Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment

Toxicology

Volumn 272, Issue 1-3, 2010, Pages 32-38

  Zou, Wei ^a,b   Roth, Robert A ^b,c   Younis, Husam S ^f   Burgoon, Lyle D ^b,d,e   Ganey, Patricia E ^b,c  

^a Michigan State University ^*  (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d Michigan State University   (United States)

^e Gene Expression in Development and Disease Initiative   (United States)

^f PFIZER INC   (United States)

Author keywords

Idiosyncratic adverse drug reactions; Lipopolysaccharide; Reactive oxygen species; Sulindac; Tumor necrosis factor alpha

Indexed keywords

CARBONYL DERIVATIVE; CASPASE 3; CASPASE 7; DICHLOROFLUORESCEIN; DIMETHYL SULFOXIDE; EBSELEN; HYDROGEN PEROXIDE; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; SULINDAC; SULINDAC SULFIDE; TEMPOL; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; GENE CONTROL; GENE EXPRESSION PROFILING; IN VITRO STUDY; IN VIVO STUDY; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE, TUMOR; CELLS, CULTURED; GENE EXPRESSION; HEP G2 CELLS; HUMANS; LIPOPOLYSACCHARIDES; LIVER; MALE; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SULINDAC; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 77952878753     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.03.015     Document Type: Article

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