False-positive ethyl glucuronide immunoassay screening associated with chloral hydrate medication as confirmed by LC-MS/MS and self-medication

Forensic Science International

Volumn 184, Issue 1-3, 2009, Pages

  Arndt, Torsten ^a   Gierten, Birgit ^a   Güssregen, Brunhilde ^a   Werle, Annika ^a   Grüner, Joachim ^b  

^a Bioscientia Center for Human Genetics   (Germany)

^b NONE

Author keywords

Alcohol; Chloral hydrate; Enzyme immunoassay; Ethyl glucuronide; False positive; LC MS

Indexed keywords

BUPRENORPHINE; CHLORAL HYDRATE; CLOMETHIAZOLE; CREATININE; ETHYL GLUCURONIDE; ETIRACETAM; GABAPENTIN; TRICHLOROACETIC ACID; TRICHLOROETHANOL;

ADULT; ALCOHOL ABSTINENCE; ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; EVENING DOSAGE; FEMALE; HUMAN; IONIZATION; LABORATORY DIAGNOSIS; LIQUID CHROMATOGRAPHY; MORNING DOSAGE; PRIORITY JOURNAL; SELF MEDICATION; SLEEP DISORDER; TANDEM MASS SPECTROMETRY;

EID: 58249143990     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2008.10.022     Document Type: Article

References (9)

1. Schmitt G., Aderjan R., Keller T., and Wu M. Ethyl glucuronide: an unusual ethanol metabolite in humans. Synthesis, analytical data, and determination in serum and urine. J. Anal. Toxicol. 19 (1995) 91-94
2. Helander A., Olsson I., and Dahl H. Postcollection synthesis of ethyl glucuronide by bacteria in urine may cause false identification of alcohol consumption. Clin. Chem. 35 (2007) 1855-1857
3. ® ethyl glucuronide assay, Package insert, Thermo Fisher Scientific Microgenics, August 2008.
4. Böttcher M., Beck O., and Helander A. Evaluation of a new immunoassay for urinary ethyl glucuronide testing. Alcohol Alcohol. 43 (2008) 46-48
5. Constantino A., Digregorio E.J., Korn W., Spayd S., and Rieders F. The effect of the mouthwash on ethyl glucuronide concentrations in urine. J. Anal. Toxicol. 30 (2006) 659-662
6. ® 500, Package insert 228200001/17 80/6/2000.
7. Baselt R.C. Disposition of Toxic Drugs and Chemicals in Man. seventh edition (2004), Biomedical Publications, Foster City, California
8. T. Arndt, Urine-creatinine concentration as a marker of urine dilution: reflections using a cohort of 45000 samples, Forensic Sci. Int., submitted for publication.
9. Mazzachi B.C., Peake M.J., and Ehrhardt V. Reference range and method comparison studies for enzymatic and Jaffé creatinine assays in plasma and serum and early morning urine. Clin. Lab. 46 (2000) 53-55