Comparison between the urinary alcohol markers EtG, EtS, and GTOL/5-HIAA in a controlled drinking experiment

Alcohol and Alcoholism

Volumn 43, Issue 2, 2008, Pages 187-191

  Høiseth, Gudrun ^a   Bernard, Jean Paul ^a   Stephanson, Nicolai ^b   Normann, Per T ^a   Christophersen, Asbjørg S ^a   Mørland, Jørg ^a   Helander, Anders ^b  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; 5 HYDROXYTRYPTOPHOL GLUCURONIDE; ALCOHOL; BIOLOGICAL MARKER; ETHYL GLUCURONIDE; ETHYL SULFATE; UNCLASSIFIED DRUG;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TIME; URINALYSIS; URINARY EXCRETION;

ADULT; ALCOHOL DRINKING; BIOLOGICAL MARKERS; GLUCURONATES; GLUCURONIDES; HUMANS; HYDROXYINDOLEACETIC ACID; HYDROXYTRYPTOPHOL; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; SULFURIC ACID ESTERS;

EID: 41749101589     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agm175     Document Type: Article

References (43)

1. Beck, O. and Helander, A. (2003) 5-hydroxytryptophol as a marker for recent alcohol intake. Addiction 98, 63-72.
2. Bergstrom, J., Helander, A. and Jones, A. W. (2003) Ethyl glucuronide concentrations in two successive urinary voids from drinking drivers: Relationship to creatinine content and blood and urine ethanol concentrations. Forensic Science International 133, 86-94.
3. Borucki, K., Schreiner, R., Dierkes, J. et al. (2005) Detection of recent ethanol intake with new markers: Comparison of fatty acid ethyl esters in serum and of ethyl glucuronide and the ratio of 5-hydroxytryptophol to 5-hydroxyindole acetic acid in urine. Alcoholism: Clinical and Experimental Research 29, 781-787.
4. Costantino, A., Digregorio, E. J., Korn, W. et al. (2006) The effect of the use of mouthwash on ethylglucuronide concentrations in urine. Journal of Analytical Toxicology 30, 659-662.
5. Dahl, H., Stephanson, N., Beck, O. et al. (2002) Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide. Journal of Analytical Toxicology 26, 201-204.
6. Farinati, E, Lieber, C. S. and Garro, A. J. (1989) Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue. Alcoholism: Clinical and Experimental Research 13, 357-360.
7. Finley, B. L., Ashley, P. J., Neptune, A. G. et al. (1986) Substrate-selective induction of rabbit hepatic UDP-glucuronyltransferases by ethanol and other xenobiotics. Biochemical Pharmacology 35, 2875-2881.
8. Foster-Swanson, A., Swartzentruber, M., Roberts P, et al. (1994) Reference interval studies of the rate-blanked creatinine/jaffe method on BM/Hitachi systems in six U.S. laboratories. Clinical Chemistry.
9. Foti, R. S. and Fisher, M. B. (2005) Assessment of UDP-glucuronosyltransferase catalyzed formation of ethyl glucuronide in human liver microsomes and recombinant UGTs. Forensic Science International 153, 109-116.
10. Helander, A. (2003) Biological markers in alcoholism. Journal of Neural Transmission Suppl, 15-32.
11. Helander, A. and Beck, O. (2004) Mass spectrometric identification of ethyl sulfate as an ethanol metabolite in humans. Clinical Chemistry 50, 936-937.
12. Helander, A. and Beck, O. (2005) Ethyl sulfate: A metabolite of ethanol in humans and a potential biomarker of acute alcohol intake. Journal of Analytical Toxicology 29, 270-274.
13. Helander, A., Beck, O. and Jones, A. W. (1996) Laboratory testing for recent alcohol consumption: Comparison of ethanol, methanol, and 5-hydroxytryptophol. Clinical Chemistry 42, 618-624.
14. Helander, A. and Jones, A. W. (2002) 5-HTOL-a new biochemical alcohol marker with forensic applications. Lakartidningen 99, 3950-3954.
15. Iwama, M., Tojima, T., Iitoi, Y. et al. (1990) Effects of capsaicin and ethanol on hepatic drug-metabolizing enzymes in rat. International Journal for Vitamin and Nutrition Research 60, 100-103.
16. Jones, A. W. (1992) Ethanol distribution ratios between urine and capillary blood in controlled experiments and in apprehended drinking drivers. Journal of Forensic Sciences 37, 21-34.
17. Kostrubsky, V. E., Strom, S. C., Wood, S. G. et al. (1995) Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes. Archives of Biochemistry and Biophysics 322, 516-520.
18. Kristoffersen, L., Stormyhr, L. E. and Smith-Kielland, A. (2006) Headspace gas chromatographic determination of ethanol: The use of factorial design to study effects of blood storage and headspace conditions on ethanol stability and acetaldehyde formation in whole blood and plasma. Forensic Science International 161, 151-157.
19. Li, Y. Q., Prentice, D. A., Howard, M. L. et al. (2000) Alcohol up-regulates UDP-glucuronosyltransferase mRNA expression in rat liver and in primary rat hepatocyte culture. Life Sciences 66, 575-584.
20. Politi, L., Morini, L., Groppi, A. et al. (2005) Direct determination of the ethanol metabolites ethyl glucuronide and ethyl sulfate in urine by liquid chromatography/electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry 19, 1321-1331.
