Recombinant human erythropoietin produced in milk of transgenic pigs

Journal of Biotechnology

Volumn 122, Issue 3, 2006, Pages 362-371

  Park, Jin Ki ^a   Lee, Yun Keun ^a   Lee, Poongyeon ^a   Chung, Hak Jae ^a   Kim, Sungwoo ^a   Lee, Hyun Gi ^a   Seo, Myung Kyu ^a   Han, Joo Hee ^a   Park, Chun Gyu ^a   Kim, Hun Taek ^b   Kim, Yong Kook ^b   Min, Kwan Sik ^c   Kim, Jin Hoi ^d   Lee, Hoon Taek ^e   Chang, Won Kyong ^a  

^a National Institute of Animal Science   (South Korea)

^b In2Gen Co Ltd   (South Korea)

^c Hankyong National University   (South Korea)

^d Gyeongsang National University   (South Korea)

^e Konkuk University   (South Korea)

Author keywords

Erythropoietin; Expression; Mammary gland; Microinjection; Transgenic animals

Indexed keywords

AMINO ACIDS; ANIMAL CELL CULTURE; CELLS; COMMERCE; COST EFFECTIVENESS; PROTEINS;

ERYTHROPOIETIN; EXPRESSION; MAMMARY GLAND; MICROINJECTION; TRANSGENIC ANIMALS;

GENETIC ENGINEERING;

GENOMIC DNA; RECOMBINANT ERYTHROPOIETIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MILK; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SWINE; TRANSGENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BONE MARROW CELLS; CELL LINE; CELL PROLIFERATION; ERYTHROPOIETIN, RECOMBINANT; FEMALE; HUMANS; MALE; MAMMARY GLANDS, ANIMAL; MILK; SUS SCROFA;

ANIMALIA; SUS SCROFA;

EID: 33644646257     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2005.11.021     Document Type: Article

References (48)

