A glycosylphosphatidylinositol analogue reduced prion-derived peptide mediated activation of cytoplasmic phospholipase A2, synapse degeneration and neuronal death

Neuropharmacology

Volumn 59, Issue 1-2, 2010, Pages 93-99

  Bate, Clive ^a   Tayebi, Mourad ^a   Williams, Alun ^a,b  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cholesterol; Glycosylphoshatidylinositols; Lipid rafts; Neurotoxicity; Phospholipase A2; Prion; Prostaglandins

Indexed keywords

CHOLESTEROL; CYTOSOLIC PHOSPHOLIPASE A2; DECAY ACCELERATING FACTOR; GLUCOSAMINE PHOSPHATIDYLINOSITOL; GLYCOSYLPHOSPHATIDYLINOSITOL; PRION PROTEIN; PRION PROTEIN 82; THY 1 ANTIGEN; UNCLASSIFIED DRUG; CENTRAL NERVOUS SYSTEM AGENTS; PEPTIDE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPASE A2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DRUG PROTEIN BINDING; EMBRYO; ENZYME ACTIVATION; ENZYME REGULATION; MOUSE; NERVE CELL CULTURE; NERVE CELL MEMBRANE; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; ANIMAL; BRAIN CORTEX; CELL CULTURE; CELL MEMBRANE; CYTOPLASM; DRUG EFFECTS; LYSOSOME; METABOLISM; NERVE CELL; PHYSIOLOGY; SYNAPSE;

ANIMALS; ANTIGENS, CD55; ANTIGENS, THY-1; CELL MEMBRANE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM AGENTS; CEREBRAL CORTEX; CHOLESTEROL; CYTOPLASM; GLYCOSYLPHOSPHATIDYLINOSITOLS; LYSOSOMES; MICE; NERVE DEGENERATION; NEURONS; PEPTIDES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASES A2; PRPC PROTEINS; SYNAPSES;

EID: 77953287394     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.04.002     Document Type: Article

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