Lipid content in the musculature of the lower leg assessed by fat selective MRI: Intra- and interindividual differences and correlation with anthropometric and metabolic data

Journal of Magnetic Resonance Imaging

Volumn 17, Issue 3, 2003, Pages 350-357

  Machann, Jürgen ^a,b   Bachmann, Oliver P ^a   Brechtel, Klaus ^a   Dahl, Dominik B ^a   Wietek, Beate ^a   Klumpp, Bernhard ^a   Häring, Hans U ^a   Claussen, Claus D ^a   Jacob, Stephan ^a   Schick, Fritz ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Section on Experimental Radiology   (Germany)

Author keywords

Fat selective MRI; Lipid content; Muscular lipids; Skeletal muscle; Type 2 diabetes

Indexed keywords

INSULIN; LIPID;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY FAT; BODY MASS; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GASTROCNEMIUS MUSCLE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LEG MUSCLE; LIPID COMPOSITION; LIPID METABOLISM; LOWER LEG; MALE; MUSCLE METABOLISM; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVER VARIATION; PERONEUS MUSCLE; PRIORITY JOURNAL; TIBIALIS POSTERIOR MUSCLE;

ADULT; ANTHROPOMETRY; BODY MASS INDEX; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMANS; LEG; LIPIDS; MAGNETIC RESONANCE IMAGING; MALE; MUSCLE, SKELETAL; PROSPECTIVE STUDIES; REFERENCE VALUES; SEX DISTRIBUTION;

EID: 0037371402     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmri.10255     Document Type: Article

References (37)

1. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose-fatty acid cycle: its role in insulin and the metabolic disturbances of diabetes mellitus. Lancet 1963;281:784-789.
2. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997;46:3-10.
3. Roden M, Krssak M, Stingl H, Gruber S, Hofer A, Furnsinn C. Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans. Diabetes 1999;48:358-364.
4. Stein DT, Szczepaniak LS, Dobbins RL, Snell P, McGarry JD. Skeletal muscle triglycerides stores are increased in insulin resistant states In: Proceedings of the 6th Annual Meeting of ISMRM, Sydney. Australia. 1998. p 388.
5. 1H NMR spectroscopy study. Diabetologia 1999;42:113-116.
6. Jacob S, Machann J, Rett K, et al. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 1999;48: 1113-1119.
7. Brechtel K, Machann J, Jacob S, et al. In-vivo 1H-MR spectroscopy: the determination of the intra- and extramyocellular lipid content depending on the insulin effect in the direct offspring of type-2 diabetics. Rofo Fortschr Geb Röntgenstr Neuen Bildgeb Verfahr 1999;171:113-120.
8. DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM. A balanced overview. Diabetes Care 1992;15:318-368.
9. Eriksson J, Franssila Kallunki A, Ekstrand A, et al. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 1989;321:337-343.
10. Polgar J, Johnson MA, Weightman D, Appleton D. Data on fibre size in thirty-six human muscles. An autopsy study. J Neurol Sci 1973; 19:307-318.
11. Edgerton VR, Smith JL, Simpson DR. Muscle fiber type populations of human leg muscles. Histochem J 1975;7:259-266.
12. Brechtel K, Niess AM, Machann J, et al. Utilisation of intramyocellular lipids (IMCLs) during exercise as assessed by proton magnetic resonance spectroscopy (1H-MRS). Horm Metab Res 2001;33:63-66.
13. Decombaz J, Fleith M, Hoppeler H, Kreis R, Boesch C. Effect of diet on the replenishment of intramyocellular lipids after exercise. Eur J Nutr 2000;39:244-247.
14. Bachmann OP, Dahl DB, Brechtel K, et al. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes 2001;50: 2579-2584.
15. Boden G, Lebed B, Schatz M, Homko C, Lemieux S. Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 2001;50:1612-1617.
16. Schick F, Eismann B, Jung WI, Bongers H, Bunse M, Lutz O. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med 1993;29:158-167.
17. Boesch C, Slotboom J, Hoppeler H, Kreis R. In vivo determination of intra-myocellular lipids in human muscle by means of localized H-1-MR-spectroscopy. Magn Reson Med 1997;37:484-493.
18. Bydder GM, Young IR. MR imaging: clinical use of the inversion recovery sequence. J Comput Assist Tomogr 1985;9:659-675.
19. Fleckenstein JL, Archer BT, Barker BA, Vaughan JT, Parkey RW, Peshock RM. Fast short-tau inversion-recovery MR imaging. Radiology 1991;179:499-504.
20. Laurent WM, Bonny JM, Renou JP. Imaging of water and fat fractions in high-field MRI with multiple slice chemical shift-selective inversion recovery. J Magn Reson Imaging 2000;12:488-496.
21. Haase A, Frahm J, Hanicke W, Matthaei D. 1H NMR chemical shift selective (CHESS) imaging. Phys Med Biol 1985;30:341-344.
22. Dixon WT. Simple proton spectroscopic imaging. Radiology 1984; 153:189-194.
23. Szumowski J, Coshow W, Li F, Coombs B, Quinn SF. Double-echo three-point-Dixon method for fat suppression MRI. Magn Reson Med 1995;34:120-124.
24. Brateman L. Chemical shift imaging: a review. Am J Roentgenol 1986;146:971-980.
25. Meyer CH, Pauly JM, Macovski A, Nishimura DG. Simultaneous spatial and spectral selective excitation. Magn Reson Med 1990;15: 287-304.
26. Schick F, Forster J, Machann J, Huppert P, Claussen CD. Highly selective water and fat imaging applying multislice sequences without sensitivity to B1 field inhomogeneities. Magn Reson Med 1997; 38:269-274.
27. Schick F. Simultaneous highly selective MR water and fat imaging using a simple new type of spectral-spatial excitation. Magn Reson Med 1998;40:194-202.
28. Schick F, Forster J, Machann J, Kuntz R, Claussen CD. Improved clinical echo-planar MRI using spatial-spectral excitation. J Magn Reson Imaging 1998;8:960-967.
29. Zur Y. Design of improved spectral-spatial pulses for routine clinical use. Magn Reson Med 2000;43:410-420.
30. Schick F, Bongers H, Aicher K, Jung WI, Duda S, Lutz O. Subtle bone marrow edema assessed by frequency selective chemical shift MRI. J Comput Assist Tomogr 1992;16:454-460.
31. Schick F, Machann J, Brechtel K, et al. MRI of muscular fat. Magn Reson Med 2002;47:720-727.
32. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:E214-E223.
33. Miller AJ, Joseph PM. The use of power images to perform quantitative analysis on low SNR MR images. Magn Reson Imaging 1993; 11:1051-1056.
34. Hwang JH, Pan JW, Heydari S, Hetherington HP, Stein DT. Regional differences in intramyocellular lipids in humans observed by in vivo 1H-MR spectroscopic imaging. J Appl Physiol 2001;90: 1267-1274.
35. Scott W, Stevens J, Binder-Macleod SA. Human skeletal muscle fiber type classifications. Phys Ther 2001;81:1810-1816.
36. Perseghin G, Scifo P, De Cobelli F, et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 1999;48: 1600-1606.
37. Forouhi NG, Jenkinson G, Thomas EL, et al. Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men. Diabetologia 1999;42: 932-935.