Inhibition of osteoclast differentiation and bone resorption by cathepsin k antisense oligonucleotides

Molecular Carcinogenesis

Volumn 32, Issue 2, 2001, Pages 84-91

  Ishikawa, Takashi ^a   Kamiyama, Masako ^a   Tani Ishii, Nobuyuki ^b   Suzuki, Hiroaki ^c   Ichikawa, Yasushi ^a   Hamaguchi, Yohei ^a   Momiyama, Nobuyoshi ^a   Shimada, Hiroshi ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b KANAGAWA DENTAL COLLEGE   (Japan)

^c ASAHI CHEMICAL INDUSTRY CO   (Japan)

Author keywords

Antisense oligonucleotide; Bone metastasis; Breast cancer; Cathepsin K; Osteoclast

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CATHEPSIN K; MESSENGER RNA;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE METASTASIS; BREAST CANCER; CANCER PREVENTION; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; METASTASIS INHIBITION; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

ANIMALS; BONE RESORPTION; BREAST NEOPLASMS; CATHEPSINS; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDES, ANTISENSE; OSTEOCLASTS;

EID: 0035173085     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.1067     Document Type: Article

References (20)

1. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: Two cellular mechanisms explain joint destruction?
2. Relationship between the secretion of cysteine proteine proteinases and their inhibitors and malignant potential
3. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts
4. Molecular cloning of human cDNA for cathepsin K: Novel cysteine proteinase predominantly expressed in bone
5. Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas
6. Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution
7. Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme
8. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts
9. Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification
10. The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma
11. Direct resorption of bone by human breast cancer cells in vitro
12. Oligonucleotide probe design - A new approach
13. Software to determine optimal oligonucleotide sequences based on hybridization simulation data
14. Suppression of c-jun by antisense oligonucleotides inhibits cell adhesion but not respiratory burst during phorbol ester-induced differentiation of U937 human monoblastic cells
15. Osteoblastic cells are involved in osteoclast formation
16. Preparation and characterization of a mouse osteoclast-like multinucleated cell population
17. Localization of rat cathepsin K in osteoclasts and resorption pits: Inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones
18. Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption
19. Characterization of mouse cathepsin K gene, the gene promoter, and the gene expression
20. Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization