-
1
-
-
0020554087
-
The pharmacology and clinical use of methotrexate
-
Jolivet J, Cowan KH, Curt GA, Clendeninn NJ, Chabner BA. The pharmacology and clinical use of methotrexate. N Engl J Med 1983;309:1094-104.
-
(1983)
N Engl J Med
, vol.309
, pp. 1094-1104
-
-
Jolivet, J.1
Cowan, K.H.2
Curt, G.A.3
Clendeninn, N.J.4
Chabner, B.A.5
-
2
-
-
3042575322
-
Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent
-
s
-
Adjei AA. Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent. Clin Cancer Res 2004;10:4276-80s.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4276-4280
-
-
Adjei, A.A.1
-
3
-
-
0032950347
-
Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis
-
Mendelsohn LG, Shih C, Chen VJ, Habeck LL, Gates SB, Shackelford KA. Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis. Semin Oncol 1999;26:42-7.
-
(1999)
Semin Oncol
, vol.26
, pp. 42-47
-
-
Mendelsohn, L.G.1
Shih, C.2
Chen, V.J.3
Habeck, L.L.4
Gates, S.B.5
Shackelford, K.A.6
-
4
-
-
0024552914
-
Inhibition of human dihydrofolate reductase by antifolyl polyglutamates
-
Kumar P, Kisliuk RL, Gaumont Y, Freisheim JH, Nair MG. Inhibition of human dihydrofolate reductase by antifolyl polyglutamates. Biochem Pharmacol 1989;38:541-3.
-
(1989)
Biochem Pharmacol
, vol.38
, pp. 541-543
-
-
Kumar, P.1
Kisliuk, R.L.2
Gaumont, Y.3
Freisheim, J.H.4
Nair, M.G.5
-
5
-
-
0344393780
-
Resistance to antifolates
-
Zhao R, Goldman ID. Resistance to antifolates. Oncogene 2003;22:7431-57.
-
(2003)
Oncogene
, vol.22
, pp. 7431-7457
-
-
Zhao, R.1
Goldman, I.D.2
-
6
-
-
0017125903
-
Folate metabolism in mammalian cells in culture. I. Partial characterization of the folate derivatives present in L1210 mouse leukemia cells
-
Moran RG, Werkheiser WC, Zakrzewski SF. Folate metabolism in mammalian cells in culture. I. Partial characterization of the folate derivatives present in L1210 mouse leukemia cells. J Biol Chem 1976;251:3569-75.
-
(1976)
J Biol Chem
, vol.251
, pp. 3569-3575
-
-
Moran, R.G.1
Werkheiser, W.C.2
Zakrzewski, S.F.3
-
7
-
-
0024511031
-
Interaction of folylpolyglutamates with enzymes in one-carbon metabolism
-
Schirch V, Strong WB. Interaction of folylpolyglutamates with enzymes in one-carbon metabolism. Arch Biochem Biophys 1989;269:371-80.
-
(1989)
Arch Biochem Biophys
, vol.269
, pp. 371-380
-
-
Schirch, V.1
Strong, W.B.2
-
8
-
-
0031852056
-
Multiple folate enzyme inhibition: Mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)
-
Shih C, Habeck LL, Mendelsohn LG, Chen VJ, Schultz RM. Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). Adv Enzyme Regul 1998;38:135-52.
-
(1998)
Adv Enzyme Regul
, vol.38
, pp. 135-152
-
-
Shih, C.1
Habeck, L.L.2
Mendelsohn, L.G.3
Chen, V.J.4
Schultz, R.M.5
-
9
-
-
0025302665
-
Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: A pilot prognostic factor analysis
-
Whitehead VM, Rosenblatt DS, Vuchich MJ, Shuster JJ, Witte A, Beaulieu D. Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis. Blood 1990;76:44-9.
-
(1990)
Blood
, vol.76
, pp. 44-49
-
-
Whitehead, V.M.1
Rosenblatt, D.S.2
Vuchich, M.J.3
Shuster, J.J.4
Witte, A.5
Beaulieu, D.6
-
10
-
-
0030034467
-
Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate
-
Masson E, Relling MV, Synold TW, et al. Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate. J Clin Invest 1996;97:73-80.
