Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats

Carcinogenesis

Volumn 25, Issue 10, 2004, Pages 1961-1966

  Fujita, Ken Ichi ^a   Matsuda, Eiji ^a   Sekine, Kazunori ^a   Iigo, Masaaki ^a   Tsuda, Hiroyuki ^a,b  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; CASPASE 3; CASPASE 8; DNA FRAGMENT; FAS ANTIGEN; FAS LIGAND; LACTOFERRIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASCENDING COLON; CANCER CELL; CANCER INHIBITION; CANCER STAGING; CATTLE; CHEMICAL CARCINOGENESIS; CHEMOPROPHYLAXIS; COLON CARCINOGENESIS; COLON CARCINOMA; COLON MUCOSA; CONTROLLED STUDY; EARLY CANCER; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RAT; TOXICITY TESTING; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; AZOXYMETHANE; CARCINOGENS; CASPASES; CATTLE; CELL TRANSFORMATION, NEOPLASTIC; CHEMOPREVENTION; COLON; COLONIC NEOPLASMS; ENZYME ACTIVATION; IMMUNOENZYME TECHNIQUES; LACTOFERRIN; MALE; PROTEINS; RATS; RATS, INBRED F344; RECEPTORS, TUMOR NECROSIS FACTOR;

EID: 6444230922     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh205     Document Type: Article

References (44)

