Thermal stability of ricin in orange and apple juices

Journal of Food Science

Volumn 75, Issue 4, 2010, Pages

  Jackson, Lauren S ^a   Zhang, Zhe ^b   Tolleson, William H ^c  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b ILLINOIS INSTITUTE OF TECHNOLOGY   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Bioterrorism; Fruit juice; Ricin; Thermal stability; Toxicity

Indexed keywords

CHEMICAL WARFARE AGENT; CYTOTOXIN; RICIN;

ALGORITHM; ANIMAL; APPLE; ARTICLE; BEVERAGE; CELL LINE; CHEMISTRY; DRUG EFFECT; FOOD CONTAMINATION; FOOD HANDLING; FOOD POISONING; FRUIT; HALF LIFE TIME; HEAT; IC 50; KINETICS; MACROPHAGE; MOUSE; PROTEIN STABILITY; SWEET ORANGE; ANALYSIS; DRUG EFFECTS; FOODBORNE DISEASES; IC50; MALUS; TOXICITY;

ALGORITHMS; ANIMALS; BEVERAGES; CELL LINE; CHEMICAL WARFARE AGENTS; CITRUS SINENSIS; CYTOTOXINS; FOOD CONTAMINATION; FOOD HANDLING; FOODBORNE DISEASES; FRUIT; HALF-LIFE; HOT TEMPERATURE; INHIBITORY CONCENTRATION 50; KINETICS; MACROPHAGES; MALUS; MICE; PROTEIN STABILITY; RICIN;

MALUS X DOMESTICA; RICINUS COMMUNIS;

EID: 77952910547     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2010.01570.x     Document Type: Article

References (39)

