메뉴 건너뛰기




Volumn 34, Issue 3, 2008, Pages 236-250

Antiphospholipid antibodies and the antiphospholipid syndrome: Pathogenic mechanisms

Author keywords

Anti 2 glycoprotein I antibodies; Antiphospholipid antibodies; Decidual cells; Endothelial cell activation; Lupus anticoagulant; Platelet activation; Pregnancy loss; Thrombosis; Trophoblast

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ABCIXIMAB; ACTIVATED PROTEIN C; ANTICOAGULANT AGENT; APOLIPOPROTEIN E2; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; CYCLIC AMP; DILAZEP; FIBRINOGEN RECEPTOR; FLUINDOSTATIN; HEPARIN; LUPUS ANTICOAGULANT; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE A2; PHOSPHOLIPID ANTIBODY; THEOPHYLLINE; THROMBOPLASTIN; VON WILLEBRAND FACTOR;

EID: 50249189294     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0028-1082267     Document Type: Review
Times cited : (197)

References (132)
  • 1
    • 0023434038 scopus 로고
    • Syndrome of the black swan
    • Harris EN. Syndrome of the black swan. Br J Rheumatol 1987;26:324-326
    • (1987) Br J Rheumatol , vol.26 , pp. 324-326
    • Harris, E.N.1
  • 2
    • 0033512274 scopus 로고    scopus 로고
    • International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome:report of an international workshop
    • Wilson WA, Gharavi AE, Koike T, et al. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome:report of an international workshop. Arthritis Rheum 1999;42:1309-1311
    • (1999) Arthritis Rheum , vol.42 , pp. 1309-1311
    • Wilson, W.A.1    Gharavi, A.E.2    Koike, T.3
  • 3
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    • Miyakis S, Lockshin MD, Atsumi I, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295-306
    • (2006) J Thromb Haemost , vol.4 , pp. 295-306
    • Miyakis, S.1    Lockshin, M.D.2    Atsumi, I.3
  • 6
    • 0141957076 scopus 로고    scopus 로고
    • Clinical relevance of antiprothrombin antibodies
    • Atsumi T, Koike T. Clinical relevance of antiprothrombin antibodies. Autoimmun Rev 2002;1:49-53
    • (2002) Autoimmun Rev , vol.1 , pp. 49-53
    • Atsumi, T.1    Koike, T.2
  • 7
    • 0023772539 scopus 로고
    • Antiprothrombin antibodies and the lupus anticoagulant
    • Fleck RA, Rapaport SI, Rao LV. Antiprothrombin antibodies and the lupus anticoagulant. Blood 1988;72:512-519
    • (1988) Blood , vol.72 , pp. 512-519
    • Fleck, R.A.1    Rapaport, S.I.2    Rao, L.V.3
  • 8
    • 0027253088 scopus 로고
    • Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C or protein S: An explanation for their pathogenic mechanism?
    • Oosting JD, Derksen RHWM, Bobbink IWG, Hacking TM, Bouma BN, deGroot PG. Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C or protein S: an explanation for their pathogenic mechanism? Blood 1993;83:2618-2625
    • (1993) Blood , vol.83 , pp. 2618-2625
    • Oosting, J.D.1    Derksen, R.H.W.M.2    Bobbink, I.W.G.3    Hacking, T.M.4    Bouma, B.N.5    deGroot, P.G.6
  • 9
    • 0028209969 scopus 로고
    • 2glycoprotein I in the expression of lupus anticoagulant activity
    • 2glycoprotein I in the expression of lupus anticoagulant activity. Blood 1994;83:2878-2892
    • (1994) Blood , vol.83 , pp. 2878-2892
    • Permpikul, P.1    Rao, L.V.M.2    Rapaport, S.I.3
  • 10
    • 0024433923 scopus 로고
    • Impaired catalytic function of activated protein C: A new in vitro manifestation of lupus anticoagulant
    • Marciniak E, Romond EH. Impaired catalytic function of activated protein C: a new in vitro manifestation of lupus anticoagulant. Blood 1989;74:2426-2432
    • (1989) Blood , vol.74 , pp. 2426-2432
    • Marciniak, E.1    Romond, E.H.2
  • 11
    • 34248523994 scopus 로고    scopus 로고
    • 2glycoprotein I and the homologous catalytic domains of several serine proteases
    • 2glycoprotein I and the homologous catalytic domains of several serine proteases. Arthritis Rheum 2007;56:1638-1647
    • (2007) Arthritis Rheum , vol.56 , pp. 1638-1647
    • Lin, W.S.1    Chen, P.C.2    Yang, C.D.3
  • 12
    • 34247153549 scopus 로고    scopus 로고
    • Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetal loss in mice
    • Chen XX, Gu YY, Li SJ, et al. Some plasmin-induced antibodies bind to cardiolipin, display lupus anticoagulant activity and induce fetal loss in mice. J Immunol 2007;178:5351-5356
    • (2007) J Immunol , vol.178 , pp. 5351-5356
    • Chen, X.X.1    Gu, Y.Y.2    Li, S.J.3
  • 13
    • 33744481250 scopus 로고    scopus 로고
    • Autoantibodies against the fibrinolytic receptor, annexin A2, in antiphospholipid syndrome
    • Cesarman-Maus G, Rios-Luna NP, Deora AB, et al. Autoantibodies against the fibrinolytic receptor, annexin A2, in antiphospholipid syndrome. Blood 2006;107:4375-4382
    • (2006) Blood , vol.107 , pp. 4375-4382
    • Cesarman-Maus, G.1    Rios-Luna, N.P.2    Deora, A.B.3
  • 14
    • 0026492990 scopus 로고
    • Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis
    • Ginsburg KS, Liang MH, Newcomer L, et al. Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis. Ann Intern Mcd 1992;117:997-1002
    • (1992) Ann Intern Mcd , vol.117 , pp. 997-1002
    • Ginsburg, K.S.1    Liang, M.H.2    Newcomer, L.3
  • 15
    • 0037297853 scopus 로고    scopus 로고
    • Pregnancy complications of the antiphospholipid syndrome
    • Tincani A, Balestrieri G, Danieli E, et al. Pregnancy complications of the antiphospholipid syndrome. Autoimmunity 2003;36:27-32
    • (2003) Autoimmunity , vol.36 , pp. 27-32
    • Tincani, A.1    Balestrieri, G.2    Danieli, E.3
  • 17
    • 33646462158 scopus 로고    scopus 로고
    • 2glycoprotein I antibodies are associated with pregnancy loss in women with the lupus anticoagulant
    • 2glycoprotein I antibodies are associated with pregnancy loss in women with the lupus anticoagulant. Thromb Haemost 2006;95:796-801
    • (2006) Thromb Haemost , vol.95 , pp. 796-801
    • Sailer, T.1    Zoghlami, C.2    Kurz, C.3
  • 18
    • 1842783797 scopus 로고    scopus 로고
    • The prevalence, onset and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus
    • McClain MT, Arbuckle MR, Heinlen LD, et al. The prevalence, onset and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus. Arthritis Rheum 2004;50:1226-1232
    • (2004) Arthritis Rheum , vol.50 , pp. 1226-1232
