메뉴 건너뛰기




Volumn 14, Issue 2, 2009, Pages 299-310

Emerging molecular targeted therapies in the treatment of head and neck cancer

Author keywords

Angiogenesis; Cetuximab; EGFR; Head and neck squamous cell carcinoma; Molecular targeted therapies

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; ANTINEOPLASTIC METAL COMPLEX; BEVACIZUMAB; CARBOPLATIN; CEDIRANIB; CELECOXIB; CETUXIMAB; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROURACIL; GEFITINIB; HYDROXYUREA; LAPATINIB; METHOTREXATE; N (5 CHLORO 1,3 BENZODIOXOL 4 YL) 7 [2 (4 METHYL 1 PIPERAZINYL)ETHOXY] 5 (TETRAHYDRO 2H PYRAN 4 YLOXY) 4 QUINAZOLINAMINE; N ACETYLCOLCHINOL PHOSPHATE; PACLITAXEL; PANITUMUMAB; RAPAMYCIN; SEMAXANIB; SORAFENIB; SUNITINIB; TRASTUZUMAB; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VECTBIX;

EID: 67649371250     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728210902997947     Document Type: Review
Times cited : (39)

References (107)
  • 1
    • 33847066782 scopus 로고    scopus 로고
    • The epidemiology and risk factors of head and neck cancer: A focus on human papillomavirus
    • Ragin CC, Modugno F, Gollin SM. The epidemiology and risk factors of head and neck cancer: a focus on human papillomavirus. J Dent Res 2007;86(2):104-114
    • (2007) J Dent Res , vol.86 , Issue.2 , pp. 104-114
    • Ragin, C.C.1    Modugno, F.2    Gollin, S.M.3
  • 2
    • 33847273041 scopus 로고    scopus 로고
    • EGFR-targeting therapies: Monoclonal antibodies versus tyrosine kinase inhibitors. Similarities and differences
    • Dassonville O, Bozec A, Fischel JL, Milano G. EGFR-targeting therapies: monoclonal antibodies versus tyrosine kinase inhibitors. Similarities and differences. Crit Rev Oncol Hematol 2007;62(1):53-61
    • (2007) Crit Rev Oncol Hematol , vol.62 , Issue.1 , pp. 53-61
    • Dassonville, O.1    Bozec, A.2    Fischel, J.L.3    Milano, G.4
  • 4
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • DOI 10.1200/JCO.2005.11.890
    • Baselga J, Arteaga CL. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 2005;23(11):2445-2459 (Pubitemid 47050835)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.11 , pp. 2445-2459
    • Baselga, J.1    Arteaga, C.L.2
  • 6
    • 27144509126 scopus 로고    scopus 로고
    • Promising new advances in head and neck radiotherapy
    • DOI 10.1093/annonc/mdi453
    • Harari PM. Promising new advances in head and neck radiotherapy. Ann Oncol 2005;16(Suppl 6):vi13-9 (Pubitemid 41487946)
    • (2005) Annals of Oncology , vol.16 , Issue.SUPPL. 6
    • Harari, P.M.1
  • 7
    • 34548428839 scopus 로고    scopus 로고
    • Meta-Analyses of Chemotherapy in Head and Neck Cancer (MACH-NC): An update
    • Pignon JP, le Maitre A, Bourhis J. Meta-Analyses of Chemotherapy in Head and Neck Cancer (MACH-NC): an update. Int J Radiat Oncol Biol Phys 2007;69(2 Suppl):S112-4
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , Issue.2 SUPPL.
