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Volumn 34, Issue 6, 2010, Pages 968-975

Clinical (Nonforensic) application of ethyl glucuronide measurement: Are we ready?

Author keywords

Alcohol Screening; Ethanol Metabolite; Ethyl Glucuronide; Ethyl Sulfate; Laboratory Test

Indexed keywords

ALCOHOL; ETHYL GLUCURONIDE; BIOLOGICAL MARKER; DIETHYL SULFATE; GLUCURONIC ACID; SULFATE;

EID: 77952916485     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2010.01171.x     Document Type: Review
Times cited : (41)

References (46)
  • 1
    • 0036667836 scopus 로고    scopus 로고
    • Carbohydrate-deficient transferrin and gamma-glutamyltransferase for the detection and monitoring of alcohol use: Results from a multisite study
    • Tabakoff B. and the CDTECT Study Group
    • Anton RF, Lieber C, Tabakoff B. and the CDTECT Study Group (2002) Carbohydrate-deficient transferrin and gamma-glutamyltransferase for the detection and monitoring of alcohol use: results from a multisite study. Alcohol Clin Exp Res 26 : 1215 1222.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1215-1222
    • Anton, R.F.1    Lieber, C.2
  • 2
    • 33750360497 scopus 로고    scopus 로고
    • Factors affecting %CDT status at entry into a multisite clinical treatment trial: Experience from the COMBINE Study
    • Anton RF, Youngblood M (2006) Factors affecting %CDT status at entry into a multisite clinical treatment trial: experience from the COMBINE Study. Alcohol Clin Exp Res 30 : 1878 1883.
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 1878-1883
    • Anton, R.F.1    Youngblood, M.2
  • 3
    • 58249143990 scopus 로고    scopus 로고
    • False-positive ethyl glucuronide immunoassay screening associated with chloral hydrate medication as confirmed by LC-MS/MS and self-medication
    • Arndt T, Gierten B, Güssregen B, Wurle A, Grüner J (2009) False-positive ethyl glucuronide immunoassay screening associated with chloral hydrate medication as confirmed by LC-MS/MS and self-medication. Forensic Sci Int 184 : e27 e29.
    • (2009) Forensic Sci Int , vol.184
    • Arndt, T.1    Gierten, B.2    Güssregen, B.3    Wurle, A.4    Grüner, J.5
  • 4
    • 0032493441 scopus 로고    scopus 로고
    • Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: A balanced polymorphism for regulation of bilirubin metabolism?
    • Beutler E, Gelbart T, Demina A (1998) Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci U S A 95 : 8170 8174.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8170-8174
    • Beutler, E.1    Gelbart, T.2    Demina, A.3
  • 5
    • 33747615266 scopus 로고    scopus 로고
    • Validated method for the determination of the ethanol consumption markers ethyl glucuronide, ethyl phosphate, and ethyl sulfate in human urine by reversed-phase/weak anion exchange liquid chromatography-tandem mass spectrometry
    • Bicker W, Lammerhofer M, Keller T, Schuhmacker R, Krska R, Lindner W (2006) Validated method for the determination of the ethanol consumption markers ethyl glucuronide, ethyl phosphate, and ethyl sulfate in human urine by reversed-phase/weak anion exchange liquid chromatography-tandem mass spectrometry. Anal Chem 78 : 5884 5892.
    • (2006) Anal Chem , vol.78 , pp. 5884-5892
    • Bicker, W.1    Lammerhofer, M.2    Keller, T.3    Schuhmacker, R.4    Krska, R.5    Lindner, W.6
  • 6
    • 18844384624 scopus 로고    scopus 로고
    • Detection of recent ethanol intake with new markers: Comparison of fatty acid ethyl esters in serum and of ethyl glucuronide and the ratio of 5-hydroxytryptophol to 5-hydroxyindole acetic acid in urine
    • Borucki KS, Dierkes J, Jachau K, Krause D, Westphal S, Wurst F, Luley C, Schmidt-Gayk H (2005) Detection of recent ethanol intake with new markers: comparison of fatty acid ethyl esters in serum and of ethyl glucuronide and the ratio of 5-hydroxytryptophol to 5-hydroxyindole acetic acid in urine. Alcohol Clin Exp Res 29 : 781 787.
