8,8″-Biapigeninyl stimulates osteoblast functions and inhibits osteoclast and adipocyte functions: Osteoprotective action of 8,8″-biapigeninyl in ovariectomized mice

Molecular and Cellular Endocrinology

Volumn 323, Issue 2, 2010, Pages 256-267

  Siddiqui, Jawed A ^a   Swarnkar, Gaurav ^a   Sharan, Kunal ^a   Chakravarti, Bandana ^a   Sharma, Gunjan ^a   Rawat, Preeti ^a   Kumar, Manmeet ^a   Khan, Faheem M ^a   Pierroz, Dominique ^b   Maurya, Rakesh ^a   Chattopadhyay, Naibedya ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Adipogenesis; Biflavone; Bone microarchitecture; Estrogenicity; Osteogenic

Indexed keywords

8,8 BIAPIGENINYL; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ANTIESTROGEN; APIGENIN; APIGENIN DERIVATIVE; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; CORE BINDING FACTOR BETA; ESTROGEN RECEPTOR; FULVESTRANT; INTERLEUKIN 6; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TRANSCRIPTION FACTOR RUNX; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BONE CELL; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORTICAL BONE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ESTROGEN ACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MICRO-COMPUTED TOMOGRAPHY; MINERALIZATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OVARIECTOMY; PRIORITY JOURNAL; TRABECULAR BONE; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CUPRESSUS; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FEMALE; MALE; MEDICINAL PLANT; PHYSIOLOGY; SIGNAL TRANSDUCTION; STEM CELL;

ADIPOCYTES; ANIMALS; APIGENIN; APOPTOSIS; CELL DIFFERENTIATION; CELLS, CULTURED; CUPRESSUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; OSTEOBLASTS; OSTEOCLASTS; OVARIECTOMY; PLANTS, MEDICINAL; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 77952954226     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.03.024     Document Type: Article

References (44)