    • Pignon, J.P.1    Le Maitre, A.2    Bourhis, J.3
  • 11
    • 43449132987 scopus 로고    scopus 로고
    • Head and neck cancer
    • DOI 10.1016/S0140-6736(08)60728-X, PII S014067360860728X
    • Argiris A, Karamouzis MV, Raben D, Ferris RL. Head and neck cancer. Lancet 2008;371(9625):1695-1709 (Pubitemid 351671886)
    • (2008) The Lancet , vol.371 , Issue.9625 , pp. 1695-1709
    • Argiris, A.1    Karamouzis, M.V.2    Raben, D.3    Ferris, R.L.4
  • 12
    • 61449104877 scopus 로고    scopus 로고
    • Targeted therapies in squamous cell carcinoma of the head and neck
    • Gold KA, Lee HY, Kim ES. Targeted therapies in squamous cell carcinoma of the head and neck. Cancer 2009;115(5):922-935
    • (2009) Cancer , vol.115 , Issue.5 , pp. 922-935
    • Gold, K.A.1    Lee, H.Y.2    Kim, E.S.3
  • 14
    • 24944490558 scopus 로고    scopus 로고
    • Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck
    • DOI 10.1200/JCO.2005.07.120
    • Herbst RS, Arquette M, Shin DM, et al. Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck. J Clin Oncol 2005;23(24):5578-5587 (Pubitemid 46300152)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.24 , pp. 5578-5587
    • Herbst, R.S.1    Arquette, M.2    Shin, D.M.3    Dicke, K.4    Vokes, E.E.5    Azarnia, N.6    Hong, W.K.7    Kies, M.S.8
  • 15
    • 23844523253 scopus 로고    scopus 로고
    • Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck
    • DOI 10.1200/JCO.2005.07.119
    • Baselga J, Trigo JM, Bourhis J, et al. Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck. J Clin Oncol 2005;23(24):5568-5577 (Pubitemid 46300151)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.24 , pp. 5568-5577
    • Baselga, J.1    Trigo, J.M.2    Bourhis, J.3    Tortochaux, J.4    Cortes-Funes, H.5    Hitt, R.6    Gascon, P.7    Amellal, N.8    Harstrick, A.9    Eckardt, A.10
  • 16
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group Study
    • DOI 10.1200/JCO.2005.02.4646
    • Burtness B, Goldwasser MA, Flood W, et al. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol 2005;23(34):8646-8654 (Pubitemid 46211507)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.34 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3    Mattar, B.4    Forastiere, A.A.5
  • 17
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008;359(11):1116-1127
    • (2008) N Engl J Med , vol.359 , Issue.11 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 20
    • 49149087647 scopus 로고    scopus 로고
    • Promising newer molecular-targeted therapies in head and neck cancer
    • Wang LX, Agulnik M. Promising newer molecular-targeted therapies in head and neck cancer. Drugs 2008;68(12):1609-1619
    • (2008) Drugs , vol.68 , Issue.12 , pp. 1609-1619
    • Wang, L.X.1    Agulnik, M.2
  • 21
    • 67349108318 scopus 로고    scopus 로고
    • Dysregulated molecular networks in head and neck carcinogenesis
    • In press, doi:10.1016/j.oraloncology.2008.07.011
    • Molinolo AA, Amornphimoltham P, Squarize CH, et al. Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 2008; In press, doi:10.1016/j.oraloncology.2008.07.011
    • (2008) Oral Oncol
    • Molinolo, A.A.1    Amornphimoltham, P.2    Squarize, C.H.3
  • 22
    • 0027183870 scopus 로고
    • Elevated levels of transforming growth factor α and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer
    • Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 1993;53(15):3579-3584 (Pubitemid 23229640)
    • (1993) Cancer Research , vol.53 , Issue.15 , pp. 3579-3584
    • Grandis, J.R.1    Tweardy, D.J.2
  • 23
    • 31544433743 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors in cancer treatment
    • Ciardiello F. Epidermal growth factor receptor inhibitors in cancer treatment. Future Oncol 2005;1(2):221-234
    • (2005) Future Oncol , vol.1 , Issue.2 , pp. 221-234
    • Ciardiello, F.1
  • 24
    • 40749106939 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells
    • Iwase M, Takaoka S, Uchida M, et al. Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells. Oral Oncol 2008;44(4):361-368
    • (2008) Oral Oncol , vol.44 , Issue.4 , pp. 361-368
    • Iwase, M.1    Takaoka, S.2    Uchida, M.3
  • 26
    • 0036570203 scopus 로고    scopus 로고
    • ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
    • Hirata A, Ogawa S, Kometani T, et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res 2002;62(9):2554-2560 (Pubitemid 34462734)
    • (2002) Cancer Research , vol.62 , Issue.9 , pp. 2554-2560
    • Hirata, A.1    Ogawa, S.-I.2    Kometani, T.3    Kuwano, T.4    Naito, S.5    Kuwano, M.6    Ono, M.7
  • 27
    • 65549139376 scopus 로고    scopus 로고
    • FcgammaRIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck
    • In press, doi:10.1007/s00262-008-0613-3
    • Taylor RJ, Chan SL, Wood A, et al. FcgammaRIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck. Cancer Immunol Immunother 2008; In press, doi:10.1007/s00262-008-0613-3
    • (2008) Cancer Immunol Immunother
    • Taylor, R.J.1    Chan, S.L.2    Wood, A.3
  • 28
    • 0345098557 scopus 로고    scopus 로고
    • Monoclonal antibodies in human cancer
    • Mellstedt H. Monoclonal antibodies in human cancer. Drugs Today (Barc) 2003;39(Suppl C):1-16 (Pubitemid 37509400)
    • (2003) Drugs of Today , vol.39 , Issue.SUPPL. C , pp. 1-16
    • Mellstedt, H.1
  • 29
    • 0035524114 scopus 로고    scopus 로고
    • Improving the efficacy of antibody-based cancer therapies
    • Carter P. Improving the efficacy of antibody-based cancer therapies. Nat Rev Cancer 2001;1(2):118-129 (Pubitemid 33741887)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.2 , pp. 118-129
    • Carter, P.1
  • 30
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • DOI 10.1200/JCO.2005.06.081
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23(5):1011-1027 (Pubitemid 46202320)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 33
    • 49549123352 scopus 로고    scopus 로고
    • Vertical VEGF targeting: A combination of ligand blockade with receptor tyrosine kinase inhibition
    • Bozec A, Gros FX, Penault-Llorca F, et al. Vertical VEGF targeting: A combination of ligand blockade with receptor tyrosine kinase inhibition. Eur J Cancer 2008;44(13):1922-1930
    • (2008) Eur J Cancer , vol.44 , Issue.13 , pp. 1922-1930
    • Bozec, A.1    Gros, F.X.2    Penault-Llorca, F.3
  • 34
    • 0842311621 scopus 로고    scopus 로고
    • Vascular Targeting Agents As Cancer Therapeutics
    • DOI 10.1158/1078-0432.CCR-0642-03
    • Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 2004;10(2):415-427 (Pubitemid 38173977)
    • (2004) Clinical Cancer Research , vol.10 , Issue.2 , pp. 415-427
    • Thorpe, P.E.1
  • 38
    • 4444230648 scopus 로고    scopus 로고
    • Ionizing radiation causes a dose-dependent release of transforming growth factor α in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma
    • DOI 10.1158/1078-0432.CCR-04-0420
    • Hagan M, Yacoub A, Dent P. Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma. Clin Cancer Res 2004;10(17):5724-5731 (Pubitemid 39180948)
    • (2004) Clinical Cancer Research , vol.10 , Issue.17 , pp. 5724-5731
    • Hagan, M.1    Yacoub, A.2    Dent, P.3
  • 39
    • 39949084155 scopus 로고    scopus 로고
    • Chemoradiotherapy in head and neck squamous cell carcinoma: Focus on targeted therapies
    • Bozec A, Thariat J, Bensadoun RJ, Milano G. Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies. Cancer Radiother 2008;12(1):14-24
    • (2008) Cancer Radiother , vol.12 , Issue.1 , pp. 14-24
    • Bozec, A.1    Thariat, J.2    Bensadoun, R.J.3    Milano, G.4
  • 40
    • 33845780061 scopus 로고    scopus 로고
    • Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer
    • DOI 10.1158/0008-5472.CAN-06-2414
    • Cao C, Albert JM, Geng L, et al. Vascular endothelial growth factor tyrosine kinase inhibitor AZD2171 and fractionated radiotherapy in mouse models of lung cancer. Cancer Res 2006;66(23):11409-11415 (Pubitemid 46009972)
    • (2006) Cancer Research , vol.66 , Issue.23 , pp. 11409-11415
    • Cao, C.1    Albert, J.M.2    Geng, L.3    Ivy, P.S.4    Sandler, A.5    Johnson, D.H.6    Lu, B.7
  • 41
    • 46349090009 scopus 로고    scopus 로고
    • Combined effects of bevacizumab with erlotinib and irradiation: A preclinical study on a head and neck cancer orthotopic model
    • DOI 10.1038/sj.bjc.6604429, PII 6604429
    • Bozec A, Sudaka A, Fischel JL, et al. Combined effects of bevacizumab with erlotinib and irradiation: a preclinical study on a head and neck cancer orthotopic model. Br J Cancer 2008;99(1):93-99 (Pubitemid 351920227)
