A comprehensive investigation of plasma and brain regional pharmacokinetics of imipramine and its metabolites during and after chronic administration in the rat

Journal of Pharmaceutical Sciences

Volumn 85, Issue 3, 1996, Pages 291-295

  Besret, Laurent ^a,b   Debruyne, Danièle ^a,b   Rioux, Patrice ^b,c   Bonvalot, Thierry ^d,e   Moulin, Maurice ^a,b   Zarifian, Edouard ^b,d   Baron, Jean Claude ^b  

^a CHU CÔTE DE NACRE   (France)

^b INSERM   (France)

^c NEUROMED GRP   (France)

^d Centre Esquirol   (France)

^e Centre Cyceron   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYIMIPRAMINE; DESIPRAMINE; DRUG METABOLITE; IMIPRAMINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; DEPRESSION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT;

EID: 0029968839     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js950110h     Document Type: Article

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