-
(1996)
J Clin Invest
, vol.97
, pp. 73-80
-
-
Masson, E.1
Relling, M.V.2
Synold, T.W.3
-
11
-
-
34548772193
-
-
Available from
-
UCSC Genome Browser. 2006. Available from: http://www.genome.ucsc.edu/ cgi-bin/htGateway.
-
(2006)
UCSC Genome Browser
-
-
-
12
-
-
0028818711
-
Structural organization of the human folypoly-γ-glutamate synthetase gene: Evidence for a single genomic locus
-
Taylor SM, Freemantle SJ, Moran RG. Structural organization of the human folypoly-γ-glutamate synthetase gene: evidence for a single genomic locus. Cancer Res 1995;55:6030-4.
-
(1995)
Cancer Res
, vol.55
, pp. 6030-6034
-
-
Taylor, S.M.1
Freemantle, S.J.2
Moran, R.G.3
-
13
-
-
0028921872
-
Upstream organization of and multiple transcripts from the human folylpoly-γ-glutamate synthetase gene
-
Freemantle SJ, Taylor SM, Krystal G, Moran RG. Upstream organization of and multiple transcripts from the human folylpoly-γ-glutamate synthetase gene. J Biol Chem 1995;270:9579-84.
-
(1995)
J Biol Chem
, vol.270
, pp. 9579-9584
-
-
Freemantle, S.J.1
Taylor, S.M.2
Krystal, G.3
Moran, R.G.4
-
14
-
-
0037377560
-
Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line
-
Wang Y, Zhao R, Goldman ID. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. Biochem Pharmacol 2003;65:1163-70.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 1163-1170
-
-
Wang, Y.1
Zhao, R.2
Goldman, I.D.3
-
15
-
-
0043264010
-
Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania
-
El-Fadili A, Richard D, Kundig C, Ouellette M. Effect of polyglutamylation of methotrexate on its accumulation and the development of resistance in the protozoan parasite Leishmania. Biochem Pharmacol 2003;66:999-1008.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 999-1008
-
-
El-Fadili, A.1
Richard, D.2
Kundig, C.3
Ouellette, M.4
-
16
-
-
0034714363
-
Molecular analysis of murine leukemia cell lines resistant to 5,10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase
-
Zhao R, Titus S, Gao F, Moran RG, Goldman ID. Molecular analysis of murine leukemia cell lines resistant to 5,10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase. J Biol Chem 2000;275:26599-606.
-
(2000)
J Biol Chem
, vol.275
, pp. 26599-26606
-
-
Zhao, R.1
Titus, S.2
Gao, F.3
Moran, R.G.4
Goldman, I.D.5
-
17
-
-
0037455808
-
Loss of folylpoly-γ-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines
-
Liani E, Rothem L, Bunni MA, Smith CA, Jansen G, Assaraf YG. Loss of folylpoly-γ-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer 2003;103:587-99.
-
(2003)
Int J Cancer
, vol.103
, pp. 587-599
-
-
Liani, E.1
Rothem, L.2
Bunni, M.A.3
Smith, C.A.4
Jansen, G.5
Assaraf, Y.G.6
-
18
-
-
28244452912
-
Human aromatase: Gene resequencing and functional genomics
-
Ma CX, Adjei AA, Salavaggione OE, et al. Human aromatase: gene resequencing and functional genomics. Cancer Res 2005;65:11071-82.
-
(2005)
Cancer Res
, vol.65
, pp. 11071-11082
-
-
Ma, C.X.1
Adjei, A.A.2
Salavaggione, O.E.3
-
19
-
-
0034141427
-
Purification and characteristics of recombinant human folylpoly-γ-glutamate synthetase expressed at high levels in insect cells
-
Sanghani PC, Moran RG. Purification and characteristics of recombinant human folylpoly-γ-glutamate synthetase expressed at high levels in insect cells. Protein Expr Purif 2000;18:36-45.
