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Volumn 5, Issue 2, 2010, Pages 66-73

Epigenetic signatures in breast cancer: Clinical perspective

Author keywords

Breast cancer; DNA methylation; Early detection

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; DNA METHYLTRANSFERASE; HISTONE DEACETYLASE INHIBITOR; ZEBULARINE;

EID: 77952798832     PISSN: 16613791     EISSN: 16613805     Source Type: Journal    
DOI: 10.1159/000309138     Document Type: Review
Times cited : (38)

References (59)
  • 1
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M: Epigenetics in cancer. N Engl J Med 2008;358:1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 2
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3: 415-428.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 3
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M, Bell DW, Haber DA, Li E: DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999;99:247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 4
    • 0025716314 scopus 로고
    • DNA methylation and epigenetic inheritance
    • Holliday R: DNA methylation and epigenetic inheritance. Philos Trans R Soc Lond B Biol Sci 1990; 326:329-338.
    • (1990) Philos Trans R Soc Lond B Biol Sci , vol.326 , pp. 329-338
    • Holliday, R.1
  • 5
    • 0035962668 scopus 로고    scopus 로고
    • Methyl CpG binding proteins: Coupling chromatin architecture to gene regulation
    • Wade PA: Methyl CpG binding proteins: coupling chromatin architecture to gene regulation. Oncogene 2001;20:3166-3173.
    • (2001) Oncogene , vol.20 , pp. 3166-3173
    • Wade, P.A.1
  • 6
    • 0035325163 scopus 로고    scopus 로고
    • Histone acetylation and chromatin remodeling
    • Gregory PD, Wagner K, Horz W: Histone acetylation and chromatin remodeling. Exp Cell Res 2001; 265:195-202.
    • (2001) Exp Cell Res , vol.265 , pp. 195-202
    • Gregory, P.D.1    Wagner, K.2    Horz, W.3
  • 7
    • 65549159993 scopus 로고    scopus 로고
    • Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary
    • Witcher M, Emerson BM: Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell 2009;34:271-284.
    • (2009) Mol Cell , vol.34 , pp. 271-284
    • Witcher, M.1    Emerson, B.M.2
  • 11
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA: Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004;429:457-463.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 14
    • 40449132791 scopus 로고    scopus 로고
    • Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling
    • Bicaku E, Marchion DC, Schmitt ML, Munster PN: Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res 2008;68:1513-1519.
    • (2008) Cancer Res , vol.68 , pp. 1513-1519
    • Bicaku, E.1    Marchion, D.C.2    Schmitt, M.L.3    Munster, P.N.4
  • 16
    • 56149090684 scopus 로고    scopus 로고
    • Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead
    • Mai A, Altucci L: Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead. Int J Biochem Cell Biol 2009;41:199-213.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 199-213
    • Mai, A.1    Altucci, L.2
  • 20
    • 0034662645 scopus 로고    scopus 로고
    • Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer
    • Nass SJ, Herman JG, Gabrielson E, Iversen PW, Parl FF, Davidson NE, Graff JR: Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer. Cancer Res 2000;60:4346- 4348.
    • (2000) Cancer Res , vol.60 , pp. 4346-4348
    • Nass, S.J.1    Herman, J.G.2    Gabrielson, E.3    Iversen, P.W.4    Parl, F.F.5    Davidson, N.E.6    Graff, J.R.7
  • 22
    • 0036170908 scopus 로고    scopus 로고
    • Quantitative assessment of promoter hypermethylation during breast cancer development
    • Lehmann U, Langer F, Feist H, Glockner S, Hasemeier B, Kreipe H: Quantitative assessment of promoter hypermethylation during breast cancer development. Am J Pathol 2002;160:605-612.
    • (2002) Am J Pathol , vol.160 , pp. 605-612
    • Lehmann, U.1    Langer, F.2    Feist, H.3    Glockner, S.4    Hasemeier, B.5    Kreipe, H.6
  • 23
    • 58049221118 scopus 로고    scopus 로고
    • RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression
