On the growth and internal structure of the human lens

Experimental Eye Research

Volumn 90, Issue 6, 2010, Pages 643-654

  Augusteyn, Robert C ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b LA TROBE UNIVERSITY   (Australia)

Author keywords

Compaction; Cortex; Gradients; Growth; Lens; Nucleus; Zones of discontinuity

Indexed keywords

AGING; ARTICLE; CATARACT; DEVELOPMENTAL STAGE; EYE DEVELOPMENT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LENS; LENS FIBER; LENS NUCLEUS; POSTNATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRESBYOPIA; PRIORITY JOURNAL; SLIT LAMP; WATER CONTENT; BODY WATER; CYTOLOGY; METABOLISM; ORGAN SIZE; REVIEW;

CRYSTALLIN;

BODY WATER; CRYSTALLINS; HUMANS; LENS CORTEX, CRYSTALLINE; LENS NUCLEUS, CRYSTALLINE; ORGAN SIZE;

EID: 77952788436     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2010.01.013     Document Type: Review

References (89)

1. Al-Ghoul K.J., Nordgren R.K., Kuszak A.J., Freel C.D., Costello M.J., Kuszak J.R. Structural evidence of human nuclear fiber compaction as a function of ageing and cataractogenesis. Exp. Eye Res. 2001, 72:199-214.
2. Atchison D.A., Markwell E.L., Kasthurirangan S., Pope J.M., Smith G., Swann P. Age-related changes in optical and biometric characteristics of emmetropic eyes. J. Vis. 2008, 8(29):1-20.
3. Augusteyn R.C. Growth of the human eye lens. Mol. Vis. 2007, 13:252-257.
4. Augusteyn R.C. Growth of the lens: in vitro observations. Clin. Exp. Optom. 2008, 91:226-239.
5. Augusteyn R.C., Cake M.A. Post mortem uptake of water by sheep lenses left in the eye. Mol. Vis. 2005, 11:749-751.
6. Augusteyn R.C., Rosen A.M., Borja D., Ziebarth N.M., Parel J.M. Biometry of primate lenses during immersion in preservation media. Mol. Vis. 2006, 12:740-747.
7. Augusteyn R.C., Jones C., Pope J. Age-related development of a RI plateau in the human lens: evidence for a distinct nucleus. Clin. Exp. Optom. 2008, 91. 296-30.
8. Augusteyn R.C., Vrensen G.J.M., Willekins B. The effect of paraformaldehyde fixation and PBS storage on the water content of the human lens. Mol. Vis. 2008, 14:90-94.
9. Ayaki M., Onde H., Yokoyama N. Size of the lens nucleus separated by hydrodissection. Ophthal. Surg. 1993, 24:492-493.
10. Bellows J. Phakochronology. The study of dating structural changes in the lens. Br. J. Ophthalmol. 1968, 52:540-545.
11. Bours J., Fodisch H.J. Human fetal lens: wet and dry weight with increasing gestational age. Ophthal. Res. 1986, 18:363-368.
12. Bron A.J., Vrensen G.F.J.M., Koretz J.F., Maraini G., Harding J.J. The ageing lens. Ophthalmologica 2000, 214:86-104.
13. Brown N.A. Lens changes with age and cataract; slit-image photography. The Human Lens in Relation to Cataract, Ciba Symposium 1973, vol. 19:65-71. Elsevier, London.
14. Brown N.A., Tripathi R. The loss of the anterior sub-capsular clear zone of the lens; prognostic significance in cataract formation. Trans. Ophthalmol. Soc. U.K. 1974, 94:29-45.
15. Burd H.J., Wilde G.S., Judge S.J. Can reliable values of Young's Modulus be deduced from Fisher's (1971) spinning lens measurements?. Vis. Res. 2006, 46:1346-1360.
16. Carstensen E.L., Schwan H.P. Acoustic properties of haemoglobin solutions. J. Acoust. Soc. Am. 1959, 31:305-311.
17. Clapp C.A. A communication upon the weight of infants' lenses and their solids. Arch. Ophthalmol. 1913, 42:619-624.
18. Cook C.A., Koretz J.F., Pfahnl A., Hyun J., Kaufman P.L. Aging of the human crystalline lens and anterior segment. Vis. Res. 1994, 34:2945-2954.
19. Dubbelman M., van der Heijde R., Weeber H.A., Vrensen G.F.J.M. Changes in the internal structure of the human crystalline lens with age and accommodation. Vis Res. 2003, 43:2363-2375.
20. Dubbelman M., van der Heijde R., Weeber H.A. The thickness of the aging human lens obtained from corrected Scheimpflug images. Optom. Vis. Sci. 2001, 78:411-416.
