Plasma nitrites/nitrates in HCV infection and hepatocellular carcinoma

European Journal of Gastroenterology and Hepatology

Volumn 12, Issue 2, 2000, Pages 159-163

  Moussa, Youssif I ^a   Plevris, John N ^a   Hayes, Peter C ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Chronic hepatitis; Cirrhosis; HCV; Hepatocellular carcinoma; Nitric oxide; Nitrites nitrates

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; NITRATE; NITRIC OXIDE; NITRITE;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CARCINOGENESIS; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS C; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NORMAL HUMAN; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0034026736     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200012020-00005     Document Type: Article

References (31)

1. 1 Moncada SR, Palmer MJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43:109-142.
2. 2 Bredt DS, Synder SH. Nitric oxide: a physiological messenger molecule. Annu Rev Biochem 1994; 63:175-195.
3. 3 Geller DA, Nussler AK, DiSilvio M. Cytokines, endotoxin and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci USA 1993; 90:522-526.
4. 4 Nakazaki H. Preoperative and postoperative cytokines in patients with cancer. Cancer 1992; 70:709-713.
5. 5 Nathan C, Xie QW. Nitric oxide synthases: role, tolls, controls. Cell 1994; 78:915-918.
6. 6 Goorsdrof S, Appel KE, Engeholm C, Obe G. Nitrogen dioxide induces DNA single-strand breaks in cultured Chinese hamster cells. Carcinogenesis (Lond) 1990; 11:37-41.
7. 7 Wink DA, Kasprzak KS, Maragos CM, Elespuru RK, Misra Mdunams TM, Cebula TA, et al. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science 1991; 254:1001-1003.
8. 8 Marletta MA. Mammalian synthesis of nitrite, nitrate and nitric oxide, and N-nitrosating agents. Chem Res Toxicol 1988; 1:249-257.
9. 9 Henry Y, Lepoivre M, Drapier JC, Ducrocq C, Boucher JL, Guissani A. EPR characterization of molecular targets for NO in mammalian cells and organelles. FASEB J 1993; 7:1124-1134.
10. 10 Liu RH, Baldwin B, Tennant BC, Hotchkiss JH. Elevated formation of nitrate and N-nitroso dimethylamine in woodchucks (Marmota monax) associated with chronic woodchuck hepatitis virus infection. Cancer Res 1991; 51:3925-3929.
11. 11 Nguyen T, Brunson D, Crespi CL, Penman BW, Wishnok JS, Tannenhaum SR. DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc Natl Acad Sci USA 1992; 89:3030-3034.
12. 12 Calmels S, Hainaut P, Ohshima H. Nitric oxide induces conformational and functional modifications of wild-type p53 tumour suppressor protein. Cancer Res 1997; 57:3365-3369.
13. 13 Kane JM, Shears LL, Hierholzer C, Ambs S, Billiar TR. Chronic hepatitis C virus infection in humans: induction of nitric oxide synthase and proposed mechanisms for carcinogenesis. J Surg Res 1997; 69:321-324.
14. 14 Moriyama A, Masumoto A, Nanri H, Tabaru A, Unoki H, Imoto I, et al. High plasma concentrations of nitrite/nitrate in patients with hepatocellular carcinoma. Am J Gastroenterol 1997; 92:1520-1523.
15. 15 Amaro MJ, Bartolomé J, Pardo M, Cotonat T, López-Farré A, Carreño V. Decreased nitric oxide production in chronic viral hepatitis B and C. J Med Virol 1997; 51:326-331.
16. 16 Mihm S, Fayyazi A, Ramadori G. Hepatitis expression of inducible nitric oxide synthase transcripts in chronic hepatitis C virus infection: relation to hepatic viral load and liver injury. Hepatology 1997; 26:451-458.
17. 17 Tankurt E, Kirkali G, Ozcan MA, Mersin N, Ellidokuz E, Akpinar HA. Increased serum nitrite and nitrate concentrations in chronic hepatitis. J Hepatol 1998; 29:512-513.
18. 18 Miles AM, Wink DA, Cook JC, Grisham MB. Determination of nitric oxide using fluorescence spectroscopy. Methods Enzymol 1996; 268:105-120.
19. 19 Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60:646-648.
20. 20 Guarner C, Soriano G, Tomas A, Bulbena O, Novella MT, Balanzo J, et al. Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia. Hepatology 1993; 18:1139-1143.
21. 21 Batista S, Bar F, Mongozzi G, Zanon E, Grosso M, Molino G. Hyperdynamic circulation in patients with cirrhosis: direct measurement of nitric oxide levels in hepatic and portal veins. J Hepatol 1997; 26:75-80.
22. 22 Moncada S. The L-arginine:nitric oxide pathway. Acta Physiol Scand 1992; 145:201-227.
23. 23 Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992; 6:3051-3064.
24. 24 Yoshioka K, Kakumu S, Arao M, Tsutsumi Y, Inoue M. Tumour necrosis factor alpha production by peripheral blood mononuclear cells of patients with chronic viral disease. Hepatology 1989; 10:769-773.
25. 25 Sheron N, Lau JYN, Daniels H, Goka J, Eddleston ALDF, Alexander GJM, Williams R. Increased production of tumour necrosis factor alpha in chronic hepatitis B virus infection. J Hepatol 1991; 12:241-245.
26. 26 Quiroga JA, Martin J, Pardo M, Carreño V. Serum levels of soluble immune factors and pathogenesis of chronic hepatitis C, and their relation to therapeutic response to interferon alpha. Dig Dis Sci 1994; 39:2485-2496.
27. 27 Kurose I, Miura S, Fukumura D, Yonei Y, Saito H, Tada S, et al. Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells: a comparison with oxidative burst. Cancer Res 1993; 53:2676-2682.
28. 28 Andrene P, Nussler A, Cursaro C, Di Silvio M, Gramenzi A, Caraceni P, et al. Effect of acute α-IFN administration on serum nitric oxide levels in patients with chronic viral hepatitis [Abstract]. Hepatology 1998; 20:859A.
29. 29 Karupiah G, Xie Q, Mark R, Buller L, Nathan C, Durate C, MacMicking JD. Inhibition of viral replication by interferon gamma-induced nitric oxide synthase. Science 1993; 261:1445-1448.
30. 30 Kenneth DC. Evidence for an antiviral effect of nitric oxide. J Clin Invest 1993; 91:2446-2452.
31. 31 Lowenstein CJ, Hill SL, Lafondwalker A, Wu J, Allen G, Landavere M, et al. Nitric oxide inhibits viral replication in murine myocarditis. J Clin Invest 1996; 97:1837-1843.