    • (2008) British Journal of Cancer , vol.99 , Issue.1 , pp. 93-99
    • Bozec, A.1    Sudaka, A.2    Fischel, J.-L.3    Brunstein, M.-C.4    Etienne-Grimaldi, M.-C.5    Milano, G.6
  • 42
    • 34347333556 scopus 로고    scopus 로고
    • Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: Antitumour supra-additive effects on human head and neck cancer xenografts
    • DOI 10.1038/sj.bjc.6603791, PII 6603791
    • Bozec A, Formento P, Lassalle S, et al. Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: antitumour supra-additive effects on human head and neck cancer xenografts. Br J Cancer 2007;97(1):65-72 (Pubitemid 47012080)
    • (2007) British Journal of Cancer , vol.97 , Issue.1 , pp. 65-72
    • Bozec, A.1    Formento, P.2    Lassalle, S.3    Lippens, C.4    Hofman, P.5    Milano, G.6
  • 43
    • 0036145292 scopus 로고    scopus 로고
    • The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation
    • Ning S, Laird D, Cherrington JM, Knox SJ. The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Radiat Res 2002;157(1):45-51 (Pubitemid 34073387)
    • (2002) Radiation Research , vol.157 , Issue.1 , pp. 45-51
    • Ning, S.1    Laird, D.2    Cherrington, J.M.3    Knox, S.J.4
  • 44
    • 0036569804 scopus 로고    scopus 로고
    • Enhancement of radiation therapy by the novel vascular targeting agent ZD6126
    • DOI 10.1016/S0360-3016(02)02742-6, PII S0360301602027426
    • Siemann DW, Rojiani AM. Enhancement of radiation therapy by the novel vascular targeting agent ZD6126. Int J Radiat Oncol Biol Phys 2002;53(1):164-171 (Pubitemid 34465821)
    • (2002) International Journal of Radiation Oncology Biology Physics , vol.53 , Issue.1 , pp. 164-171
    • Siemann, D.W.1    Rojiani, A.M.2
  • 46
    • 48749113487 scopus 로고    scopus 로고
    • Antitumor effect of gefitinib on head and neck squamous cell carcinoma enhanced by trastuzumab
    • Kondo N, Ishiguro Y, Kimura M, et al. Antitumor effect of gefitinib on head and neck squamous cell carcinoma enhanced by trastuzumab. Oncol Rep 2008;20(2):373-378
    • (2008) Oncol Rep , vol.20 , Issue.2 , pp. 373-378
    • Kondo, N.1    Ishiguro, Y.2    Kimura, M.3
  • 47
    • 33846709211 scopus 로고    scopus 로고
    • Lapatinib: A dual inhibitor of EGFR and HER2 tyrosine kinase activity
    • DOI 10.1517/14712598.7.2.257
    • Montemurro F, Valabrega G, Aglietta M. Lapatinib: a dual inhibitor of EGFR and HER2 tyrosine kinase activity. Expert Opin Biol Ther 2007;7(2):257-268 (Pubitemid 46192173)
    • (2007) Expert Opinion on Biological Therapy , vol.7 , Issue.2 , pp. 257-268
    • Montemurro, F.1    Valabrega, G.2    Aglietta, M.3
  • 48
    • 33846850223 scopus 로고    scopus 로고
    • Vandetanib (ZD6474): An orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis
    • DOI 10.1517/13543784.16.2.239
    • Herbst RS, Heymach JV, O'Reilly MS, et al. Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin Investig Drugs 2007;16(2):239-249 (Pubitemid 46206638)
    • (2007) Expert Opinion on Investigational Drugs , vol.16 , Issue.2 , pp. 239-249
    • Herbst, R.S.1    Heymach, J.V.2    O'Reilly, M.S.3    Onn, A.4    Ryan, A.J.5
  • 49
    • 33947732141 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474 on head and neck squamous cell carcinoma
    • Sano D, Kawakami M, Fujita K, et al. Antitumor effects of ZD6474 on head and neck squamous cell carcinoma. Oncol Rep 2007;17(2):289-295
    • (2007) Oncol Rep , vol.17 , Issue.2 , pp. 289-295
    • Sano, D.1    Kawakami, M.2    Fujita, K.3
  • 50
    • 36348941014 scopus 로고    scopus 로고
    • Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib (ZD6474, Zactima) in combination with radiotherapy in EGFR-positive and EGFR-null human head and neck tumor xenografts
    • DOI 10.1007/s00280-007-0460-5
    • Gustafson DL, Frederick B, Merz AL, Raben D. Dose scheduling of the dual VEGFR and EGFR tyrosine kinase inhibitor vandetanib (ZD6474, Zactima) in combination with radiotherapy in EGFR-positive and EGFR-null human head and neck tumor xenografts. Cancer Chemother Pharmacol 2008;61(2):179-188 (Pubitemid 350160317)