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 781-787
    • Borucki, K.S.1    Dierkes, J.2    Jachau, K.3    Krause, D.4    Westphal, S.5    Wurst, F.6    Luley, C.7    Schmidt-Gayk, H.8
  • 8
    • 37749033178 scopus 로고    scopus 로고
    • Evaluation of a new immunoassay for urinary ethyl glucuronide testing
    • Bottcher M, Beck O, Helander A (2008) Evaluation of a new immunoassay for urinary ethyl glucuronide testing. Alcohol Alcohol 43 : 46 48.
    • (2008) Alcohol Alcohol , vol.43 , pp. 46-48
    • Bottcher, M.1    Beck, O.2    Helander, A.3
  • 9
    • 33845486079 scopus 로고    scopus 로고
    • The effect of the use of mouthwash on ethylglucuronide concentrations in urine
    • Costantino A, DiGregorio JE, Korn W, Spayd S, Reiders F (2006) The effect of the use of mouthwash on ethylglucuronide concentrations in urine. J Anal Toxicol 30 : 659 662.
    • (2006) J Anal Toxicol , vol.30 , pp. 659-662
    • Costantino, A.1    Digregorio, J.E.2    Korn, W.3    Spayd, S.4    Reiders, F.5
  • 10
    • 0036014541 scopus 로고    scopus 로고
    • Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide
    • Dahl H, Stephanson N, Beck O, Helander A (2002) Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide. J Anal Toxicol 26 : 201 204.
    • (2002) J Anal Toxicol , vol.26 , pp. 201-204
    • Dahl, H.1    Stephanson, N.2    Beck, O.3    Helander, A.4
  • 12
    • 0346199330 scopus 로고    scopus 로고
    • The validity of self-reports of alcohol consumption:state of the science and challenges for research
    • Del Boca F, Darkes J (2003) The validity of self-reports of alcohol consumption:state of the science and challenges for research. Addiction 98 : 1 12.
    • (2003) Addiction , vol.98 , pp. 1-12
    • Del Boca, F.1    Darkes, J.2
  • 13
    • 0037187679 scopus 로고    scopus 로고
    • A kinetic model describing the pharmacokinetics of ethyl glucuronide in humans
    • Droenner P, Schmitt G, Aderjan R, Zimmer H (2002) A kinetic model describing the pharmacokinetics of ethyl glucuronide in humans. Forensic Sci Int 126 : 24 29.
    • (2002) Forensic Sci Int , vol.126 , pp. 24-29
    • Droenner, P.1    Schmitt, G.2    Aderjan, R.3    Zimmer, H.4
  • 14
    • 4544275672 scopus 로고    scopus 로고
    • A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levels
    • Fleming M, Anton RF, Spies C (2004) A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levels. Alcohol Clin Exp Res 28 : 1347 1355.
    • (2004) Alcohol Clin Exp Res , vol.28 , pp. 1347-1355
    • Fleming, M.1    Anton, R.F.2    Spies, C.3
  • 15
    • 24044431556 scopus 로고    scopus 로고
    • Assessment of UDP glucuronosyltransferase catalyzed formation of ethyl glucuronide in human liver microsomes and recombinant UGT's
    • Folti RS, Fisher MB (2005) Assessment of UDP glucuronosyltransferase catalyzed formation of ethyl glucuronide in human liver microsomes and recombinant UGT's. Forensic Sci Int 153 : 109 116.
    • (2005) Forensic Sci Int , vol.153 , pp. 109-116
    • Folti, R.S.1    Fisher, M.B.2
  • 16
    • 38649085337 scopus 로고    scopus 로고
    • Kinetics in serum and urinary excretion of ethyl sulfate and ethyl glucuronide after medium dose ethanol intake
    • Halter C, Dresen S, Auwaerter V, Wurst FM, Weinmann W (2008) Kinetics in serum and urinary excretion of ethyl sulfate and ethyl glucuronide after medium dose ethanol intake. Int J Legal Med 122 : 123 128.
