Improved production of the tallysomycin H-1 in Streptoalloteichus hindustanus SB8005 strain by fermentation optimization

Applied Microbiology and Biotechnology

Volumn 86, Issue 5, 2010, Pages 1345-1353

  Zhang, Ningning ^a   Zhu, Xiangcheng ^a,b   Yang, Dong ^a   Cai, Jin ^a   Tao, Meifeng ^c   Wang, Liyan ^c   Duan, Yanwen ^b   Shen, Ben ^c   Xu, Zhinan ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery   (China)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Bleomycin; Fermentation optimization; Plackett Burman design; Response surface methodology; Streptoalloteichus hindustanus; Tallysomycin

Indexed keywords

ANTI-CANCER AGENTS; BLEOMYCIN; BLEOMYCINS; CLINICAL DEVELOPMENT; COPPER SULFATE; DISTILLER'S GRAINS; DNA CLEAVAGE; FACTOR OPTIMIZATION; FERMENTATION MEDIUM; FERMENTORS; GLYCOPEPTIDES; MECHANISTIC STUDIES; PARENT COMPOUNDS; PLACKETT-BURMAN DESIGNS; RESPONSE SURFACE METHODOLOGY; STRUCTURAL COMPARISON; WILD-TYPE STRAIN;

FERMENTATION; GENETIC ENGINEERING; PEPTIDES; SURFACE PROPERTIES;

OPTIMIZATION;

BLEOMYCIN; CARBON; COPPER SULFATE; MALTOSE; METAL ION; NITROGEN; PHOSPHATE; TALLYSOMYCIN; TALLYSOMYCIN H 1; UNCLASSIFIED DRUG;

ANTIBIOTICS; BACTERIUM; CANCER; FERMENTATION; GENETIC ENGINEERING; GENETICALLY MODIFIED ORGANISM; PARAMETERIZATION; SUGAR;

ARTICLE; BATCH FERMENTATION; CONTROLLED STUDY; CULTURE MEDIUM; CULTURE OPTIMIZATION; DNA CLEAVAGE; DRUG SYNTHESIS; FUNGAL STRAIN; FUNGUS; NONHUMAN; RESPONSE SURFACE METHOD; STREPTOALLOTEICHUS HINDUSTANUS;

ACTINOMYCETALES; AMINO ACIDS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CARBON; CULTURE MEDIA; FERMENTATION; NITROGEN; PHOSPHATES; SALTS;

STREPTOALLOTEICHUS HINDUSTANUS;

EID: 77952890930     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2406-9     Document Type: Article

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