    • McClain, M.T.1    Arbuckle, M.R.2    Heinlen, L.D.3
  • 19
    • 28044458991 scopus 로고    scopus 로고
    • Multiorgan failure and antiphospholipid antibodies: The catastrophic antiphospholipid (Asherson's) syndrome
    • Ashcrson RA. Multiorgan failure and antiphospholipid antibodies: the catastrophic antiphospholipid (Asherson's) syndrome. Immunobiology 2005;210:727-733
    • (2005) Immunobiology , vol.210 , pp. 727-733
    • Ashcrson, R.A.1
  • 21
    • 0141791073 scopus 로고    scopus 로고
    • A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome
    • Crowther MA, GinsbergJS, Julian J, et al. A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome. N Engl J Med 2003;349:1133-1138
    • (2003) N Engl J Med , vol.349 , pp. 1133-1138
    • Crowther, M.A.1    Ginsberg, J.S.2    Julian, J.3
  • 22
    • 23844437705 scopus 로고    scopus 로고
    • A randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS)
    • Finazzi G, Marchioli R, Brancaccio V, et al. A randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS). J Thromb Haemost 2005;3:848-853
    • (2005) J Thromb Haemost , vol.3 , pp. 848-853
    • Finazzi, G.1    Marchioli, R.2    Brancaccio, V.3
  • 23
    • 0036045796 scopus 로고    scopus 로고
    • A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome
    • Erkan D, Yazici Y, Peterson MG, Sammaritano L, Lockshin MD. A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome. Rheumatology (Oxford) 2002;41:924-929
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 924-929
    • Erkan, D.1    Yazici, Y.2    Peterson, M.G.3    Sammaritano, L.4    Lockshin, M.D.5
  • 24
    • 36148929074 scopus 로고    scopus 로고
    • How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: A case-based review
    • Garcia DA, Khamashta MA, Crowther MA. How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: a case-based review. Blood 2007;110:3122-3127
    • (2007) Blood , vol.110 , pp. 3122-3127
    • Garcia, D.A.1    Khamashta, M.A.2    Crowther, M.A.3
  • 25
    • 34547407889 scopus 로고    scopus 로고
    • Aspirin for primary thrombosis prevention in the antiphospholipid syndrome
    • Erkan D, Harrison MJ, Levy R, et al. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome. Arthritis Rheum 2007;56:2382-2391
    • (2007) Arthritis Rheum , vol.56 , pp. 2382-2391
    • Erkan, D.1    Harrison, M.J.2    Levy, R.3
  • 26
    • 0033586656 scopus 로고    scopus 로고
    • Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo
    • Pierangeli SS, Colden-Stanfield M, Liu X, et al. Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 1999;99:1997-2000
    • (1999) Circulation , vol.99 , pp. 1997-2000
    • Pierangeli, S.S.1    Colden-Stanfield, M.2    Liu, X.3
  • 27
    • 0037217897 scopus 로고    scopus 로고
    • 2 glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster
    • 2 glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster. Blood 2003;101:157-162
    • (2003) Blood , vol.101 , pp. 157-162
    • Jankowski, M.1    Vreys, I.2    Wittevrongel, C.3
  • 28
    • 0025001363 scopus 로고
    • Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies
    • Malia RG, Kitchen S, Greaves M, Preston FE. Inhibition of activated protein C and its cofactor protein S by antiphospholipid antibodies. Br J Haematol 1990;76:101-107
    • (1990) Br J Haematol , vol.76 , pp. 101-107
    • Malia, R.G.1    Kitchen, S.2    Greaves, M.3    Preston, F.E.4
  • 29
    • 0032590070 scopus 로고    scopus 로고
    • 2-glycoprotein I is necessary to inhibit protein C activity by monoclonal anticardiolipin antibodies
    • 2-glycoprotein I is necessary to inhibit protein C activity by monoclonal anticardiolipin antibodies. Arthritis Rheum 1999;42:167-174
    • (1999) Arthritis Rheum , vol.42 , pp. 167-174
    • Ieko, M.1    Ichikawa, K.2    Triplett, D.A.3
  • 30
    • 0026582938 scopus 로고
    • Plasma from systemic lupus erythematosus patients with antiphospholipid antibodies promotes platelet aggregation
    • Escolar G, Font J, Reverter JC, et al. Plasma from systemic lupus erythematosus patients with antiphospholipid antibodies promotes platelet aggregation. Arterioscler Thromb 1992;12:196-200
    • (1992) Arterioscler Thromb , vol.12 , pp. 196-200
    • Escolar, G.1    Font, J.2    Reverter, J.C.3
  • 31
    • 0028959014 scopus 로고
    • Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation
    • Campbell AL, Pierangeli SS, Wellhausen S, Harris EN. Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid syndrome and with syphilis on platelet activation and aggregation. Thromb Haemost 1995;73:529-534
    • (1995) Thromb Haemost , vol.73 , pp. 529-534
    • Campbell, A.L.1    Pierangeli, S.S.2    Wellhausen, S.3    Harris, E.N.4
  • 32
    • 0023678887 scopus 로고
    • Immune mediated mechanism for thrombosis:antiphospholipid antibody binding to platelet membranes
    • Khamashta MA, Harris EN, Gharavi AE, et al. Immune mediated mechanism for thrombosis:antiphospholipid antibody binding to platelet membranes. Ann Rheum Dis 1988;47:849-854
    • (1988) Ann Rheum Dis , vol.47 , pp. 849-854
    • Khamashta, M.A.1    Harris, E.N.2    Gharavi, A.E.3
  • 33
    • 0028365677 scopus 로고
    • Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies
    • Kornberg A, Blank M, Kaufman S, Shoenfeld Y. Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J Immunol 1994;153:1328-1332
    • (1994) J Immunol , vol.153 , pp. 1328-1332
    • Kornberg, A.1    Blank, M.2    Kaufman, S.3    Shoenfeld, Y.4
  • 34
    • 0028883356 scopus 로고
    • Activation of cultured vascular endothelial cells by antiphospholipid antibodies
    • Simantov R, LaSala JM, Lo SK, et al. Activation of cultured vascular endothelial cells by antiphospholipid antibodies. J Clin Invest 1995;96:2211-2219
    • (1995) J Clin Invest , vol.96 , pp. 2211-2219
    • Simantov, R.1    LaSala, J.M.2    Lo, S.K.3
  • 36
    • 1842413134 scopus 로고    scopus 로고
    • Thrombosis in primary antiphospholipid syndrome - a pivotal role for monocyte tissue factor expression
    • Cuadrado MJ, Lopez-Pedrera C, Khamashta MA, et al. Thrombosis in primary antiphospholipid syndrome - a pivotal role for monocyte tissue factor expression. Arthritis Rheum 1997;40:834-841
