Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ

Cancer Immunology, Immunotherapy

Volumn 59, Issue 8, 2010, Pages 1223-1233

  Dubrot, Juan ^a   Milheiro, Francisca ^a   Alfaro, Carlos ^a   Palazón, Asis ^a   Martinez Forero, Ivan ^a   Perez Gracia, Jose L ^b   Morales Kastresana, Aizea ^a   Romero Trevejo, José L ^a   Ochoa, María C ^a   Hervás Stubbs, Sandra ^a   Prieto, Jesús ^a,b   Jure Kunkel, Maria ^c   Chen, Lieping ^d   Melero, Ignacio ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

^c BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

CD137 (4 1BB); Immunostimulatory monoclonal antibodies; Liver

Indexed keywords

AMINOTRANSFERASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD137; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; COLON CARCINOMA; CONTROLLED STUDY; DRUG SELECTIVITY; FLOW CYTOMETRY; HEPATITIS; HISTOPATHOLOGY; INTRAHEPATIC CHOLESTASIS; LEUKOCYTE; LIVER CARCINOMA; LIVER PARENCHYMA; LYMPHOCYTIC INFILTRATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AMIDINOTRANSFERASES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD137; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELL LINE, TUMOR; CELL MOVEMENT; COLONIC NEOPLASMS; IMMUNOTHERAPY; LIVER; LYMPHOCYTES, TUMOR-INFILTRATING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASM TRANSPLANTATION; ORGAN SPECIFICITY; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

EID: 77953229126     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-010-0846-9     Document Type: Article

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