Exposure of young men to organochlorine pesticides in Southern Spain

Environmental Research

Volumn 103, Issue 1, 2007, Pages 55-61

  Carreño, Javier ^a   Rivas, Ana ^a   Granada, Alicia ^a   Jose Lopez Espinosa, Maria ^a   Mariscal, Miguel ^a   Olea, Nicolas ^a   Olea Serrano, Fatima ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

Endocrine disruptors; Male; Pesticides; Reproductive health; Serum

Indexed keywords

ALDRIN; DIELDRIN; ENDOSULFAN; ENDRIN; HEXACHLOROBENZENE; LINDANE; METHOXYCHLOR; ORGANOCHLORINE PESTICIDE; SULFATE;

ENDOCRINE DISRUPTOR; ESTROGENIC COMPOUND; ETIOLOGY; METABOLITE; ORGANOCHLORINE; PESTICIDE; POLLUTION EXPOSURE; REPRODUCTIVE HEALTH; YOUNG POPULATION;

ADULT; AGRICULTURE; ARTICLE; BLOOD LEVEL; CONCENTRATION (PARAMETERS); CRYPTORCHISM; ENVIRONMENTAL EXPOSURE; GREENHOUSE; HUMAN; HYPOSPADIAS; MALE; MALE GENITAL SYSTEM; METABOLITE; NORMAL HUMAN; PRIORITY JOURNAL; REPRODUCTIVE HEALTH; SAMPLING; SERUM; SPAIN; SPERMATOZOON COUNT; TESTIS CANCER;

ADULT; BODY MASS INDEX; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; HYDROCARBONS, CHLORINATED; MALE; MATERNAL EXPOSURE; OCCUPATIONAL EXPOSURE; PESTICIDES; PREGNANCY; SPAIN;

EURASIA; EUROPE; MEDITERRANEAN COAST [SPAIN]; SOUTHERN EUROPE; SPAIN;

EID: 33845453623     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2006.06.007     Document Type: Article

References (65)

