The Obligate Intracellular Pathogen Chlamydia trachomatis Targets Host Lipid Droplets

Current Biology

Volumn 16, Issue 16, 2006, Pages 1646-1651

  Kumar, Yadunanda ^a   Cocchiaro, Jordan ^a   Valdivia, Raphael H ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

CELLBIO; MICROBIO

Indexed keywords

BACTERIAL PROTEIN; GREEN FLUORESCENT PROTEIN; LIPID;

ARTICLE; CELL VACUOLE; CHLAMYDIA TRACHOMATIS; COMPARATIVE STUDY; FLUORESCENCE MICROSCOPY; GENETICS; HELA CELL; HUMAN; METABOLISM; OPEN READING FRAME; PATHOGENICITY; YEAST;

BACTERIAL PROTEINS; CHLAMYDIA TRACHOMATIS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LIPIDS; MICROSCOPY, FLUORESCENCE; OPEN READING FRAMES; VACUOLES; YEASTS;

BACTERIA (MICROORGANISMS); CHLAMYDIA TRACHOMATIS; EUKARYOTA; MAMMALIA;

EID: 33747171783     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2006.06.060     Document Type: Article

References (25)

1. Martin S., and Parton R.G. Lipid droplets: A unified view of a dynamic organelle. Nat. Rev. Mol. Cell Biol. 7 (2006) 373-378
2. Schachter J. Infection and disease epidemiology. In: Stephens R.S. (Ed). Chlamydia: Intracellular Biology, Pathogenesis and Immunity (1999), A.S.M, Washington, D.C. 139-169
3. Fields K.A., and Hackstadt T. The chlamydial inclusion: Escape from the endocytic pathway. Annu. Rev. Cell Dev. Biol. 18 (2002) 221-245
4. van Ooij C., Kalman L., van Ijzendoorn S., Nishijima M., Hanada K., Mostov K., and Engel J.N. Host cell-derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis. Cell Microbiol. 2 (2000) 627-637
5. Su H., McClarty G., Dong F., Hatch G.M., Pan Z.K., and Zhong G. Activation of Raf/MEK/ERK/cPLA2 signaling pathway is essential for chlamydial acquisition of host glycerophospholipids. J. Biol. Chem. 279 (2004) 9409-9416
6. Stephens R.S., Kalman S., Lammel C., Fan J., Marathe R., Aravind L., Mitchell W., Olinger L., Tatusov R.L., Zhao Q., et al. Genome sequence of an obligate intracellular pathigen of humans: Chlamydia trachomatis. Science 282 (1998) 754-759
7. Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., et al. Illuminating the evolutionary history of chlamydiae. Science 304 (2004) 728-730
8. Sisko J.L., Spaeth K., Kumar Y., and Valdivia R.H. Multifunctional analysis of Chlamydia-specific genes in a yeast expression system. Mol. Microbiol. 60 (2006) 51-66
9. Miura S., Gan J.W., Brzostowski J., Parisi M.J., Schultz C.J., Londos C., Oliver B., and Kimmel A.R. Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. J. Biol. Chem. 277 (2002) 32253-32257
10. Smirnova E., Goldberg E.B., Makarova K.S., Lin L., Brown W.J., and Jackson C.L. ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells. EMBO Rep. 7 (2006) 106-113
11. Martin S., Driessen K., Nixon S.J., Zerial M., and Parton R.G. Regulated localization of Rab18 to lipid droplets: Effects of lipolytic stimulation and inhibition of lipid droplet catabolism. J. Biol. Chem. 280 (2005) 42325-42335
12. Ohashi M., Mizushima N., Kabeya Y., and Yoshimori T. Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets. J. Biol. Chem. 278 (2003) 36819-36829
13. Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J., Utterback T., Berry K., et al. Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39. Nucleic Acids Res. 28 (2000) 1397-1406
14. Nelson D.E., Crane D.D., Taylor L.D., Dorward D.W., Goheen M.M., and Caldwell H.D. Inhibition of chlamydiae by primary alcohols correlates with the strain-specific complement of plasticity zone phospholipase D genes. Infect. Immun. 74 (2006) 73-80
15. Marchesan D., Rutberg M., Andersson L., Asp L., Larsson T., Boren J., Johansson B.R., and Olofsson S.O. A phospholipase D-dependent process forms lipid droplets containing caveolin, adipocyte differentiation-related protein, and vimentin in a cell-free system. J. Biol. Chem. 278 (2003) 27293-27300
16. Ohsaki Y., Maeda T., and Fujimoto T. Fixation and permeabilization protocol is critical for the immunolabeling of lipid droplet proteins. Histochem. Cell Biol. 124 (2005) 445-452
17. Mullner H., and Daum G. Dynamics of neutral lipid storage in yeast. Acta Biochim. Pol. 51 (2004) 323-347
18. Sorger D., Athenstaedt K., Hrastnik C., and Daum G. A yeast strain lacking lipid particles bears a defect in ergosterol formation. J. Biol. Chem. 279 (2004) 31190-31196
19. Igal R.A., Wang P., and Coleman R.A. Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: Evidence for functionally separate pools of acyl-CoA. Biochem. J. 324 (1997) 529-534
20. Brasaemle D.L., Dolios G., Shapiro L., and Wang R. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J. Biol. Chem. 279 (2004) 46835-46842
21. Liu P., Ying Y., Zhao Y., Mundy D.I., Zhu M., and Anderson R.G. Chinese hamster ovary K2 cell lipid droplets appear to be metabolic organelles involved in membrane traffic. J. Biol. Chem. 279 (2004) 3787-3792
22. Umlauf E., Csaszar E., Moertelmaier M., Schuetz G.J., Parton R.G., and Prohaska R. Association of stomatin with lipid bodies. J. Biol. Chem. 279 (2004) 23699-23709
23. Pol A., Martin S., Fernandez M.A., Ingelmo-Torres M., Ferguson C., Enrich C., and Parton R.G. Cholesterol and fatty acids regulate dynamic caveolin trafficking through the Golgi complex and between the cell surface and lipid bodies. Mol. Biol. Cell 16 (2005) 2091-2105
24. Sandager L., Gustavsson M.H., Stahl U., Dahlqvist A., Wiberg E., Banas A., Lenman M., Ronne H., and Stymne S. Storage lipid synthesis is non-essential in yeast. J. Biol. Chem. 277 (2002) 6478-6482
25. Leber R., Zinser E., Zellnig G., Paltauf F., and Daum G. Characterization of lipid particles of the yeast, Saccharomyces cerevisiae. Yeast 10 (1994) 1421-1428