    • (2008) Int J Legal Med , vol.122 , pp. 123-128
    • Halter, C.1    Dresen, S.2    Auwaerter, V.3    Wurst, F.M.4    Weinmann, W.5
  • 17
    • 33947182580 scopus 로고    scopus 로고
    • Phosphatidylethanol as a sensitive and specific biomarker - Comparison with gamma-glutamyltranspeptidase, mean corpuscular volume and carbohydrate-deficient transferrin
    • Hartmann S, Aradottir S, Graf M, Wiesbeck G, Lesch O, Ramskogler K, Wolfersdorf M, Alling C, Wurst F (2006) Phosphatidylethanol as a sensitive and specific biomarker - comparison with gamma-glutamyltranspeptidase, mean corpuscular volume and carbohydrate-deficient transferrin. Addict Biol 12 : 81 84.
    • (2006) Addict Biol , vol.12 , pp. 81-84
    • Hartmann, S.1    Aradottir, S.2    Graf, M.3    Wiesbeck, G.4    Lesch, O.5    Ramskogler, K.6    Wolfersdorf, M.7    Alling, C.8    Wurst, F.9
  • 18
    • 2142823658 scopus 로고    scopus 로고
    • Mass spectrometric identification of ethyl sulfate as an ethanol metabolite in humans
    • Helander A, Beck O (2004) Mass spectrometric identification of ethyl sulfate as an ethanol metabolite in humans. Clin Chem 50 : 936 937.
    • (2004) Clin Chem , vol.50 , pp. 936-937
    • Helander, A.1    Beck, O.2
  • 19
    • 23944442971 scopus 로고    scopus 로고
    • Ethyl sulfate: A metabolite of ethanol in humans and a potential biomarker of acute alcohol intake
    • Helander A, Beck O (2005) Ethyl sulfate: a metabolite of ethanol in humans and a potential biomarker of acute alcohol intake. J Anal Toxicol 29 : 270 274.
    • (2005) J Anal Toxicol , vol.29 , pp. 270-274
    • Helander, A.1    Beck, O.2
  • 20
    • 85042617232 scopus 로고    scopus 로고
    • Detection times for urinary ethyl glucuronide and ethyl sulfate in heavy drinkers during alcohol detoxification
    • Helander A, Bottcher M, Fehr C, Dahmen N, Beck O (2009) Detection times for urinary ethyl glucuronide and ethyl sulfate in heavy drinkers during alcohol detoxification. Alcohol Alcohol 44 : 55 61.
    • (2009) Alcohol Alcohol , vol.44 , pp. 55-61
    • Helander, A.1    Bottcher, M.2    Fehr, C.3    Dahmen, N.4    Beck, O.5
  • 21
    • 24144484154 scopus 로고    scopus 로고
    • Urinary track infection: A risk factor for false-negative urinary ethyl glucuronide but not ethyl sulfate in the detection of recent alcohol consumption
    • Helander A, Dahl H (2005) Urinary track infection: a risk factor for false-negative urinary ethyl glucuronide but not ethyl sulfate in the detection of recent alcohol consumption. Clin Chem 51 : 1728 1730.
    • (2005) Clin Chem , vol.51 , pp. 1728-1730
    • Helander, A.1    Dahl, H.2
  • 22
    • 34848895756 scopus 로고    scopus 로고
    • Post collection synthesis of ethyl glucuronide by bacteria in urine may cause false identification of alcohol consumption
    • Helander A, Olsson I, Dahl H (2007) Post collection synthesis of ethyl glucuronide by bacteria in urine may cause false identification of alcohol consumption. Clin Chem 53 : 1855 1857.
    • (2007) Clin Chem , vol.53 , pp. 1855-1857
    • Helander, A.1    Olsson, I.2    Dahl, H.3
  • 23
    • 38949096559 scopus 로고    scopus 로고
    • A test for alcohol - And its flaws
    • 8/12 pageA1
    • Helliker K (2006) A test for alcohol - and its flaws. Wall St J 8/12 page A1.
    • (2006) Wall St J
    • Helliker, K.1
  • 27
    • 34247380374 scopus 로고    scopus 로고
    • Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method
    • Jeppsson J-O, Arndt T, Schellenberg F, Wielders JPM, Anton RF, Whitfield JB, Helander A (2007) Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method. Clin Chem Lab Med 45 : 558 562.
