Applications of transgenic pigs in biomedicine and animal production;Aplicaciones de los cerdos transgénicos en biomedicina y producción animal

ITEA Informacion Tecnica Economica Agraria

Volumn 106, Issue 1, 2010, Pages 30-45

  Gadea, J ^a   Garcia Vazquez F A ^a  

^a Campus de Espinardo   (Spain)

Author keywords

Bio pharmacology; Disease model; Food products; Health; Pollution; Xenotransplantation

Indexed keywords

EID: 77953062224     PISSN: 16996887     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (71)

1. Bleck GT, White BR, Miller DJ, Wheeler MB. Production of bovine alpha-lactalbumin in the milk of transgenic pigs. J Anim Sci. 1998 Dec; 76(12):3072-3078 (Pubitemid 128462796)
2. Brem G, Brenig B, Goodman HM, Selden RC, Graf F, Kruff B, Springmann K, Hondele J, Meyer J, Winnacker EL, Kräusslich H. Production of transgenic mice, rabbits and pigs by microinjection into pronuclei. Zuchthygiene, 1985,20: 251-252.
3. Castilla J, Sola I, Pintado B, Sánchez-Morgado JM, Enjuanes L (1998) Lactogenic immunity in transgenic mice producing recombinant antibodies neutralizing coronavirus. Adv Exp Med Biol 440: 675-686 (Pubitemid 28405952)
4. Cho SK, Hwang KC, Choi YJ, Bui HT, Nguyen VT, Park C, Kim JH, Kim JH. Production of transgenic pigs harboring the human erythropoietin (hEPO) gene using somatic cell nuclear transfer. J Reprod Dev. 2009 Apr; 55(2):128-136
5. Cifone D, Dominici FP, Pursel VG, Turyn D. Inability of heterologous growth hormone (GH) to regulate GH binding protein in GH-transgenic swine. J Anim Sci. 2002 Jul; 80(7):1962-1969 (Pubitemid 41138424)
6. Costa C, Brokaw JL, Fodor WL. Characterization of cartilage from H-transferase transgenic pigs. Transplant Proc. 2008 Mar; 40(2):554-556
7. Deschamps JY, Roux FA, Saï P, Gouin E. History of xenotransplantation. Xenotransplantation. 2005 Mar; 12(2):91-109.
8. Dyck MK, Gagné D, Ouellet M, Sénéchal JF, Bélanger E, Lacroix D, Sirard MA, Pothier F. Seminal vesicle production and secretion of growth hormone into seminal fluid. Nat Biotechnol. 1999 Nov; 17(11):1087-1090
9. Ekser B, Cooper DK. Update: cardiac xenotransplantation. Curr Opin Organ Transplant. 2008 Oct; 13(5):531-535
10. Golovan SP, Meidinger RG, Ajakaiye A, Cottrill M, Wiederkehr MZ, Barney DJ, Plante C, Pollard JW, Fan MZ, Hayes MA, Laursen J, Hjorth JP, Hacker RR, Phillips JP, Forsberg CW. Pigs expressing salivary phytase produce low-phosphorus manure. Nat Biotechnol. 2001 Aug; 19(8):741-745
11. Grindon C, Bhogal N. The fourth EC report on the statistics of laboratory animal use: trends, recommendations and future prospects. Altern Lab Anim. 2005 Aug; 33(4):417-426
12. Hammer RE, Pursel VG, Rexroad CE Jr, Wall RJ, Bolt DJ, Ebert KM, Palmiter RD, Brinster RL. Production of transgenic rabbits, sheep and pigs by microinjection. Nature. 1985 Jun 20-26; 315(6021):680-683
13. Hao YH, Yong HY, Murphy CN, Wax D, Samuel M, Rieke A, Lai L, Liu Z, Durtschi DC, Weibern VR, Price EM, McAllister RM, Turk JR, Laughlin MH, Prather RS, Rucker EB. Production of endothelial nitric oxide synthase (eNOS) over-expressing piglets. Transgenic Res. 2006 Dec; 15(6):739-750