21. Duke-Elder S., Wybar K.C. System of Ophthalmology. The Anatomy of the Visual System 1961, vol. II. The CV Mosby Company, St Louis.
22. Ehlers N., Matthieson M.E., Andersen H. Prenatal growth of the human eye. Acta Ophthalmol. (Copenh.) 1968, 46:329-349.
23. Fagerholm P.P., Philipson B.T., Lindstrom B. Normal human lens- the distribution of protein. Exp. Eye Res. 1981, 33:615-620.
24. Farnsworth P.N., Shyne S.E. Anterior zonular shifts with age. Exp Eye Res. 1979, 28:291-297.
25. Fisher R.F. The elastic constants of the human lens. J. Physiol. 1971, 212:147-180.
26. Fisher R.F., Pettet B.E. Presbyopia and the water content of the human crystalline lens. J. Physiol. 1973, 234:443-447.
27. Friedrich M.G., Truscott R.W.E. Membrane association of proteins in the aging human lens: profound changes take place in the fifth decade of life. Invest. Ophthalmol. Vis. Sci. 2009, 50:4786-4793.
28. Garland D.L., Douglas-Tabor Y., Jimenez-Asensio J., Datiles M.B., Magno B. Nucleus of the human lens: demonstration of a highly characteristic protein pattern by two-dimensional electrophoresis and a new method of lens dissection. Exp. Eye Res. 1996, 62:285-291.
29. Gilliland, K.O., Metlapally, S., Costello, M.J., 2009. Morphological analysis of extensive fiber cell compaction in the adult nucleus of aged human transparent lenses. IOVS 2009, vol. 50. ARVO E-Abstract 4388.
30. Glasser A., Campbell M.C.W. Biometric, optical and physical changes in the isolated human crystalline lens with age in relation to presbyopia. Vis. Res. 1999, 39:1991-2015.
31. Goldstein I., Tamir A., Zimmer E.Z., Itskovitz-Eldor J. Growth of the fetal orbit and lens during normal regnancies. Ultrasound Obstet. Gynecol. 1998, 12:175-179.
32. Goss S.A., Frizzel L.A., Dunn F. Dependence of the ultrasonic properties of biological tissues on constituent proteins. J. Acoustic Soc. Am. 1980, 67:1041-1044.
33. Grey A.C., Jacobs M.D., Gonen T., Joerg Kistler J., Donaldson P.J. Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier. Exp. Eye Res. 2003, 77:567-574.
34. Gullapalli V.K., Murthy P.R., Murthy K.R. Colour of the nucleus as a marker of nuclear hardness diameter and central thickness. Indian J. Opthalmol. 1995, 44:181-184.
35. Harding J.J., Rixon K.C., Marriott F.H.C. Men have heavier lenses than women of the same age. Exp. Eye Res. 1977, 25:651.
36. Hermans E., Dubbelman M., van der Heijde R., Heethaar R. The shape of the human lens nucleus with accommodation. J. Vis. 2007, 7(16):1-10. http://journalofvision.org/7/10/16/, 10.1167/7.10.16.
37. Heys K.R., Cram S.L., Truscott R.J.W. Massive increase in the stiffness of the lens nucleus with age: the basis for presbyopia?. Mol. Vis. 2005, 10:256-263.
38. Heys K.R., Friedrich M.G., Truscott R.J.W. Presbyopia and heat: changes associated with aging of the human lens suggest a functional role for the small heat shock protein, α-crystallin, in maintaining lens flexibility. Aging Cel. 2007, 6:807-815.
39. Hockwin O., Dragomirescu V., Laser H. Measurements of lens transparency or its disturbances by densitometric image analysis of Scheimpflug photographs. Albrecht Graef. Arch. Klin. Exp. Ophthalmol. 1982, 219:255-262.
40. Hollmann K.W., O'Donell M., Erpelding T.N. Mapping elasticity in human lenses using bubble-based acoustic radiation force. Exp. Eye Res. 2007, 85:890-893.
41. Huggert A. The thickness of the cortex of the crystalline lens in different ages. Acta Ophthalmol. 1946, 24:43-62.
42. Jones C., Atchison D.A., Meder R., Pope J.M. Refractive index distribution and optical properties of the isolated human lens measured using magnetic resonance imaging (MRI). Vis. Res. 2005, 45:2352-2366.
43. Jones C., Atchison D.A., Pope J.M. Changes in lens dimensions and refractive index with age and accommodation. Optom. Vis. Sci. 2007, 84:990-995.