    • (1997) Arthritis Rheum , vol.40 , pp. 834-841
    • Cuadrado, M.J.1    Lopez-Pedrera, C.2    Khamashta, M.A.3
  • 37
    • 0031886679 scopus 로고    scopus 로고
    • The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome
    • Amengual O, Atsumi T, Khamashta MA, Hughes GRV. The role of the tissue factor pathway in the hypercoagulable state in patients with the antiphospholipid syndrome. Thromb Haemost 1998;79:276-281
    • (1998) Thromb Haemost , vol.79 , pp. 276-281
    • Amengual, O.1    Atsumi, T.2    Khamashta, M.A.3    Hughes, G.R.V.4
  • 38
    • 18644361988 scopus 로고    scopus 로고
    • Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies
    • Vega-Ostertag M, Casper K, Swerlick R, Ferrara D, Harris EN, Pierangeli SS. Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies. Arthritis Rheum 2005;52:1545-1554
    • (2005) Arthritis Rheum , vol.52 , pp. 1545-1554
    • Vega-Ostertag, M.1    Casper, K.2    Swerlick, R.3    Ferrara, D.4    Harris, E.N.5    Pierangeli, S.S.6
  • 39
    • 0027256798 scopus 로고
    • Inhibition of heparin/antithrombin III cofactor activity by anticardiolipin antibodies: A mechanism for thrombosis
    • Chamley LW, McKay EJ, Pattison NS. Inhibition of heparin/antithrombin III cofactor activity by anticardiolipin antibodies: a mechanism for thrombosis. Thromb Res 1993;71:103-111
    • (1993) Thromb Res , vol.71 , pp. 103-111
    • Chamley, L.W.1    McKay, E.J.2    Pattison, N.S.3
  • 40
    • 0037148520 scopus 로고    scopus 로고
    • Complement C3 activation is required for antiphospholipid antibody-induced fetal loss
    • Holers VM, Girardi G, Mo L, et al. Complement C3 activation is required for antiphospholipid antibody-induced fetal loss. J Exp Med 2002;195:211-220
    • (2002) J Exp Med , vol.195 , pp. 211-220
    • Holers, V.M.1    Girardi, G.2    Mo, L.3
  • 41
    • 22244485396 scopus 로고    scopus 로고
    • Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia
    • Pierangeli SS, Girardi G, Vega-Ostertag M, Liu X, Espinola RG, Salmon J. Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Arthritis Rheum 2005;52:2120-2124
    • (2005) Arthritis Rheum , vol.52 , pp. 2120-2124
    • Pierangeli, S.S.1    Girardi, G.2    Vega-Ostertag, M.3    Liu, X.4    Espinola, R.G.5    Salmon, J.6
  • 42
    • 0036123462 scopus 로고    scopus 로고
    • Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies
    • Espinola RG, Pierangeli SS, Gharavi AE, Harris EN. Hydroxychloroquine reverses platelet activation induced by human IgG antiphospholipid antibodies. Thromb Haemost 2002;87:518-522
    • (2002) Thromb Haemost , vol.87 , pp. 518-522
    • Espinola, R.G.1    Pierangeli, S.S.2    Gharavi, A.E.3    Harris, E.N.4
  • 43
    • 0031442025 scopus 로고    scopus 로고
    • Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice
    • Edwards MH, Pierangeli S, Liu X, Barker JH, Anderson G, Harris EN. Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice. Circulation 1997;96:4380-4384
    • (1997) Circulation , vol.96 , pp. 4380-4384
    • Edwards, M.H.1    Pierangeli, S.2    Liu, X.3    Barker, J.H.4    Anderson, G.5    Harris, E.N.6
  • 44
    • 0027375161 scopus 로고
    • Antiphospholipid antibodies enhance thrombin-induced platelet activation and thromboxane formation
    • Martinuzzo ME, Maclouf J, Carreras LO, Levy-Toledano S. Antiphospholipid antibodies enhance thrombin-induced platelet activation and thromboxane formation. Thromb Haemost 1993;70:667-671
    • (1993) Thromb Haemost , vol.70 , pp. 667-671
    • Martinuzzo, M.E.1    Maclouf, J.2    Carreras, L.O.3    Levy-Toledano, S.4
  • 45
    • 0031594156 scopus 로고    scopus 로고
    • 2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: Association with increased excretion of platelet-derived thromboxane urinary metabolites
    • 2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. Thromb Haemost 1998;79:42-45
    • (1998) Thromb Haemost , vol.79 , pp. 42-45
    • Forastiero, R.1    Martinuzzo, M.2    Carreras, L.O.3    Maclouf, J.4
  • 46
    • 0031594519 scopus 로고    scopus 로고
    • 2 glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the antiphospholipid syndrome
    • 2 glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the antiphospholipid syndrome. J Rheumatol 1998;25:51-56
    • (1998) J Rheumatol , vol.25 , pp. 51-56
    • Robbins, D.L.1    Leung, S.2    Miller-Blair, D.J.3    Ziboh, V.4
  • 47
    • 12244286755 scopus 로고    scopus 로고
    • 2glycoprotein I induced synthesis of human platelet thromboxane A2 in vitro
    • 2glycoprotein I induced synthesis of human platelet thromboxane A2 in vitro. J Rheumatol 2003;30:55-59
    • (2003) J Rheumatol , vol.30 , pp. 55-59
    • Opara, R.1    Robbins, D.L.2    Ziboh, V.A.3
  • 48
    • 4444273214 scopus 로고    scopus 로고
    • Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin
    • Vega-Ostertag M, Harris EN, Pierangeli SS. Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin. Arthritis Rheum 2004;50:2911-2919
    • (2004) Arthritis Rheum , vol.50 , pp. 2911-2919
    • Vega-Ostertag, M.1    Harris, E.N.2    Pierangeli, S.S.3
  • 49
    • 27744494859 scopus 로고    scopus 로고
    • 2glycoprotein I for apoER2' on platelets is located in domain V
    • 2glycoprotein I for apoER2' on platelets is located in domain V. J Biol Chem 2005;280:36729-36736
    • (2005) J Biol Chem , vol.280 , pp. 36729-36736
    • van Lummel, M.1    Pennings, M.T.2    Derksen, R.H.3
  • 51
    • 33747023522 scopus 로고    scopus 로고
    • 2glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib/IX-V
    • 2glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib/IX-V. Arthritis Rheum 2006;54:2558-2567
    • (2006) Arthritis Rheum , vol.54 , pp. 2558-2567
    • Shi, T.1    Giannakopulos, B.2    Yan, X.3
  • 52
    • 34548816709 scopus 로고    scopus 로고
    • 2glycoprotein I inhibits von Willebrand factor-dependent platelet adhesion and aggregation
    • 2glycoprotein I inhibits von Willebrand factor-dependent platelet adhesion and aggregation. Blood 2007;110:1483-1491
    • (2007) Blood , vol.110 , pp. 1483-1491
    • Hulstein, J.J.1    Lenting, P.J.2    De Laat, B.3
  • 53
    • 0035793334 scopus 로고    scopus 로고
    • Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin
    • Pierangeli SS, Espinola RG, Liu X, Harris EN. Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin. Circ Res 2001;88:245-250
    • (2001) Circ Res , vol.88 , pp. 245-250
    • Pierangeli, S.S.1    Espinola, R.G.2    Liu, X.3    Harris, E.N.4
  • 55
    • 14744275911 scopus 로고    scopus 로고
    • Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprous related antiphospholipid antibodies
    • Forastiero RR, Martinuzzo M, De Larranaga G. Circulating levels of tissue factor and proinflammatory cytokines in patients with primary antiphospholipid syndrome or leprous related antiphospholipid antibodies. Lupus 2005;14:129-136
    • (2005) Lupus , vol.14 , pp. 129-136
    • Forastiero, R.R.1    Martinuzzo, M.2    De Larranaga, G.3
  • 56
    • 0033694198 scopus 로고    scopus 로고
    • Systemic endothelial cell markers in primary antiphospholipid syndrome
    • Williams FMK, Parmar K, Hughes GRV, Hunt BJ. Systemic endothelial cell markers in primary antiphospholipid syndrome. Thromb Haemost 2000;84:742-746
    • (2000) Thromb Haemost , vol.84 , pp. 742-746
    • Williams, F.M.K.1    Parmar, K.2    Hughes, G.R.V.3    Hunt, B.J.4
  • 58
    • 0029949753 scopus 로고    scopus 로고
    • Antiphospholipid antibodies (aPL) increase the potential monocyte procoa-gulant activity in patients with systemic lupus erythematosus
    • Martini F, Farsi A, Gori AM, et al. Antiphospholipid antibodies (aPL) increase the potential monocyte procoa-gulant activity in patients with systemic lupus erythematosus. Lupus 1996;5:206-211
    • (1996) Lupus , vol.5 , pp. 206-211
    • Martini, F.1    Farsi, A.2    Gori, A.M.3
  • 59
    • 0031876263 scopus 로고    scopus 로고
    • Effects of human monoclonal anticardiolipin antibodies on platelet function and on tissue factor expression on monocytes
    • Reverter JC, Tassies D, Font J, et al. Effects of human monoclonal anticardiolipin antibodies on platelet function and on tissue factor expression on monocytes. Arthritis Rheum 1998;41:1420-1427
    • (1998) Arthritis Rheum , vol.41 , pp. 1420-1427
    • Reverter, J.C.1    Tassies, D.2    Font, J.3
  • 60
    • 3242697048 scopus 로고    scopus 로고
    • Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep
    • Zhou H, Wolberg AS, Roubey RA. Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep. Blood 2004;104:2353-2358
    • (2004) Blood , vol.104 , pp. 2353-2358
    • Zhou, H.1    Wolberg, A.S.2    Roubey, R.A.3
  • 61
    • 0242721975 scopus 로고    scopus 로고
    • Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model
    • Ferrara DE, Liu X, Espinola RG, et al. Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model. Arthritis Rheum 2003;48:3272-3279
    • (2003) Arthritis Rheum , vol.48 , pp. 3272-3279
    • Ferrara, D.E.1    Liu, X.2    Espinola, R.G.3
  • 62
    • 7244237671 scopus 로고    scopus 로고
    • Fluvastatin inhibits upregulation of tissue factor expression by antiphospholipid antibodies on endothelial cells
    • Ferrara DE, Swerlick R, Casper K, et al. Fluvastatin inhibits upregulation of tissue factor expression by antiphospholipid antibodies on endothelial cells. J Thromb Haemost 2004;2:1558-1563
    • (2004) J Thromb Haemost , vol.2 , pp. 1558-1563
    • Ferrara, D.E.1    Swerlick, R.2    Casper, K.3
  • 63
    • 33750091036 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome
    • Cuadrado MJ, Buendia P, Velasco F, et al. Vascular endothelial growth factor expression in monocytes from patients with primary antiphospholipid syndrome. J Thromb Haemost 2006;4:2461-2469
    • (2006) J Thromb Haemost , vol.4 , pp. 2461-2469
    • Cuadrado, M.J.1    Buendia, P.2    Velasco, F.3
  • 65
    • 31044449865 scopus 로고    scopus 로고
    • Antiphopholipid antibodies from patients with the antiphospholipid syndrome induce tissue factor expression through the simultaneous activation of NF-KappaB/Rel proteins via p38 mitogen activated protein kinase pathway, and of the MEK-1/ERK pathway
    • López-Pedrera C, Buendia P, Cuadrado MJ, et al. Antiphopholipid antibodies from patients with the antiphospholipid syndrome induce tissue factor expression through the simultaneous activation of NF-KappaB/Rel proteins via p38 mitogen activated protein kinase pathway, and of the MEK-1/ERK pathway. Arthritis Rheum 2006;54:301-311
    • (2006) Arthritis Rheum , vol.54 , pp. 301-311
    • López-Pedrera, C.1    Buendia, P.2    Cuadrado, M.J.3
  • 66
    • 17644365392 scopus 로고    scopus 로고
    • Role of reactive oxygen species and p38 MAPK in the induction of the proadhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome
    • Simoncini S, Sapet C, Camoin-Jau L, et al. Role of reactive oxygen species and p38 MAPK in the induction of the proadhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome. Int Immunol 2005;17:489-500
    • (2005) Int Immunol , vol.17 , pp. 489-500
    • Simoncini, S.1    Sapet, C.2    Camoin-Jau, L.3
  • 67
    • 34548079756 scopus 로고    scopus 로고
    • Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation
    • Vega-Ostertag ME, Ferrara DE, Romay-Penabad Z, et al. Role of p38 mitogen-activated protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell activation. J Thromb Haemost 2007;5:1828-1834
    • (2007) J Thromb Haemost , vol.5 , pp. 1828-1834
    • Vega-Ostertag, M.E.1    Ferrara, D.E.2    Romay-Penabad, Z.3
  • 68
    • 34948875756 scopus 로고    scopus 로고
    • In vivo effects of an inhibitor of nuclear factor-kappa (k) B on thrombogenic properties of anti-phospholipid antibodies
    • Montiel-Manzano G, Romay-Penabad E, Papalardo de Martinez E, et al. In vivo effects of an inhibitor of nuclear factor-kappa (k) B on thrombogenic properties of anti-phospholipid antibodies. Ann N Y Acad Sci 2007;1108:540-553
    • (2007) Ann N Y Acad Sci , vol.1108 , pp. 540-553
    • Montiel-Manzano, G.1    Romay-Penabad, E.2    Papalardo de Martinez, E.3
  • 71
    • 36348953247 scopus 로고    scopus 로고
    • 2glycoprotein I ameliorates thrombosis induced by antiphospholipid antibodies in mice [abstract]
    • 2glycoprotein I ameliorates thrombosis induced by antiphospholipid antibodies in mice [abstract]. Arthritis Rheum 2006;54(Suppl):S559
    • (2006) Arthritis Rheum , vol.54 , Issue.SUPPL.