14. Heppner FL, Musahl C, Arrighi I, Klein MA, Rülicke T, Oesch B, Zinkernagel RM, Kalinke U, Aguzzi A. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science. 2001 Oct 5; 294(5540):178-182
15. Hering BJ, Walawalkar N. Pig-to-nonhuman primate islet xenotransplantation. Transpl Immunol. 2009 Jun; 21(2):81-86
16. Houdebine LM. Production of pharmaceutical proteins by transgenic animals.Comp Immunol Microbiol Infect Dis. 2009 Mar; 32(2):107-121
17. Ibrahim Z, Busch J, Awwad M, Wagner R, Wells K, Cooper DK. Selected physiologic compatibilities and incompatibilities between human and porcine organ systems. Xenotransplantation. 2006 Nov; 13(6):488-499
18. Kragh PM, Nielsen AL, Li J, Du Y, Lin L, Schmidt M, Bøgh IB, Holm IE, Jakobsen JE, Johansen MG, Purup S, Bolund L, Vajta G, Jørgensen AL. Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw. Transgenic Res. 2009 Aug; 18(4):545-558
19. Keefer CL. Production of bioproducts through the use of transgenic animal models. Anim Reprod Sci. 2004 Jul; 82-83:5-12.
20. Kerr DE, Liang F, Bondioli KR, Zhao H, Kreibich G, Wall RJ, Sun TT. The bladder as a bioreactor: urothelium production and secretion of growth hormone into urine. Nat Biotechnol. 1998 Jan; 16(1):75-79
21. Kolber-Simonds D, Lai L, Watt SR, Denaro M, Arn S, Augenstein ML, Betthauser J, Carter DB, Greenstein JL, Hao Y, Im GS, Liu Z, Mell GD, Murphy CN, Park KW, Rieke A, Ryan DJ, Sachs DH, Forsberg EJ, Prather RS, Hawley RJ. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA. 2004 May 11; 101(19):7335-7340
22. Kuwaki K, Tseng YL, Dor FJ, Shimizu A, Houser SL, Sanderson TM, Lancos CJ, Prabharasuth DD, Cheng J, Moran K, Hisashi Y, Mueller N, Yamada K, Greenstein JL, Hawley RJ, Patience C, Awwad M, Fishman JA, Robson SC, Schuurman HJ, Sachs DH, Cooper DK. Heart transplantation in baboons using alpha 1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med. 2005 Jan; 11(1):29-31.
23. Lai L, Kolber-Simonds D, Park KW, Cheong HT, Greenstein JL, Im GS, Samuel M, Bonk A, Rieke A, Day BN, Murphy CN, Carter DB, Hawley RJ, Prather RS. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science. 2002 Feb 8; 295(5557): 1089-1092
24. Lai L, Kang JX, Li R, Wang J, Witt WT, Yong HY, Hao Y, Wax DM, Murphy CN, Rieke A, Samuel M, Linville ML, Korte SW, Evans RW, Starzl TE, Prather RS, Dai Y. Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nat Biotechnol. 2006 Apr; 24(4):435-436
25. Laible G. Enhancing livestock through genetic engineering-recent advances and future prospects. Comp Immunol Microbiol Infect Dis. 2009 Mar; 32(2):123-137
26. Langford GA, Yannoutsos N, Cozzi E, Lancaster R, Elsome K, Chen P, Richards A, White DJ. Production of pigs transgenic for human decay accelerating factor. Transplant Proc. 1994 Jun; 26(3):1400-1401
27. Lee HG, Lee HC, Kim SW, Lee P, Chung HJ, Lee YK, Han JH, Hwang IS, Yoo JI, Kim YK, Kim HT, Lee HT, Chang WK, Park JK. Production of Recombinant Human von Willebrand Factor in the Milk of Transgenic Pigs. J Reprod Dev. 2009 Jun 11.
28. Li ZY, Wong F, Chang JH, Possin DE, Hao Y, Petters RM, Milam AH. Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1998 Apr; 39(5):808-819
