Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 10, 2010, Pages 3361-3370

  Jarmuła, Adam ^a   Fraczyk, Tomasz ^a   Cieplak, Piotr ^b   Rode, Wojciech ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Essential dynamics; MM GBSA; Molecular dynamics; Serine phosphorylation; Thymidylate synthase

Indexed keywords

DEOXYURIDINE PHOSPHATE; PTERIN; PYRIMIDINE DERIVATIVE; SERINE; TETRAHYDROFOLIC ACID; THYMIDYLATE SYNTHASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PREDICTION; STATIC ELECTRICITY; STRUCTURE ANALYSIS;

CATALYSIS; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTEIN CONFORMATION; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE;

EID: 77953139949     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.019     Document Type: Article

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