α,β-unsaturated β-silyl lmide substrates for catalytic, enantioselective conjugate additions: A total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor

Journal of the American Chemical Society

Volumn 128, Issue 21, 2006, Pages 6810-6812

  Balskus, Emily P ^a   Jacobsen, Eric N ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA SILYL IMIDE; IMIDE; LACTACYSTIN; LACTAM; PROTEASOME INHIBITOR; SILANE DERIVATIVE; SPIRO BETA LACTONE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CATALYST; CHEMICAL BINDING; DIASTEREOISOMER; DISSOCIATION; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; HYDROLYSIS; ISOMERIZATION; MOLECULAR WEIGHT; OXIDATION REDUCTION REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

ACETYLCYSTEINE; ANIMALS; CATALYSIS; DRUG EVALUATION, PRECLINICAL; IMIDES; LACTAMS; LACTONES; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; RABBITS; STEREOISOMERISM;

EID: 33744805367     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja061970a     Document Type: Article

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