Quantification of lipids in human lower limbs using yellow bone marrow as the internal reference: Gender-related effects

Magnetic Resonance Imaging

Volumn 28, Issue 5, 2010, Pages 676-682

  Ortiz Nieto, Francisco ^a   Johansson, Lars ^a   Ahlström, Håkan ^a   Weis, Jan ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Intramyocellular lipids; Quantitation; Skeletal muscle; Spectroscopic imaging; Total fat

Indexed keywords

FAT; LIPID;

ADULT; ARTICLE; BONE MARROW; CONTROLLED STUDY; DIET; FAT CONTENT; FEMALE; GASTROCNEMIUS MUSCLE; HUMAN; HUMAN EXPERIMENT; LEG; LIPID ANALYSIS; LIPID METABOLISM; MALE; METABOLIC DISORDER; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEX DIFFERENCE; THIGH; ALGORITHM; METABOLISM; PHYSIOLOGY; PROCEDURES; REFERENCE VALUE; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SKELETAL MUSCLE; STANDARDS; YOUNG ADULT;

ADULT; ALGORITHMS; BONE MARROW; FEMALE; HUMANS; LIPIDS; LOWER EXTREMITY; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUSCLE, SKELETAL; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEX FACTORS; YOUNG ADULT;

EID: 77952951695     PISSN: 0730725X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mri.2010.03.014     Document Type: Article

References (32)

1. Schick F., Eismann B., Jung W.I., Bongers H., Bunse M., Lutz O. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med 1993, 29:158-167.
2. 1H-MR-spectroscopy. Magn Reson Med 1997, 37:484-493.
3. 1H-NMR spectroscopy study. Diabetologia 1999, 42:113-116.
4. Goodpaster B.H., Thaete F.Z., Simoneau J.A., Kelley D.E. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 1997, 46:1579-1585.
5. 1H nuclear magnetic resonance spectroscopy in lean and obese adolescent: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 2002, 51:1022-1027.
6. Jacob S., Machann J., Rett K., Brechtel K., Volk A., Renn W., et al. Association of increased intramyocellular lipid content with insulin resistance in lean non-diabetic offspring of type 2 diabetic subjects. Diabetes 1999, 48:1113-1119.
7. 13C nuclear resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 1999, 48:1600-1606.
8. Decombaz J., Hoppeler H., Kreis R., Boesch C. Effect of diet on the replenishment of intramyocellular lipids after exercise. Eur J Nutr 2000, 39:244-247.
9. 1H NMR study. Am J Physiol Endocrinol Metab 2002, 282:E95-106.
10. Schrauwen-Hinderling V.B., Schrauwen P., Hesseling M.K., van Engelshoven J.M., Nicolay K., Saris W.H., et al. The increase in intramyocellular lipid content is a very early response to training. J Clin Endocrinol Metab 2003, 88:1610-1616.
11. Zehnder M., Saillen P., Kreis R., Boesch C., Vermathen P. Evaluation of intramyocellular lipids concentration in the different thigh and calf muscles before and after endurance exercise. Book of abstracts: Thirteenth Annual Meeting of the International Society for Magnetic Resonance in Medicine 2005, 298. ISMRM, Miami Beach, FL.
12. 1H-MRSI at 4T. Book of abstracts: Thirteenth Annual Meeting of the International Society for Magnetic Resonance in Medicine 2005, 2033. ISMRM, Miami Beach, FL.
13. Weis J., Johansson L., Courivaud F., Karlsson F.A., Ahlström H. Quantification of intramyocellular lipids in obese subjects using spectroscopic imaging with high spatial resolution. Magn Reson Med 2007, 57:22-28.
14. Machann J., Thamer C., Schnoedt B., Stefan N., Stumvoll M., Haring H.U., et al. Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: a whole body MRI/MRS study. MAGMA 2005, 18:128-137.
15. Zehnder M., Ith M., Kreis R., Saris W., Boutellier U., Boesch C. Gender-specific usage of intramyocellular lipids and glycogen during exercise. Med Sci Sports Exerc 2005, 37:1517-1524.
16. Petersen K.F., Befroy D., Dufour S., Dziura J., Ariyan C., Rothman D.L., et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003, 300:1140-1142.
17. 1H-MR spectroscopic imaging. J Appl Physiol 2001, 90:1267-1274.
18. Vermathen P., Kreis R., Boesch C. Distribution of intramyocellular lipids in human calf muscles as determined by MR spectroscopic imaging. Magn Reson Med 2004, 51:253-262.
19. Weis J., Courivaud F., Schacht Hansen M., Johansson L., Riisgaard Ribe L., Ahlström H. Lipid content in the musculature of the lower leg: evaluation with high-resolution spectroscopic imaging. Magn Reson Med 2005, 54:152-158.
20. Philips D.I.W., Caddy S., Ilic V., Fielding B.A., Frayn K.N., Borthwick A.C., et al. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 1996, 45:947-950.
21. Goodpaster B.H., Theriault R., Watkins S.C., Kelley D.E. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism 2000, 49:467-472.
22. Boesch C., Machann J., Vermathen P., Schick F. Role of proton MR for the study of muscle lipid metabolism. NMR Biomed 2006, 19:968-988.
23. Boesch C. Musculoskeletal spectroscopy. J Magn Reson Imag 2007, 25:321-338.
24. 1H-MRS. J Appl Physiol 1999, 87:2068-2072.
25. Hatakenaka M., Ueda M., Ishigami K., Otsuka M., Masuda K. Effects of aging on muscle T2 relaxation time difference between fast- and slow-twitch muscles. Inv Radiol 2001, 36:692-698.
26. 1H NMR relaxation times of skeletal muscle metabolites at 3 T. MAGMA 2004, 16:155-159.
27. Weis J., Johansson L., Ortiz-Nieto F., Ahlström H. Assessment of lipids in skeletal muscle by high-resolution spectroscopic imaging using fat as the internal standard: comparison with water referenced spectroscopy. Magn Reson Med 2008, 59:1259-1265.
28. Naressi A., Couturier C., Devos J.M., Janssen M., Mangeat C., de Beer R., et al. Java-based graphical user interface for the MRUI quantitation package. MAGMA 2001, 12:141-152.
29. Perseghin G., Scifo P., Pagliato E., Battezzaeti A., Benedini S., Soldini L., et al. Gender factors affect fatty acids-induced insulin resistance in nonobese humans: effects of oral steroidal contraception. J Clin Endocrin Metab 2001, 86:3188-3196.
30. 1H-magnetic resonance study. J Clin Endocrin Metab 2003, 88:5638-5643.
31. Schick F., Machann J., Brechtel K., Strempfer A., Klumpp B., Stein D.T., et al. MRI of muscular fat. Magn Reson Med 2002, 47:720-727.
32. Machann J., Bachman O.P., Brechtel K., Dahl D.B., Wietek B., Klump B., et al. Lipid content in the musculature of the lower leg assessed by fat selective MRI: Intra- and interindividual differences and correlation with anthropometric and metabolic data. J Magn Reson Imag 2003, 17:350-357.