    • Ioannou, J.1    Harper, T.2    Romay-Penabad, Z.3
  • 73
    • 14944367961 scopus 로고    scopus 로고
    • 2glycoprotein I antibodies
    • 2glycoprotein I antibodies. Blood 2005;105:1964-1969
    • (2005) Blood , vol.105 , pp. 1964-1969
    • Zhang, J.1    McCrae, K.R.2
  • 74
    • 0037528699 scopus 로고    scopus 로고
    • Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    • Raschi E, Testoni C, Bosisio D, et al. Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 2003;101:3495-3500
    • (2003) Blood , vol.101 , pp. 3495-3500
    • Raschi, E.1    Testoni, C.2    Bosisio, D.3
  • 75
    • 34250721890 scopus 로고    scopus 로고
    • Toll like receptor 4 is involved in antiphospholipid-mediated thrombosis: In vivo studies
    • Pierangeli SS, Vega-Ostertag ME, Raschi E, et al. Toll like receptor 4 is involved in antiphospholipid-mediated thrombosis: in vivo studies. Ann Rheum Dis 2007;66:1327-1333
    • (2007) Ann Rheum Dis , vol.66 , pp. 1327-1333
    • Pierangeli, S.S.1    Vega-Ostertag, M.E.2    Raschi, E.3
  • 76
    • 34547733912 scopus 로고    scopus 로고
    • 2glycoprotein I antibodies induce monocyte release of tumor necrosis factor alpha and tissue factor by signal transduction pathways involving lipid rafts
    • 2glycoprotein I antibodies induce monocyte release of tumor necrosis factor alpha and tissue factor by signal transduction pathways involving lipid rafts. Arthritis Rheum 2007;56:2687-2697
    • (2007) Arthritis Rheum , vol.56 , pp. 2687-2697
    • Sorice, M.1    Longo, A.2    Capozzi, A.3
  • 77
    • 34948885608 scopus 로고    scopus 로고
    • C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies
    • Romay-Penabad Z, Liu X, Montiel-Manzano G, et al. C5a receptor-deficient mice are protected from thrombophilia and endothelial cell activation induced by some antiphospholipid antibodies. Ann N Y Acad Sci 2007;1108:554-566
    • (2007) Ann N Y Acad Sci , vol.1108 , pp. 554-566
    • Romay-Penabad, Z.1    Liu, X.2    Montiel-Manzano, G.3
  • 78
    • 27144494245 scopus 로고    scopus 로고
    • 2glycoprotein I is complement-dependent and requires a priming factor
    • 2glycoprotein I is complement-dependent and requires a priming factor. Blood 2005;106:2340-2346
    • (2005) Blood , vol.106 , pp. 2340-2346
    • Fischetti, F.1    Durigutto, P.2    Pellis, V.3
  • 79
    • 0034100612 scopus 로고    scopus 로고
    • Detection of complement-fixing antiphospholipid antibodies in association with thrombosis
    • Munakata Y, Saito T, Matsuda K, Seino J, Shibata S, Sasaki T. Detection of complement-fixing antiphospholipid antibodies in association with thrombosis. Thromb Haemost 2000;83:728-731
    • (2000) Thromb Haemost , vol.83 , pp. 728-731
    • Munakata, Y.1    Saito, T.2    Matsuda, K.3    Seino, J.4    Shibata, S.5    Sasaki, T.6
  • 80
    • 0033009331 scopus 로고    scopus 로고
    • Immunological abnormalities in primary APS evolving into SLE: 6 years follow-up in women with repeated pregnancy loss
    • Carbone J, Orera M, Rodriguez-Mahou M, et al. Immunological abnormalities in primary APS evolving into SLE: 6 years follow-up in women with repeated pregnancy loss. Lupus 1999;8:274-278
    • (1999) Lupus , vol.8 , pp. 274-278
    • Carbone, J.1    Orera, M.2    Rodriguez-Mahou, M.3
  • 81
    • 0026706529 scopus 로고
    • Antiphospholipid antibodies and complement activation in patients with cerebral ischemia
    • Davis WD, Brey RL. Antiphospholipid antibodies and complement activation in patients with cerebral ischemia. Clin Exp Rheumatol 1992;10:455-460
    • (1992) Clin Exp Rheumatol , vol.10 , pp. 455-460
    • Davis, W.D.1    Brey, R.L.2
  • 82
    • 0033495741 scopus 로고    scopus 로고
    • An IgG anti-prothrombin antibody enhances prothrombin binding to damaged endothelial cells and shortens plasma coagulation times
    • Zhao Y, Rumold R, Ahmed AE, et al. An IgG anti-prothrombin antibody enhances prothrombin binding to damaged endothelial cells and shortens plasma coagulation times. Arthritis Rheum 1999;42:2132-2138
    • (1999) Arthritis Rheum , vol.42 , pp. 2132-2138
    • Zhao, Y.1    Rumold, R.2    Ahmed, A.E.3
  • 83
    • 33748748970 scopus 로고    scopus 로고
    • A human monoclonal antiprothrombin antibody is thrombogenic in vivo and upregulates expression of tissue factor and E-selectin on endothelial cells
    • Vega-Ostertag M, Liu X, Kwna-ki H, Chen P, Pierangeli S. A human monoclonal antiprothrombin antibody is thrombogenic in vivo and upregulates expression of tissue factor and E-selectin on endothelial cells. Br J Haematol 2006;135:214-219
    • (2006) Br J Haematol , vol.135 , pp. 214-219
    • Vega-Ostertag, M.1    Liu, X.2    Kwna-ki, H.3    Chen, P.4    Pierangeli, S.5
  • 84
    • 0035893021 scopus 로고    scopus 로고
    • Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin bv antithrombin
    • Hwang KK, Grossman J, Visvanathan S, et al. Identification of anti-thrombin antibodies in the antiphospholipid syndrome that interfere with the inactivation of thrombin bv antithrombin. J Immunol 2001;167:7192-7198
    • (2001) J Immunol , vol.167 , pp. 7192-7198
    • Hwang, K.K.1    Grossman, J.2    Visvanathan, S.3
  • 85
    • 0037975660 scopus 로고    scopus 로고
    • A thrombin cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein C
    • Hwang KK, Yang CD, Yan W, et al. A thrombin cross-reactive anticardiolipin antibody binds to and inhibits the anticoagulant function of activated protein C. Arthritis Rheum 2003;48:1622-1630
    • (2003) Arthritis Rheum , vol.48 , pp. 1622-1630
    • Hwang, K.K.1    Yang, C.D.2    Yan, W.3
  • 86
    • 2142704424 scopus 로고    scopus 로고
    • Identification of anti-plasmin antibodies in the antiphospholipid syndrome that inhibit degradation of fibrin