    • Subramaniam MM, Chan JY, Soong R, Ito K, Ito Y, Yeoh KG, Salto-Tellez M, Putti TC: RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression. Breast Cancer Res Treat 2009;113:113-121.
    • (2009) Breast Cancer Res Treat , vol.113 , pp. 113-121
    • Subramaniam, M.M.1    Chan, J.Y.2    Soong, R.3    Ito, K.4    Ito, Y.5    Yeoh, K.G.6    Salto-Tellez, M.7    Putti, T.C.8
  • 26
    • 0033566692 scopus 로고    scopus 로고
    • Quantitative analysis of aberrant p16 methylation using real-time quantitative methylation- specific polymerase chain reaction
    • Lo YM, Wong IH, Zhang J, Tein MS, Ng MH, Hjelm NM: Quantitative analysis of aberrant p16 methylation using real-time quantitative methylation- specific polymerase chain reaction. Cancer Res 1999;59:3899-3903.
    • (1999) Cancer Res , vol.59 , pp. 3899-3903
    • Lo, Y.M.1    Wong, I.H.2    Zhang, J.3    Tein, M.S.4    Ng, M.H.5    Hjelm, N.M.6
  • 28
    • 0022497977 scopus 로고
    • Fine-needle aspiration of breast cancer.Relationship of clinical factors to cytology results in 689 primary malignancies
    • Barrows GH, Anderson TJ, Lamb JL, Dixon JM: Fine-needle aspiration of breast cancer. Relationship of clinical factors to cytology results in 689 primary malignancies. Cancer 1986;58:1493-1498.
    • (1986) Cancer , vol.58 , pp. 1493-1498
    • Barrows, G.H.1    Anderson, T.J.2    Lamb, J.L.3    Dixon, J.M.4
  • 29
    • 0242439295 scopus 로고    scopus 로고
    • Methylation profiling of benign and malignant breast lesions and its application to cytopathology
    • Pu RT, Laitala LE, Alli PM, Fackler MJ, Sukumar S, Clark DP: Methylation profiling of benign and malignant breast lesions and its application to cytopathology. Mod Pathol 2003;16:1095-1101.
    • (2003) Mod Pathol , vol.16 , pp. 1095-1101
    • Pu, R.T.1    Laitala, L.E.2    Alli, P.M.3    Fackler, M.J.4    Sukumar, S.5    Clark, D.P.6
  • 32
    • 0038159962 scopus 로고    scopus 로고
    • Methylated DNA as a possible screening marker for neoplastic disease in several body fluids
    • Muller HM, Widschwendter M: Methylated DNA as a possible screening marker for neoplastic disease in several body fluids. Expert Rev Mol Diagn 2003;3:443-458.
    • (2003) Expert Rev Mol Diagn , vol.3 , pp. 443-458
    • Muller, H.M.1    Widschwendter, M.2
  • 33
    • 4644297522 scopus 로고    scopus 로고
    • Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients
    • DOI 10.1158/1078-0432.CCR-04-0597
    • Dulaimi E, Hillinck J, Ibanez de Caceres I, Al- Saleem T, Cairns P: Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients. Clin Cancer Res 2004;10:6189-6193. (Pubitemid 39287525)
    • (2004) Clinical Cancer Research , vol.10 , Issue.18 , pp. 6189-6193
    • Dulaimi, E.1    Hillinck, J.2    De Caceres, I.I.3    Al-Saleem, T.4    Cairns, P.5
  • 34
    • 34147158249 scopus 로고    scopus 로고
    • Detection of RASSF1A and RARbeta hypermethylation in serum DNA from breast cancer patients
    • Shukla S, Mirza S, Sharma G, Parshad R, Gupta SD, Ralhan R: Detection of RASSF1A and RARbeta hypermethylation in serum DNA from breast cancer patients. Epigenetics 2006;1:88-93.
    • (2006) Epigenetics , vol.1 , pp. 88-93
    • Shukla, S.1    Mirza, S.2    Sharma, G.3    Parshad, R.4    Gupta, S.D.5    Ralhan, R.6
  • 35
    • 34447100205 scopus 로고    scopus 로고
    • Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients
    • Mirza S, Sharma G, Prasad CP, Parshad R, Srivastava A, Gupta SD, Ralhan R: Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. Life Sci 2007;81:280-287.
    • (2007) Life Sci , vol.81 , pp. 280-287
    • Mirza, S.1    Sharma, G.2    Prasad, C.P.3    Parshad, R.4    Srivastava, A.5    Gupta, S.D.6    Ralhan, R.7
  • 36
    • 34147134560 scopus 로고    scopus 로고
    • ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients
    • DOI 10.1016/j.lfs.2007.02.026, PII S0024320507001828
    • Sharma G, Mirza S, Prasad CP, Srivastava A, Gupta SD, Ralhan R: Promoter hypermethylation of p16INK4A, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients. Life Sci 2007;80:1873-1881. (Pubitemid 46562520)
    • (2007) Life Sciences , vol.80 , Issue.20 , pp. 1873-1881
