Chapter 9 Obstetric Manifestations of the Antiphospholipid Syndrome

Handbook of Systemic Autoimmune Diseases

Volumn 10, Issue , 2009, Pages 117-124

  Tincani, Angela ^a   Nuzzo, Monica ^a   Filippini, Matteo ^a   Rovetto, Bettina ^a   Gatti, Giorgia ^a   Barbolini, Edoardo ^a   Zatti, Sonia ^a   Ramazzotto, Francesca ^a   Lojacono, Andrea ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

antiphospholipid syndrome; early miscarriages; fetal loss; HELLP syndrome; preeclampsia; pregnancy

Indexed keywords

EID: 67649639147     PISSN: 15715078     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1571-5078(08)00409-1     Document Type: Review

References (55)

1. ACOG Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin. Diagnosis and management of pre-eclampsia and eclampsia. Obstet. Gynecol. 99 (2002) 1959-1967
2. Asherson R.A. New subsets of the antiphospholipid syndrome in 2006: "PRE-APS" (probable APS) and microangiopathic antiphospholipid syndromes ("MAPS"). Autoimmun. Rev. 6 (2006) 76-80
3. Bar J., Mashiah R., Cohen-Sacher B., Hod M., Orvieto R., Ben-Rafael Z., and Lahav J. Effect of thromboprophylaxis on uterine and fetal circulation in pregnant women with a history of pregnancy complications. Thromb. Res. 101 (2001) 235-241
4. Bats A.S., Lejeune V., Cynober E., Safar E., Gonzales M., Milliez J., and Carbonne B. Antiphospholipid syndrome and second or third trimester fetal death: follow up in the next pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol. 114 (2004) 125-129
5. Benifla J.L., Tchobroutsky C., Uzan M., Sultan Y., Weill B.J., and Laumond-Barny S. Predictive value of uterine artery velocity wave forms in pregnancies complicated by systemic lupus erythematosus and antiphospholipid syndrome. Fetal. Diagn. Ther. 7 (1992) 195-202
6. Blumenfeld Z., Weiner Z., Lorber M., Sujov P., and Thaler I. Anticardiolipin antibodies in patients with recurrent pregnancy wastage: treatment and uterine blood flow. Obstet. Gynecol. 78 (1991) 584-589
7. Branch D.W. Antiphospholipid antibodies and fetal compromise. Thromb. Res. 114 (2004) 415-418
8. Branch D.W., Andres R., Digre K.B., Rote N.S., and Scott J.R. The association of antiphospholipid antibodies with severe pre-eclampsia. Obstet. Gynecol. 73 (1989) 541-545
9. Branch D.W., Scott J.R., Kochenour N.K., and Hershgold E. Obstetric complication associated with the lupus anticoagulant. N. Engl. J. Med. 313 (1985) 1322-1326
10. Branch D.W., Silver R.M., Blackwell J.L., Reading J.C., and Scott J.R. Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience. Obstet. Gynecol. 80 (1992) 614-620
11. Carreras L.O., Vermylen J., Spitz B., and Van Assche A. Lupus anticoagulant and inhibition of prostacyclin formation in patients with repeated abortion, intrauterine growth retardation and intrauterine death. Br. J. Obstet. Gynaecol. 88 (1981) 890-894
12. Caruso A., De Carolis S., Ferrazzani S., Valesini G., Caforio L., and Mancuso S. Pregnancy outcome in relation to uterine artery flow velocity wave forms and clinical characteristics in women with antiphospholipid syndrome. Obstet. Gynecol. 82 (1993) 970-977
13. D'Anna R., Scilipoti A., Leonardi J., Scuderi M., Jasonni V.M., and Leonardi R. Anticardiolipin antibodies in pre-eclampsia and intrauterine growth retardation. Clin. Exp. Obstet. Gynecol. 24 (1997) 135-137
14. De Carolis S., Botta A., Garofalo S., Ferrazzani S., Martino C., Fatigante G., Caforio L., and Caruso A. Uterine artery velocity waveforms as predictors of pregnancy out come in patients with antiphospholipid syndrome. Ann. N.Y. Acad. Sci. 1108 (2007) 530-539
15. Dekker G.A., de Vries J.I., Doelitzsch P.M., Huijgens P.C., von Blomberg B.M., Jakobs C., and van Geijn H.P. Underlying disorders associated with severe early-onset pre-eclampsia. Am. J. Obstet. Gynecol. 173 (1995) 1042-1048