1. A. Aguirre, N. Castro-Palomino, J. De la Fuente, and F.O. Castro Expression of human erythropoietin transgenes and of the endogenous WAP gene in the mammary gland of transgenic rabbits during gestation and lactation Transgenic Res. 7 1998 311 317
2. G.T. Bleck, B.R. White, D.J. Miller, and M.B. Wheeler Production of bovine alpha-lactalbumin in the milk of transgenic pigs J. Anim. Sci. 76 1998 3072 3078
3. E.R. Cameron, M.J. Harvey, and D.E. Onions Transgenic science Br. Vet. J. 150 1994 9 24
4. S. Chiba, F. Takaku, T. Tange, K. Shibuya, C. Misawa, K. Sasaki, K. Miyagawa, Y. Yazaki, and H. Hirai Establishment and erythroid differentiation of a cytokine-dependent human leukemic cell line F-36: a parental line requiring granulocyte-macrophage colony-stimulating factor or interleukin-3, and a subline requiring erythropoietin Blood 78 1991 2261 2268
5. P.M. Cotes Immunoreactive erythropoietin in serum Br. J. Haematol. 50 1982 427 438
6. J.P. Doweiko Management of the hematologic manifestations of HIV disease Blood Rev. 7 1993 121 126
7. J.W. Fisher Erythropoiet: physiologic and pharmacology update Exp. Biol. Med. 228 2003 1 14
8. A. Gokana, J.J. Winchennw, A. Ben-Ghanem, A. Ahaded, J.P. Cartron, and P. Lambin Chromatographic separation of recombinant human erythropoietin isoforms J. Chromatogr. A 791 1997 109 118
9. T. Gregory, C. Yu, A. Ma, S.S. Orkin, G.A. Blobel, and M.J. Weiss GATA-1 and erythropoietin cooperate to promote erythroid cell survival by regulating bcl-xL expression Blood 94 1999 87 96
10. R.E. Hammer, V.G. Pursel, C.E. Rexroad, R.J. Wall, D.J. Bolt, and K.M. Ebert Production of transgenic rabbits, sheep and pigs Nature 315 1985 680 683
11. L.G. Hennighausen, and A.E. Sippel Characterization and cloning of the mRNAs specific for the lactating mouse mammary gland Eur. J. Biochem. 125 1982 131 141
12. H.C. Hughes Swine in cardiovascular research Lab. Anim. Sci. 36 1986 348 350
13. J.M. Hyttinen, T. Peura, M. Tolvanen, J. Aalto, L. Alhonen, R. Sinervirta, M. Halmekyto, S. Myohanen, and J. Janne Generation of transgenic dairy cattle from transgene analyzed and sexed embryos produced in vitro Biotechnology 12 1994 606 608
14. W. Jelkmann The role of the liver in the production of thrombopoietin compared with erythropoietin Eur. J. Gastro. 13 2001 791 801
15. S.E. Juul, Y. Zhao, J.B. Dame, Y. Du, A.D. Hutson, and R.D. Christensen Origin and fate of erythropoietin in human milk Pediatr. Res. 48 2000 660 667
16. R.G. Kendall Erythropoietin Clin. Lab. Haematol. 23 2001 71 80
17. A. Kurtz, and K.U. Eckardt Erythropoietin production in chronic renal disease before and after transplantation Contrib. Nephrol. 87 1990 15 25
18. F.K. Lin, S. Suggs, C.H. Lin, J.K. Browne, R. Smalling, J.C. Egrie, K.K. Chen, G.M. Fox, F. Martin, and Z. Stabinsky Cloning and expression of the human erythropoietin gene Proc. Natl. Acad. Sci. U.S.A. 82 1985 7580 7584
19. D. Lo, V. Pursel, P.J. Linton, E. Sandgren, R. Behringer, C. Rexroad, R.D. Palmiter, and R.L. Brinster Expression of mouse IgA by transgenic mice, pigs and sheep Eur. J. Immunol. 21 1991 1001 1006
20. M.J. Martin, and C.A. Pinkert Production of transgenic swine C.A. Pinkert Transgenic Animal Technology 1994 Academic Press San Diego 118 125
21. M. Massoud, J. Attal, D. Thepot, H. Pointu, M.G. Stinnakre, M.C. Theron, C. Lopez, and L.M. Houdebine The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits Reprod. Nutr. Dev. 36 1996 555 563
22. R.T. Means Jr. Pathogenesis of the anemia of chronic disease: a cytokine-mediated anemia Stem Cells 13 1995 32 37
23. Morcol et al., 2001. Method for processing milk. US Patent 6,183,803.
24. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1983 55 63
25. K. Muta, S.B. Krantz, M.C. Bondurant, and A. Wickrema Distinct roles of erythropoietin, insulin-like growth factor I, and stem cell factor in the development of erythroid progenitor cells J. Clin. Invest. 94 1994 34 43
26. T. Nakano, Y. Sugimoto, H.R. Ibrahim, Y. Toba, S. Aoe, and T. Aoki Preparation and characterization of milk calcium salts by using casein phosphopeptide Prep. Biochem. Biotechnol. 30 2000 155 166