    • Sharma, G.1    Mirza, S.2    Prasad, C.P.3    Srivastava, A.4    Gupta, S.D.5    Ralhan, R.6
  • 37
    • 33749571963 scopus 로고    scopus 로고
    • Epigenetic analysis of body fluids and tumor tissues: Application of a comprehensive molecular assessment for early-stage breast cancer patients
    • Taback B, Giuliano AE, Lai R, Hansen N, Singer FR, Pantel K, Hoon DS: Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients. Ann N Y Acad Sci 2006; 1075:211-221.
    • (2006) Ann N y Acad Sci , vol.1075 , pp. 211-221
    • Taback, B.1    Giuliano, A.E.2    Lai, R.3    Hansen, N.4    Singer, F.R.5    Pantel, K.6    Hoon, D.S.7
  • 42
    • 66149102406 scopus 로고    scopus 로고
    • Methylation as a novel prognostic biomarker in early breast cancer
    • (KLK10)
    • (KLK10) methylation as a novel prognostic biomarker in early breast cancer. Ann Oncol 2009;20: 1020-1025.
    • (2009) Ann Oncol , vol.20 , pp. 1020-1025
  • 43
    • 47249164378 scopus 로고    scopus 로고
    • Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis
    • Veeck J, Geisler C, Noetzel E, Alkaya S, Hartmann A, Knuchel R, Dahl E: Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. Carcinogenesis 2008;29:991-998.
    • (2008) Carcinogenesis , vol.29 , pp. 991-998
    • Veeck, J.1    Geisler, C.2    Noetzel, E.3    Alkaya, S.4    Hartmann, A.5    Knuchel, R.6    Dahl, E.7
  • 44
    • 46249090608 scopus 로고    scopus 로고
    • Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer
    • Noetzel E, Veeck J, Niederacher D, Galm O, Horn F, Hartmann A, Knuchel R, Dahl E: Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer. BMC Cancer 2008;8:154.
    • (2008) BMC Cancer , vol.8 , pp. 154
    • Noetzel, E.1    Veeck, J.2    Niederacher, D.3    Galm, O.4    Horn, F.5    Hartmann, A.6    Knuchel, R.7    Dahl, E.8
  • 47
    • 51249109684 scopus 로고    scopus 로고
    • Multigene methylation in serum of sporadic Chinese female breast cancer patients as a prognostic biomarker
    • Jing F, Jun L, Yong Z, Wang Y, Fei X, Zhang J, Hu L: Multigene methylation in serum of sporadic Chinese female breast cancer patients as a prognostic biomarker. Oncology 2008;75:60-66.
    • (2008) Oncology , vol.75 , pp. 60-66
    • Jing, F.1    Jun, L.2    Yong, Z.3    Wang, Y.4    Fei, X.5    Zhang, J.6    Hu, L.7
  • 52
    • 34447262607 scopus 로고    scopus 로고
    • DNAmethylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients - Technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group
    • Maier S, Nimmrich I, Koenig T, Eppenberger- Castori S, Bohlmann I, Paradiso A, Spyratos F, Thomssen C, Mueller V, Nahrig J, et al.: DNAmethylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients - technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group. Eur J Cancer 2007;43:1679-1686.
    • (2007) Eur J Cancer , vol.43 , pp. 1679-1686
    • Maier, S.1    Nimmrich, I.2    Koenig, T.3    Eppenberger-Castori, S.4    Bohlmann, I.5    Paradiso, A.6    Spyratos, F.7    Thomssen, C.8    Mueller, V.9    Nahrig, J.10
  • 57
    • 38949086502 scopus 로고    scopus 로고
    • Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    • Weichert W, Roske A, Gekeler V, Beckers T, Stephan C, Jung K, Fritzsche FR, Niesporek S, Denkert C, Dietel M, et al.: Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer 2008;98:604-610.
    • (2008) Br J Cancer , vol.98 , pp. 604-610
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Stephan, C.5    Jung, K.6    Fritzsche, F.R.7    Niesporek, S.8    Denkert, C.9    Dietel, M.10
  • 58
    • 50049108874 scopus 로고    scopus 로고
    • Prognostic significance of the therapeutic targets histone deacetylase 1,2,6 and acetylated histone H4 in cutaneous Tcell lymphoma
    • Marquard L, Gjerdrum LM, Christensen IJ, Jensen PB, Sehested M, Ralfkiaer E: Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous Tcell lymphoma. Histopathology 2008;53:267-277.
    • (2008) Histopathology , vol.53 , pp. 267-277
    • Marquard, L.1    Gjerdrum, L.M.2    Christensen, I.J.3    Jensen, P.B.4    Sehested, M.5    Ralfkiaer, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.