Prediction of poly(ethylene) glycol-drug eutectic compositions using an index based on the van't Hoff equation

Pharmaceutical Research

Volumn 19, Issue 3, 2002, Pages 315-321

  Law, Devalina ^a   Wang, Weili ^a   Schmitt, Eric A ^a   Long, Michelle A ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Eutectic; Monotectic; Phase diagrams; Poly(ethylene) glycol; Solid dispersion; Van't Hoff equation

Indexed keywords

FENOFIBRATE; FLURBIPROFEN; GRISEOFULVIN; IBUPROFEN; INDOMETACIN; MACROGOL; NAPROXEN; RITONAVIR; TEMAZEPAM;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; MATHEMATICAL MODEL; MELTING POINT; PHASE TRANSITION; PRIORITY JOURNAL; SCREENING; X RAY POWDER DIFFRACTION;

FORECASTING; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS;

EID: 0036200970     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014499119549     Document Type: Article

References (25)

1. Pharmaceutical applications of solid dispersion systems
2. Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man
3. Comparison of polyethylene glycol and polyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide II: Dissolution and solubility studies
4. A comparative biopharmaceutical study of fresh and aging tolbutamide-polyethyleneglycols solid dispersions
5. Physicochemical aspects of drug release. VI. Drug dissolution rate from solid particulate dispersions and the importance of carrier and drug particle properties
6. Physicochemical considerations in the preparation of amorphous ritonavir/PEG 8000 solid dispersions
7. Carbamazepine and polyethylene glycol solid dispersions: Preparation, in vitro dissolution, and characterization
8. Amorphous and eutectic solid dispersion systems of model lipophilic compound, fenofibrate
9. Phase equlibria and dissolution rates of indomethacin-polyethylene glycol 6000 solid dispersions
10. An investigation into the mechanism of dissolution of alkyl p-aminobenzoates from polyethylene glycol solid dispersions
11. Properties of solid dispersions of naproxen in various polyethylene glycols
12. An Investigation into the paracetamol solid dispersions in PEG 4000 using hot stage differential interference contrast microscopy
13. Classification of the phase diagrams of binary metallic systems according to atomic interaction forces
14. Multicomponent phase equilibria
15. Application of gas-liquid chromatography to the thermodynamics of polymer solutions
16. Predicting liquid-liquid transitions in polymer solutions using the GCLF equation of state
17. The influence of the polymer molar mass on the prediction of solvent activities in polymer solutions
18. A thermodynamic model for gas adsorption isotherms
19. Thermodynamics of concentrated polymer solutions containing polyethylene, polyisobutylene, and copolymer of ethylene with vinyl acetate and propylene
20. The nature of eutectics
21. Influence of adsorption on structure formation in eutectic systems
22. An investigation of FB interactions with poly(ethylene) glycol 6000, poly(ethylene) glycol 4000 and poly-ε-caprolactone by thermoanalytical and spectroscopic methods and modeling
23. Theory and origin of polymorphism
24. Physicochemical characterization of solid dispersions of temazepam with polyethylene glycol 6000 and PVP K30