1. Amukele TK, Schramm VL. Ricin A-chain substrate specificity in RNA, DNA, and hybrid stem-loop structures. Biochemistry 2004, 43:4913-22.
2. Acidity (titratable) of fruit products. AOAC official methods of analysis 1990, Anonymous, Method 942.15, Arlington, Va: AOAC Intl.
3. Battelli MG, Musiani S, Monti B, Buonamici L, Sparapani M, Contestabile A, Stirpe F. Ricin toxicity to microglial and monocytic cells. Neurochem Int 2001, 39:83-93.
4. Beveridge T. Opalescent and cloudy fruit juices: formation and particle stability. Crit Rev Food Sci Nutr 2002, 42:317-37.
5. Bierenbaum ML, Wolf E, Bisgeier G, Maginnis WP. Dietary calcium: a method of lowering blood pressure. Am J Hypertens 1988, 1:149S-52S.
6. Bosch AM. Classical galactosaemia revisited. J Inherit Metab Dis 2006, 29:516-25.
7. Burdock GA, Carabin IG, Griffiths JC. Toxicology and pharmacology of sodium ricinoleate. Food Chem Toxicol 2006, 44:1689-98.
8. Bushueva TL, Tonevitsky AG. The effect of pH on the conformation and stability of the structure of plant toxin-ricin. FEBS Lett 1987, 215:155-9.
9. Bushueva TL, Uroshevich OI, Maisurian NA, Mirimanova NV, Tonevitskii AG. [Features of the structure of catalytic subunits of toxins, inhibiting protein synthesis. I. The effect of pH and interaction with the B-chain of ricin. Mol Biol (Mosk) 1991, 25:422-30.
10. Composition of foods raw, processed. 2008, http://www.ars.usda.gov/nutrientdata, USDA National Nutrient Database for Standard Reference, Release 22, Beltsville, Md., U.S. Department of Agriculture, Agricultural Research Service, USDA Nutrient Data Laboratory, Available from, Accessed Jul 17, 2009
11. Endo Y, Tsurugi K. The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA. J Biol Chem 1988, 263:8735-9.
12. Ferraz AC, Angelucci ME, Da Costa ML, Batista IR, De Oliveira BH, Da Cunha C. Pharmacological evaluation of ricinine, a central nervous system stimulant isolated from Ricinus communis. Pharmacol Biochem Behav 1999, 63:367-75.
13. Franz DR, Jaax NK. Ricin toxin. Medical aspects of chemical and biological warfare 1997, 631-42. Sidell FR, Takafuji ETFranz DR. In, editors, Chapter 32, Washington, D.C., Walter Reed Army Medical Center, p
14. Gray JS, Bae HK, Li JC, Lau AS, Pestka JJ. Double-stranded RNA-activated protein kinase mediates induction of interleukin-8 expression by deoxynivalenol, Shiga toxin 1, and ricin in monocytes. Toxicol Sci 2008, 105:322-30.
15. Griffiths GD, Leek MD, Gee DJ. The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine. J Pathol 1987, 151:221-9.
16. Gustafson I. Investigating the interaction of the toxin ricin and its B-chain with immobilised glycolipids in supported phospholipid membranes by surface plasmon resonance. Colloids Surf B 2003, 30:13-24.
17. He X, Lu S, Cheng LW, Rasooly R, Carter JM. Effect of food matrices on the biological activity of ricin. J Food Prot 2008, 71:2053-8.
18. Houston LL, Dooley TP. Binding of two molecules of 4-methylumbelliferyl galactose or 4-methylumbelliferyl N-acetylgalactosamine to the B chains of ricin and Ricinus communis agglutinin and to purified ricin B chain. J Biol Chem 1982, 257:4147-51.
19. Ibanoglu E. Effect of hydrocolloids on the thermal denaturation of proteins. Food Chem 2005, 90:621-6.
20. Jackson LS, Tolleson WH, Chirtel SJ. Thermal inactivation of ricin using infant formula as a food matrix. J Agric Food Chem 2006, 54:7300-4.
21. Johnson W. Final report on the safety assessment of Ricinus communis (castor) seed oil, hydrogenated castor oil, glyceryl ricinoleate, glyceryl ricinoleate SE, ricinoleic acid, potassium ricinoleate, sodium ricinoleate, zinc ricinoleate, cetyl ricinoleate, ethyl ricinoleate, glycol ricinoleate, isopropyl ricinoleate, methyl ricinoleate, and octyldodecyl ricinoleate. Int J Toxicol 26 Suppl 2007, 3:31-77.
22. Klain GJ, Jaeger JJ. Castor seed poisoning in humans: a review. 1990, Technical Report nr 453, Presidio of San Francisco, Calif., U.S. Army, 41, p.
23. Koffi E, Phillips R, Wicker L. Characterization of cloud components from selected tropical fruits. J Food Qual 2007, 30:797-812.
24. Lam M, Shen R, Paulsen P, Corredig M. Pectin stabilization of soy protein isolates at low pH. Food Res Int 2007, 40:101-10.
25. Levy M, Benaglia AE. The influence of temperature and pH upon the rate of denaturation of ricin. J Biol Chem 1950, 186:829-47.
26. Li M, Pestka JJ. Comparative induction of 28S ribosomal RNA cleavage by ricin and the trichothecenes deoxynivalenol and T-2 toxin in the macrophage. Toxicol Sci 2008, 105:67-78.
27. Maroyi A. Ricinus communis L. PROTA 14: Vegetable oils/Oléagineux 2007, van der Vossen HAMMkamilo GS. In, editors, The Netherlands, Wageningen
28. Nass LL, Pereira PAA, Ellis D. Biofuels in Brazil: an overview. Crop Sci 2007, 47:2228-37.
29. Pallanca A, Mazzaracchio R, Brigotti M, Carnicelli D, Alvergna P, Sperti S, Montanaro L. Uncompetitive inhibition by adenine of the RNA-N-glycosidase activity of ribosome-inactivating proteins. Biochim Biophys Acta 1998, 1384:277-84.
30. Prigent SVE, Voragen AGJ, van Koningsveld GA, Baron A, Renard C, Gruppen H. Interactions between globular proteins and procyanidins of different degrees of polymerization. J Dairy Sci 2009, 92:5843-53.
31. Roberts LM, Smith DC. Ricin: the endoplasmic reticulum connection. Toxicon 2004, 44:469-72.
32. Sanchez-Ruiz JM. Ligand effects on protein thermodynamic stability. Biophys Chem 2007, 126:43-9.
33. Scaman CH, Jim VJ, Hartnett C. Free galactose concentrations in fresh and stored apples (Malus domestica) and processed apple products. J Agric Food Chem 2004, 52:511-7.
34. Siebert KJ. Effects of protein-polyphenol interactions on beverage haze, stabilization, and analysis. J Agric Food Chem 1999, 47:353-62.
35. Simmons BM, Stahl PD, Russell JH. Mannose receptor-mediated uptake of ricin toxin and ricin A chain by macrophages. Multiple intracellular pathways for a chain translocation. J Biol Chem 1986, 261:7912-20.
36. Tolleson WH, Jackson LS. RAW264.7 macrophage cells - an in vitro alternative food safety testing platform compatible with various food types and food-borne toxins. 2008, Seattle, Wash
37. Vilhjalmsdottir L, Fisher H. Castor bean meal as a protein source for chickens: detoxification and determination of limiting amino acids. J Nutr 1971, 101:1185-92.
38. Willats WG, McCartney L, Mackie W, Knox JP. Pectin: cell biology and prospects for functional analysis. Plant Mol Biol 2001, 47:9-27.
39. Zhao GY, Zong W, An GJ. Effect of storage on cloud stability of cloudy apple juice. Food Sci Technol Int 2008, 14:105-13.