-
(2000)
Protein Expr Purif
, vol.18
, pp. 36-45
-
-
Sanghani, P.C.1
Moran, R.G.2
-
20
-
-
0034680860
-
Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues
-
Turner FB, Taylor SM, Moran RG. Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues. J Biol Chem 2000;275:35960-8.
-
(2000)
J Biol Chem
, vol.275
, pp. 35960-35968
-
-
Turner, F.B.1
Taylor, S.M.2
Moran, R.G.3
-
21
-
-
28244467188
-
Organization of genetic variation
-
Chapter 3. 3rd ed. Sunderland MA, Sinauer Associates, Inc;
-
Hartl DL, Clark AG. Organization of genetic variation. In: Principles of population genetics, Chapter 3. 3rd ed. Sunderland (MA): Sinauer Associates, Inc; 2000. p. 95-107.
-
(2000)
Principles of population genetics
, pp. 95-107
-
-
Hartl, D.L.1
Clark, A.G.2
-
22
-
-
0004242267
-
-
3rd ed. Sundbury MA, Jones and Bartlett Publishers;
-
Hendrick PW. Genetics of populations. 3rd ed. Sundbury (MA): Jones and Bartlett Publishers; 2000.
-
(2000)
Genetics of populations
-
-
Hendrick, P.W.1
-
23
-
-
0024313579
-
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism
-
Tajima F. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 1989;123:585-95.
-
(1989)
Genetics
, vol.123
, pp. 585-595
-
-
Tajima, F.1
-
24
-
-
0036155283
-
Score tests for association between traits and haplotypes when linkage phase is ambiguous
-
Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002;70:425-34.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 425-434
-
-
Schaid, D.J.1
Rowland, C.M.2
Tines, D.E.3
Jacobson, R.M.4
Poland, G.A.5
-
25
-
-
0033799573
-
Apolipoprotein E variation at the sequence haplotype level: Implications for the origin and maintenance of a major human polymorphism
-
Fullerton SM, Clark AG, Weiss KM, et al. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet 2000;67:881-900.
-
(2000)
Am J Hum Genet
, vol.67
, pp. 881-900
-
-
Fullerton, S.M.1
Clark, A.G.2
Weiss, K.M.3
-
26
-
-
0032876978
-
dbSNP-database for single nucleotide polymorphisms and other classes of minor genetic variation
-
Sherry ST, Ward M, Sirotkin K. dbSNP-database for single nucleotide polymorphisms and other classes of minor genetic variation. Genome Res 1999;9:677-9.
-
(1999)
Genome Res
, vol.9
, pp. 677-679
-
-
Sherry, S.T.1
Ward, M.2
Sirotkin, K.3
-
28
-
-
0034641736
-
Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
-
Drysdale CM, McGraw DW, Stack CB, et al. Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A 2000;97:10483-8.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10483-10488
-
-
Drysdale, C.M.1
McGraw, D.W.2
Stack, C.B.3
-
29
-
-
0021984494
-
Induced reversion of a Chinese hamster ovary triple auxotroph. Validation of the system with several mutagens
-
Taylor RT, Wu R, Hanna ML. Induced reversion of a Chinese hamster ovary triple auxotroph. Validation of the system with several mutagens. Mutat Res 1985;151:293-308.
-
(1985)
Mutat Res
, vol.151
, pp. 293-308
-
-
Taylor, R.T.1
Wu, R.2
Hanna, M.L.3
-
30
-
-
0032879495
-
Folylpoly-γ-glutamate synthetase: Generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity
-
Qi H, Atkinson I, Xiao S, Choi YJ, Tobimatsu T, Shane B. Folylpoly-γ-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity. Adv Enzyme Regul 1999;39:263-73.