29. Lind NM, Moustgaard A, Jelsing J, Vajta G, Cumming P, Hansen AK. The use of pigs in neuroscience: modeling brain disorders. Neurosci Biobehav Rev. 2007; 31(5):728-751 (Pubitemid 46680451)
30. Lindsay M, Gil GC, Cadiz A, Velander WH, Zhang C, Van Cott KE. Purification of recombinant DNA-derived factor IX produced in transgenic pig milk and fractionation of active and inactive subpopulations. J Chromatogr A. 2004 Feb 13; 1026(1-2):149-157 (Pubitemid 38045275)
31. Lorson MA, Spate LD, Prather RS, Lorson CL. Identification and characterization of the porcine (Sus scrofa) survival motor neuron (SMN1) gene: an animal model for therapeutic studies. Dev Dyn. 2008 Aug; 237(8):2268-2278
32. Lubon H, Paleyanda RK, Velander WH, Drohan WN. Blood proteins from transgenic animal bioreactors. Transfus Med Rev. 1996 Apr; 10(2):131-143
33. Lunney JK. Advances in swine biomedical model genomics. Int J Biol Sci. 2007 Feb 10; 3(3):179-184 (Pubitemid 46272772)
34. Müller M, Brenig B, Winnacker EL, Brem G. Transgenic pigs carrying cDNA copies encoding the murine Mx1 protein which confers resistance to influenza virus infection. Gene. 1992 Nov 16; 121(2):263-270
35. Müller M, Brem G. Transgenic approaches to the increase of disease resistance in farm animals. Rev Sci Tech. 1998 Apr; 17(1):365-378
36. Naruse K, Ishikawa H, Kawano HO, Ueda H, Kurome M, Miyazaki K, Endo M, Sawasaki T, Nagashima H, Makuuchi M. Production of a transgenic pig expressing human albumin and enhanced green fluorescent protein. J Reprod Dev. 2005 Aug; 51(4):539-546 (Pubitemid 41379867)
37. Niemann H, Kues W, Carnwath JW. Transgenic Farm Animals: Current Status and Perspectives for Agriculture and Biomedicine. In: Engelhard M, Hagen K, Boysenln M, eds. Genetic Engineering in Livestock. New Applications and Interdisciplinary Perspectives. Berlin, Springer, 2009:1-30.
38. Noble MS, Rodriguez-Zas S, Cook JB, Bleck GT, Hurley WL, Wheeler MB. Lactational performance of first-parity transgenic gilts expressing bovine alpha-lactalbumin in their milk. J Anim Sci. 2002 Apr; 80(4):1090-1096 (Pubitemid 41138492)
39. Nottle MB, Beebe LF, Harrison SJ, Mcllfatrick SM, Ashman RJ, O'Connell PJ, Salvaris EJ, Fisicaro N, Pommey S, Cowan PJ, d'Apice AJ. Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer. Xenotransplantation. 2007 Jul; 14(4):339-344
40. O'Donnell JK, Martin MJ, Logan JS, Kumar R. Production of human hemoglobin in transgenic swine: an approach to a blood substitute. Cancer Detect Prev. 1993; 17(2):307-312
41. Paleyanda RK, Velander WH, Lee TK, Scandella DH, Gwazdauskas FC, Knight JW, Hoyer LW, Drohan WN, Lubon H. Transgenic pigs produce functional human factor VIII in milk. Nat Biotechnol 1997; 15:971-975. (Pubitemid 27425935)
42. Palmiter RD, Brinster RL, Hammer RE, Trumbauer ME (1982) Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300:611-615.
43. Park JK, Lee YK, Lee P, Chung HJ, Kim S, Lee HG, Seo MK, Han JH, Park CG, Kim HT, Kim YK, Min KS, Kim JH, Lee HT, Chang WK. Recombinant human erythropoietin produced in milk of transgenic pigs J Biotechnol. 2006 Apr 10; 122(3):362-371
44. Park KW, Choi KM, Hong SP, Han GS, Yoo JY, Jin Dl, Seol JG, Park CS. Production of transgenic recloned piglets harboring the human granulocyte-macrophage colony stimulating factor (hGM-CSF) gene from porcine fetal fibroblasts by nuclear transfer. Theriogenology. 2008 Dec; 70(9):1431-1438