1. Lonnerdal,B. and Iyer,S. (1995) Lactoferrin: molecular structure and biological function. Annu. Rev. Nutr., 15, 93-110.
2. Masson,P.L., Heremans,J.F. and Schonne,E. (1969) Lactoferrin, an iron-binding protein in nentrophilic leukocytes. J. Exp. Med., 130, 643-658.
3. Shau,H., Kim,A. and Golub,S.H. (1992) Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin. J. Leukocyte Biol., 51, 343-349.
4. Horwits,D.A., Bakke,A.C., Abo,W. and Nishiya,K. (1984) Monocyte and NK cell cytotoxic activity in human adherent cell preparations: discriminating effects of interferon and lactoferrin. J. Immunol., 132, 2370-2374.
5. Gahr,M., Speer,C.P., Damerau,B. and Sawatzki,G. (1991) Influence of lactoferrin on the function of human polymorphonuclear leukocytes and monocytes. J. Leukocyte Biol., 49, 427-433.
6. Sawatzki,G. and Rich,I.N. (1989) Lactoferrin stimulates colony stimulating factor production in vitro and in vivo. Blood Cells, 15, 371-385.
7. De Sousa,M., Breedvelt,F., Dynesius-Trentham,R., Trentham,D. and Lum,J. (1988) Iron, iron-binding proteins and immune system cells. Ann. N. Y. Acad. Sci., 526, 310-321.
8. Gentile,P. and Broxmeyer,H.E. (1983) Suppression of mouse myelopoiesis by administration of human lactoferrin in vivo and the comparative action of human transferrin. Blood, 61, 982-993.
9. Bezault,J., Bhimani,R., Wiprovnick,J. and Furmanski,P. (1994) Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. Cancer Res., 54, 2310-2312.
10. Sekine,K., Ushida,Y., Kuhara,T. et al. (1997) Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane. Cancer Lett., 121, 211-216.
11. Bird,R.P. (1995) Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett., 93, 55-71.
12. Magnuson,B.A., Carr,I. and Bird,R.P. (1993) Ability of aberrant crypt foci characteristics to predict colonic tumor incidence in rats fed cholic acid. Cancer Res., 53, 4499-4504.
13. Sekine,K., Watanabe,E., Nakamura,J. et al. (1997) Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats. Jpn. J. Cancer Res., 88, 523-526.
14. Ushida,Y., Sekine,K., Kuhara,T., Takasuka,N., Iigo,M., Maeda,M. and Tsuda,H. (1999) Possible chemopreventive effects of bovine lactoferrin on esophagus and lung carcinogenesis in the rat. Jpn. J. Cancer Res., 90, 262-267.
15. Tanaka,T., Kawabata,K., Kohno,H., Honjo,S., Murakami,M., Ota,T. and Tsuda,H. (2000) Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats. Jpn. J. Cancer Res., 91, 25-33.
16. Masuda,C., Wanibuchi,H., Sekine,K., Yano,Y., Otani,S., Kishimoto,T., Tsuda,H. and Fukushima,S. (2000) Chemopreventive effects of bovine lactoferrin on N-butyl-N (4-hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis. Jpn. J. Cancer Res., 91, 582-588.
17. Fujita,K., Ohnishi,T., Sekine,K., Iigo,M. and Tsuda,H. (2002) Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats. Jpn. J. Cancer Res., 93, 616-625.
18. Tsuda,H., Sekine,K., Fujita,K. and Iigo,M. (2002) Cancer prevention by bovine lactoferrin and underlying mechanisms - a review of experimental and clinical studies. Biochem. Cell. Biol., 80, 131-136.
19. Steller,H. (1995) Mechanisms and genes of cellular suicide. Science, 267, 1445-1449.
20. Jacobson,M.D., Weil,M. and Raff,M.C. (1997) Programmed cell death in animal development. Cell, 88, 347-354.
21. Nagata,S. (1997) Apoptosis by death factor. Cell, 88 355-365.
22. Ashkenazi,A. and Dixit,V.M. (1998) Death receptors: signaling and modulation. Science, 281, 1305-1308.
23. Medema,J.P., Scaffidi,C., Kischkel,F.C., Shevchenko,A., Mann,M., Krammer,P.H. and Peter,M.E. (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J., 16, 2794-2804.
24. Fujita,K., Matsuda,E., Sekine,K., Iigo,M. and Tsuda,H. (2004) Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat. Cancer Lett., In press.
25. Kimura,K., Wakatsuki,T. and Yamamoto,M. (1994) A variant mRNA species encoding a truncated form of Fas antigen in the rat liver. Biochem. Biophys. Res. Commun., 198, 666-674.
26. Himmler,A., Maurer-Fogy,I., Kronke,M., Scheurich,P., Pfizenmaier,K., Lantz,M., Olsson,I., Hauptmann,R., Stratowa,C. and Adolf,G.R. (1990) Molecular cloning and expression of human and rat tumor necrosis factor receptor chain, (p60) and its soluble derivative, tumor necrosis factor-binding protein. DNA Cell Biol., 9, 705-715.
27. Suda,T., Takahashi,T., Golstein,P. and Nagata,S. (1993) Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell, 75, 1169-1178.
28. Kwon,J., Chung,I.Y. and Benveniste,E.N. (1993) Cloning and sequence analysis of the rat tumor necrosis factor-encoding genes. Gene, 132, 227-236.
29. Nudel,U., Zakut,R., Shani,M., Neuman,S., Levy,Z. and Yaffe,D. (1983) The nucleotide sequence of the rat cytoplasmic β-actin gene. Nucleic Acids Res., 11, 1759-1771.
30. Gavrieli,Y., Sherman,Y. and Ben-Sasson.S.A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119, 493-501.
31. Lazebnik,Y.A., Kaufmann,S.H., Desnoyers,S., Poirier,G.G. and Earnshaw,W.C. (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature, 371, 346-347.
32. Tewari,M., Quan,L.T., O'Rourke,K., Desnoyers,S., Zeng,Z., Beidler,D.R., Poirier,G.G., Salvesen,G.S. and Dixit,V.M. (1995) Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell, 81, 801-809.
33. Leithauser,F., Dhein,J., Mechtersheimer,G., Koretz,K., Bruderlein,S., Henne,C., Schmidt,A., Debatin,K.M., Krammer,P.H. and Moller,P. (1993) Constitutive and induced expression of APO-I, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab. Invest., 69 415-429.
34. Moller,P., Koretz,K., Leithauser,F., Bruderlein,S., Henne,C., Quentmeier,A. and Krammer,P.H. (1994) Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. Int. J. Cancer, 57, 371-377.
35. Muller,M., Wilder,S., Bannasch,D. et al. (1998) p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J. Exp. Med., 188, 2033-2045.
36. Kischkel,F.C., Hellbardt,S., Behrmann,I., Germer,M., Pawlita,M., Krammer,P.H. and Peter,M.E. (1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J., 14, 5579-5588.
37. Boldin,M.P., Goncharov,T.M., Goltsev,Y.V. and Wallach,D. (1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell, 85, 803-815.
38. Muzio,M., Chinnaiyan,A.M., Kischkel,F.C. et al. (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell, 85 817-827.
39. Trinchieri,G. (1989) Biology of natural killer cells. Adv. Immunol., 47, 187-376.
40. Cerwenka,A. and Lanier,L.L. (2001) Natural killer cells, viruses and cancer. Nature Rev. Immunol., 1, 41-49.
41. Vujanovic,N.L. (2001) Role of TNF family ligands in antitumor activity of natural killer cells. Intern. Rev. Immunol., 20, 415-437.
42. Smyth,M.J., Hayakawa,Y., Takeda,K. and Yagita,H. (2002) New aspects of natural-killer-cell surveillance and therapy of cancer. Nature Rev. Cancer, 2, 850-861.
43. Iigo,M., Kuhara,T., Ushida,Y., Sekine,K., Moore,M.A. and Tsuda,H. (1999) Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice. Clin. Exp. Metast., 17, 35-40.
44. Wang,W., Iigo,M., Sato,J., Sekine,K., Adachi,I. and Tsuda,H. (2000) Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Jpn. J. Cancer Res., 91, 1022-1027.