Antiphospholipid antibodies in implantation failures

American Journal of Reproductive Immunology

Volumn 49, Issue 4, 2003, Pages 221-229

  McIntyre, John A ^a,b  

^a St Francis Hospital & Health Centers   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Anticardidipin; Antiphosphatidylethanolamine; Antiphosphatidylserine; Infertility; Lupus anticoagulant

Indexed keywords

AMINOPHOSPHOLIPID; CARDIOLIPIN; GONADOTROPIN; LOW MOLECULAR WEIGHT HEPARIN; MONOCLONAL ANTIBODY; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID ANTIBODY; POLYCLONAL ANTIBODY; SCRAMBLASE;

AMINO ACID TRANSPORT; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL DIVISION; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; CROSS REACTION; CYTOKINESIS; DRUG EFFECT; EMBRYO DEVELOPMENT; EUKARYOTIC CELL; EXPERIMENTAL MODEL; FERTILIZATION IN VITRO; HUMAN; NIDATION; NONHUMAN; PRIORITY JOURNAL; SPONTANEOUS ABORTION; SYNCYTIUM; TROPHOBLAST;

ANIMALS; ANTIBODIES, ANTIPHOSPHOLIPID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFERTILITY; MALE;

EID: 0038627715     PISSN: 87558920     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0897.2003.01197.x     Document Type: Article

References (66)