16. Di Simone N., Meroni P.L., de Papa N., Raschi E., Caliandro D., De Carolis C.S., Khamashta M.A., Atsumi T., Hughes G.R., Balestrieri G., Tincani A., Casali P., and Caruso A. Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and trough adhered beta2 glycoprotein I. Arthritis Rheum. 43 (2000) 140-150
17. Dizon-Townson D., Miller C., Sibai B., Spong C.Y., Thom E., Wendel G.J.R., Wenstrom K., Samuels P., Cotroneo M.A., Moawad A., Sorokin Y., Meis P., Miodovnik M., O'Sullivan M.J., Conway D., Wapner R.J., Gabbe S.G., and National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. Obstet. Gynecol. 106 (2005) 517-524
18. Dreyfus M., Hedelin G., Kutnahorsky R., Lehmann M., Viville B., Langer B., Fleury A., M'Barek M., Treisser A., Wiesel M.L., and Pasquali J.L. Antiphospholipid antibodies and pre-eclampsia: a case-control studies. Obstet. Gynecol. 184 (2001) 825-832
19. Faden D., Tincani A., Tanzi P., Lojacono A., Spatola L., Tarntini M., and Balestrieri G. Anti-beta 2 glycoprotein I antibodies in a general obstetric population: preliminary results on the prevalence and correlation with pregnancy outcome. Anti-beta2 glycoprotein I antibodies are associated with some obstetrical complications, mainly pre-eclampsia-eclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 73 (1997) 37-42
20. Farquharson R.G., Quenby S., and Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet. Gynecol. 100 (2002) 408-413
21. Farrel T., and Dawson T. Can uterine artery Doppler velocimetry predict adverse pregnancy outcome in women with antiphospholipid syndrome? Acta. Obstet. Gynecol. Scand. 80 (2001) 609-610
22. Frias A.E., Luikenaar R.A., Sullivan A.E., Lee R.M., Porter T.F., Branch D.W., and Silver R.M. Poor obstetric outcome in subsequent pregnancies in women with prior fetal death. Obstet. Gynecol. 104 (2004) 521-526
23. Goldstein S.R. Embryonic death in early pregnancy: a new look at the first trimester. Obstet. Gynecol. 84 (1994) 294-297
24. Harris E.N., and Spinnato J.A. Should anticardiolipin tests be performed in otherwise healthy pregnant women? Am. J. Obstet. Gynecol. 165 (1991) 1272-1277
25. Holers V.M., Girardi G., Mo L., Guthridge J.M., Molina H., Pierangeli S.S., Espinola R., Xiaowei L.E., Mao D., Vialpando C.G., and Salmon J.E. Complement C3 activation is required for antiphospholipid antibody induced fetal loss. J. Exp. Med. 195 (2002) 211-220
26. Ishihara N., Matsuo H., Murakoshi H., Laoag-Fernandez J.B., Samoto T., and Maruo T. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either pre-eclampsia or intrauterine growth retardation. Am. J. Obstet. Gynecol. 186 (2002) 158-166
27. Kutteh W.H. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am. J. Obstet. Gynecol. 174 (1996) 1584-1589
28. Le Thi Huong D., Wechsler B., Vauthier-Brouzes D., Duhaut P., Costedoat N., Andreu M.R., Lefebvre G., and Piette J.C. The second trimester doppler ultrasound examination is the best predictor of late pregnancy outcome in systemic lupus erythematosus and/or the antiphospholipid syndrome. Rheumatology 45 (2006) 332-338
29. Lee R.M., Brown M.A., Branch D.W., Ward K., and Silver R.M. Anticardiolipin and anti-beta-2-glycoprotein-I antibodies in pre-eclampsia. Obstet. Gynecol. 102 (2003) 294-300
30. Lima F., Khamashta M.A., Buchanan N.M., Kerslake S., Hunt B.J., and Hughes G.R. A study of sixty pregnancies in patients with antiphospholipid syndrome. Clin. Exp. Rheumatol. 14 (1996) 131-136
31. Lockshin M.D., Druzin M.L., Goei S., Qamar T., Magid M.S., Jovanovic L., and Ferenc M. Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N. Engl. J. Med. 313 (1985) 152-156
32. Lynch A., Marlar R., Murphy J., Davila G., Santos M., Rutledge J., and Emlen W. Antiphospholipid antibodies in predicting adverse pregnancy outcome: a prospective study. Ann. Intern. Med. 120 (1994) 470-475
33. Martinez-Abundis E., González-Ortiz M., Cortés-Llamas V., and Salazar-Páramo M. Anticardiolipin antibodies and the severity of pre-eclampsia-eclampsia. Gynecol. Obstet. Invest. 48 (1999) 168-171
34. Matthiesen L.S., Berg G., Ernerudh J., and Skogh T. A prospective study on the occurrence of autoantibodies in low risk pregnancies. Eur. J. Obstet. Gynecol. Reprod. Biol. 83 (2001) 21-26
35. Meizner I., Katz M., and Press F. Assessment of utero-placental blood flow velocity wave forms in a pregnant patient with systemic lupus erythematosus. J. Clin. Ultrasound. 16 (1988) 55-57
36. Meroni P.L., Borghi M.O., Raschi E., Ventura D., Sarzi Puttini P.C., Atzeni F., Lonati L., Parati G., Tincani A., Mari D., and Tedesco F. Inflammatory response and the endothelium. Thromb. Res. 114 (2004) 329-334
37. Meroni P.L. d.S., N., Testoni C., D'Asta M., Acaia B., and Caruso A. Antiphospholipid antibodies as cause of pregnancy loss. Lupus 13 (2004) 649-652
38. Miyakis S., Lockshin M.D., Atsumi T., et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 4 (2006) 295-306
39. Oshiro B.T., Silver R.M., Scott J.R., Yu H., and Branch D.W. aPL and fetal death. Obstet. Gynecol. 87 (1996) 489-493
40. Out H.J., Bruinse H.W., Christiaens G.C., van Vliet M., de Groot P.G., Nieuwenhuis H.K., and Derksen R.H. A prospective, controlled multicenter study on the obstetric risks of pregnant women with antiphospholipid antibodies. Am. J. Obstet. Gynecol. 167 (1992) 26-32
41. Pattison N.S., Chamley L.W., Birdsall M., Zanderico A.M., Lddell H.S., and McDougall J. Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome? A randomized controlled trial. Am. J. Obstet. Gynecol. 183 (2000) 1008-1012
42. Rai R., Cohen H., Dave M., and Regan L. Randomized controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 314 (1997) 253-257
43. Rasmussen A., and Ravn P. High frequency of congenital thrombophilia in women with pathological pregnancies?. Acta Obstet. Gynecol. Scand. 83 (2004) 808-817
44. Salafia C.M., Pezzullo J.C., Ghidini A., Lopèz-Zeno J.A., and Whittington S.S. Clinical correlations of patterns of placental pathology in preterm pre-eclampsia. Placenta 19 (1998) 67-72
45. Scott R.A. Anticardiolipin antibodies and pre-eclampsia. Br. J. Obstet. Gynaecol. 94 (1987) 604-605
46. Sebire N.J., Fox H., Backos M., Rai R., Paterson C., and Regan L. Defective endovascular trophoblast invasion in primary antiphospholipid syndrome associated early pregnancy failure. Hum. Reprod. 17 (2002) 1067-1071
47. Shamonki J.M., Salmon J.E., Hyjek E., and Baergen R.N. Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies. Am. J. Obstet. Gynecol. (2007) 196
48. Soulier B., and Boffa M. Recurrent abortion, thrombosis and circulating antithromboplastin type anticoagulant. Nouv. Presse. Med. 9 (1980) 859-864
49. Stone S., Pijnenborg R., Vercruysse L., Poston R., Khamashta M.A., Hunt B.J., and Poston L. The placental bed in pregnancies complicated by primary antiphospholipid syndrome. Placenta 27 (2006) 457-467
50. Uncu G., Ozan H., Christiaens G.C., van Vliet M., de Groot P.G., Nieuwenhuis H.K., and Derksen R.H. Anticardiolipin antibodies in pregnancy induced hypertension. Eur. J. Obstet. Gynecol. Reprod. Biol. 70 (1996) 97-100
51. Van Horn J.T., Craven C., Ward K., Branch D.W., and Silver R.M. Histologic features of placentas and abortion specimen from women with antiphospholipid and antiphospholipid like syndromes. Placenta 25 (2004) 642-648
52. Van Pampus M.G., Dekker G.A., Wolf H., Huijgens P.C., Koopman M.M., von Blomberg B.M., and Büller H.R. High prevalence of hemostatic abnormalities in women with a history of severe pre-eclampsia. Am. J. Obstet. Gynecol. 180 (1999) 1146-1150
53. Venkat-Raman N., Backos M., Teoh T.G., Lo W.T., and Regan L. Uterine artery Doppler in predicting pregnancy outcome in women with antiphospholipid syndrome. Obstet. Gynecol. 98 (2001) 235-242
54. Vianna J., Khamashta M.A., Ordi-Ros J., et al. Comparison of the primary and secondary phospholipid syndrome: a European multicenter study of 114 patients. Am. J. Med. 96 (1994) 3-9
55. Wilson W.A., Gharavi A.E., Koike T., et al. International consensus statement on preliminary classification for definite antiphospholipid sindrome. Arthritis Rheum. 42 (1999) 1309-1311