Genetics of type 2 diabetes. On overview

Endocrinologia y Nutricion

Volumn 56, Issue SUPPL. 4, 2009, Pages 34-37

  Groop, Leif ^a   Lyssenko, Valeriya ^a  

^a LUND UNIVERSITY DIABETES CENTRE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; HUMAN GENOME; INHERITANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

DIABETES MELLITUS, TYPE 2; FINLAND; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INSULIN; INSULIN RESISTANCE; JAPAN; LIFE STYLE; LINKAGE (GENETICS); RISK FACTORS; SWEDEN;

EID: 77953242228     PISSN: 15750922     EISSN: 15792021     Source Type: Journal    
DOI: 10.1016/S1575-0922(09)73515-6     Document Type: Article

References (16)

1. Lyssenko V., Almgren P., Anevski D., Perfekt R., Lahti K., Nissén M., et al. Predictors and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes. Diabetes 54 (2005) 166-174
2. Horikawa Y., Oda N., Cox N.J., Li X., Orho-Melander M., Hara M., et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26 (2000) 163-175
3. Parikh H., and Groop L. Candidate genes for type 2 diabetes. Reviews in Endocrine and Metabolic Disorders 5 (2004) 151-176
4. Deeb S.S., Fajas L., Nemoto M., Pihlajamäki J., Mykkänen L., Kuusisto J., et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20 (1998) 284-287
5. Altshuler D., Hirschhorn J.N., Klannemark M., Lindgren C.M., Vohl M.C., Nemesh J., et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26 (2000) 76-80
6. Florez J.C., Burtt N., De Bakker P.I.W., Almgren P., Tuomi T., Holmkvist J., et al. Haplotype structure and genotype-phenotype correlations of the sulfonyulrea receptor (SUR1) and the islet ATP- sensitive potassium channel (kir 6.2) gene region. Diabetes 53 (2004) 1360-1368
7. Gloyn A.L., Pearson E.R., Antcliff J.F., Proks P., Bruining G.J., Slingerland A.S., et al. Activating mutations in the gene encoding the ATP-sensitive potassium channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 350 (2004) 1838-1849
8. Grant S.F., Thorleifsson G., Reynisdottir I., Benediktsson R., Manolescu A., Sáinz J., et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38 (2006) 320-323
9. Lyssenko V., Lupi R., Marchetti P., Del Guerra S., Orho-Melander M., Almgren P., et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117 (2007) 2155-2163
10. Saxena R., Voigt B., Lyssenko V., Burtt N.P., de Bakker P.I., Chen H., et al. Diabetes Genetics Initiative: Genome wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316 (2007) 1331-1336
11. Zeggini E., Scott L.J., Saxena R., Voight B.F., Marchini J.L., Hu T., et al., For the Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium. Meta-analysis of genome-wide association data and large-scale replication identifies several additional susceptibility loci for type 2 diabetes. Nat Genet 40 (2008) 638-645
12. Lyssenko V., Jonsson A., Pulizzi N., Almgren P., Isomaa B., Tuomi T., et al. Clinical risk factors, DNA variants and the development of type 2 diabetes. New Engl J Med 359 (2008) 2220-2232
13. McPherson R., Pertsemilidis A., Kavaslar N., Stewart A., Roberts R., Cox D.R., et al. A common allele on chromosome 9 associated with coronary heart disease. Science 316 (2007) 14888-14891
14. Frayling T., Timpson N.j., Weedon M.N., Zeggini E., Freathy R.M., Lindgren C.M., et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316 (2007) 889-894
15. Yasuda K., Miyake K., Horikawa Y., Hara K., Osawa H., Furuta H., et al. Multistage genome-wide SNP association study revealed KCNQ1 as a novel susceptibility gene for type 2 diabetes mellitus in multiple ethnic groups: a report of the Millennium Genome Project of Japan. Nat Genet 40 (2008) 1092-1097
16. Lyssenko V., Nagorny C.L.F., Erdos M.R., Wierup N., Jonsson A., Spégel P., et al. A common variant in the melatonin receptor gene (MTNR1B) is associated with increased risk of future type 2 diabetes and impaired early insulin secretion. Nat Genet 41 (2008) 82-88