Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 11, 2010, Pages 3235-3239

  Wu, Frank ^a   Büttner, Frank H ^b   Chen, Rhonda ^a   Hickey, Eugene ^a   Jakes, Scott ^a   Kaplita, Paul ^a   Kashem, Mohammed A ^a   Kerr, Steven ^a   Kugler, Stanley ^a   Paw, Zofia ^a   Prokopowicz, Anthony ^a   Shih, Cheng Kon ^a   Snow, Roger ^a   Young, Erick ^a   Cywin, Charles L ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Rho Kinase inhibitors

Indexed keywords

2H ISOQUINOLINE 1 ONE; 3H QUINAZOLIN 4 ONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ANTIHYPERTENSIVE AGENT; FASUDIL; ISOQUINOLINE DERIVATIVE; MYOTONIC DYSTROPHY PROTEIN KINASE; PROTEIN CDC42; PROTEIN KINASE C; RHO KINASE; RHO KINASE 1; RHO KINASE 2; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SPECIFICITY; HYPERTENSION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DOCKING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ISOQUINOLINES; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; RATS; RHO-ASSOCIATED KINASES;

EID: 77953287632     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.070     Document Type: Article

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