    • Yang CD, Hwang KK, Yan W, et al. Identification of anti-plasmin antibodies in the antiphospholipid syndrome that inhibit degradation of fibrin. J Immunol 2004;172:5765-5773
    • (2004) J Immunol , vol.172 , pp. 5765-5773
    • Yang, C.D.1    Hwang, K.K.2    Yan, W.3
  • 87
    • 0036125784 scopus 로고    scopus 로고
    • Immunoglobulin G from patients with antiphospholipid syndrome impairs the fibrin dissolution with plasmin
    • Kolev K, Gombás J, Váradi B, et al. Immunoglobulin G from patients with antiphospholipid syndrome impairs the fibrin dissolution with plasmin. Thromb Haemost 2002;87:502-508
    • (2002) Thromb Haemost , vol.87 , pp. 502-508
    • Kolev, K.1    Gombás, J.2    Váradi, B.3
  • 88
    • 29144503118 scopus 로고    scopus 로고
    • Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome
    • Lu CS, Horizon AA, Hwang KK, et al. Identification of polyclonal and monoclonal antibodies against tissue plasminogen activator in the antiphospholipid syndrome. Arthritis Rheum 2005;52:4018-4027
    • (2005) Arthritis Rheum , vol.52 , pp. 4018-4027
    • Lu, C.S.1    Horizon, A.A.2    Hwang, K.K.3
  • 89
    • 1542373659 scopus 로고    scopus 로고
    • Antibodies to tissue plasmanogen activator (tPA) in patients with antiphospholipid syndrome: Evidence of interaction between the antibodies and the catalytic domain of tPA in patients
    • Cugno M, Caribbe M, Galli M, et al. Antibodies to tissue plasmanogen activator (tPA) in patients with antiphospholipid syndrome: evidence of interaction between the antibodies and the catalytic domain of tPA in patients. Blood 2004;103:2121-2126
    • (2004) Blood , vol.103 , pp. 2121-2126
    • Cugno, M.1    Caribbe, M.2    Galli, M.3
  • 90
    • 33751578678 scopus 로고    scopus 로고
    • Antibodies against the activated coagulation factor X (FXa) in the antiphospholipid syndrome that interfere with the FXa inactivation by antithrombin
    • Yang YH, Hwang KK, Fitzgerald J, et al. Antibodies against the activated coagulation factor X (FXa) in the antiphospholipid syndrome that interfere with the FXa inactivation by antithrombin. J Immunol 2006;177:8219-8225
    • (2006) J Immunol , vol.177 , pp. 8219-8225
    • Yang, Y.H.1    Hwang, K.K.2    Fitzgerald, J.3
  • 91
    • 34248523994 scopus 로고    scopus 로고
    • Lin WS, Chen PC, Yang CD, et al. Some antiphospholipid antibodies recognize conformational epitopes shared by ^glycoprotein I and the homologous catalytic domains of several serine proteases. Arthritis Rheum 2007;56:1638-1647
    • Lin WS, Chen PC, Yang CD, et al. Some antiphospholipid antibodies recognize conformational epitopes shared by (^glycoprotein I and the homologous catalytic domains of several serine proteases. Arthritis Rheum 2007;56:1638-1647
  • 92
    • 3242706212 scopus 로고    scopus 로고
    • Histologic features of placentas and abortion specimens from women with antiphospholipid and antiphospholipid-like syndromes
    • Van Horn JT, Craven C, Ward K, Branch DW, Silver RM. Histologic features of placentas and abortion specimens from women with antiphospholipid and antiphospholipid-like syndromes. Placenta 2004;25:642-648
    • (2004) Placenta , vol.25 , pp. 642-648
    • Van Horn, J.T.1    Craven, C.2    Ward, K.3    Branch, D.W.4    Silver, R.M.5
  • 93
    • 0030064150 scopus 로고    scopus 로고
    • Placental changes in a first trimester missed abortion in maternal systemic lupus erythematosus with antiphospholipid syndrome; a case report and review of the literature
    • Nayar R, Lage JM. Placental changes in a first trimester missed abortion in maternal systemic lupus erythematosus with antiphospholipid syndrome; a case report and review of the literature. Hum Pathol 1996;27:201-206
    • (1996) Hum Pathol , vol.27 , pp. 201-206
    • Nayar, R.1    Lage, J.M.2
  • 94
    • 0027146697 scopus 로고
    • The effect of immunoglobulin G fractions from patients with lupus anticoagulant on placental prostacyclin and thromboxane production
    • Peaceman AM, Rehnberg KA. The effect of immunoglobulin G fractions from patients with lupus anticoagulant on placental prostacyclin and thromboxane production. Am J Obstet Gynecol 1993;169:1403-1406
    • (1993) Am J Obstet Gynecol , vol.169 , pp. 1403-1406
    • Peaceman, A.M.1    Rehnberg, K.A.2
  • 95
    • 0037059463 scopus 로고    scopus 로고
    • Molecular pathogenesis of the antiphospholipid syndrome
    • Rand JH. Molecular pathogenesis of the antiphospholipid syndrome. Circ Res 2002;90:29-37
    • (2002) Circ Res , vol.90 , pp. 29-37
    • Rand, J.H.1
  • 97
    • 0028586742 scopus 로고
    • Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortion
    • Rand JH, Wu XX, Guller S, et al. Reduction of annexin-V (placental anticoagulant protein-I) on placental villi of women with antiphospholipid antibodies and recurrent spontaneous abortion. Am J Obstet Gynecol 1994;171:1566-1572
    • (1994) Am J Obstet Gynecol , vol.171 , pp. 1566-1572
    • Rand, J.H.1    Wu, X.X.2    Guller, S.3
  • 98
    • 0025823651 scopus 로고
    • Histopathological findings in placentae from patients with intra-uterine fetal death and anti-phospholipid antibodies
    • Out HJ, Kooijman CD, Bruinse HW, Derksen RH. Histopathological findings in placentae from patients with intra-uterine fetal death and anti-phospholipid antibodies. Eur J Obstet Gynecol Reprod Biol 1991;41:179-186
    • (1991) Eur J Obstet Gynecol Reprod Biol , vol.41 , pp. 179-186
    • Out, H.J.1    Kooijman, C.D.2    Bruinse, H.W.3    Derksen, R.H.4
  • 99
    • 0036117498 scopus 로고    scopus 로고
    • Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure
    • Sebire NJ, Fox H, Backos M, Rai R, Paterson C, Regan L. Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure. Hum Reprod 2002;17:1067-1071
