Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIα

Biochemistry

Volumn 48, Issue 38, 2009, Pages 8940-8947

  Deweese, Joseph E ^a   Guengerich, F Peter ^a   Burgin, Alex B ^b   Osheroff, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DeCODE Chemistry & Biostructures   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC AMINO ACIDS; ACTIVE SITE; BRIDGING OXYGEN; DIVALENT METAL ION; DNA CLEAVAGE; HUMAN TOPOISOMERASE; METAL ION INTERACTIONS; MUTANT ENZYMES; NON-BRIDGING OXYGEN; NUCLEIC ACID ENZYMES; SULFUR ATOMS; TOPOISOMERASE II; TOPOISOMERASES; TWO-METAL-ION MECHANISM; TYPE II; WILD TYPES;

AMINATION; AMINES; AMINO ACIDS; ATOMS; CALCIUM; CATALYSTS; DNA; ENZYMES; GENES; MANGANESE; MANGANESE COMPOUNDS; METAL IONS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; ORGANIC ACIDS; OXYGEN; SULFUR; TRACE ANALYSIS;

METALS;

ALANINE; AMINO ACID; CALCIUM; CYSTEINE; DNA TOPOISOMERASE (ATP HYDROLYSING); MAGNESIUM; MANGANESE; METAL ION; OLIGONUCLEOTIDE; PHOSPHATE; SULFUR; TOPOISOMERASE IIALPHA; UNCLASSIFIED DRUG; DIVALENT CATION; DNA; DNA BINDING PROTEIN; DNA TOPOISOMERASE II ALPHA; METAL; OLIGODEOXYRIBONUCLEOTIDE; PRIMER DNA; RECOMBINANT PROTEIN; TUMOR ANTIGEN;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL INTERACTION; DNA CLEAVAGE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; ENZYME SPECIFICITY; GENETICS; IN VITRO STUDY; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLASMID; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

PROKARYOTA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIGENS, NEOPLASM; BASE SEQUENCE; CATALYTIC DOMAIN; CATIONS, DIVALENT; CONSERVED SEQUENCE; DNA; DNA PRIMERS; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; HUMANS; KINETICS; METALS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; PLASMIDS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 70349762697     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900875c     Document Type: Article

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