1. Bandyopadhyay S., Lion J.M., Mentaverri R., Ricupero D.A., Kamel S., Romero J.R., Chattopadhyay N. Attenuation of osteoclastogenesis and osteoclast function by apigenin. Biochem. Pharmacol. 2006, 72:184-197.
2. Bhargavan B., Gautam A.K., Singh D., Kumar A., Chaurasia S., Tyagi A.M., Yadav D.K., Mishra J.S., Singh A.B., Sanyal S., et al. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J. Cell. Biochem. 2009, 108:388-399.
3. Blair H.C., Athanasou N.A. Recent advances in osteoclast biology and pathological bone resorption. Histol. Histopathol. 2004, 19:189-199.
4. Bouxsein M.L., Pierroz D.D., Glatt V., Goddard D.S., Cavat F., Rizzoli R., Ferrari S.L. beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice. J. Bone Miner. Res. 2005, 20:635-643.
5. Cano A., Dapia S., Noguera I., Pineda B., Hermenegildo C., del Val R., Caeiro J.R., Garcia-Perez M.A. Comparative effects of 17beta-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice. Osteoporos. Int. 2008, 19:793-800.
6. Chan H.P., Lo S.C., Niklason L.T., Ikeda D.M., Lam K.L. Image compression in digital mammography: effects on computerized detection of subtle microcalcifications. Med. Phys. 1996, 23:1325-1336.
7. Chappard D., Retailleau-Gaborit N., Legrand E., Basle M.F., Audran M. Comparison insight bone measurements by histomorphometry and microCT. J. Bone Miner. Res. 2005, 20:1177-1184.
8. Christiansen T., Richelsen B., Bruun J.M. Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int. J. Obes. (Lond.) 2005, 29:146-150.
9. Cirmanova V., Bayer M., Starka L., Zajickova K. The effect of leptin on bone: an evolving concept of action. Physiol. Res. 2008, 57(Suppl. 1):S143-S151.
10. Ebina K., Fukuhara A., Shimomura I. Role of adipocytokine in bone metabolism. Clin. Calcium 2008, 18:623-630.
11. Furukawa A., Oikawa S., Murata M., Hiraku Y., Kawanishi S. (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA. Biochem. Pharmacol. 2003, 66:1769-1778.
12. Gimble J.M., Zvonic S., Floyd Z.E., Kassem M., Nuttall M.E. Playing with bone and fat. J. Cell. Biochem. 2006, 98:251-266.
13. Gregory C.A., Gunn W.G., Peister A., Prockop D.J. An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal. Biochem. 2004, 329:77-84.
14. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol. Aspects Med. 2006, 27:1-93.
15. Heim M., Johnson J., Boess F., Bendik I., Weber P., Hunziker W., Fluhmann B. Phytanic acid, a natural peroxisome proliferator-activated receptor (PPAR) agonist, regulates glucose metabolism in rat primary hepatocytes. FASEB J. 2002, 16:718-720.
16. Hildebrand T., Laib A., Muller R., Dequeker J., Ruegsegger P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J. Bone Miner. Res. 1999, 14:1167-1174.
17. Hildebrand T., Ruegsegger P. Quantification of bone microarchitecture with the structure model index. Comput. Methods Biomech. Biomed. Eng. 1997, 1:15-23.
18. Hozumi A., Osaki M., Goto H., Sakamoto K., Inokuchi S., Shindo H. Bone marrow adipocytes support dexamethasone-induced osteoclast differentiation. Biochem. Biophys. Res. Commun. 2009, 382:780-784.
19. Ibrahim N.A., El-Seedi H.R., Mohammed M.M. Phytochemical investigation and hepatoprotective activity of Cupressus sempervirens L. leaves growing in Egypt. Nat. Prod. Res. 2007, 21:857-866.
20. Ishikawa T., Kamiyama M., Tani-Ishii N., Suzuki H., Ichikawa Y., Hamaguchi Y., Momiyama N., Shimada H. Inhibition of osteoclast differentiation and bone resorption by cathepsin K antisense oligonucleotides. Mol. Carcinog. 2001, 32:84-91.
21. Ishimi Y. Soybean isoflavones in bone health. Forum Nutr. 2009, 61:104-116.
22. Kawai M., Devlin M.J., Rosen C.J. Fat targets for skeletal health. Nat. Rev. Rheumatol. 2009, 5:365-372.
23. La Vecchia C., Brinton L.A., McTiernan A. Menopause, hormone replacement therapy and cancer. Maturitas 2001, 39:97-115.
24. Laharrague P., Truel N., Fontanilles A.M., Corberand J.X., Penicaud L., Casteilla L. Regulation by cytokines of leptin expression in human bone marrow adipocytes. Horm. Metab. Res. 2000, 32:381-385.
25. Lei Z., Xiaoying Z., Xingguo L. Ovariectomy-associated changes in bone mineral density and bone marrow haematopoiesis in rats. Int. J. Exp. Pathol. 2009, 90:512-519.
26. Liang S., Tang J., Shen Y.H., Jin H.Z., Tian J.M., Wu Z.J., Zhang W.D., Yan S.K. Biflavonoids from Daphne feddei and their inhibitory activities against nitric oxide production. Chem. Pharm. Bull. (Tokyo) 2008, 56:1729-1731.
27. Lin J., Della-Fera M.A., Baile C.A. Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes. Obes. Res. 2005, 13:982-990.
28. Maggio M. Estrogen replacement therapy and endometrial cancer: the elusive link. J. Nurse Midwifery 1980, 25:19-21.
29. Maniatopoulos C., Sodek J., Melcher A.H. Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res. 1988, 254:317-330.
30. Mothana R.A., Gruenert R., Bednarski P.J., Lindequist U. Evaluation of the in vitro anticancer, antimicrobial and antioxidant activities of some Yemeni plants used in folk medicine. Pharmazie 2009, 64:260-268.
31. Muruganandan S., Roman A.A., Sinal C.J. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell. Mol. Life Sci. 2009, 66:236-253.
32. Murti V.V.S., Raman P.V., Seshadri T.R. Cupressuflavone, a new biflavonyl pigment. Tetrahedron 1967, 23:397-404.
33. Nakamura M., Nakamichi Y., Nakamura H., Udagawa N. Osteoclastogenesis and bone resorption. Nippon Rinsho 2009, 67:889-896.
34. Papadaki H.A., Tsatsanis C., Christoforidou A., Malliaraki N., Psyllaki M., Pontikoglou C., Miliaki M., Margioris A.N., Eliopoulos G.D. Alendronate reduces serum TNFalpha and IL-1beta, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis. J. Bone Miner. Metab. 2004, 22:577-587.
35. Platt I.D., El-Sohemy A. Regulation of osteoblast and adipocyte differentiation from human mesenchymal stem cells by conjugated linoleic acid. J. Nutr. Biochem. 2008, 20:956-964.
36. Prabhakar U., James I.E., Dodds R.A., Lee-Rykaczewski E., Rieman D.J., Lipshutz D., Trulli S., Jonak Z., Tan K.B., Drake F.H., Gowen M. A novel human bone marrow stroma-derived cell line TF274 is highly osteogenic in vitro and in vivo. Calcif. Tissue Int. 1998, 63:214-220.
37. Rodriguez J.P., Astudillo P., Rios S., Seitz G., Pino A.M. Adipogenesis and osteoporosis. Rev. Med. Chil. 2009, 137:827-836.
38. Sharan K., Siddiqui J.A., Swarnkar G., Maurya R., Chattopadhyay N. Role of phytochemicals in the prevention of menopausal bone loss: evidence from in vitro and in vivo, human interventional and pharma-cokinetic studies. Curr. Med. Chem. 2009, 16:1138-1157.
39. Soltan M., Smiler D., Choi J.H. Bone marrow: orchestrated cells, cytokines, and growth factors for bone regeneration. Implant Dent. 2009, 18:132-141.
40. Takagi K., Kudo A. Bone marrow stromal cell lines having high potential for osteoclast-supporting activity express PPARgamma1 and show high potential for differentiation into adipocytes. J. Bone Miner. Metab. 2008, 26:13-23.
41. Trivedi R., Kumar A., Gupta V., Kumar S., Nagar G.K., Romero J.R., Dwivedi A.K., Chattopadhyay N. Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: possible roles of quercetin and kaempferol. Mol. Cell. Endocrinol. 2009, 302:86-91.
42. Trivedi R., Kumar S., Kumar A., Siddiqui J.A., Swarnkar G., Gupta V., Kendurker A., Dwivedi A.K., Romero J.R., Chattopadhyay N. Kaempferol has osteogenic effect in ovariectomized adult Sprague-Dawley rats. Mol. Cell. Endocrinol. 2008, 289:85-93.
43. Wang L., Zhao R., Shi X., Wei T., Halloran B.P., Clark D.J., Jacobs C.R., Kingery W.S. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone 2009, 45:309-320.
44. Wong G.L., Kent G.N., Ku K.Y., Cohn D.V. The interaction of parathormone and calcium on the hormone-regulated synthesis of hyaluronic acid and citrate decarboxylation in isolated bone cells. Endocrinology 1978, 103:2274-2282.