1. Abell A., Ernst E., and Bonde J.P. Semen quality and sexual hormones in greenhouse workers. Scand. J. Work Environ. Health 26 (2000) 492-500
2. Ahlborg U.G., Lipworth L., Titus-Ernstoff L., Hsieh C.C., Hanberg A., Baron J., Trichopoulos D., and Adami H.O. Organochlorine compounds in relation to breast cancer, endometrial cancer, and endometriosis: an assessment of the biological and epidemiological evidence. Crit. Rev. Toxicol. 25 (1995) 463-531
3. Andersen H.R., Andersson A.M., Arnold S.F., Autrup H., Barfoed M., Beresford N.A., Bjerregaard P., Christiansen L.B., Gissel B., Hummel R., Jorgensen E.B., Korsgaard B., Le Guevel R., Leffers H., McLachlan J., Moller A., Nielsen J.B., Olea N., Oles-Karasko A., Pakdel F., Pedersen K.L., Perez P., Skakkeboek N.E., Sonnenschein C., Soto A.M., et al. Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals. Environ. Health Perspect. 107 (1999) 89-108
4. Ariño A., Lazaro R., Conchello P., Bayarri S., and Herrera A. The effect of commercial processing on incurredresidues of DDE in meat products. Food Addit. Contam. 12 (1995) 559-566
5. Arrebola F.J., Egea-Gonzalez F.J., Moreno M., Fernandez-Gutierrez A., Hernandez-Torres M.E., and Martinez-Vidal J.L. Evaluation of endosulfan residues in vegetables grown in greenhouses. Pest. Manage. Sci. 57 (2001) 645-652
6. Blasco C., Lino C.M., Pico Y., Pena A., Font G., and Silveira M.I. Determination of organochlorine pesticide residues in honey from the central zone of Portugal and the Valencian community of Spain. J. Chromatogr. A 1049 (2004) 155-160
7. Botella B., Crespo J., Rivas A., Cerrillo I., Olea-Serrano M.F., and Olea N. Exposure of women to organochlorine pesticides in Southern Spain. Environ. Res. 96 (2004) 34-40
8. Campoy C., Jiménez M., Olea-Serrano M.F., Moreno-Frias M., Cañabate F., Olea N., Bayes R., and Molina-Font J.A. Analysis of organochlorine pesticides in human milk: preliminary results. Early Human Develop. 65 (2001) S183-S190
9. Cerrillo I., Granada A., Lopez-Espinosa M.J., Olmos B., Jimenez M., Cano A., Olea N., and Olea-Serrano F. Endosulfan and its metabolites in fertile women, placenta, cord blood, and human milk. Environ. Res. 98 (2005) 233-239
10. Cruz S., Lino C., and Silveira M.I. Evaluation of organochlorine pesticide residues in human serum from an urban and two rural populations in Portugal. Sci. Total Environ. 317 (2003) 23-35
11. Cooper G.S., Martin S.A., Longnecker M.P., Sandler D.P., and Germolec D.R. Associations between plasma DDE levels and immunologic measures in African-American farmers in North Carolina. Environ. Health Perspect. 112 (2004) 1080-1084
12. Deutch B., Pedersen H.S., Jorgensen E.C., and Hansen J.C. Smoking as a determinant of high organochlorine levels in Greenland. Arch. Environ. Health 58 (2003) 30-36
13. Di Muccio A., Camoni I., Citti P., and Pontecorvo D. Survey of DDT-like compounds in Dicofol formulations. Ecotoxicol. Environ. Saf. 16 (1988) 129-132
14. Dirtu A.C., Cernat R., Dragan D., Mocanu R., Van Grieken R., Neels H., and Covaci A. Organohalogenated pollutants in human serum from Iassy, Romania and their relation with age and gender. Environ. Int. 32 (2006) 797-803
15. EPA. Environmental Protection Agency, 2002, (Consulted on www.cdc.gov/exposurereport/).
16. EU Endosulfan preliminary Dossier, 2003.
17. Fernandez M., Pico Y., and Manes J. Pesticide residues in oranges from Valencia (Spain). Food Addit. Contam. 18 (2001) 615-624
18. Fernández M., Rivas A., Olea-Serrano M.F., Cerrillo I., Molina-Molina J.M., Araque P., Martinez-Vidal J.L., and Olea N. Assessment of total effective xenoestrogen burden in adipose tissue and identification of chemicals reponsible for the combined estrogenic effect. Anal. Bioanal. Chem. 379 (2004) 163-170
19. Frenich A.G., Pablos Espada M.C., Martinez Vidal J.L., and Molina L. Broad-spectrum determination of pesticides in groundwater by gas chromatography with electron capture detection, nitrogen-phosphorus detection, and tandem mass spectrometry. J. AOAC Int. 84 (2001) 1751-1762
20. Garcia-Rodriguez J., Garcia-Martin M., Nogueras-Ocana M., Luna-del-Castillo J., Espigares Garcia M., Olea N., and Lardelli-Claret P. Exposure to pesticides and cryptorchidism: geographical evidence of a possible association. Environ. Health Perspect. 104 (1996) 1090-1095
21. Glynn A.W., Granath F., Aune M., Atuma S., Darnerud P.O., Bjerselius R., Vainio H., and Weiderpass E. Organochlorines in Swedish women: determinants of serum concentrations. Environ. Health Perspect. 111 (2003) 349-355
22. Gómez-Catalán J., lezaun M., To-Figueras J., and Corbella J. Organochlroine residues in the adipose tissue of the population of Navarra (Spain). Bull. Environ. Contam. Toxicol. 54 (1995) 534-540