    • (2002) Hum Reprod , vol.17 , pp. 1067-1071
    • Sebire, N.J.1    Fox, H.2    Backos, M.3    Rai, R.4    Paterson, C.5    Regan, L.6
  • 100
    • 0026600163 scopus 로고
    • Monoclonal antiphospholipid antibody reactivity against human placental trophoblast
    • Lyden TW, Vogt E, Ng AK, Johnson PM, Rote NS. Monoclonal antiphospholipid antibody reactivity against human placental trophoblast. J Reprod Immunol 1992;22:1-14
    • (1992) J Reprod Immunol , vol.22 , pp. 1-14
    • Lyden, T.W.1    Vogt, E.2    Ng, A.K.3    Johnson, P.M.4    Rote, N.S.5
  • 101
    • 0027199779 scopus 로고
    • Anti-cardiolipin antibodies induce pregnancy failure by impairing embryonic implantation
    • Sthoeger ZM, Mozes E, Tartakovsky B. Anti-cardiolipin antibodies induce pregnancy failure by impairing embryonic implantation. Proc Natl Acad Sci U S A 1993;90:6464-6467
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6464-6467
    • Sthoeger, Z.M.1    Mozes, E.2    Tartakovsky, B.3
  • 103
    • 0038714887 scopus 로고    scopus 로고
    • The effects of antiphospholipid antibodies obtained from women with SLE/APS and associated pregnancy loss on rat embryos and placental explants in culture
    • Ornoy A, Yacobi S, Matalon S, et al. The effects of antiphospholipid antibodies obtained from women with SLE/APS and associated pregnancy loss on rat embryos and placental explants in culture. Lupus 2003;12:573-578
    • (2003) Lupus , vol.12 , pp. 573-578
    • Ornoy, A.1    Yacobi, S.2    Matalon, S.3
  • 105
    • 0030027557 scopus 로고    scopus 로고
    • A model for the antiphospholipid antibody syndrome: Monoclonal antiphosphatidylserine antibody induces intrauterine growth restriction in mice
    • Vogt E, Ng AK, Rote NS. A model for the antiphospholipid antibody syndrome: monoclonal antiphosphatidylserine antibody induces intrauterine growth restriction in mice. Am J Obstet Gynecol 1996;174:700-707
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 700-707
    • Vogt, E.1    Ng, A.K.2    Rote, N.S.3
  • 106
    • 0031021017 scopus 로고    scopus 로고
    • Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion
    • Katsuragawa H, Kanzaki H, Inoue T, Hirano T, Mori T, Rote NS. Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion. Biol Reprod 1997;56:50-58
    • (1997) Biol Reprod , vol.56 , pp. 50-58
    • Katsuragawa, H.1    Kanzaki, H.2    Inoue, T.3    Hirano, T.4    Mori, T.5    Rote, N.S.6
  • 107
    • 0026322836 scopus 로고
    • Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies
    • Blank M, Cohen J, Toder V, Shoenfeld Y. Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc Natl Acad Sci U S A 1991;88:3069-3073
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 3069-3073
    • Blank, M.1    Cohen, J.2    Toder, V.3    Shoenfeld, Y.4
  • 108
    • 0031778067 scopus 로고    scopus 로고
    • Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c mice
    • Ikematsu W, Luan FL, La Rosa L, et al. Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c mice. Arthritis Rheum 1998;41:1026-1039
    • (1998) Arthritis Rheum , vol.41 , pp. 1026-1039
    • Ikematsu, W.1    Luan, F.L.2    La Rosa, L.3
  • 110
    • 0033798974 scopus 로고    scopus 로고
    • Leptin modulates extracellular matrix molecules and metallo-proteinases: Possible implications for trophoblast invasion
    • Castellucci M, De Matteis R, Meisser A, et al. Leptin modulates extracellular matrix molecules and metallo-proteinases: possible implications for trophoblast invasion. Mol Hum Reprod 2000;6:951-958
    • (2000) Mol Hum Reprod , vol.6 , pp. 951-958
    • Castellucci, M.1    De Matteis, R.2    Meisser, A.3
  • 111
    • 0036009815 scopus 로고    scopus 로고
    • Antiphospholid antibodies regulate the expression of trophoblast cell adhesion molecules
    • Di Simone N, Castellani R, Calandro D, Caruso A. Antiphospholid antibodies regulate the expression of trophoblast cell adhesion molecules. Fertil Steril 2002;77:805-811
    • (2002) Fertil Steril , vol.77 , pp. 805-811
    • Di Simone, N.1    Castellani, R.2    Calandro, D.3    Caruso, A.4
  • 112
    • 33747871430 scopus 로고    scopus 로고
    • Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome
    • Francis J, Rai R, Sebire NJ, et al. Impaired expression of endometrial differentiation markers and complement regulatory proteins in patients with recurrent pregnancy loss associated with antiphospholipid syndrome. Mol Hum Reprod 2006;12:435-442
    • (2006) Mol Hum Reprod , vol.12 , pp. 435-442
    • Francis, J.1    Rai, R.2    Sebire, N.J.3
  • 114
    • 10044247005 scopus 로고    scopus 로고
    • Adverse effects of lupus anticoagulant positive blood sera on placental viability can be prevented by heparin in vitro
    • Bose P, Black S, Kadyrov M, et al. Adverse effects of lupus anticoagulant positive blood sera on placental viability can be prevented by heparin in vitro. Am J Obstet Gynecol 2004;191:2125-2131
    • (2004) Am J Obstet Gynecol , vol.191 , pp. 2125-2131
    • Bose, P.1    Black, S.2    Kadyrov, M.3
  • 115
    • 1242308292 scopus 로고    scopus 로고
    • Antiphosphatidylserine antibodies affect rat yolk sacs in culture: A mechanism for fetal loss in antiphospholipid syndrome
    • Matalon ST, Shoenfeld Y, Blank M, Yacobi S, von Landenberg P, Ornoy A. Antiphosphatidylserine antibodies affect rat yolk sacs in culture: a mechanism for fetal loss in antiphospholipid syndrome. Am J Reprod Immunol 2004;51:144-151
    • (2004) Am J Reprod Immunol , vol.51 , pp. 144-151
    • Matalon, S.T.1    Shoenfeld, Y.2    Blank, M.3    Yacobi, S.4    von Landenberg, P.5    Ornoy, A.6
  • 117
    • 34547491690 scopus 로고    scopus 로고
    • The Th1/Th2 paradigm: Still important in pregnancy?