27. M.B. Nottle, K.A. Haskard, P.J. Verna, Z.T. Du, C.G. Grupen, S.M. McIlfatrick, R.J. Ashman, S.J. Harrison, H. Barlow, P.L. Wigley, I.G. Lyons, P.J. Cowan, R.J. Crawford, P.L. Tolstoshev, M.J. Pearse, A.J. Robins, and A.J.F. Apice Effect of DNA concentration on transgenesis rates in mice and pigs Transgenic Res. 10 2001 523 531
28. M. Ogilvie, X. Yu, V. Nicolas-Metral, S.M. Pulido, C. Liu, U.T. Ruegg, and C.T. Noguchi Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts J. Biol. Chem. 275 2000 39754 39761
29. A.J. Owen, and A.T. Andrews A procedure for the complete clarification of milk of various species and its suitability for use with colorimetric measurements J. Dairy Res. 51 1984 307 315
30. R.K. Paleyanda, W.H. Velander, T.K. Lee, D.H. Seandella, F.C. Gwazdauskas, J.W. Knight, L.W. Hoyer, W.N. Drohan, and H. Lubon Transgenic pigs produce functional human factor VIII in milk Nat. Biotechnol. 15 1997 971 975
31. J.E. Piletz, M. Heinlen, and R.E. Ganschow Biochemical characterization of a novel whey protein from murine milk J. Biol. Chem. 256 1981 11509 11516
32. V.G. Pursel, and L.A. Johnson Freezing of boar spermatozoa: fertilizing capacity with concentrated semen and a new thawing procedure J. Anim. Sci. 40 1975 99 102
33. D.C. Salsbury Anemia of prematurity Neonat. Netw. 20 2001 13 20
34. A. Shamay, S. Solinas, V.G. Pursel, R.A. McKnight, L. Alexander, C. Beattie, L. Hennighausen, and R.J. Wall Production of the mouse whey acidic protein in transgenic pigs during lactation J. Anim. Sci. 69 1991 4552 4562
35. J.B. Sherwood, and E. Goldwasser A radioimmunoassay for erythropoietin Blood 54 1979 885 893
36. J. Shibata, J. Hasegawa, H.J. Siemens, E. Wolber, L. Dibbelt, D. Li, D.M. Katschinski, J. Fandrey, W. Jelkmann, M. Gassmann, and K.F. Wenger Hematostasis and coagulation at a hematocrit of 0.85: functional consequences of erythrocytosis Blood 101 2003 4416 4422
37. V. Skibeli, G. Nissen-Lie, and P. Torjesen Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietin Blood 98 2001 3626 3634
38. M. Socolovsky, I. Dusanter-Fourt, and H.F. Lodish The prolactin receptor and severely truncated erythropoietin receptors support differentiation of erythroid progenitors J. Biol. Chem. 272 1997 14009 14012
39. M.E. Swanson, M.J. Martin, J.K. O'Donnell, K. Hoover, W. Lago, V. Huntress, C.T. Parsons, C.A. Pinkert, S. Pilder, and J.S. Logan Production of functional human hemoglobin in transgenic swine Biotechnology (NY) 10 1992 557 559
40. N. Tanaka, K. Ito, S. Ishii, and I. Yamazaki Autologous blood transfusion with recombinant erythropoietin treatment in anaemic patients with rheumatoid arthritis Clin. Rheumatol. 18 1999 293 299
41. D. Tsakiris Morbidity and mortality reduction associated with the use of erythropoietin Nephron 85 2000 2 8
42. P.H. Van Berkel, M.M. Welling, M. Geerts, H.A. van Veen, B. Ravensbergen, M. Salaheddine, E.K. Pauwels, F. Pieper, J.H. Nuijens, and P.H. Nibbering Large scale production of recombinant human lactoferrin in the milk of transgenic cows Nat. Biotechnol. 20 2002 484 487
43. W.H. Velander, J.L. Johnson, R.L. Page, C.G. Russell, A. Subramanian, T.D. Wilkins, F.C. Gwazdauskas, and W.N. Drohan High-level expression of a heterologous protein in the milk of transgenic swine using the cDNA encoding human protein C Proc. Natl. Acad. Sci. U.S.A. 89 1992 12003 12007
44. J. Wagner, F. Thiele, and D. Ganten Transgenic animals as models for human disease Clin. Exper. Hypertens. 17 1995 593 605
45. R.J. Wall, V.G. Pursel, A. Shamay, R.A. McKnight, C.W. Pittius, and L. Hennighausen High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine Proc. Natl. Acad. Sci. U.S.A. 88 1991 1696 1700
46. L.N. Wei Transgenic animals are new approaches in pharmacological studies Annu. Rev. Pharmacol. Toxicol. 37 1997 119 141
47. U.H. Weidle, H. Lenz, and G. Brem Genes encoding a mouse monoclonal antibody are expressed in transgenic mice, rabbits and pigs Gene 98 1991 185 191
48. D.M. Wojchowski, J.M. Sue, and A.J. Sytkowski Site-specific antibodies to human erythropoietin: immunoaffinity purification of urinary and recombinant hormone Biochim. Biophys. Acta 913 1987 170 178