Fluid bed granulation of a poorly water soluble, low density, micronized drug: Comparison with high shear granulation

International Journal of Pharmaceutics

Volumn 237, Issue 1-2, 2002, Pages 1-14

  Gao, Julia Z H ^a   Jain, A ^b   Motheram, R ^a   Gray, D B ^a   Hussain, M A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b DUQUESNE UNIVERSITY   (United States)

Author keywords

Fluid bed granulation; Granule size; High dose, poorly water soluble, low density, micronized drug; High shear granulation; Tablet dissolution

Indexed keywords

DRUG; GRAL 10L;

AIR TEMPERATURE; AIRFLOW; ARTICLE; DEVICE; DRUG GRANULATION; DRUG GRANULE; DRUG SOLUBILITY; INTERMETHOD COMPARISON; NEBULIZATION; PARTICLE SIZE; PHYSICAL CHEMISTRY; POROSITY; PRIORITY JOURNAL; SHEAR STRESS; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET HARDNESS; TABLET MANUFACTURE; TABLET PROPERTY;

POWDERS; SOLUBILITY; STRESS, MECHANICAL; TABLETS; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 0037177510     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00982-6     Document Type: Article

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