Melt granulation of pharmaceutical powders: A comparison of high-shear mixer and fluidised bed processes

International Journal of Pharmaceutics

Volumn 391, Issue 1-2, 2010, Pages 177-186

  Passerini, Nadia ^a   Calogerà, Giacomo ^a   Albertini, Beatrice ^a   Rodriguez, Lorenzo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Drug dissolution; Fluid bed; High shear mixer; Melt agglomeration; Poorly water soluble drugs; Technological properties

Indexed keywords

IBUPROFEN; KETOPROFEN; LACTOSE; MACROGOL 6000;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DETERMINATION; DRUG GRANULATION; DRUG GRANULE; DRUG SOLUBILITY; FLUIDIZED BED; INTERMETHOD COMPARISON; MELTING POINT; MIXER; MOLECULAR WEIGHT; PARTICLE SIZE; PH MEASUREMENT; PHYSICAL CHEMISTRY; POWDER; PRIORITY JOURNAL; PROCESS TECHNOLOGY; SHEAR RATE; SOLID STATE; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

COMPRESSIVE STRENGTH; DRUG COMPOUNDING; DRUG STABILITY; DRUG STORAGE; IBUPROFEN; LACTOSE; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POROSITY; POWDERS; RHEOLOGY; SOLUBILITY; TEMPERATURE;

EID: 77952887876     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.03.013     Document Type: Article

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