    • (2008) Cancer Chemotherapy and Pharmacology , vol.61 , Issue.2 , pp. 179-188
    • Gustafson, D.L.1    Frederick, B.2    Merz, A.L.3    Raben, D.4
  • 51
    • 4344610825 scopus 로고    scopus 로고
    • Src family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells
    • DOI 10.1158/0008-5472.CAN-04-0504
    • Zhang Q, Thomas SM, Xi S, et al. SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. Cancer Res 2004;64(17):6166-6173 (Pubitemid 39129418)
    • (2004) Cancer Research , vol.64 , Issue.17 , pp. 6166-6173
    • Zhang, Q.1    Thomas, S.M.2    Xi, S.3    Smithgall, T.E.4    Siegfried, J.M.5    Kamens, J.6    Gooding, W.E.7    Grandis, J.R.8
  • 52
    • 48249097921 scopus 로고    scopus 로고
    • Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma
    • Koppikar P, Choi SH, Egloff AM, et al. Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma. Clin Cancer Res 2008;14(13):4284-4291
    • (2008) Clin Cancer Res , vol.14 , Issue.13 , pp. 4284-4291
    • Koppikar, P.1    Choi, S.H.2    Egloff, A.M.3
  • 54
    • 44249117111 scopus 로고    scopus 로고
    • Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck
    • Boehm AL, Sen M, Seethala R, et al. Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck. Mol Pharmacol 2008;73(6):1632-1642
    • (2008) Mol Pharmacol , vol.73 , Issue.6 , pp. 1632-1642
    • Boehm, A.L.1    Sen, M.2    Seethala, R.3
  • 55
    • 39449120471 scopus 로고    scopus 로고
    • A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer
    • DOI 10.1158/0008-5472.CAN-07-1756
    • Amornphimoltham P, Patel V, Leelahavanichkul K, et al. A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer. Cancer Res 2008;68(4):1144-1153 (Pubitemid 351272233)
    • (2008) Cancer Research , vol.68 , Issue.4 , pp. 1144-1153
    • Amornphimoltham, P.1    Patel, V.2    Leelahavanichkul, K.3    Abraham, R.T.4    Gutkind, J.S.5
  • 56
    • 43749116022 scopus 로고    scopus 로고
    • Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines
    • DOI 10.1007/s00280-007-0609-2
    • Aissat N, Le Tourneau C, Ghoul A, et al. Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines. Cancer Chemother Pharmacol 2008;62(2):305-313 (Pubitemid 351692089)
    • (2008) Cancer Chemotherapy and Pharmacology , vol.62 , Issue.2 , pp. 305-313
    • Aissat, N.1    Le Tourneau, C.2    Ghoul, A.3    Serova, M.4    Bieche, I.5    Lokiec, F.6    Raymond, E.7    Faivre, S.8
  • 57
    • 41949091830 scopus 로고    scopus 로고
    • Molecular-targeted therapies in the treatment of squamous cell carcinomas of the head and neck
    • Le Tourneau C, Siu LL. Molecular-targeted therapies in the treatment of squamous cell carcinomas of the head and neck. Curr Opin Oncol 2008;20(3):256-263
    • (2008) Curr Opin Oncol , vol.20 , Issue.3 , pp. 256-263
    • Le Tourneau, C.1    Siu, L.L.2
  • 58
    • 34547107855 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor as a therapeutic target in head and neck cancer
    • Barnes CJ, Ohshiro K, Rayala SK, et al. Insulin-like growth factor receptor as a therapeutic target in head and neck cancer. Clin Cancer Res 2007;13(14):4291-4299
    • (2007) Clin Cancer Res , vol.13 , Issue.14 , pp. 4291-4299
    • Barnes, C.J.1    Ohshiro, K.2    Rayala, S.K.3
  • 59
    • 67649344865 scopus 로고    scopus 로고
    • Prolongation of survival with the addition of cetuximab to radiation in patients with locoregionally advanced head and neck cancer (SCCHN): Five-year results from a randomized trial
    • Presented at
    • Bonner JA. Prolongation of survival with the addition of cetuximab to radiation in patients with locoregionally advanced head and neck cancer (SCCHN): five-year results from a randomized trial. Presented at: American Society for Therapeutic Radiology and Oncology's 50th Annual Meeting, Boston, 2008 September 21-25
    • American Society for Therapeutic Radiology and Oncology's 50th Annual Meeting, Boston, 2008 September 21-25
    • Bonner, J.A.1
  • 60
    • 39049165254 scopus 로고    scopus 로고
    • Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck
    • Bernier J, Bonner J, Vermorken JB, et al. Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. Ann Oncol 2008;19(1):142-149
    • (2008) Ann Oncol , vol.19 , Issue.1 , pp. 142-149
