Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice

Journal of Neuroscience

Volumn 30, Issue 22, 2010, Pages 7453-7465

  McDowell, Kelli A ^a   Hutchinson, Ashley N ^a   Wong Goodrich, Sarah J E ^a   Presby, Matthew M ^a   Su, Dan ^a   Rodriguiz, Ramona M ^a   Law, Krystal C ^b   Williams, Christina L ^a   Wetsel, William C ^a   West, Anne E ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; EMBRYO; EXON; FEAR; GABAERGIC SYSTEM; HIPPOCAMPUS; IN VIVO STUDY; KNOCKOUT MOUSE; LONG TERM MEMORY; MALE; MAZE TEST; MEMORY; MOUSE; NERVE FUNCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOGNITION; SHORT TERM MEMORY; SYNAPTIC MEMBRANE; TRANSCRIPTION REGULATION; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CEREBRAL CORTEX; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EMBRYO, MAMMALIAN; EXPLORATORY BEHAVIOR; FEAR; FIBROBLASTS; HUMANS; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; SYNAPSES; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 77953228130     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3997-09.2010     Document Type: Article

References (41)

1. Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T (2007) Mouse and rat BDNF gene structure and expression revisited. J Neurosci Res 85:525-535. (Pubitemid 46318317)
2. Angrand PO, Daigle N, van der Hoeven F, Scholer HR, Stewart AF (1999) Simplified generation of targeting constructs using ET recombination. Nucleic Acids Res 27:e16.
3. Bading H, Ginty DD, Greenberg ME (1993) Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260:181-186. (Pubitemid 23140883)
4. Blendy JA, Kaestner KH, Schmid W, Gass P, Schutz G (1996) Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. EMBO J 15:1098-1106. (Pubitemid 26077838)
5. Chen WG, West AE, Tao X, Corfas G, Szentirmay M, Sawadogo M, Vinson C, Greenberg ME (2003) Upstream stimulatory factors are mediators of calcium-responsive transcription in neurons. J Neurosci 23:2572-2581.
6. Clark RE, Martin SJ (2005) Interrogating rodents regarding their object and spatial memory. Curr Opin Neurobiol 15:593-598.
7. Crawley JN (2007) Mouse behavioral assays relevant to the symptoms of autism. Brain Pathol 17:448-459.
8. Fanselow MS, Poulos AM (2005) The neuroscience of mammalian associative learning. Annu Rev Psychol 56:207-234.
9. Farley FW, Soriano P, Steffen LS, Dymecki SM (2000) Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28:106-110.
10. Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME (2006) Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311:1008-1012.
11. Frankland PW, Bontempi B (2005) The organization of recent and remote memories. Nat Rev Neurosci 6:119-130.
12. Gorski JA, Balogh SA, Wehner JM, Jones KR (2003) Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience 121:341-354.
13. Greer PL, Greenberg ME (2008) From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. Neuron 59:846-860.
14. Heldt SA, Ressler KJ (2007) Training-induced changes in the expression of GABAA-associated genes in the amygdala after the acquisition and extinction of Pavlovian fear. Eur J Neurosci 26:3631-3644.
15. Heldt SA, Stanek L, Chhatwal JP, Ressler KJ (2007) Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry 12:656-670.
16. Hong EJ, McCord AE, Greenberg ME (2008) A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron 60:610-624.
17. Hsu FC, Zhang GJ, Raol YS, Valentino RJ, Coulter DA, Brooks-Kayal AR (2003) Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses. Proc Natl Acad Sci U S A 100:12213-12218.
18. Jacob TC, Moss SJ, Jurd R (2008) GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci 9:331-343.
19. Korzus E, Rosenfeld MG, Mayford M (2004) CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron 42:961-972.
20. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E, Alt FW, Westphal H (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93:5860-5865.
21. Lin Y, Bloodgood BL, Hauser JL, Lapan AD, Koon AC, Kim TK, Hu LS, Malik AN, Greenberg ME (2008) Activity-dependent regulation of inhibitory synapse development by Npas4. Nature 455:1198-1204.
22. Liu QR, Lu L, Zhu XG, Gong JP, Shaham Y, Uhl GR (2006) Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res 1067:1-12. (Pubitemid 43133069)
23. Myers KM, Davis M (2007) Mechanisms of fear extinction. Mol Psychiatry 12:120-150.
24. Nguyen PV, Abel T, Kandel ER (1994) Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265:1104-1107. (Pubitemid 24293080)
25. Poo MM (2001) Neurotrophins as synaptic modulators. Nat Rev Neurosci 2:1-9.
26. Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A, Russo SJ, Sikder D, Dewey CM, Davis MM, Greengard P, Nairn AC, Nestler EJ, Cowan CW (2008) Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59:621-633.
27. Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schutz G, Linden DJ, Ginty DD (2005) SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. Nat Neurosci 8:759-767. (Pubitemid 43085842)
28. Rodriguiz RM, Gadnidze K, Ragnauth A, Dorr N, Yanagisawa M, Wetsel WC, Devi LA (2007) Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. Genes Brain Behav 7:418-426. (Pubitemid 351590928)
29. Rogers DC, Fisher EM, Brown SD, Peters J, Hunter AJ, Martin JE (1997) Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm Genome 8:711-713. (Pubitemid 127739700)
30. Schmalzigaug R, Rodriguiz RM, Bonner PE, Davidson CE, Wetsel WC, Premont RT (2009) Impaired fear response in mice lacking GIT1. Neurosci Lett 458:79-83.
31. Sohal VS, Zhang F, Yizhar O, Deisseroth K (2009) Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature 459:698-702.
32. Soliman F, Glatt CE, Bath KG, Levita L, Jones RM, Pattwell SS, Jing D, Tottenham N, Amso D, Somerville L, Voss HU, Glover G, Ballon DJ, Liston C, Teslovich T, Van Kempen T, Lee FS, Casey BJ (2010) A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 327:863-866.
33. Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME (1998) Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron 20:709-726. (Pubitemid 28199050)
34. Tao X, West AE, Chen WG, Corfas G, Greenberg ME (2002) A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron 33:383-395. (Pubitemid 34158842)
35. Timmusk T, Palm K, Metsis M, Reintam T, Paalme V, Saarma M, Persson H (1993) Multiple promoters direct tissue-specific expression of the rat BDNF gene. Neuron 10:475-489. (Pubitemid 23111738)
36. Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848-858.
37. West AE (2008) Activity-dependent regulation of brain-derived neurotrophic factor transcription. In: Transcriptional regulation by neuronal activity (Dukek S, ed), pp 155-174. New York: Springer.
38. West AE, Griffith EC, Greenberg ME (2002) Regulation of transcription factors by neuronal activity. Nat Rev Neurosci 3:921-931. (Pubitemid 135715879)
39. Xiong H, Futamura T, Jourdi H, Zhou H, Takei N, Diverse-Pierluissi M, Plevy S, Nawa H (2002) Neurotrophins induce BDNF expression through the glutamate receptor pathway in neocortical neurons. Neuropharmacology 42:903-912. (Pubitemid 34628621)
40. Xu J (2005) Preparation, culture, and immortalization of mouse embryonic fibroblasts. Curr Protoc Mol Biol 28.21.21-28.21.28.
41. Zhang SJ, Steijaert MN, Lau D, Schutz G, Delucinge-Vivier C, Descombes P, Bading H (2007) Decoding NMDA receptor signaling: identification of genomic programs specifying neuronal survival and death. Neuron 53: 549-562. (Pubitemid 46216756)