Gender-specific usage of intramyocellular lipids and glycogen during exercise

Medicine and Science in Sports and Exercise

Volumn 37, Issue 9, 2005, Pages 1517-1524

  Zehnder, Monica ^a,b,c   Ith, Michael ^b   Kreis, Roland ^b   Saris, Wim ^c   Boutellier, Urs ^a   Boesch, Chris ^b,d  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

1H and 13C magnetic resonance spectroscopy; Endurance exercise and training; Fat and carbohydrate metabolism

Indexed keywords

CARBON DIOXIDE; GLYCOGEN; LIPID; OXYGEN;

ADULT; ARTICLE; BICYCLE ERGOMETRY; CARBOHYDRATE METABOLISM; CARBOHYDRATE OXIDATION; CONTROLLED STUDY; ENDURANCE; ENDURANCE EXERCISE; ENERGY RESOURCE; EXERCISE; FEMALE; GENDER; GLYCOGEN METABOLISM; HEART RATE; HUMAN; HUMAN EXPERIMENT; LIPID METABOLISM; LIPID OXIDATION; LUNG GAS EXCHANGE; MALE; MUSCLE CELL; MUSCLE METABOLISM; MUSCLE STRENGTH; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; OXYGEN CONSUMPTION; PERCENT MAXIMUM HEART RATE; RELATIVE POWER OUTPUT; RESPIRATORY EXCHANGE RATIO; SEX DIFFERENCE; SPIROMETRY; TRAINING; WORKLOAD;

ADULT; BLOOD GLUCOSE; DIETARY CARBOHYDRATES; DIETARY FATS; ENERGY METABOLISM; EXERCISE; FEMALE; GLYCOGEN; HEART RATE; HUMANS; LACTIC ACID; LIPID METABOLISM; MALE; MUSCLE FIBERS; NUTRITION ASSESSMENT; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE; SEX FACTORS; SPORTS;

EID: 25444519525     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.mss.0000177478.14500.7c     Document Type: Article

References (37)