    • Chaouat G. The Th1/Th2 paradigm: still important in pregnancy? Semin Immunopathol 2007;29:95-113
    • (2007) Semin Immunopathol , vol.29 , pp. 95-113
    • Chaouat, G.1
  • 118
    • 0346969977 scopus 로고    scopus 로고
    • Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
    • Girardi G, Berman J, Redecha P, et al. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 2003;112:1644-1654
    • (2003) J Clin Invest , vol.112 , pp. 1644-1654
    • Girardi, G.1    Berman, J.2    Redecha, P.3
  • 119
    • 10844288801 scopus 로고    scopus 로고
    • TNF-α is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss
    • Berman J, Girardi G, Salmon JE. TNF-α is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss. J Immunol 2005;174:485-490
    • (2005) J Immunol , vol.174 , pp. 485-490
    • Berman, J.1    Girardi, G.2    Salmon, J.E.3
  • 120
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation
    • Girardi G, Redecha P, Salmon J. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 2004;10:1222-1226
    • (2004) Nat Med , vol.10 , pp. 1222-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.3
  • 121
    • 0028925978 scopus 로고
    • Placental thrombosis and fetal loss after passive transfer of mouse lupus monoclonal or human polyclonal anti-cardiolipin antibodies in pregnant naive BALB/c mice
    • Piona A, La Rosa L, Tincani A, et al. Placental thrombosis and fetal loss after passive transfer of mouse lupus monoclonal or human polyclonal anti-cardiolipin antibodies in pregnant naive BALB/c mice. Scand J Immunol 1995;41:427-432
    • (1995) Scand J Immunol , vol.41 , pp. 427-432
    • Piona, A.1    La Rosa, L.2    Tincani, A.3
  • 122
    • 33847794404 scopus 로고    scopus 로고
    • Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6
    • Martinez de la Torre Y, Buracchi C, Borroni EM, et al. Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. Proc Natl Acad Sci U S A 2007;104:2319-2324
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2319-2324
    • Martinez de la Torre, Y.1    Buracchi, C.2    Borroni, E.M.3
  • 123
    • 34948903311 scopus 로고    scopus 로고
    • Tissue factor: A link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury
    • Redecha P, Tilley R, Tentati M, et al. Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 2007;110:2423-2431
    • (2007) Blood , vol.110 , pp. 2423-2431
    • Redecha, P.1    Tilley, R.2    Tentati, M.3
  • 124
    • 33846930928 scopus 로고    scopus 로고
    • Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies
    • Shamonki JM, Salmon JE, Hyjek E, Baergen RN. Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies. Am J Obstet Gynecol 2007;196:167el-5
    • (2007) Am J Obstet Gynecol , vol.196
    • Shamonki, J.M.1    Salmon, J.E.2    Hyjek, E.3    Baergen, R.N.4
  • 125
    • 34247571341 scopus 로고    scopus 로고
    • Complement activation in anti-phospholipid syndrome: A clue for an inflammatory process?
    • Cavazzana I, Nebuloni M, Cetin I, et al. Complement activation in anti-phospholipid syndrome: a clue for an inflammatory process? J Autoimmun 2007;28:160-164
    • (2007) J Autoimmun , vol.28 , pp. 160-164
    • Cavazzana, I.1    Nebuloni, M.2    Cetin, I.3
  • 126
    • 0027057206 scopus 로고
    • Immune recognition at the maternal-fetal interface: Overview
    • McIntyre JA. Immune recognition at the maternal-fetal interface: overview. Am J Reprod Immunol 1992;28:127-131
    • (1992) Am J Reprod Immunol , vol.28 , pp. 127-131
    • McIntyre, J.A.1
  • 127
    • 0028030602 scopus 로고
    • 2glycoprotein I and placental anticoagulant protein I in placentae from patients with antiphospholipid syndrome
    • 2glycoprotein I and placental anticoagulant protein I in placentae from patients with antiphospholipid syndrome. J Rheumatol 1994;21:1684-1693
    • (1994) J Rheumatol , vol.21 , pp. 1684-1693
    • La Rosa, L.1    Meroni, P.L.2    Tincani, A.3
  • 128
    • 0028181357 scopus 로고
    • 2glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies
    • 2glycoprotein I contains a phospholipid binding site (Cys281-Cys288) and a region recognized by anticardiolipin antibodies. J Immunol 1994;152:653-659
    • (1994) J Immunol , vol.152 , pp. 653-659
    • Hunt, J.1    Krilis, S.A.2
  • 129
    • 0030587953 scopus 로고    scopus 로고
    • 2glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity
    • 2glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity. J Immunol 1996;157:3744-3751
    • (1996) J Immunol , vol.157 , pp. 3744-3751
    • Sheng, Y.1    Sali, A.2    Herzog, H.3    Lhanstein, J.4    Krilis, S.A.5
  • 131
    • 27144485326 scopus 로고    scopus 로고
    • Humoral autoimmunity against endothelium: Theory or reality?
    • Meroni P, Raschi E, Ronda N, Borghi MO. Humoral autoimmunity against endothelium: theory or reality? Trends Immunol 2005;26:275-281
    • (2005) Trends Immunol , vol.26 , pp. 275-281
    • Meroni, P.1    Raschi, E.2    Ronda, N.3    Borghi, M.O.4
  • 132
    • 0037169563 scopus 로고    scopus 로고
    • 2glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the antiphospholipid syndrome
    • 2glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the antiphospholipid syndrome. J Biol Chem 2002;277:2644-2649
    • (2002) J Biol Chem , vol.277 , pp. 2644-2649
    • Guerin, J.1    Sheng, Y.2    Reddel, S.3    Iverson, G.M.4    Chapman, M.G.5    Krilis, S.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.