-
(1999)
Adv Enzyme Regul
, vol.39
, pp. 263-273
-
-
Qi, H.1
Atkinson, I.2
Xiao, S.3
Choi, Y.J.4
Tobimatsu, T.5
Shane, B.6
-
31
-
-
0032499731
-
Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase
-
Sun X, Bognar AL, Baker EN, Smith CA. Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase. Proc Natl Acad Sci U S A 1998;95:6647-52.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6647-6652
-
-
Sun, X.1
Bognar, A.L.2
Baker, E.N.3
Smith, C.A.4
-
32
-
-
21444443996
-
Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy
-
Mathieu M, Debousker G, Vincent S, Viviani F, Bamas-Jacques N, Mikol V. Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy. J Biol Chem 2005;280:18916-22.
-
(2005)
J Biol Chem
, vol.280
, pp. 18916-18922
-
-
Mathieu, M.1
Debousker, G.2
Vincent, S.3
Viviani, F.4
Bamas-Jacques, N.5
Mikol, V.6
-
33
-
-
33745149993
-
Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS)
-
Young PG, Smith CA, Sun X, Baker EN, Metcalf P. Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS). Acta Crystallograph Sect F Struct Biol Cryst Commun 2006;62:579-82.
-
(2006)
Acta Crystallograph Sect F Struct Biol Cryst Commun
, vol.62
, pp. 579-582
-
-
Young, P.G.1
Smith, C.A.2
Sun, X.3
Baker, E.N.4
Metcalf, P.5
-
34
-
-
0035958665
-
Folate-binding triggers the activation of folylpolyglutamate synthetase
-
Sun X, Cross JA, Bognar AL, Baker EN, Smith CA. Folate-binding triggers the activation of folylpolyglutamate synthetase. J Mol Biol 2001;310:1067-78.
-
(2001)
J Mol Biol
, vol.310
, pp. 1067-1078
-
-
Sun, X.1
Cross, J.A.2
Bognar, A.L.3
Baker, E.N.4
Smith, C.A.5
-
36
-
-
33646596910
-
Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops
-
Smith CA, Cross JA, Bognar AL, Sun X. Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops. Acta Crystallogr D Biol Crystallogr 2006;62:548-58.
-
(2006)
Acta Crystallogr D Biol Crystallogr
, vol.62
, pp. 548-558
-
-
Smith, C.A.1
Cross, J.A.2
Bognar, A.L.3
Sun, X.4
-
37
-
-
0036612958
-
Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding
-
Sheng Y, Cross JA, Shen Y, Smith CA, Bognar AL. Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding. Arch Biochem Biophys 2002;402:94-103.
-
(2002)
Arch Biochem Biophys
, vol.402
, pp. 94-103
-
-
Sheng, Y.1
Cross, J.A.2
Shen, Y.3
Smith, C.A.4
Bognar, A.L.5
-
38
-
-
7644241595
-
Aggresome formation and pharmacogenetics: Sulfotransferase 1A3 as a model system
-
Wang L, Yee VC, Weinshilboum RM. Aggresome formation and pharmacogenetics: sulfotransferase 1A3 as a model system. Biochem Biophys Res Commun 2004;325:426-33.
-
(2004)
Biochem Biophys Res Commun
, vol.325
, pp. 426-433
-
-
Wang, L.1
Yee, V.C.2
Weinshilboum, R.M.3
-
39
-
-
29144481765
-
Human phenylethanolamine N-methyltransferase pharmacogenomics: Gene re-sequencing and functional genomics
-
Ji Y, Salavaggione OE, Wang L, et al. Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics. J Neurochem 2005;95:1766-76.
-
(2005)
J Neurochem
, vol.95
, pp. 1766-1776
-
-
Ji, Y.1
Salavaggione, O.E.2
Wang, L.3
-
41
-
-
0141761407
-
Thiopurine S-methyltransferase pharmacogenetics: Chaperone protein association and allozyme degradation
-
Wang L, Sullivan W, Toft D, Weinshilboum R. Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation. Pharmacogenetics 2003;13:555-64.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 555-564
-
-
Wang, L.1
Sullivan, W.2
Toft, D.3
Weinshilboum, R.4
|