteins required for antiphospholipid antibody detection - an overview. Am J Reprod Immunol 37:101-110
60. Katsunuma J, Sugi T, Inomo A, Matsubayashi H, Izumi SI, Makino T (2003) Kininogen domain 3 contains regions recognized by antiphosphatidyl-ethanolamine antibodies. J Thromb Haemost 1:132-138
61. Krikun G, Lockwood CJ, Wu XX, Zhou XD, Guller S, Calandri C, Guha A, Nemerson Y, Rand JH (1994) The expression of the placental anticoagulant protein, Annexin-V, by villous trophoblasts: immunolocalization and in vitro regulation. Placenta 15:601-612
62. Rand JH, Wu XX, Quinn AS, Taatjes DJ (2008) Resistance to annexin A5 anticoagulant activity: a thrombogenic mechanism for the antiphospholipid syndrome. Lupus 17:922-930
63. Rand JH, Wu XX, Guller S, Gil J, Guha A, Scher J, Lockwood CJ (1994) Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with aPL Abs and recurrent spontaneous abortion. Am J Obstet Gynecol 171:1566-1572
64. Rand JH, Wu XX, Quinn AS, Chen PP, McCrae KR, Bovill EG, Taatjes DJ (2003) Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay. Am J Pathol 163:1193-1200
65. Rand JH (2000) Antiphospholipid antibody-mediated disruption of the annexin-Vantithrombotic shield: a thrombogenic mechanism for the antiphospholipid syndrome. J Autoimmun 15:107-111
66. Matsubayashi H, Arai T, Izumi S, Sugi T, McIntyre JA, Makino T (2001) Anti-annexin V antibodies in patients with early pregnancy loss or implantation failure. Fertil Steril 76:694-699
67. Han X, Fiehler R, Broze GJ Jr (2000) Characterization of the protein Z-dependent protease inhibitor. Blood 96:3049-3055
68. Yin ZF, Huang ZF, Cui J, Fiehler R, Lasky N, Ginsburg D, Broze GJ Jr (2000) Prothrombotic phenotype of protein Z deficiency. Proc Natl Acad Sci USA 97:6734-6738
69. Forastiero RR, Martinuzzo ME, Lu L, Broze GJ (2003) Autoimmune antiphospholipid antibodies impair the imbition of activated factor X by protein Z/protein Z-dependent protease inhibitor. Thrombosis and Haemostasis 1:1764-1768
70. Gris JC, Amadio C, Mercier E, Lavigne-Lissalde G, Dechaud H, Hoffet M, Quere I, Amiral J, Dauzat M, Mares P (2003) Anti-protein Z antibodies in women with pathologic pregnancies. Blood 101:4850-4852
71. Font J, Lopez-Soto A, Cervera R, Casals FJ, Reverter JC, Munoz FJ, Miret C, Bove A, Ordinas A, Ingelmo M (1997) Antibodies to thromboplastin in systemic lupus erythematosus: isotype distribution and clinical significance in a series of 92 patients. Thromb Res 86:37-48
72. Tincani A, Meroni PL, Brucato A, Zanussi C, Allegri F, Mantelli P, Cattaneo RP, Balestrieri G (1985) Antiphospholipid and anti mitochondrial type 5 antibodies in systemic lupus erythematosus. Clin Exp Rheumatol 3:321-326
73. La Rosa L, Covini G, Galperin C, Catelli L, Del Papa N, Reina G, Morabito A, Balestrieri G, Tincani A, Gershwin ME, Meroni PL (1998) Anti-mitochondrial M5 type antibody represents one of serological markers for anti-phospholipid syndrome distinct from anti-cardiolipin and anti-β2 glycoprotein I antibodies. Clin Exp Immunol 112:144-151