Differential effects of anti-β2-glycoprotein I antibodies on endothelial cells and on the manifestations of experimental antiphospholipid syndrome

Circulation

Volumn 97, Issue 9, 1998, Pages 900-906

  George, Jacob ^d   Blank, Miri ^d   Levy, Yair ^d   Meroni, Pierluigi ^a   Damianovich, Maya ^d   Tincani, Angela ^b   Shoenfeld, Yehuda ^c  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b SPEDALI CIVILI   (Italy)

^c SHEBA MEDICAL CENTER   (Israel)

^d NONE

Author keywords

Adhesion molecules; Antibodies; Endothelium; Immune system

Indexed keywords

BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; CELL ADHESION MOLECULE; EPITOPE; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; PHOSPHOLIPID ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CASE REPORT; CELL ADHESION; CELL LINE; CLINICAL FEATURE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FETUS RESORPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; THROMBOCYTOPENIA; UMBILICAL VEIN;

EID: 0032502289     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.97.9.900     Document Type: Article

References (31)

1. Hughes GRV. The antiphospholipid syndrome: ten years on. Lancet. 1993; 342:341-344.
2. Galli M, Comfurius MP, Maassen C, Hemker HC, De-Bates MH, vanBreda-Vriesman PJ, Barbui T, Zwaal RFA, Bevers EM. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet. 1990;335:1544-1547.
3. Matsuura E, Igarashi Y, Fujimoto M, Ichikawa K, Suzuki T, Sumida T, Yasuda T, Koike T. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol. 1992;148:3885-3891.
4. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Antiphospholipid antibodies are directed against a complex antigen that includes a lipid binding inhibitor of coagulation: β32GPI (apolipoprotein H). Proc Natl Acad Sci U S A. 1990;87:4120-4124.
5. Roubey RAS. Immunology of the antiphospholipid antibody syndrome. Arthritis Rheum. 1996;39:1444-1454.
6. Valesini G, Shoenfeld Y. A new player in the antiphospholipid syndrome: the β2 glycoprotein I cofactor. Autoimmunity. 1992;14:105-110.
7. Schultze HE, Heide H, Haput H. Uber ein bisher ubekanntes niedermole- kuaars β2-globin des humanserums. Naturwissenschften. 1961;48:719.
8. Kandiah DA, Krilis SA. Beta2-glycoprotein. Lupus. 1994;3:207-212.
9. Hunt JE, Krilis SA. The fifth domain of β2-glycoprotein-I contains a phospholipid binding site (Cys 281-Cys 288) and a region recognized by anticardiolipin antibodies. J Immunol. 1994;152:653-659.
10. Hunt JE, Simspon RJ, Krilis SA. Identification of a region of β2-glycoprotein I critical for lipid binding and anti-cardiolipin cofactor activity. Proc Natl Acad Sci U S A. 1993;90:2141-2145.
11. Roubey RAS. Eisenberg RA, Harper MF, Winfield JB. 'Anticardiolipin antibodies' recognize β2-glycoprotein in the absence of phospholipids: importance of antigen density and bivalent binding. J Immunol. 1995;154: 954-960.
12. 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J Exp Med. 1994;179:457-462.
13. Pengo V, Biasiolo A, Fior MG. Autoimmune antiphospholipid antibodies are directed against a cryptic epitope expressed when β2 glycoprotein I is bound to a suitable surface. Thromb Haemost. 1995;73:29-34.
14. Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Kobayashi S, Koike T. Antibodies to β2GPI and clinical manifestations in patients with systemic lupus erythematosus. Arthritis Rheum. 1996;39:1466-1474.
15. Cabral AR, Cabiedes J, Alarcon-Segovia D. Antibodies to phospholipid free β2 glycoprotein I in patients with primary antiphospholipid syndrome. J Rheumatol. 1995;24:1894-1898.
16. Arvieux J, Roussel B, Pouzol P, Colomb MG. Platelet activating properties of murine antibodies to β2GPI. Thromb Haemost. 1993;70:336-341.
17. Shi W, Chong BH, Chesterman CN. β2-Glycoprotein-I is a requirement for anticardiolipin antibodies binding to activated platelets: differences with lupus anticoagulants. Blood. 1993;81:1255-1262.
18. Del Papa N, Guidali L, Sala A, Buccellati C, Khamashta MA, Ichikawa K, Koike T, Balestrieri G, Tincani A, Hughes GRV, Meroni PL. Endothelial cells as target for antiphospholipid antibodies. Arthritis Rheum. 1997;3:551-561.
19. Simantov R, LaSala JM, Lo SK, Gharavi AE, Sammaritano LR, Salmon JE, Silverstein RL. Activation of cultured endothelial cells by antiphopholipid antibodies. J Clin Invest. 1995;96:2211-2219.
20. Blank M, Cohen J, Toder V, Shoenfeld Y. Induction of anti-phospholipid syndrome in naive mice with lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc Natl Acad Sci U S A. 1991;88:3069-3073.
21. Bakimer R, Fishman P, Blank M, Sredni B, Djaldetti M, Shoenfeld Y. Induction of primary antiphospholipid syndrome in mice by immunization with a human monoclonal anticardiolipin antibody (H-3). J Clin Invest. 1992;89:1558-1563.
22. 2 glycoprotein 1 and human immunoglobulin G antiphopholipid antibodies. Circulation. 1996;94:1746-1751.
23. Olee T, Pierangeli S, Handley HH, Le DT, Wei X, Lai CJ, En J. Novotny W, Harris EN, Woods VL, Chen PP. A monoclonal IgG anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in mice. Proc Natl Acad Sci U S A. 1996;93:8606-8611.
24. Shoenfeld Y, Hizi A, Tal R, Smorodinsky N, Gad L, Mor C, Schteren S, Mammon Z, Pinkhas J, Keydar I. Human monoclonal antibodies derived from lymph nodes of a patient with breast carcinoma react with MuMTV polypeptides. Cancer. 1987;59:43-50.
25. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. J Clin Invest. 1973;52:2745-2756.
26. Damianovich M, Gilburd B, George J, Del Papa N, Afek A, Goldberg I, Kopolovic Y, Roth D, Barkai G, Meroni PL, Shoenfeld Y. Pathogenic role of antiendothelial cell antibodies (AECA) in vasculitis: an idiotypic experimental model. J Immunol. 1996;156:4946-4951.
27. Carvalho D, Savage COS, Black CM, Pearson J. IgG anti-endothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. J Clin Invest. 1996;97:111-119.
28. Adamson P, Tighe M, Pearson JD. Protein tyrosine kinase inhibitor act downstream of IL-1 and LPS stimulated MAP-Kinas phosphorylation to inhibit expression of E-selectin on human umbilical vein endothelial cells. Cell Adhes Commun. 1996;3:511-525.
29. La Tonqueze M, Salozhin K, Dueymes M, Piette JC, Kovalev V, Shoenfeld Y, Nassonov E, Youinou P. Role of β2-glycoprotein I in the antiphospholipid antibody binding to endothelial cells. Lupus. 1995;4:179-186.
30. Blank M, Faden D, Tincani A, Kopolovic J, Goldberg I, Gilburd B, Allegri F, Balestrieri G, Valsini G, Shoenfeld Y. Immunization with anticardiolipin cofactor (beta-2 glycoprotein-I) induces antiphospholipid syndrome in naive mice. J Autoimmun. 1994;7:441-448.
31. Kornberg A, Blank M, Kaufman S, Shoenfeld Y. Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J Immunol. 1994;153:1328-1332.