Identification of a second DNA binding site in human DNA methyltransferase 3A by substrate inhibition and domain deletion

Archives of Biochemistry and Biophysics

Volumn 498, Issue 1, 2010, Pages 13-22

  Purdy, Matthew M ^a   Holz Schietinger, Celeste ^a   Reich, Norbert O ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Allosteric binding; DNA methylation; Enzyme kinetics; Non specific DNA binding; Protein DNA interaction

Indexed keywords

DNA; DNA METHYLTRANSFERASE 3A;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; DNA BINDING; DNA METHYLATION; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; HUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; CATTLE; CONSERVED SEQUENCE; DNA; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; ENZYME INHIBITORS; HUMANS; INOSINE NUCLEOTIDES; KINETICS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES; POLYMERS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION;

MAMMALIA;

EID: 77952952302     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2010.03.007     Document Type: Article

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