Rotaviruses associate with cellular lipid droplet components to replicate in viroplasms, and compounds disrupting or blocking lipid droplets inhibit viroplasm formation and viral replication

Journal of Virology

Volumn 84, Issue 13, 2010, Pages 6782-6798

  Cheung, Winsome ^a   Gill, Michael ^b   Esposito, Alessandro ^b   Kaminski, Clemens F ^b   Courousse, Nathalie ^c   Chwetzoff, Serge ^c   Trugnan, Germain ^c   Keshavan, Nandita ^a   Lever, Andrew ^a   Desselberger, Ulrich ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL EXTRACT; DOUBLE STRANDED RNA; FAT DROPLET; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; NONSTRUCTURAL PROTEIN 5; PERILIPIN; PERILIPIN A; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACUTE GASTROENTERITIS; ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENSITY GRADIENT; FLUORESCENCE RESONANCE ENERGY TRANSFER; NONHUMAN; PRIORITY JOURNAL; ROTAVIRUS; VIROPLASM; VIRUS ASSEMBLY; VIRUS INCLUSION; VIRUS INFECTION; VIRUS REPLICATION;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; ISOPROTERENOL; LIPIDS; MICROSCOPY, CONFOCAL; ORGANELLES; PHOSPHOPROTEINS; ROTAVIRUS; TRIAZENES; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

ROTAVIRUS;

EID: 77953300336     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01757-09     Document Type: Article

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