Diabetes correction in pancreatectomized canines by orally absorbable insulin-deoxycholate complex

Molecular Pharmaceutics

Volumn 7, Issue 3, 2010, Pages 708-717

  Kim, Sang Kyoon ^a   Lee, Seulki ^a   Jin, Sunji ^a   Moon, Hyun Tae ^b   Jeon, Ok Cheol ^b   Lee, Dong Yun ^c   Byun, Youngro ^d  

^a Seoul National University   (South Korea)

^b Mediplex Corporation   (South Korea)

^c Hanyang University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Insulin; Lipophilicity; N deoxycholyl L lysyl methylester (DCK); Oral absorption; Pancreatectomized canines; Permeability

Indexed keywords

DEOXYCHOLIC ACID; ENZYME; EUDRAGIT; GELATIN; GLUCOSE; INSULIN; PLACEBO;

ALTERNATIVE MEDICINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; COMPLEX FORMATION; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG STABILITY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; INSULIN BLOOD LEVEL; LIPOPHILICITY; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS RESECTION; POWDER; PRIORITY JOURNAL; REPRODUCIBILITY; THERAPY EFFECT;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CACO-2 CELLS; CHOLAGOGUES AND CHOLERETICS; DEOXYCHOLIC ACID; DIABETES MELLITUS; DOGS; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PANCREATECTOMY;

EID: 77953280029     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp9002688     Document Type: Article

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