1. ACHTEN, J., M. GLEESON, and A. E. JEUKENDRUP. Determination of the exercise intensity that elicits maximal fat oxidation. Med. Sci. Sports Exerc. 34:92-97, 2002.
2. BACHMANN, O. P., D. B. DAHL, K. BRECHTEL, et al. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes 50:2579-2584, 2001.
3. BOESCH, C., J. DECOMBAZ, J. SLOTBOOM, and R. KREIS. Observation of intramyocellular lipids by means of 1H magnetic resonance spectroscopy. Proc. Nutr. Soc. 58:841-850, 1999.
4. BOESCH, C., J. SLOTBOOM, H. HOPPELER, and R. KREIS. In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn. Reson. Med. 37:484-493, 1997.
5. BORG, G. A. Psychophysical bases of perceived exertion. Med. Sci. Sports Exerc. 14:377-381, 1982.
6. CARTER, S. L., C. RENNIE, and M. A. TARNOPOLSKY. Substrate utilization during endurance exercise in men and women after endurance training. Am. J. Physiol. Endocrinol. Metab. 280:E898-E907, 2001.
7. CLEROUX, J., P. VAN NGUYEN, A. W. TAYLOR, and F. H. LEENEN. Effects of beta 1- vs. beta 1 + beta 2-blockade on exercise endurance and muscle metabolism in humans. J. Appl. Physiol. 66:548-554, 1989.
8. DECOMBAZ, J., M. FLEITH, H. HOPPELER, R. KREIS, and C. BOESCH. Effect of diet on the replenishment of intramyocellular lipids after exercise. Eur. J. Nutr. 39:244-247, 2000.
9. DECOMBAZ, J., B. SCHMITT, M. ITH, et al. Post-exercise fat intake repletes intramyocellular lipids, but no faster in trained than in sedentary subjects. Am. J. Physiol. 281:R760-R769, 2001.
10. FROBERG, S. O., E. HULTMAN, and L. H. NILSSON. Effect of noradrenaline on triglyceride and glycogen concentrations in liver and muscle from man. Metabolism 24:119-126, 1975.
11. GUO, Z., B. BURGUERA, and M. D. JENSEN. Kinetics of intramuscular triglyceride fatty acids in exercising humans. J. Appl. Physiol. 89:2057-2064, 2000.
12. HORTON, T. J., E. K. MILLER, D. GLUECK, and K. TENCH. No effect of menstrual cycle phase on glucose kinetics and fuel oxidation during moderate-intensity exercise. Am. J. Physiol. Endocrinol. Metab. 282:E752-E762, 2002.
13. HORTON, T. J., M. J. PAGLIASSOTTI, K. HOBBS, and J. O. HILL. Fuel metabolism in men and women during and after long-duration exercise. J. Appl. Physiol. 85:1823-1832, 1998.
14. HOWALD, H., C. BOESCH, R. KREIS, et al. Content of intramyocellular lipids derived by electron microscopy, biochemical assays, and (1)H-MR spectroscopy. J. Appl. Physiol. 92:2264-2272, 2002.
15. HOWALD, H., H. HOPPELER, H. CLAASSEN, O. MATHIEU, and R. STRAUB. Influences of endurance training on the ultrastructural composition of the different muscle fiber types in humans. Pflugers Arch. 403:369-376, 1985.
16. JOHNSON, N. A., S. R. STANNARD, K. MEHALSKI, et al. Intramyocellular triacylglycerol in prolonged cycling with high- and low-carbohydrate availability. J. Appl. Physiol. 94:1365-1372, 2003.
17. KIENS, B., B. ESSEN-GUSTAVSSON, N. J. CHRISTENSEN, and B. SALTIN. Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J. Physiol. 469:459-478, 1993.
18. KOMI, P.V., and J. KARLSSON. Skeletal muscle fibre types, enzyme activities and physical performance in young males and females. Acta Physiol. Scand. 103:210-218, 1978.
19. LANGFORT, J., M. DONSMARK, T. PLOUG, C. HOLM, and H. GALBO. Hormone-sensitive lipase in skeletal muscle: regulatory mechanisms. Acta Physiol. Scand. 178:397-403, 2003.
20. MACINTOSH, B. R., R. R. NEPTUNE, and J. F. HORTON. Cadence, power, and muscle activation in cycle ergometry. Med. Sci. Sports Exerc. 32:1281-1287, 2000.
21. PERONNET, F., and D. MASSICOTTE. Table of nonprotein respiratory quotient: an update. Can. J. Sport Sci. 16:23-29, 1991.
22. PERSEGHIN, G., P. SCIFO, E. PAGLIATO, et al. Gender factors affect fatty acids-induced insulin resistance in nonobese humans: effects of oral steroidal contraception. J. Clin. Endocrinol. Metab. 86: 3188-3196, 2001.
23. RICO-SANZ, J., M. ZEHNDER, R. BUCHLI, M. DAMBACH, and U. BOUTELLIER. Muscle glycogen degradation during simulation of a fatiguing soccer match in elite soccer players examined noninvasively by 13C-MRS. Med. Sci. Sports Exerc. 31:1587-1593, 1999.
24. ROEPSTORFF, C., C. H. STEFFENSEN, M. MADSEN, et al. Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects. Am. J. Physiol. Endocrinol. Metab. 282:E435-E447, 2002.
25. ROMIJN, J. A., E. F. COYLE, L. S. SIDOSSIS, et al. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am. J. Physiol. 265:E380-E391, 1993.
26. RUBY, B. C., A. R. COGGAN, and T. W. ZDERIC. Gender differences in glucose kinetics and substrate oxidation during exercise near the lactate threshold. J. Appl. Physiol. 92:1125-1132, 2002.
27. SCHICK, F., B. EISMANN, W. I. JUNG, H. BONGERS, M. BUNSE, and O. LUTZ. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn. Reson. Med. 29:158-167, 1993.
28. SINNING, W. E., D. G. DOLNY, K. D. LITTLE, et al. Validity of "generalized" equations for body composition analysis in male athletes. Med. Sci. Sports Exerc. 17:124-130, 1985.
29. STARON, R. S., F. C. HAGERMAN, R. S. HIKIDA, et al. Fiber type composition of the vastus lateralis muscle of young men and women. J. Histochem. Cytochem. 48:623-629, 2000.
30. STEFFENSEN, C. H., C. ROEPSTORFF, M. MADSEN, and B. KIENS. Myocellular triacylglycerol breakdown in females but not in males during exercise. Am. J. Physiol. Endocrinol. Metab. 282:E634-E642, 2002.
31. THAMER, C., J. MACHANN, O. BACHMANN, et al. Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity. J. Clin. Endocrinol. Metab. 88:1785-1791, 2003.
32. VAN LOON, L. J., R. KOOPMAN, J. H. STEGEN, A. J. WAGENMAKERS, H. A. KEIZER, and W. H. SARIS. Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted state. J. Physiol. 553:611-625, 2003.
33. WATT, M. J., G. J. HEIGENHAUSER, D. J. DYCK, and L. L. SPRIET. Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man. J. Physiol. 541: 969-978, 2002.
34. WATT, M. J., G. J. HEIGENHAUSER, and L. L. SPRIET. Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy? J. Appl. Physiol. 93:1185-1195, 2002.
35. WENDLING, P. S., S. J. PETERS, G. J. HEIGENHAUSER, and L. L. SPRIET. Variability of triacylglycerol content in human skeletal muscle biopsy samples. J. Appl. Physiol. 81:1150-1155, 1996.
36. WHITE, L. J., M. A. FERGUSON, S. C. MCCOY, and H. KIM. Intramyocellular lipid changes in men and women during aerobic exercise: a (1)H-magnetic resonance spectroscopy study. J. Clin. Endocrinol. Metab. 88:5638-5643, 2003.
37. ZEHNDER, M., P., SAILLEN, R., KREIS, C., and BOESCH, P. VERMATHEN, Evaluation of intramyocellular lipids concentration in the different thigh and calf muscles before and after endurance exercise. Proceedings of the International Society for Magnetic Resonance in Medicine 13, 798, 2005.