1. Triplett DA: Antiphospholipid antibodies and recurrent pregnancy loss. Am J Repro Immunol 1989; 20:52-67.
2. Rote NS: Antiphospholipid antibodies and recurrent pregnancy loss. Am J Repro Immunol 1996; 35:394-401.
3. Khamashta MA: Management of thrombosis and pregnancy loss in the antiphospholipid syndrome. Lupus 1998; 1998:S162-S165.
4. Vinatier D, Dufour P, Cosson M, Houpeau JL: Antiphospholipid syndrome and recurrent miscarriages. Eur J Obstet Gynecol Reprod Biol 2001; 96:37-50.
5. Sugi T, Katsunuma J, Izumi S-I, McIntyre JA, Makino T: Prevalence and heterogeneity of antiphosphatidylethanolamine antibodies in patients with recurrent early pregnancy losses. Fertil Steril 1999; 71:1060-1065.
6. Birkenfeld A, Mukaida T, Minichiello L, Jackson M, Kase NG, Yemini M: Incidence of autoimmune antibodies in failed embryo transfer cycles. Am J Repro Immunol 1994; 31:65-68.
7. Denis AL, Guido M, Adler RD, Bergh PA, Brenner C, Scott RT Jr: Antiphospholipid antibodies and pregnancy rates and outcome in in vitro fertilization patients. Fertil Steril 1997; 67:1084-1090.
8. Di Simone N, Meroni PL, Del Papa N, Raschi E, Caliandro D, De Carolis CS, Khamashta MA, Atsumi T, Hughes GR, Balestrieri G, Tincani A, Casali P, Caruso A: Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I. Arthritis Rheum 2000; 43:140-150.
9. Favaloro EJ, Silvestrini R, Mohammed A: Clinical utility of anticardiolipin antibody assays: High inter-laboratory variation and limited consensus by participants of external quality assurance programs signals a cautious approach. Pathology 1999; 31:142-147.
10. Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch DW, Piette JC, Brey R, Derksen RD, Harris EN, Hughes GR, Triplett DA, Khamashta MA: International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an international workshop. Arthritis Rheum 1999; 42:1309-1311.
11. Wilson WA, Gharavi AE, Piette JC: International classification criteria for antiphospholipid syndrome. Synopsis of a post-conference workshop held at the Ninth International (Tours) aPL Symposium. Lupus 2001;10:457-460.
12. McIntyre JA, Wagenknecht DR: Antiphospholipid antibodies. Risk assessments for solid organ, bone marrow, and tissue transplantation. Rheum Dis Clin North Am 2001; 27:611-631.
13. McCarty GA, Baddour VT, Giesler L, Wagenknecht DR, McIntyre JA: Antiphospholipid antibody syndrome (APS) patients with antiphosphatidylethanolamine antibodies (aPE) have APS clinical symptoms. J Autoimmun 2000; 15:A58.
14. McCarty GA, Wagenknecht DR, McIntyre JA: Antiphospholipid antibody syndrome (APS) patients with antiphosphatidylcholine antibodies (aPC) have APS clinical criteria. J Autoimmun 2000; 15:A59.
15. Lopez LR, Whittier AM, Dier KJ, Taylor DO, Buckner TR, Olsen LW, Fink CA: Clinical performance (sensitivity and agreement with thrombosis) of four antiphospholipid antibody assays. Am Clin Laboratory 2002; 21:41-44.
16. Matsuura E, Igarashi Y, Fujimoto M, Ichikawa K, Koike T: Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 1990; 336:177-178.
17. McIntyre JA, Wagenknecht DR, Sugi T: Phospholipid binding plasma proteins required for antiphospholipid antibody detection - An overview. Am J Reprod Immunol 1997; 37:101-110.
18. Wagenknecht DR, McIntyre JA: Characterization of a serum component necessary for detection of human antiphosphatidylcholine antibodies (aPC). Lupus 1998; 7:S207.
19. Chavez DJ, McIntyre JA: Sera from women with histories of repeated pregnancy losses cause abnormalities in mouse peri-implantation blastocysts. J Reprod Immunol 1984; 6:273-281.
20. Matalon ST, Shoenfeld Y, Blank M, Yacobi S, Blumenfeld Z, Ornoy A: The effects of IgG purified from women with SLE and associated pregnancy loss on rat embryos in in-vitro culture. Am J Repro Immunol 2002;48:296-303.
21. Di Simone N, Caliandro D, Castellani R, Ferrazzani S, De Carolis S, Caruso A: Low-molecular weight heparin restores in-vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G fractions obtained from patients with antiphospholipid syndrome. Hum Reprod 1999; 14:489-495.
22. Katsuragawa H, Kanzaki H, Inoue T, Hirano T, Mori T, Rote NS: Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion. Biol Reprod 1997; 56:50-58.
23. Rote NS, Vogt E, DeVere G, Obringer AR, Ng AK: The role of placental trophoblast in the pathophysiology of the antiphospholipid antibody syndrome. Am J Repro Immunol 1998; 39:125-136.
24. Wagenknecht DR, McIntyre JA: Interaction of heparin with B2-glycoprotein I and antiphospholipid antibodies in vitro. Thromb Res 1992; 68:495-500.
25. Shibata S, Harpel PC, Gharavi A, Rand J, Fillit H: Autoantibodies to heparin from patients with antiphospholipid antibody syndrome inhibit formation of antithrombin III-thrombin complexes. Blood 1994; 83:2532-2540.
26. Di Simone N, Castellani R, Caliandro D, Caruso A: Antiphospholipid antibodies regulate the expression of trophoblast cell adhesion molecules. Fertil Steril 2002; 77:805-811.
27. Merviel P, Challier J-C, Carbillion L, Foidart J-M, Uzan S: The role of integrins in human embryo implantation. Fetal Diagn Ther 2001; 16:364-371.
28. Gleicher N. Editorial. Am J Repro Immunol 2001; 46:330-331.
29. El-Roeiy A, Gleicher N, Friberg J, Confino E, Dudkiewicz A: Correlation between peripheral blood and follicular fluid autoantibodies and impact on in vitro fertilization. Obstet Gynecol 1987; 70:163-169.
30. Fisch B, Rikover Y, Shohat L, Zurgil N, Tadir Y, Ovadia J, Witz IP, Yron I: The relationship between in vitro fertilization and naturally occurring antibodies: Evidence for increased production of antiphospholipid autoantibodies. Fertil Steril 1991; 56:718-724.
31. Yron I, Tadir J, Ovadia J, Zurgil N, Firer M, Witz IP, Fisch B: Evidence for increased levels of circulating antiphospholipid autoantibodies in patients undergoing in vitro fertilization treatment. Ann N Y Acad Sci 1992; 651:599-601.
32. Geva E, Yaron Y, Lessing JB, Yovel I, Vardinon N, Burke M, Amit A: Circulating autoimmune antibodies may be responsible for implantation failure in in vitro fertilization. Fertil Steril 1994; 62:802-806.
33. Nip MM, Taylor PV, Rutherford AJ, Hancock KW: Autoantibodies and antisperm antibodies in sera and follicular fluids of infertile patients; Relation to reproductive outcome after in-vitro fertilization. Hum Reprod 1995; 10:2564-2569.
34. Fisch B, Fried S, Manor Y, Ovadia J, Witz IB, Yron I: Increased antiphospholipid antibody activity in in-vitro fertilization patients is not treatment-dependent but rather an inherent characteristic of the infertile state. Am J Repro Immunol 1995; 34:370-374.
35. Geva E, Amit A, Lerner-Geva L, Azem F, Yovel I, Lessing JB: Autoimmune disorders, another possible cause for in-vitro fertilization and embryo transfer failure. Hum Reprod 1995; 10:2560-2563.
36. Kaider BD, Price DE, Roussev RG, Coulam CB: Antiphospholipid antibody prevalence in patients with IVF failure. Am J Repro Immunol 1996; 35:388-393.
37. Balasch J, Creus M, Fabregues F, Reverter JC, Carmona F, Tassies D, Font J, Vanrell JA: Antiphospholipid antibodies and human reproductive failure. Hum Reprod 1996; 11:2310-2315.
38. Coulam CB, Kaider BD, Janowicz AS, Roussev RG: Antiphospholipid antibodies associated with implantation failure after IVF/ET. J Assist Reprod Genet 1997; 14:608-608.
39. Sher G, Zouves C, Feinman M, Maassarani G, Matzner W, Chong P, Ching W: A rational basis for the use of combined heparin/aspirin and IVIG immunotherapy in the treatment of recurrent IVF failure associated with antiphospholipid antibodies. Am J Repro Immunol 1998; 39:391-394.
40. Balasch J, Creus M, Fabregues F, Civico S, Reverter JC, Carmona F, Tassies D, Vanrell JA: Antiphospholipid antibodies and the outcome of pregnancy after the first in-vitro fertilization and embryo transfer cycle. Hum Reprod 1998; 13:1180-1183.
41. Beer AE, Kwak-Kim JY, Beaman KD, Gilman-Sachs A: Clinical utility of antiphospholipid antibodies? A Negative Study with Power! Fertil Steril 1998; 69:166-168.
42. Stern C, Chamley L, Hale L, Kloss M, Speirs A, Baker WG: Antibodies to B2 glycoprotein I are associated with in vitro fertilization implantation failure as well as recurrent miscarriage. Results of a prevalence study. Fertil Steril 1998; 70:938-943.
43. Sherer Y, Shoenfeld Y: Anti-phospholipid autoantibodies - Do they have a pathogenic role in infertility? Scand J Rheumatol 1998; 27:40-43.