    • Bernier, J.1    Bonner, J.2    Vermorken, J.B.3
  • 61
    • 55849139425 scopus 로고    scopus 로고
    • Molecularly targeted agents in the treatment of recurrent or metastatic squamous cell carcinomas of the head and neck
    • ix
    • Le Tourneau C, Chen EX. Molecularly targeted agents in the treatment of recurrent or metastatic squamous cell carcinomas of the head and neck. Hematol Oncol Clin North Am 2008;22(6):1209-20, ix
    • (2008) Hematol Oncol Clin North Am , vol.22 , Issue.6 , pp. 1209-1220
    • Le Tourneau, C.1    Chen, E.X.2
  • 62
    • 46049093437 scopus 로고    scopus 로고
    • Targeted therapy in head and neck cancer: State of the art 2007 and review of clinical applications
    • Langer CJ. Targeted therapy in head and neck cancer: state of the art 2007 and review of clinical applications. Cancer 2008;112(12):2635-2645
    • (2008) Cancer , vol.112 , Issue.12 , pp. 2635-2645
    • Langer, C.J.1
  • 63
    • 37349063195 scopus 로고    scopus 로고
    • Immune activation by epidermal growth factor receptor-specific monoclonal antibody therapy for head and neck cancer
    • DOI 10.1001/archotol.133.12.1277
    • Lopez-Albaitero A, Ferris RL. Immune activation by epidermal growth factor receptor specific monoclonal antibody therapy for head and neck cancer. Arch Otolaryngol Head Neck Surg 2007;133(12):1277-1281 (Pubitemid 350294259)
    • (2007) Archives of Otolaryngology - Head and Neck Surgery , vol.133 , Issue.12 , pp. 1277-1281
    • Lopez-Albaitero, A.1    Ferris, R.L.2
  • 64
    • 51449117743 scopus 로고    scopus 로고
    • Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer
    • Kruser TJ, Armstrong EA, Ghia AJ, et al. Augmentation of radiation response by panitumumab in models of upper aerodigestive tract cancer. Int J Radiat Oncol Biol Phys 2008;72(2):534-542
    • (2008) Int J Radiat Oncol Biol Phys , vol.72 , Issue.2 , pp. 534-542
    • Kruser, T.J.1    Armstrong, E.A.2    Ghia, A.J.3
  • 65
    • 47349117201 scopus 로고    scopus 로고
    • Current aspects of targeted therapy in head and neck tumors
    • Dietz A, Boehm A, Mozet C, et al. Current aspects of targeted therapy in head and neck tumors. Eur Arch Otorhinolaryngol 2008;265(Suppl 1):S3-12
    • (2008) Eur Arch Otorhinolaryngol , vol.265 , Issue.SUPPL. 1
    • Dietz, A.1    Boehm, A.2    Mozet, C.3
  • 67
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • DOI 10.1200/JCO.2004.06.075
    • Soulieres D, Senzer NN, Vokes EE, et al. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 2004;22(1):77-85 (Pubitemid 41095117)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.1 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarvala, S.S.5    Siu, L.L.6
  • 69
    • 31344471197 scopus 로고    scopus 로고
    • Preliminary results of a phase II study to evaluate gefitinib combined with docetaxel and cisplatin in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck
    • abstract 5563
    • Belon J, Irigoyen A, Rodriguez I, et al. Preliminary results of a phase II study to evaluate gefitinib combined with docetaxel and cisplatin in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck [abstract 5563]. J Clin Oncol 2005;23(Suppl)
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL.
    • Belon, J.1    Irigoyen, A.2    Rodriguez, I.3
  • 70
    • 41949113428 scopus 로고    scopus 로고
    • Final results of a phase II study of erlotinib, docetaxel and cisplatin in patients with recurrent / metastatic head and neck cancer
    • abstract 6013
    • Kim ES, Kies M, Glisson BS, et al. Final results of a phase II study of erlotinib, docetaxel and cisplatin in patients with recurrent / metastatic head and neck cancer [abstract 6013]. J Clin Oncol 2007;25(Suppl)
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL.
    • Kim, E.S.1    Kies, M.2    Glisson, B.S.3
  • 72
    • 33748636081 scopus 로고    scopus 로고
    • A phase II study of lapatinib (GW572016) in recurrent / metastatic squamous cell carcinoma of the head and neck
    • abstract 5568
    • Abidoye OO, Cohen EE, Wong SJ, et al. A phase II study of lapatinib (GW572016) in recurrent / metastatic squamous cell carcinoma of the head and neck [abstract 5568]. J Clin Oncol 2006;24(Suppl)
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL.