    • (2007) Clin Chem Lab Med , vol.45 , pp. 558-562
    • Jeppsson, J.-O.1    Arndt, T.2    Schellenberg, F.3    Wielders, J.P.M.4    Anton, R.F.5    Whitfield, J.B.6    Helander, A.7
  • 29
    • 65549109873 scopus 로고    scopus 로고
    • Urinary ethyl glucuronide (EtG) and ethyl sulfate (EtS) assessment: Valuable tools to improve verification of abstention in alcohol-dependent patients during in-patient treatment and at follow-ups
    • Junghanns K, Graf I, Pflüger J, Wetterling G, Ziems C, Ehrenthal D, Zöllner M, Diebbelt L, Backhaus J, Weinmann W, Wurst FM (2009) Urinary ethyl glucuronide (EtG) and ethyl sulfate (EtS) assessment: valuable tools to improve verification of abstention in alcohol-dependent patients during in-patient treatment and at follow-ups. Addiction 104 : 921 926.
    • (2009) Addiction , vol.104 , pp. 921-926
    • Junghanns, K.1    Graf, I.2    Pflüger, J.3    Wetterling, G.4    Ziems, C.5    Ehrenthal, D.6    Zöllner, M.7    Diebbelt, L.8    Backhaus, J.9    Weinmann, W.10    Wurst, F.M.11
  • 30
    • 0035317281 scopus 로고    scopus 로고
    • The validity of self-reported cost events by substance abusers: Limits, liabilities, and future directions
    • Langenbucher J, Merrill J (2001) The validity of self-reported cost events by substance abusers: limits, liabilities, and future directions. Eval Rev 25 : 184 210.
    • (2001) Eval Rev , vol.25 , pp. 184-210
    • Langenbucher, J.1    Merrill, J.2
  • 31
    • 0030030762 scopus 로고    scopus 로고
    • Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome
    • Monaghan G, Ryan MF, Seddon R, Hume R, Burchell B (1996) Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome. Lancet 347 : 578 581.
    • (1996) Lancet , vol.347 , pp. 578-581
    • Monaghan, G.1    Ryan, M.F.2    Seddon, R.3    Hume, R.4    Burchell, B.5
  • 33
    • 59249096912 scopus 로고    scopus 로고
    • A review of the use of ethyl glucukronide as a marker for ethanol consumption in forensic and clinical medicine
    • Palmer RB (2009) A review of the use of ethyl glucukronide as a marker for ethanol consumption in forensic and clinical medicine. Semin Diagn Pathol 26 : 18 27.
    • (2009) Semin Diagn Pathol , vol.26 , pp. 18-27
    • Palmer, R.B.1
  • 34
    • 33845476041 scopus 로고    scopus 로고
    • Detection of ethylglucuronide in urine following the application of Germ-X
    • Rohrig TP, Huber C, Goodson L, Ross W (2006) Detection of ethylglucuronide in urine following the application of Germ-X. J Anal Toxicol 30 : 703 704.
    • (2006) J Anal Toxicol , vol.30 , pp. 703-704
    • Rohrig, T.P.1    Huber, C.2    Goodson, L.3    Ross, W.4
  • 35
    • 56449090849 scopus 로고    scopus 로고
    • Ethyl glucuronide excretion in humans following oral administration of and dermal exposure to ethanol
    • Rosano T, Lin J (2008) Ethyl glucuronide excretion in humans following oral administration of and dermal exposure to ethanol. J Anal Toxicol 32 : 594 600.
    • (2008) J Anal Toxicol , vol.32 , pp. 594-600
    • Rosano, T.1    Lin, J.2
  • 36
    • 34848832526 scopus 로고    scopus 로고
    • The role of biomarkers in the treatment of alcohol use disorders
    • SAMHSA
    • SAMHSA (2006) The role of biomarkers in the treatment of alcohol use disorders. Substance Abuse Treatment Advisor 5 : 1 7.