44. Kasthurirangan S., Markwell E.L., Atchison D.A., Pope J.M. In vivo study of changes in refractive index distribution in the human crystalline lens with age and accommodation. Invest. Ophthalmol. Vis. Sci. 2008, 49:2531-2540.
45. Koretz J.F., Kaufman P.L., Neider M.W., Goeckner P.A. Accommodation and presbyopia in the human eye: aging of the anterior segment. Vis. Res. 1989, 29:1685-1692.
46. Koretz J.F., Cook C.A., Kuszak J.R. The zones of discontinuity in the human lens: development and distribution with age. Vis. Res. 1994, 34:2955-2962.
47. Koretz J.F., Strenk S.A., Strenk J.M., Semmlow J.L. Scheimpflug and high-resolution magnetic resonance imaging of the anterior segment; a comparative study. J. Opt. Soc. Am. A Opt. Image Sci. Vis. 2004, 21:346-354.
48. Korlimbinis A., Berry Y., Thibault D., Schey K., Truscott R.J.W. Protein ageing: Truncation of aquaporin 0 in human lens regions is a continual age-dependent process. Exp. Eye Res. 2009, 88:966-973.
49. Kuszak J.R. Development of sutures in the lens. Progr. Retin. Eye Res. 1995, 14:567-591.
50. Larsen J.S. The saggital growth of the eye. II Ultrasonic measurements of the axial diameter of the lens and the anterior segment from birth to puberty. Acta Ophthalmol. 1971, 49.
51. Lim J.C., Walker K.L., Sherwin T., Schey K.L., Donaldson P.J. Confocal microscopy reveals zones of membrane remodelling in the outer cortex of the human lens. Invest. Ophthalmol. Vis. Sci. 2009, 50:4304-4310.
52. Mutti D.O., Zadnik K., Fusari R.E., Friedman N.E., Sholtz R.I., Adamas A.J. Optical and structural development of the crystalline lens in childhood. Invest. Ophthalmol. Vis. Sci. 1998, 39:120-133.
53. Moffatt B.A., Landman K.A., Sweeney M.H.J., Truscott R.J.W., Pope J.M. Age-related changes in the kinetics of water transport in normal human lenses. Exp. Eye Res. 1999, 69:663-669.
54. Nordmann J., Mack G., Mack G. Nucleus of the human lens III Its separation, its hardness. Ophthalmic Res. 1974, 6:216-222.
55. Nordmann J., Fink H., Hockwin O. Die wachstunkurve der menschenlichen lines. Albrecht Graefs. Arch. Klin. Exp. Ophthalmol. 1974, 191:165-175.
56. Pau H., Kranz J. The increasing sclerosis of the human lens with age and its relevance to accommodation and presbyopia. Graefe's. Arch. Clin. Exp. Opthalmol. 1991, 229:294-296.
57. Philipson B.T., Fagerholm P.P. Lens changes responsible for increased light scattering in some types of senile cataract. The Human Lens in Relation to Cataract, CIBA Symposium 19 1973, 45-58. Associated Scientific Publishers, Amsterdam.
58. Pierscionek B.K. Refractive index contours in the human lens. Exp. Eye Res. 1997, 64:887-893.
59. Pierscionek B.K., Augusteyn R.C. Shape and dimensions of in vitro human lenses. Clin. Exp. Optom. 1991, 74:223-228.
60. Pierscionek B.K., Augusteyn R.C. Species variations in optical parameters of the eye lens. Clin. Exp. Optom. 1993, 76:22-26.
61. Pierscionek B.K., Chan D.Y.C. The refractive index gradient of the human lens. Optom. Vis. Sci. 1989, 66:822-829.
62. Richdale K., Bullimore M., Zadnik K. Lens thickness with age and accommodation by optical coherence tomography. Ophthalmic Physiol. Optics 2008, 28:441-447.
63. Rosen A.M., Denham D.B., Fernandez V., Borja D., Ho A., Manns F., Parel J.M., Augusteyn R.C. In vitro dimensions and curvatures of human lenses. Vis. Res. 2006, 46:1002-1009.
64. Roy D., Spector A. Absence of low molecular weight α-crystallin in nuclear region of old human lenses. Proc. Natl. Acad. Sci. U.S.A. 1976, 73:3484-3487.
65. Schachar R.A. Growth patterns of fresh human crystalline lenses measured by in vitro photographic biometry. J. Anat. 2005, 206:575-580.
66. Schachar R.A., Pierscionek B.K. Lens hardness not related to the age-related decline of accommodative amplitude. Mol. Vis. 2007, 13:1010-1011.