23. Hardell L., van Bavel B., Lindstrom G., Carlberg M., Dreifaldt A.C., Wijkstrom H., Starkhammar H., Eriksson M., Hallquist A., and Kolmert T. Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer. Environ. Health Perspect. 111 (2003) 930-934
24. Hernandez F., Pitarch E., Serrano R., Gaspar J.V., and Olea N. Multiresidue determination of endosulfan and metabolic derivatives in human adipose tissue using automated liquid chromatographic cleanup and gas chromatographic analysis. J. Anal. Toxicol. 26 (2002) 94-103
25. Hernandez L.M., Fernandez M.A., and Gonzalez M.J. Organochlorine pollutants in water, soils, and earthworms in the Guadalquivir River, Spain. Bull. Environ. Contam. Toxicol. 49 (1992) 192-198
26. Hosie S., Loff S., Witt K., Niessen K., and Waag K.L. Is there a correlation between organochlorine compounds and undescended testes?. Eur. J. Pediatr. Surg. 10 (2000) 304-309
27. Ibarluzea J.M.J., Fernandez M.F., Santa-Marina L., Olea-Serrano M.F., Rivas A.M., Aurrekoetxea J.J., Exposito J., Lorenzo M., Torne P., Villalobos M., Pedraza V., Sasco A., and Olea N. Breast cancer risk and the combined effect of environmental estrogens. Cancer Causes Control 15 (2004) 591-600
28. Kalantzi O.I., Alcock R.E., Johnston P.A., Santillo D., Stringer R.L., Thomas G.O., and Jones K.C. The global distribution of PCBs and organochlorine pesticides in butter. Environ. Sci. Technol. 35 (2001) 1013-1018
29. Kang I.H., Kim H.S., Shin J.H., Kim T.S., Moon H.J., Kim I.Y., Choi K.S., Kil K.S., Park Y.I., Dong M.S., and Han S.Y. Comparison of anti-androgenic activity of flutamide, vinclozolin, procymidone, linuron, and p,p′-DDE in rodent 10-day Hershberger assay. Toxicology 199 (2004) 145-159
30. Kelce W.R., Lambright C.R., Gray Jr. L.E., and Roberts K.P. Vinclozolin and p,p′-DDE alter androgen-dependent gene expression: in vivo confirmation of an androgen receptor-mediated mechanism. Toxicol. Appl. Pharmacol. 142 (1997) 192-200
31. Kemper F.H. Human organ specimen banking-15 years of experience. Sci. Total Environ. 140 (1993) 13-25
32. Kojima H., Katsura E., Takeuchi S., Niiyama K., and Kobayashi K. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ. Health Perspect. 112 (2004) 524-531
33. Lino C.M., and Silveira M.I. Evaluation of organochlorine pesticides in serum from students in Coimbra, Portugal: 1997-2001. Environ. Res. (2006) [Epub ahead of print]
34. Long G.L., and Wineffordener J.D. Limit of detection. A closer look at the IUPAC definition. Anal. Chem. 55 (1983) 712-714
35. Manosa S., Mateo R., and Guitart R. A review of the effects of agricultural and industrial contamination on the Ebro delta biota and wildlife. Environ. Monit. Assess. 71 (2001) 187-205
36. Martinez Vidal J.L., Moreno Frias M., Garrido Frenich A., Olea-Serrano F., and Olea N. Determination of endocrine-disrupting pesticides and polychlorinated biphenyls in human serum by GC-ECD and GC-MS-MS and evaluation of contributions to the uncertainty of the results. Anal. Bioanal. Chem. 372 (2002) 766-775
37. Moreno Frias M., Garrido Frenich A., Martinez Vidal J.L., Mateu Sanchez M., Olea F., and Olea N. Analyses of lindane, vinclozolin, aldrin, p,p′-DDE, o,p′-DDT and p,p′-DDT in human serum using gas chromatography with electron capture detection and tandem mass spectrometry. J. Chromatogr. B Biomed. Sci. Appl. 760 (2001) 1-15
38. Moysich K.B., Ambrosone C.B., Mendola P., Kostyniak P.J., Greizerstein H.B., Vena J.E., Menezes R.J., Swede H., Shields P.G., and Freudenheim J.L. Exposures associated with serum organochlorine levels among postmenopausal women from western New York State. Am. J. Ind. Med. 41 (2002) 102-110
39. Olea N., Olea-Serrano F., Lardelli-Claret P., Rivas A., and Barba-Navarro A. Inadvertent exposure to xenoestrogens in children. Toxicol. Ind. Health 15 (1999) 151-158
40. Olea N., Pazos P., Fernández M.F., Rivas A., Olea Serrano M.F., and Pedraza V. Phyto and mycoestrogens (Xenoestrogens) as a preventable cause of breast cancer. Med. Biol. Environ. Int. J. 27 (1999) 55-60
41. Pauwels A., Covaci A., Weyler J., Delbeke L., Dhont M., De Sutter P., D'Hooghe T., and Schepens P.J. Comparison of persistent organic pollutant residues in serum and adipose tissue in a female population in Belgium, 1996-1998. Arch. Environ. Contam. Toxicol. 39 (2000) 265-270
42. Petreas M., Smith D., Hurley S., Jeffrey S.S., Gilliss D., and Reynolds P. Distribution of persistent, lipid-soluble chemicals in breast and abdominal adipose tissues: lessons learned from a breast cancer study. Cancer Epidemiol. Biomarkers Prev. 13 (2004) 416-424
43. Petrik J., Drobna B., Pavuk M., Jursa S., Wimmerova S., and Chovancova J. Serum PCBs and organochlorine pesticides in Slovakia: Age, gender, and residence as determinants of organochlorine concentrations. Chemosphere (2006) [Epub ahead of print]