21. Sarkola, T., Dahl, H., Eriksson, C. J. et al. (2003) Urinary ethyl glucuronide and 5-hydroxytryptophol levels during repeated ethanol ingestion in healthy human subjects. Alcohol and Alcoholism 38 347-351.
22. Schmitt, G., Aderjan, R., Keller, T. et al. (1995) Ethyl glucuronide: An unusual ethanol metabolite in humans. Synthesis, analytical data, and determination in serum and urine. Journal of Analytical Toxicology 19, 91-94.
23. Skipper, G. E., Weinmann, W., Thierauf, A. et al. (2004) Ethyl glucuronide: A biomarker to identify alcohol use by health professionals recovering from substance use disorders. Alcohol and Alcoholism 39, 445-449.
24. Stephanson, N., Dahl, H., Helander, A. et al. (2002) Direct quantification of ethyl glucuronide in clinical urine samples by liquid chromatography-mass spectrometry. Therapeutic Drug Monitoring 24, 645-651.
25. Stephanson, N., Dahl, H., Helander, A. et al. (2005) Determination of urinary 5-hydroxytryptophol glucuronide by liquid chromatography-mass spectrometry. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences 816, 107-112.
26. Stephanson, N., Helander, A. and Beck, O. (2007) Simultaneous determination of 5-hydroxytryptophol glucuronide and 5-hydroxyindoleacetic acid by direct injection of urine using ultra-performance liquid chromatography-tandem mass spectrometry. Journal of Mass Spectrometry In press.
27. Wurst, F. M., Dresen, S., Allen, J. P. et al. (2006) Ethyl sulphate: A direct ethanol metabolite reflecting recent alcohol consumption. Addiction 101, 204-211.
28. Wurst, F. M., Seidl, S., Ladewig, D. et al. (2002) Ethyl glucuronide: On the time course of excretion in urine during detoxification. Addiction Biology 7, 427-434.
29. Wurst, F. M., Skipper, G. E. and Weinmann, W. (2003a) Ethyl glucuronide-the direct ethanol metabolite on the threshold from science to routine use. Addiction 98 (Suppl 2), 51-61.
30. Wurst, F. M., Vogel, R., Jachau, K. et al. (2003b) Ethyl glucuronide discloses recent cover alcohol use not detected by standard testing in forensic psychiatric inpatients. Alcoholism: Clinical and Experimental Research 27, 471-476.
31. Kristoffersen, L., Stormyhr, L. E. and Smith-Kielland, A. (2006) Headspace gas chromatographic determination of ethanol: The use of factorial design to study effects of blood storage and headspace conditions on ethanol stability and acetaldehyde formation in whole blood and plasma. Forensic Science International 161, 151-157.
32. Li, Y. Q., Prentice, D. A., Howard, M. L. et al. (2000) Alcohol up-regulates UDP-glucuronosyltransferase mRNA expression in rat liver and in primary rat hepatocyte culture. Life Sciences 66, 575-584.
33. Politi, L., Morini, L., Groppi, A. et al. (2005) Direct determination of the ethanol metabolites ethyl glucuronide and ethyl sulfate in urine by liquid chromatography/electrospray tandem mass spectrometry. Rapid Communications in Mass Spectrometry 19, 1321-1331.
34. Sarkola, T., Dahl, H., Eriksson, C. J. et al. (2003) Urinary ethyl glucuronide and 5-hydroxytryptophol levels during repeated ethanol ingestion in healthy human subjects. Alcohol and Alcoholism 38 347-351.
35. Schmitt, G., Aderjan, R., Keller, T. et al. (1995) Ethyl glucuronide: An unusual ethanol metabolite in humans. Synthesis, analytical data, and determination in serum and urine. Journal of Analytical Toxicology 19, 91-94.
36. Skipper, G. E., Weinmann, W., Thierauf, A. et al. (2004) Ethyl glucuronide: A biomarker to identify alcohol use by health professionals recovering from substance use disorders. Alcohol and Alcoholism 39, 445-449.
37. Stephanson, N., Dahl, H., Helander, A. et al. (2002) Direct quantification of ethyl glucuronide in clinical urine samples by liquid chromatography-mass spectrometry. Therapeutic Drug Monitoring 24, 645-651.
38. Stephanson, N., Dahl, H., Helander, A. et al. (2005) Determination of urinary 5-hydroxytryptophol glucuronide by liquid chromatography-mass spectrometry. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences 816, 107-112.
39. Stephanson, N., Helander, A. and Beck, O. (2007) Simultaneous determination of 5-hydroxytryptophol glucuronide and 5-hydroxyindoleacetic acid by direct injection of urine using ultra-performance liquid chromatography-tandem mass spectrometry. Journal of Mass Spectrometry In press.
40. Wurst, F. M., Dresen, S., Allen, J. P. et al. (2006) Ethyl sulphate: A direct ethanol metabolite reflecting recent alcohol consumption. Addiction 101, 204-211.
41. Wurst, F. M., Seidl, S., Ladewig, D. et al. (2002) Ethyl glucuronide: On the time course of excretion in urine during detoxification. Addiction Biology 7, 427-434.
42. Wurst, F. M., Skipper, G. E. and Weinmann, W. (2003a) Ethyl glucuronide-the direct ethanol metabolite on the threshold from science to routine use. Addiction 98 (Suppl 2), 51-61.
43. Wurst, F. M., Vogel, R., Jachau, K. et al. (2003b) Ethyl glucuronide discloses recent cover alcohol use not detected by standard testing in forensic psychiatric inpatients. Alcoholism: Clinical and Experimental Research 27, 471-476.