    • (2006) Substance Abuse Treatment Advisor , vol.5 , pp. 1-7
  • 38
    • 0030689680 scopus 로고    scopus 로고
    • Ethyl glucuronide concentration in serum of human volunteers, teetotalers, and suspected drinking drivers
    • Schmitt G, Droenner P, Skopp G, Aderjan R (2007) Ethyl glucuronide concentration in serum of human volunteers, teetotalers, and suspected drinking drivers. J Forensic Sci 42 : 1099 1102.
    • (2007) J Forensic Sci , vol.42 , pp. 1099-1102
    • Schmitt, G.1    Droenner, P.2    Skopp, G.3    Aderjan, R.4
  • 40
    • 0842288855 scopus 로고    scopus 로고
    • Confirmatory analysis of ethylglucuronide in urine by liquid chromatography/electrospray ionization/tandem mass spectrometry according to forensic guidelines
    • Weinmann W, Schaeffer P, Thierauf A (2004) Confirmatory analysis of ethylglucuronide in urine by liquid chromatography/electrospray ionization/tandem mass spectrometry according to forensic guidelines. J Am Soc Mass Spectrom 15 : 188 193.
    • (2004) J Am Soc Mass Spectrom , vol.15 , pp. 188-193
    • Weinmann, W.1    Schaeffer, P.2    Thierauf, A.3
  • 42
    • 33644806582 scopus 로고    scopus 로고
    • Ethyl sulphate: A direct ethanol metabolite reflecting recent alcohol consumption
    • Wurst FM, Dresen S, Allen J, Wiesbeck G, Graf M, Weinmann W (2006) Ethyl sulphate: a direct ethanol metabolite reflecting recent alcohol consumption. Addiction 101 : 204 211.
    • (2006) Addiction , vol.101 , pp. 204-211
    • Wurst, F.M.1    Dresen, S.2    Allen, J.3    Wiesbeck, G.4    Graf, M.5    Weinmann, W.6
  • 43
    • 0035995997 scopus 로고    scopus 로고
    • The ethanol conjugate ethyl glucuronide is a useful marker of recent alcohol consumption
    • Wurst FM, Metzger J (2002) The ethanol conjugate ethyl glucuronide is a useful marker of recent alcohol consumption. Alcohol Clin Exp Res 26 : 1114 1119.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1114-1119
    • Wurst, F.M.1    Metzger, J.2
  • 44
    • 0347460658 scopus 로고    scopus 로고
    • Ethyl glucuronide-the direct ethanol metabolite on the threshold from science to routine use
    • Wurst FM, Skipper G, Weinmann W (2003a) Ethyl glucuronide-the direct ethanol metabolite on the threshold from science to routine use. Addiction 98 (suppl.2 51 61.
    • (2003) Addiction , vol.98 , Issue.SUPPL.2 , pp. 51-61
    • Wurst, F.M.1    Skipper, G.2    Weinmann, W.3
  • 45
    • 0037343727 scopus 로고    scopus 로고
    • Ethyl glucuronide discloses recent covert alcohol use not detected by standard testing in forensic psychiatric inpatients
    • Wurst FM, Vogel R, Jachau K, Varga A, Alling C, Alt A, Skipper G (2003b) Ethyl glucuronide discloses recent covert alcohol use not detected by standard testing in forensic psychiatric inpatients. Alcohol Clin Exp Res 27 : 471 476.
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 471-476
    • Wurst, F.M.1    Vogel, R.2    Jachau, K.3    Varga, A.4    Alling, C.5    Alt, A.6    Skipper, G.7
  • 46
    • 4243191482 scopus 로고    scopus 로고
    • On sensitivity, specificity, and the influence of various parameters on ethyl glucuronide levels in urine-results from the WHO/ISBRA study
    • Wurst FM, Wiesbeck G, Metzger J, Weinmann W, Graf M (2004) On sensitivity, specificity, and the influence of various parameters on ethyl glucuronide levels in urine-results from the WHO/ISBRA study. Alcohol Clin Exp Res 28 : 1220 1228.
    • (2004) Alcohol Clin Exp Res , vol.28 , pp. 1220-1228
    • Wurst, F.M.1    Wiesbeck, G.2    Metzger, J.3    Weinmann, W.4    Graf, M.5


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