    • Abidoye, O.O.1    Cohen, E.E.2    Wong, S.J.3
  • 73
    • 67649368458 scopus 로고    scopus 로고
    • Available from
    • Available from: www.clinicaltrials.gov
  • 76
    • 43249128897 scopus 로고    scopus 로고
    • Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer
    • Seiwert TY, Haraf DJ, Cohen EE, et al. Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer. J Clin Oncol 2008;26(10):1732-1741
    • (2008) J Clin Oncol , vol.26 , Issue.10 , pp. 1732-1741
    • Seiwert, T.Y.1    Haraf, D.J.2    Cohen, E.E.3
  • 77
    • 62349097073 scopus 로고    scopus 로고
    • Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: A phase I/II study
    • Cohen EE, Davis DW, Karrison TG, et al. Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study. Lancet Oncol 2009;10(3):247-257
    • (2009) Lancet Oncol , vol.10 , Issue.3 , pp. 247-257
    • Cohen, E.E.1    Davis, D.W.2    Karrison, T.G.3
  • 80
    • 30544434038 scopus 로고    scopus 로고
    • Quantitative molecular diagnosis of axillary drainage fluid for prediction of locoregional failure in patients with one to three positive axillary nodes after mastectomy without adjuvant radiotherapy
    • DOI 10.1016/j.ijrobp.2005.07.984, PII S0360301605023783
    • Zhang Y, Ma QY, Dang CX, et al. Quantitative molecular diagnosis of axillary drainage fluid for prediction of locoregional failure in patients with one to three positive axillary nodes after mastectomy without adjuvant radiotherapy. Int J Radiat Oncol Biol Phys 2006;64(2):505-511 (Pubitemid 43083439)
    • (2006) International Journal of Radiation Oncology Biology Physics , vol.64 , Issue.2 , pp. 505-511
    • Zhang, Y.1    Ma, Q.Y.2    Dang, C.X.3    Moureau-Zabotto, M.4    Chen, W.K.5
  • 81
    • 19444363601 scopus 로고    scopus 로고
    • Abdominal surgical interventions: Local and systemic consequences for the immune system - A prospective study on elective gastrointestinal surgery
    • DOI 10.1016/j.jss.2005.01.006, PII S0022480405000119
    • Decker D, Tolba R, Springer W, et al. Abdominal surgical interventions: local and systemic consequences for the immune system - a prospective study on elective gastrointestinal surgery. J Surg Res 2005;126(1):12-18 (Pubitemid 40726240)
    • (2005) Journal of Surgical Research , vol.126 , Issue.1 , pp. 12-18
    • Decker, D.1    Tolba, R.2    Springer, W.3    Lauschke, H.4    Hirner, A.5    Von Ruecker, A.6
  • 83
    • 34147170787 scopus 로고    scopus 로고
    • Neo-adjuvant treatment with erlotinib in squamous cell carcinoma head and neck (SCCHN) patients before surgery provides an opportunity to find predictive factors of response
    • abstract 5513
    • Delord J, Thomas A, Benlyazid J, et al. Neo-adjuvant treatment with erlotinib in squamous cell carcinoma head and neck (SCCHN) patients before surgery provides an opportunity to find predictive factors of response [abstract 5513]. J Clin Oncol 2006;18(Suppl)
    • (2006) J Clin Oncol , vol.18 , Issue.SUPPL.
    • Delord, J.1    Thomas, A.2    Benlyazid, J.3
  • 84
    • 67649323799 scopus 로고    scopus 로고
    • Erlotinib (E) as adjuvant treatment for patients (pts) with resected head and neck squamous cell carcinoma (HNSCC) with evaluation of neoadjuvant biomarker modulation with e with or without sulindac (S): A feasibility report
    • abstract 6037
    • Grandis JR, Lai SY, Esteve FR, et al. Erlotinib (E) as adjuvant treatment for patients (pts) with resected head and neck squamous cell carcinoma (HNSCC) with evaluation of neoadjuvant biomarker modulation with E with or without sulindac (S): a feasibility report [abstract 6037]. J Clin Oncol 2008;20(Suppl)
    • (2008) J Clin Oncol , vol.20 , Issue.SUPPL.
    • Grandis, J.R.1    Lai, S.Y.2    Esteve, F.R.3
  • 85
    • 77951448831 scopus 로고    scopus 로고
    • Phase II study of bevacizumab with docetaxel and radiation in locally advanced head and neck squamous cell cancer
    • abstract 6071
    • Savvides P, Greskovich J, Bokar JA, et al. Phase II study of bevacizumab with docetaxel and radiation in locally advanced head and neck squamous cell cancer [abstract 6071]. J Clin Oncol 2008;20(Suppl)
    • (2008) J Clin Oncol , vol.20 , Issue.SUPPL.
    • Savvides, P.1    Greskovich, J.2    Bokar, J.A.3
  • 86
    • 63149136088 scopus 로고    scopus 로고
    • Cetuximab (C) and bevacizumab (B) in patients with recurrent or metastatic head and neck squamous cell carcinoma (SCCHN): An interim analysis
    • abstract 6072
    • Kies MS, Gibson MK, Kim SW, et al. Cetuximab (C) and bevacizumab (B) in patients with recurrent or metastatic head and neck squamous cell carcinoma (SCCHN): an interim analysis [abstract 6072]. J Clin Oncol 2008;20(Suppl)
    • (2008) J Clin Oncol , vol.20 , Issue.SUPPL.