44. Azem F, Geva E, Amit A, Lerner-Geva L, Shwartz T, Ben-Yosef D, Yovel I, Lessing JB: High levels of anticardiolipin antibodies in patients with abnormal embryo morphology who attended an in vitro fertilization program. Am J Reprod Immunol 1998; 39:161-163.
45. Egbase PE, Sharhan MA, Diejomaoh M, Grudzinskas JG: Antiphospholipid antibodies in infertile couples with two consecutive miscarriages after in-vitro fertilization and embryo transfer. Hum Reprod 1999; 14:1483-1486.
46. Bulla R, DeGuarrini F, Pausa M, Fischetti F, Meroni PL, DeSeta F, Guaschino S, Tedesco F: Inhibition of trophoblast adhesion to endothelial cells by the sera of women with recurrent spontaneous abortion. Am J Reprod Immunol 1999; 42:116-123.
47. Bick RL: Recurrent miscarriage syndrome due to blood coagulation protein/platelet defects, prevalence, treatment and outcome results. DRW Metroplex Recurrent Miscarriage Syndrome Cooperative Group. Clin Appl Thromb Hemost 2000; 6:115-125.
48. Vials JM: A literature review on the antiphospholipid syndrome and the effect on childbearing. Midwifery 2001; 17:142-149.
49. Matsubayashi H, Sugi T, Arai T, Kondo A, Suzuki T, Izumi S-I, McIntyre JA, Makino T: Different antiphospholipid antibody specificities are found in association with early repeated pregnancy loss versus recurrent IVF-failure patients. Am J Reprod Immunol 2001; 46:323-329.
50. Birdsall MA, Lockwood GM, Ledger WL, Johnson PM, Chamley LW: Antiphospholipid antibodies in women having in-vitro fertilization. Hum Reprod 1996; 11:1185-1189.
51. Branch DW, Hatasaka HH: Antiphospholipid antibodies and infertility: Fact or fallacy. Lupus 1998; 7:S90-S94.
52. Eldar-Geva T, Wood C, Lolatgis N, Rombauts L, Kovacs G, Fuscaldo J, Trounson AO: Cumulative pregnancy and live birth rates in women with antiphospholipid antibodies undergoing assisted reproduction. Hum Reprod 1999; 14:1461-1466.
53. Chilcott IT, Margara R, Cohen H, Rai R, Skull J, Pickering W, Regan L: Pregnancy outcome is not affected by antiphospholipid antibody status in women referred for in vitro fertilization. Fertil Steril 2000; 73:526-530.
54. Porter TF: Antiphospholipid antibodies and infertility. Clin Obstet Gynecol 2001; 44:29-35.
55. Hornstein MD, Davis OK, Massey JB, Paulson RJ, Collins JA: Antiphospholipid antibodies and in vitro fertilization success: A meta-analysis. Fertil Steril 2000; 73:330-333.
56. Hornstein MD: Antiphospholipid antibodies in patients undergoing IVF: The data do not support testing. Fertil Steril 2000; 74:635-636.
57. Backos M, Rai R, Regan L: Antiphospholipid antibodies and infertility. Hum Fertil 2002; 5:35-36.
58. Rai R, Regan L: Antiphospholipid antibodies in women undergoing in-vitro fertilization. Hum Reprod 1997; 12:197-199.
59. Empson M, Lassere M, Craig JC, Scott JR: Recurrent pregnancy loss with antiphospholipid antibody: A systematic review of therapeutic trials. Obstet Gynecol 2002; 99:135-144.
60. Kutteh WH, Yetman KL, Chantilis SJ, Crain J: Effect of antiphospholipid antibodies in women undergoing in-vitro fertilization: Role of heparin and aspirin. Hum Reprod 1997; 12:1171-1175.
61. Fisch B, Peled Y, Fried S, Ovadia J, Witz IP, Yron I: Detection of immunoglobulin A anticardiolipin antibodies in cervical mucus from in vitro fertilization patients and fertile women. Fertil Steril 1995; 64:441-443.
62. El-Roeiy A, Valesini G, Friberg J, Shoenfeld Y, Kennedy RC, Tincani A, Balestrieri G, Gleicher N: Autoantibodies and common idiotypes in men and women with sperm antibodies. Am J Obstet Gynecol 1988; 158:596-603.
63. Ulcova-Gallova Z, Krauz V, Rokyta Z: Six kinds of antiphospholipid antibodies (aPLs) in ovulatory mucus and seminal plasma from couples with repeated miscarriages. Int J Fertil Womens Medical 2000; 45:292-296.
64. Emoto K, Kobayashi T, Yamaji A, Aizawa H, Yahara I, Inoue K, Umeda M: Redistribution of phosphatidylethanolamine at the cleavage furrow of dividing cells during cytokinesis. Proc Natl Acad Sci U S A 1996; 93:12867-12872.
65. Emoto K, Umeda M: An essential role for a membrane lipid in cytokinesis. Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine. J Cell Biol 2000; 149:1215-1224.
66. Kaider BD, Coulam CB, Roussev RG: Murine embryos as a direct target for some human autoantibodies in vitro. Hum Reprod 1999; 14:2556-2561.