Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase

Plant Molecular Biology

Volumn 73, Issue 4, 2010, Pages 399-407

  Mina, J G ^a   Okada, Y ^a   Wansadhipathi Kannangara, N K ^a   Pratt, S ^a   Shams Eldin, H ^b   Schwarz, R T ^b,c   Steel, P G ^a   Fawcett, T ^a   Denny, P W ^a  

^a DURHAM UNIVERSITY   (United Kingdom)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITÉ DES SCIENCES ET TECHNOLOGIES DE LILLE   (France)

Author keywords

Arabidopsis; AUR1; Expression; Inositol phosphorylceramide; IPC synthase; Sphingolipids

Indexed keywords

AUREOBASIDIN A; DEPSIPEPTIDE; GLYCOSYLTRANSFERASE; ISOENZYME; MESSENGER RNA; PHOSPHATIDYLINOSITOL CERAMIDE PHOSPHOINOSITOL TRANSFERASE; PHOSPHATIDYLINOSITOL-CERAMIDE PHOSPHOINOSITOL TRANSFERASE;

ARABIDOPSIS; ARTICLE; DNA MICROARRAY; DRUG EFFECT; DRUG RESISTANCE; ENZYMOLOGY; EXPRESSED SEQUENCE TAG; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; METABOLISM; MUTATION; SACCHAROMYCES CEREVISIAE;

ARABIDOPSIS; DEPSIPEPTIDES; DRUG RESISTANCE; EXPRESSED SEQUENCE TAGS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, PLANT; GENETIC COMPLEMENTATION TEST; HEXOSYLTRANSFERASES; ISOENZYMES; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE;

ARABIDOPSIS; EUKARYOTA; FUNGI; MAMMALIA; PROTOZOA;

EID: 77953230675     PISSN: 01674412     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11103-010-9626-3     Document Type: Article

References (30)

1. Boyes DC, Zayed AM, Ascenzi R, McCaskill AJ, Hoffman NE, Davis KR, Gorlach J (2001) Growth stage-based phenotypic analysis of arabidopsis: a model for high throughput functional genomics in plants. Plant Cell 13: 1499-1510.
2. Brodersen P, Petersen M, Pike HM, Olszak B, Skov S, Odum N, Jorgensen LB, Brown RE, Mundy J (2002) Knockout of Arabidopsis accelerated-cell-death11 encoding a sphingosine transfer protein causes activation of programmed cell death and defense. Genes Dev 16: 490-502.
3. Bromley PE, Li YNO, Murphy SM, Sumner CM, Lynch DV (2003) Complex sphingolipid synthesis in plants: characterization of inositolphosphorylceramide synthase activity in bean microsomes. Arch Biochem Biophys 417: 219-226.
4. Brown DA, London E (1998) Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14: 111-136.
5. Chen M, Han G, Dietrich CR, Dunn TM, Cahoon EB (2006) The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase. Plant Cell 18: 3576-3593.
6. Denny PW, Field MC, Smith DF (2001) GPI-anchored proteins and glycoconjugates segregate into lipid rafts in Kinetoplastida. FEBS Lett 491: 148-153.
7. Denny PW, Shams-Eldin H, Price HP, Smith DF, Schwarz RT (2006) The protozoan inositol phosphorylceramide synthase: a novel drug target which defines a new class of sphingolipid synthase. J Biol Chem 281: 28200-28209.
8. Dickson RC, Sumanasekera C, Lester RL (2006) Functions and metabolism of sphingolipids in Saccharomyces cerevisiae. Prog Lipid Res 45: 447-465.
9. Dunn TM, Lynch DL, Michaelson LV, Napier JA (2004) A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana. Ann Bot 93: 483-497.
10. Fernandis AZ, Wenk MR (2007) Membrane lipids as signaling molecules. Curr Opin Lipidol 18: 121-128.
11. Futerman AH, Hannun YA (2004) The complex life of simple sphingolipids. EMBO reports 5: 777-782.
12. Grennan AK (2006) Genevestigator. Facilitating web-based gene-expression analysis. Plant Physiol 141: 1164-1166.
13. Guan XL, Wenk MR (2006) Mass spectrometry-based profiling of phospholipids and sphingolipids in extracts from Saccharomyces cerevisiae. Yeast 23: 465-477.
14. Hanada K, Nishijima M, Kiso M, Hasegawa A, Fujita S, Ogawa T, Akamatsu Y (1992) Sphingolipids are essential for the growth of Chinese hamster ovary cells. Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids. J Biol Chem 267: 23527-23533.
15. Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC (2004) Identification of a family of animal sphingomyelin synthases. EMBO J 23: 33-44.
16. Liang H, Yao N, Song JT, Luo S, Lu H, Greenberg JT (2003) Ceramides modulate programmed cell death in plants. Genes Dev 17: 2636-2641.
17. Luberto C, Stonehouse MJ, Collins EA, Marchesini N, El-Bawab S, Vasil AI, Vasil ML, Hannun YA (2003) Purification, characterization, and identification of a sphingomyelin synthase from Pseudomonas aeruginosa. PlcH is a multifunctional enzyme. J Biol Chem 278: 32733-32743.
18. Magee T, Prinen N, Alder J, Pagakis SN, Parmryd I (2002) Lipid rafts: cell surface platforms for T-cell signalling. Biol Res 35: 127-131.
19. Mina JG, Pan SY, Wansadhipathi NK, Bruce CR, Shams-Eldin H, Schwarz RT, Steel PG, Denny PW (2009) The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target. Mol Biochem Parasitol 168: 16-23.
20. Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL, Dickson RC (1997) Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem 272: 9809-9817.
21. Nagiec MM, Young CL, Zaworski PG, Kobayashi SD (2003) Yeast sphingolipid bypass mutants as indicators of antifungal agents selectively targeting sphingolipid synthesis. Biochem Biophys Res Commun 307: 369-374.
22. Neuwald AF (1997) An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases. Protein Sci 6: 1764-1767.
23. Pierce SK (2002) Lipid rafts and B-cell activation. Nature Rev Immunol 2: 96-105.
24. Ralton JE, McConville MJ (1998) Delineation of three pathways of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana. Precursors from different pathways are assembled on distinct pools of phosphatidylinositol and undergo fatty acid remodeling. J Biol Chem 273: 4245-4257.
25. Sato K, Noda Y, Yoda K (2009) Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Mol Biol Cell 20: 4444-4457.
26. Smith WL, Merrill AH (2002) Sphingolipid metabolism and signaling. J Biol Chem 277: 25841-25842.
27. Thompson W, MacDonald G (1975) Isolation and characterization of cytidine diphosphate diglyceride from beef liver. J Biol Chem 250: 6779-6785.
28. Thompson W, MacDonald G (1976) Cytidine diphosphate diglyceride of bovine brain. Positional distribution of fatty acids and analysis of major molecular species. Eur J Biochem 65: 107-111.
29. Wang W, Yang X, Tangchaiburana S, Ndeh R, Markham JE, Tsegaye Y, Dunn TM, Wang GL, Bellizzi M, Parsons JF, Morrissey D, Bravo JE, Lynch DV, Xiao S (2008) An inositolphosphorylceramide synthase is involved in regulation of plant programmed cell death associated with defense in Arabidopsis. Plant Cell 20: 3163-3179.
30. Zhong W, Murphy DJ, Georgopapadakou NH (1999) Inhibition of yeast inositol phosphorylceramide synthase by aureobasidin A measured by a fluorometric assay. FEBS Lett 463: 241-244.