44. Porta M., Kogevineas M., Zumeta E., Sunyer J., and Ribas-Fito N. Concentraciones de compuestos tóxicos persistentes en la población española: el rompecabezas sin piezas y la protección de la salud pública. Gac. Sanit. 16 (2002) 257-266
45. Potti A., Panwalkar A.W., and Langness E. Prevalence of pesticide exposure in young males (
46. Quintana P.J., Delfino R.J., Korrick S., Ziogas A., Kutz F.W., Jones E.L., Laden F., and Garshick E. Adipose tissue levels of organochlorine pesticides and polychlorinated biphenyls and risk of non-Hodgkin's lymphoma. Environ. Health Perspect. 112 (2004) 854-861
47. Raaschou-Nielsen O., Pavuk M., Leblanc A., Dumas P., Philippe Weber J., Olsen A., Tjonneland A., Overvad K., and Olsen J.H. Adipose organochlorine concentrations and risk of breast cancer among postmenopausal Danish women. Cancer Epidemiol. Biomarkers Prev. 14 (2005) 67-74
48. Ramesh A., and Ravi P.E. Determination of residues of endosulfan in human blood by a negative ion chemical ionization gas chromatographic/mass spectrometric method: impact of long-term aerial spray exposure. Pest Manage. Sci. 59 (2003) 252-258
49. Rivas A., Fernández M.F., Cerrillo I., Ibarluzea J., Olea-Serrano M.F., Pedraza V., and Olea N. Human exposure to endocrine disrupters: standardisation of a marker of estrogenic exposure in adipose tissue. APMIS 109 (2001) 1-13
50. Rufingier C., Pasteur N., Lagnel J., Martin C., and Navajas M. Mechanism of insecticide resistence in the aphid Nasonovia ribisnigri (Mosley) (Homoptera: Aphididae) from France. Insect Biochem. Mol. Biol. 29 (1999) 385-391
51. Sala M., Sunyer J., Otero R., Santiago-Silva M., Camps C., and Grimalt J. Association of hexachlorobenzene serum levels with gammaglutamy transpeptidase and other biomarkers of early effects in humans. Occup. Environ. Med. 58 (2001) 172-177
52. Schildkraut J.M., Demark-Wahnefried W., DeVoto E., Hughes C., Laseter J.L., and Newman B. Environmental contaminants and body fat distribution. Cancer Epidemiol. Biomarkers Prev. 8 (1999) 179-183
53. Schrader T.J., and Cooke G.M. Examination of selected food additives and organochlorine food contaminants for androgenic activity in vitro. Toxicol. Sci. 53 (2000) 278-288
54. Soto A.M., Sonnenschein C., Cheng K.L., Fernandez M.F., Olea N., and Serrano F.O. The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ. Health Perspect. 103 (1995) 113-122
55. Stellman S.D., Djordjevic M.V., Muscat J.E., Gong L., Bernstein D., Citron M.L., White A., Kemeny M., Bush E., and Nafziger A.N. Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York. Cancer Epidemiol. Biomarkers Prev. 7 (1998) 489-496
56. Stellman S.D., Djordjevic M.V., Britton J.A., Muscat J.E., Citron M.L., Kemeny M., Busch E., and Gong L. Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York. Cancer Epidemiol. Biomarkers Prev. 11 (2000) 1241-1249
57. Tsukino H., Hanaoka T., Sasaki H., Motoyama H., Hiroshima M., Tanaka T., Kabuto M., Niskar A.S., Rubin C., Patterson Jr. D.G., Turner W., Needham L., and Tsugane S. Associations between serum levels of selected organochlorine compounds and endometriosis in infertile Japanese women. Environ. Res. 99 (2005) 118-125
58. United Nations Economic Commission for Europe. Environment and Human Settlements Division, Geneva, Switzerland.
59. Van't Veer P., Lobbezoo I.E., Martin-Moreno J.M., Guallar E., Gomez-Aracena J., Cardinal A.F., Kohlmeier L., Martin B.C., Strain J.J., Thamm M., Van Zoonen P., Baumann B.A., Huttunen J.K., and Kok F.J. DDT (dicophane) and postmenopausal breast cancer in Europe: case-control study. BMJ 315 (1997) 81-85
60. Van Maele-Fabry G., and Willems J.L. Prostate cancer among pesticide applicators: a meta-analysis. Int. Arch. Occup. Environ. Health. 77 (2004) 559-570
61. Wolff M.S., Toniolo P.G., Lee E.W., Rivera M., and Dubin N. Blood levels of organochlorine residues and risk of breast cancer. J. Natl. Cancer Inst. 85 (1993) 648-652
62. Wolff M.S., Zeleniuch-Jaquote A., Dubin N., and Toniolo P. Risk of breast cancer and organochlorine exposure. Cancer Epidemiol. Biomarkers Prev. 9 (2000) 271-277
63. Wolff M.S., Deych E., Ojo F., and Berkowitz G.S. Predictors of organochlorines in New York City pregnant women, 1998-2001. Environ. Res. 97 (2005) 170-177
64. Younglai E.V., Foster W.G., Hughes E.G., Trim K., and Jarrell J.F. Levels of environmental contaminants in human follicular fluid, serum, and seminal plasma of couples undergoing in vitro fertilization. Arch. Environ. Contam. Toxicol. 43 (2002) 121-126
65. Zumbado M., Goethals M., Alvarez-Leon E.E., Luzardo O.P., Cabrera F., Serra-Majem L., and Dominguez-Boada L. Inadvertent exposure to organochlorine pesticides DDT and derivatives in people from the Canary Islands (Spain). Sci. Total Environ. 339 (2005) 49-62