45. Phelps CJ, Koike C, Vaught TD, Boone J, Wells KD, Chen SH, Ball S, Specht SM, Polejaeva IA, Monahan JA, Jobst PM, Sharma SB, Lamborn AE, Garst AS, Moore M, Demetris AJ, Rudert WA, Bottino R, Bertera S, Trueco M, Starzl TE, Dai Y, Ayares DL. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science. 2003 Jan 17; 299(5605):411-414
46. Petersen B, Carnwath JW, Niemann H. The perspectives for porcine-to-human xenografts. Comp Immunol Microbiol Infect Dis. 2009 Mar; 32(2):91-105.
47. Petters RM, Alexander CA, Wells KD, Collins EB, Sommer JR, Blanton MR, Rojas G, Hao Y, Flowers WL, Banin E, Cideciyan AV, Jacobson SG, Wong F. Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. Nat Biotechnol. 1997 Oct; 15(10):965-970
48. Pursel VG, Pinkert CA, Miller KF, Bolt DJ, Campbell RG, Palmiter RD, Brinster RL, Hammer RE. Genetic engineering of livestock. Science. 1989 Jun 16; 244(4910):1281-1288
49. Pursel VG, Sutrave P, Wall RJ, Kelly AM, Hughes SH.. Transfer of cSKI gene into swine to enhance muscle development. Theriogenology. 1992; 37:278. (Abstr.).
50. Pursel VG, Rexroad RE Status of research with transgenic farm animals. J Anim Sci (Suppl). 1993; 71:10-19.
51. Pursel VG, Wall RJ, Mitchell AD, Elsasser TH, Solomon MB, Coleman ME, DeMayo F, Schwartz RJ. Expression of insulin-like growth factor I in skeletal muscle of transgenic swine. In: Murray JD, Anderson GB, McGloughlin MM, Oberbauer AM, eds. Transgenic Animals in Agriculture. Wallingford, UK: CAB International, 1999:131-144.
52. Pursel VG, Mitchell AD, Bee G, Elsasser TH, McMurtry JP, Wall RJ, Coleman ME, Schwartz RJ. Growth and tissue accretion rates of swine expressing an insulin-like growth factor I transgene. Anim Biotechnol. 2004 May; 15(1):33-45.
53. Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Hanfland RA, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB Jr, Zabner J, Prather RS, Welsh MJ. Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science. 2008 Sep 26; 321(5897):1837-1841
54. Saeki K, Matsumoto K, Kinoshita M, Suzuki I, Tasaka Y, Kano K, Taguchi Y, Mikami K, Hirabayashi M, Kashiwazaki N, Hosoi Y, Murata N, Iritani A. Functional expression of a Delta 12 fatty acid desaturase gene from spinach in transgenic pigs. Proc Natl Acad Sci USA. 2004 Apr 27; 101(17):6361-6366
55. Sharma A, Okabe JF, Birch P, Piatt JL, Logan JS (1996) Reduction in the level of gal a(1-3) gal in transgenic mice and pigs by the expression of an a(1.2) fucosyl transferase. Proc Natl Acad Sci USA. USA 93:7190-7195.
56. Shaw LC, Skold A, Wong F, Petters R, Hauswirth WW, Lewin AS. An allele-specific hammerhead ribozyme gene therapy for a porcine model of autosomal dominant retinitis pigmentosa. Mol Vis. 2001 Jan 26; 7:6-13.
57. Smolenski RT, Forni M, Maccherini M, Bacci ML, Slominska EM, Wang H, Fornasari P, Giovannoni R, Simeone F, Zannoni A, Frati G, Suzuki K, Yacoub MH, Lavitrano M. Reduction of hyperacute rejection and protection of metabolism and function in hearts of human decay accelerating factor (hDAF)-expressing pigs. Cardiovasc Res. 2007 Jan 1; 73(1):143-152
