Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: Asparagine-229 in thymidylate synthase

Biochemistry

Volumn 35, Issue 16, 1996, Pages 5125-5136

  Finer Moore, Janet S ^a   Liu, Lu ^a   Schafmeister, Christian E ^a   Birdsall, David L ^a   Mau, Ted ^a   Santi, Daniel V ^a   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; DEOXYCYTIDINE PHOSPHATE; DEOXYURIDINE PHOSPHATE; THYMIDYLATE SYNTHASE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HYDROGEN BOND; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ASPARAGINE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DEOXYCYTIDINE MONOPHOSPHATE; DEOXYURACIL NUCLEOTIDES; HYDROGEN BONDING; KINETICS; METHYLATION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THYMIDYLATE SYNTHASE;

FELIS CATUS;

EID: 0029923190     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi952751x     Document Type: Article

References (36)

1. Blum, M., Metcalf, P., Harrison, S. C., & Wiley, D. C. (1987) J. Appl. Crystallogr. 20, 235-242.
2. Brunger, A. T., Kuriyan, J., & Karplus, M. (1987) Science 235, 458-460.
3. Chaiet, L., & Wolf, F. J. (1964) Arch. Biochem. Biophys. 106, 1-5.
4. Chambers, J. L., & Stroud, R. M. (1979) Acta Crystallogr. B35, 1861-1874.
5. Climie, S., Ruiz-Perez, L., Gonzalez-Pacanowska, D., Prapunwattana, P., Cho, S.-W., Stroud, R., & Santi, D. V. (1990) J. Biol. Chem. 265, 18776-18779.
6. Costi, P. M., Liu, L., Finer-Moore, J. S., Stroud, R. M., & Santi, D. V. (1996) Biochemistry (in press).
7. Davies, D. R. (1990) Annu. Rev. Biophys. Biophys. Chem. 19, 189-215.
8. Derewenda, Z. S., Derewenda, U., & Kobos, P. M. (1994) J. Mol. Biol. 241, 83-93.
9. Ferrin, T. E., Huang, C. C., Jarvis, L. E., & Langridse, R. (1988) J. Mol. Graphics 6, 2-12.
10. Fersht, A. (1985) Enzyme Structure and Mechanism, pp 317-319, W. H. Freeman and Co., New York.
11. Finer-Moore, J., Fauman, E. B., Foster, P. G., Perry, K. M., Santi, D. V., & Stroud, R. M. (1993) J. Mol. Biol. 232, 1101-1116.
12. Finer-Moore, J. S., Fauman, E. B., Morse, R. J., Santi, D. V., & Stroud, R. M. (1996) Protein Eng. (in press).
13. Graves, K. L., Butler, M. M., & Hardy, L. W. (1992) Biochemistry 31, 10315-10321.
14. Hardy, L. W., & Nalivaika, E. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 9725-9729.
15. Hardy, L. W., Finer-Moore, J. S., Montfort, W. R., Jones, M. O., Santi, D. V., & Stroud, R. M. (1987) Science 235, 448-455.
16. Higashi, T. (1990) J. Appl. Crystallogr. 23, 253-257.
17. Jones, T. A. (1985) Methods Enzymol. 115, 157-171.
18. Kabsch, W. (1988) J. Appl. Crystallogr. 21, 916-924.
19. Kealey, J. T., & Santi, D. V. (1992) Protein Expression Purif. 3, 380-385.
20. Klimasauskas, S., & Roberts, R. J. (1995) Nucleic Acids Res. 23, 1388-1395.
21. Klimasauskas, S., Kumar, S., Roberts, R. J., & Cheng, X. (1994) Cell 76, 357-369.
22. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
23. Langsetmo, K., Fuchs, J. A., & Woodward, C. (1991) Biochemistry 30, 7603-7609.
24. Liu, L., & Santi, D. V. (1992) Biochemistry 31, 5100-5104.
25. Liu, L., & Santi, D. V. (1993a) Biochemistry 32, 9263-9267.
26. Liu, L., & Santi, D. V. (1993b) Proc. Natl. Acad. Sci. U.S.A. 90, 8604-8608.
27. Maley, G. F. (1978) Methods Enzymol. 51, 412-418.
28. Matthews, D. A., Villafranca, J. E., Janson, C. A., Smith, W. W., Welsh, K., & Freer, S. (1990) J. Mol. Biol. 214, 937-948.
29. Montfort, W. R., Perry, K. M., Fauman, E. B., Finer-Moore, J. S., Maley, G. F., Hardy, L., Maley, F., & Stroud, R. M. (1990) Biochemistry 29, 6964-6977.
30. Perry, K. M., Fauman, E. B., Finer-Moore, J. S., Montfort, W. R., Maley, G. F., Maley, F., & Stroud, R. M. (1990) Proteins: Struct., Funct., Genet. 8, 315-333.
31. Rastelli, G., Thomas, B., Kollman, P. A., & Santi, D. V. (1995) J. Am. Chem. Soc. 117, 7213-7227.
32. Reinisch, K. M., Chen, L., Verdine, G. L., & Lipscomb, W. N. (1995) Cell 82, 143-153.
33. Sack, J. S. (1988) J. Mol. Graphics 6, 224-225.
34. Sato, M., Yamamoto, M., Imada, K., Katsube, Y., Tanaka, N., & Higashi, T. (1992) J. Appl. Crystallogr. 25, 348-357.
35. Stroud, R. M., & Fauman, E. B. (1995) Protein Sci. 4, 2392-2404.
36. Wentworth, D. F., & Wolfenden, R. (1978) Methods Enzymol. 51, 401-407.