    • Kies, M.S.1    Gibson, M.K.2    Kim, S.W.3
  • 87
    • 34250220692 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition in head and neck cancer - More insights, but more questions
    • DOI 10.1200/JCO.2007.10.9017
    • Forastiere AA, Burtness BA. Epidermal growth factor receptor inhibition in head and neck cancer-more insights, but more questions. J Clin Oncol 2007;25(16):2152-2155 (Pubitemid 46954634)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.16 , pp. 2152-2155
    • Forastiere, A.A.1    Burtness, B.A.2
  • 90
    • 33646154001 scopus 로고    scopus 로고
    • Detection of EGFR- and HER2-activating mutations in squamous cell carcinoma involving the head and neck
    • Willmore-Payne C, Holden JA, Layfield LJ. Detection of EGFR- and HER2-activating mutations in squamous cell carcinoma involving the head and neck. Mod Pathol 2006;19(5):634-640
    • (2006) Mod Pathol , vol.19 , Issue.5 , pp. 634-640
    • Willmore-Payne, C.1    Holden, J.A.2    Layfield, L.J.3
  • 91
    • 14444288522 scopus 로고    scopus 로고
    • The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
    • DOI 10.1074/jbc.272.5.2927
    • Huang HS, Nagane M, Klingbeil CK, et al. The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling. J Biol Chem 1997;272(5):2927-2935 (Pubitemid 27053343)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.5 , pp. 2927-2935
    • Su Huang, H.-J.1    Nagane, M.2    Klingbeil, C.K.3    Lin, H.4    Nishikawa, R.5    Ji, X.-D.6    Huang, C.-M.7    Gill, G.N.8    Wiley, H.S.9    Cavenee, W.K.10
  • 92
    • 0029025332 scopus 로고
    • Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas
    • Wikstrand CJ, Hale LP, Batra SK, et al. Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res 1995;55(14):3140-3148
    • (1995) Cancer Res , vol.55 , Issue.14 , pp. 3140-3148
    • Wikstrand, C.J.1    Hale, L.P.2    Batra, S.K.3
  • 93
    • 0030832167 scopus 로고    scopus 로고
    • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII
    • Wikstrand CJ, McLendon RE, Friedman AH, Bigner DD. Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. Cancer Res 1997;57(18):4130-4140 (Pubitemid 27427708)
    • (1997) Cancer Research , vol.57 , Issue.18 , pp. 4130-4140
    • Wikstrand, C.J.1    McLendon, R.E.2    Friedman, A.H.3    Bigner, D.D.4
  • 95
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre A, Bachet JB, Le Corre D, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006;66(8):3992-3995
    • (2006) Cancer Res , vol.66 , Issue.8 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 96
    • 0030598156 scopus 로고    scopus 로고
    • The activation of K-ras gene at an early stage of lung tumorigenesis in mice
    • DOI 10.1016/0304-3835(96)04351-0, PII S0304383596043510
    • Ichikawa T, Yano Y, Uchida M, et al. The activation of K-ras gene at an early stage of lung tumorigenesis in mice. Cancer Lett 1996;107(2):165-170 (Pubitemid 26381984)
    • (1996) Cancer Letters , vol.107 , Issue.2 , pp. 165-170
    • Ichikawa, T.1    Yano, Y.2    Uchida, M.3    Otani, S.4    Hagiwara, K.5    Yano, T.6
  • 97
    • 0028897398 scopus 로고
    • Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon
    • Yamashita N, Minamoto T, Ochiai A, et al. Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon. Gastroenterology 1995;108(2):434-440
    • (1995) Gastroenterology , vol.108 , Issue.2 , pp. 434-440
    • Yamashita, N.1    Minamoto, T.2    Ochiai, A.3
  • 100
    • 0025732716 scopus 로고
    • High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India
    • Saranath D, Chang SE, Bhoite LT, et al. High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India. Br J Cancer 1991;63(4):573-578
    • (1991) Br J Cancer , vol.63 , Issue.4 , pp. 573-578
    • Saranath, D.1    Chang, S.E.2    Bhoite, L.T.3
  • 101
    • 0029073913 scopus 로고
    • Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas
    • Spencer JM, Kahn SM, Jiang W, et al. Activated ras genes occur in human actinic keratoses, premalignant precursors to squamous cell carcinomas. Arch Dermatol 1995;131(7):796-800
    • (1995) Arch Dermatol , vol.131 , Issue.7 , pp. 796-800
    • Spencer, J.M.1    Kahn, S.M.2    Jiang, W.3
  • 103
    • 0037115610 scopus 로고    scopus 로고
    • Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma
    • Hoa M, Davis SL, Ames SJ, Spanjaard RA. Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma. Cancer Res 2002;62(24):7154-7156 (Pubitemid 36025228)
    • (2002) Cancer Research , vol.62 , Issue.24 , pp. 7154-7156
    • Hoa, M.1    Davis, S.L.2    Ames, S.J.3    Spanjaard, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.