67. Siebinga I., Vrensen G.F.J.M., De Mu F.F., Greve J. Age-related changes in local water and protein content of human eye lenses measured by Raman Spectroscopy. Exp. Eye Res. 1991, 153:233-239.
68. Smith P. Diseases of crystalline lens and capsule. 1. On the growth of the crystalline lens. Trans. Ophthalmol. Soc. U.K. 1883, 3:79-99.
69. Sparrow J.M., Bron A.J., Brown N.A., Ayliffe W., Hill A.R. The oxford clinical cataract classification and grading system. Int. Ophthalmol. 1986, 9:207-225.
70. Strenk S.A., Semmlow J.L., Strenk L.M., Munoz P., Gronlund-Jacob J., DeMarco K. Age-related changes in human ciliary muscle and lens; a magnetic resonance imaging study. Invest. Ophthalmol. Vis. Sci. 1999, 40:1162-1169.
71. Strenk S.A., Strenk L.M., Koretz J.F. The mechanism of presbyopia. Prog. Retin. Eye Res. 2005, 24:379-393.
72. Sweeney M.H.J., Truscott R.J.W. An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract. Exp. Eye Res. 1998, 67:587-595.
73. Tabendah H., Thompson G.M., Heysworth P., Dorey S., Woods A.J., Lynch D. Water content, lens hardness and cataract appearance. Eye 1994, 8:125-129.
74. Tardieu A., Veretout F., Krop B., Slingsby C. Protein interactions in the calf lens; interactions between beta-crystallins are repulsive whereas in gamma-crystallins they are attractive. Eur. Biophys. J. 1992, 21:1-12.
75. Taylor L., Al-Ghoul K.J., Lane C.W., Davis V.A., Kuszak J.R., Costello M.J. Morphology of the normal human lens. Invest. Ophthalmol. Vis Sci. 1996, 37:1396-1410.
76. Thomson J.A., Augusteyn R.C. Ontogeny of human lens crystallins. Exp. Eye Res. 1985, 40:393-410.
77. Truscott R.J.W., Augusteyn R.C. Changes in human lens proteins during nuclear cataract formation. Exp. Eye Res. 1977, 24:159-170.
78. Uhlhorn S., Borja D., Manns F., Parel J.-M. Refractive index measurement of the isolated crystalline lens using optical coherence tomography. Vis. Res. 2008, 48:2732-2738.
79. Urs, R., Fabrice Manns, F., Arrieta, E., Ziebarth, N., Uhlhorn, S., Dunne, S., Ho, A., Augusteyn, R., Parel, J.-M., 2010. Speed of sound gradient across the equatorial profile of the isolated human crystalline lens. IOVS 2010, vol. 51. ARVO E-Abstract to be advised.
80. van Alpen G.W.H., Graebel W.P. Elasticity of tissues involved in accommodation. Vis. Res. 1991, 31:1417-1438.
81. Van Heyningen R. The human lens. 3. Some observations on the post-mortem lens. Exp. Eye. Res. 1972, 13:155-160.
82. Vogt A. Das farbenschillen des hinteren linsenbildes. Klin. Mbl. Augen-helik 1919, 62:582.
83. Vogt A. Lehrbuch und atlas der spaltlampenmikroskopie des auges 1931, Zweiter Teil, Springer, Berlin.
84. Weeber H.A., Eckert G., Soergel F., Meyer C.H., Pechhold W., van der Heijde R.G.L. Dynamic mechanical properties of human lenses. Exp. Eye Res. 2005, 80:425-434.
85. Weeber H.A., Eckert G., Pechfold W., van den Heijde R.G.L. Stiffness gradient in the crystalline lens. Graefe's Arhiv. Clin. Exp. Ophthalmol 2007, 10.1007/s00417-007-0537-1.
86. Weekers R., Delmarcelle Y., Luyckx-Bacus J., Collignon J. Morphological changes of the lens with age and cataract. CIBA Foundation Symposium 19 1973, 25-40. Elsevier, London.
87. Wegener A., Laser-Junga H. Photography of the anterior eye segment according to Scheimpflug's principle: options and limitations - a review. Clin. Exp. Ophthalmol. 2009, 37:144-154.
88. Wilmarth P.A., Tanner S., Dasari S.R., Nagalla S.R., Riviere M.A., Bafna V., Pevzner P.A., David L.L. Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility?. J. Proteome Res. 2006, 5:2554-2566.
89. Wong T.Y., Foster P.J., Ng T.P., Tielsch J.M., Johnson G.J., Seah S.K.L. Variations in ocular biometry in an adult Chinese population in Singapore: the Tanjong Pagar study. Invest. Ophthalmol. Vis. Sci. 2001, 42:73-80.