58. Sola I, Castilla J, Pintado B, Sánchez-Morgado JM, Whitelaw CB, Clark AJ, Enjuanes L (1998) Transgenic mice secreting coronavirus neutralizing antibodies into the milk. J Virol 72:3762-3772. (Pubitemid 28188674)
59. Swanson ME, Martin MJ, O'Donnell JK, Hoover K, Lago W, Huntress V, Parsons CT, Pinkert CA, Pilder S, Logan JS. Production of functional human hemoglobin in transgenic swine. Biotechnology (N Y). 1992 May; 10(5):557-559
60. Tso MO, Li WW, Zhang C, Lam TT, Hao Y, Petters RM, Wong F. A pathologic study of degeneration of the rod and cone populations of the rhodopsin Pro347Leu transgenic pigs. Trans Am Ophthalmol Soc. 1997; 95:467-479 (Pubitemid 27519960)
61. Umeyama K, Watanabe M, Nagashima H. Expression of dominant-negative mutant hepatocyte nuclear factor 1 alpha transgene leads to impaired islet development and diabetes in pigs. Proceedings of the Swine in Biomedical Research Conference. San Diego, 2008 abstract 54.
62. Van Cott KE, Butler SP, Russell CG, Subramanian A, Lubon H, Gwazdauskas FC, Knight J, Drohan WN, Velander WH. Transgenic pigs as bio-reactors: a comparison of gamma-carboxylation of glutamic acid in recombinant human protein C and factor IX by the mammary gland. Genet Anal Biomol Eng 1999; 15:155-160. (Pubitemid 29531539)
63. Van Cott KE, Monahan PE, Nichols TC, Velander WH. Haemophilic factors produced by transgenic livestock: abundance that can enable alternative therapies worldwide. Haemophilia. 2004 Oct; 10 Suppl 4:70-76
64. Varzakas TH, Arvanitoyannis IS, Baltas H. The politics and science behind GMO acceptance. Crit Rev Food Sci Nutr. 2007; 47(4):335-361
65. Velander WH, Johnson JL, Page RL, Russell CG, Subramanian A, Wilkins TD, Gwazdauskas FC, Pittius C, Drohan WN. High level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein. Proc Natl Acad Sci USA 1992; 89:12003-12007. (Pubitemid 23004773)
66. Wall RJ, Pursel VG, Shamay A, McKnight RA, Pittius CW, Hennighausen L. High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine. Proc Natl Acad Sci USA. 1991 Mar 1; 88(5):1696-1700
67. Weissmann C, Fischer M, Raeber A, Büeler H, Sailer A, Shmerling D, Rülicke T, Brandner S, Aguzzi A (1996) The use of transgenic mice in the investigation of transmissible spongiform encephalopathies. Int J Exp Pathol 77:283-293. (Pubitemid 27141646)
68. Whitelaw CB, Sang HM. Disease-resistant genetically modified animals. Rev Sci Tech. 2005 Apr; 24(1):275-283
69. Yamada K, Yazawa K, Shimizu A, Iwanaga T, Hisashi Y, Nuhn M, O'Malley P, Nobori S, Vagefi PA, Patience C, Fishman J, Cooper DK, Hawley RJ, Greenstein J, Schuurman HJ, Awwad M, Sykes M, Sachs DH. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha 1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med. 2005 Jan; 11(1):32-34
70. Yan X, Voutetakis A, Zheng C, Hai B, Zhang C, Baum BJ, Wang S. Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer. J Gene Med. 2007 Sep; 9(9):779-787 (Pubitemid 47386862)
71. Zhu X, Cheng J, Huang L, Gao J, Zhang ZT, Pak J, Wu XR. Renal tubule-specific expression and urinary secretion of human growth hormone: a kidney-based transgenic bioreactor growth. Transgenic Res. 2003 Apr; 12(2): 155-162