Morphology of the normal human lens

Investigative Ophthalmology and Visual Science

Volumn 37, Issue 7, 1996, Pages 1396-1410

  Taylor, Virginia L ^a   Al Ghoul, Kristin J ^a   Lane, C Wesley ^a   Davis, V Andrew ^a   Kuszak, Jerome R ^b   Costello, M Joseph ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

electron microscopy; fiber cells; image analysis; lens senescence; lens ultrastructure

Indexed keywords

ARTICLE; CELL STRUCTURE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; LENS; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

ADULT; AGED; AGING; CELL DIFFERENTIATION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LENS CORTEX, CRYSTALLINE; LENS NUCLEUS, CRYSTALLINE; LENS, CRYSTALLINE; MICROSCOPY, ELECTRON, SCANNING; MIDDLE AGED;

EID: 0029977659     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Trokel S. The physical basis for transparency of the crystalline lens. Invest Ophthalmol. 1962;1:493-501.
2. Rabl C. Über den Bau und die Entwicklung der Linse. Ztschr F Wissensch Zool. 1900;67:1-138.
3. Rae JL, Truitt KD, Kuszak JR. The use of procion dyes for light microscopy of the frog lens. Invest Ophthalmol Vis Sci. 1983;24:1167-1171.
4. Costello MJ, Oliver TN. Fiber cell architecture in the nuclei of bovine and senescent human lenses. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1992;33:1170.
5. Al-Ghoul KJ, Lane CW, Costello MJ. Fiber cell shape and cytoplasmic texture in human lens nuclei. Curr Eye Res. 1996; in press.
6. Taylor VL, Al-Ghoul KJ, Lane CW, Davis VA, Kuszak JR, Costello MJ. Morphology of the normal human lens. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995;36:S261.
7. Delaye M, Tardieu A. Short range order of crystallin proteins accounts for eye lens transparency. Nature. 1983;302:415-417.
8. Wanko T, Gavin N. Electron microscope study of lens fibers. J Biophys Biochem Cytol. 1959;6:97-102.
9. Cohen AI. The electron microscopy of the normal human lens. Invest Ophthalmol. 1965;4:433-446.
10. Hansson HA. Scanning electron microscopy of the lens of the adult rat. Z Zellforsch. 1970;107:187-198.
11. Farnsworth SC, Fu SCJ, Burke PA, Bahia I. Ultrastructure of rat eye lens fibers. Invest Ophthalmol. 1974;13:274-279.
12. Harding CV, Susan S, Murphy H. Scanning electron microscopy of the adult rabbit lens. Ophthalmic Res. 1976;8:443-455.
13. Hoyer HE. Scanning electron-microscopic study of lens fibers of the pig. Cell Tissue Res. 1982;224:225-232.
14. Dickson DH, Crock GW. Fine structure of primate lens fibers. In: Bellows JG, ed. Cataract and Abnormalities of the Lens. New York: Grune & Stratton Inc; 1975:49-59.
15. Kuwabara T. The maturation of the lens cell: A morphologic study. Exp Eye Res. 1975;20:427-443.
16. Kuszak JR, Ennesser CA, Umlas J, Macsai-Kaplan MS, Weinstein RS. The ultrastructure of fiber cells in primate lenses: A model for studying membrane senescence. J Ultrastruct Mol Struct Res. 1988;100:60-74.
17. Willekens B, Vrensen G. The three-dimensional organization of lens fibers in the rhesus monkey. Graefe's Arch Clin Exp Ophthalmol. 1982;219:112-120.
18. Hogan MJ, Alvarado JA, Weddell JE. Lens. In: Histology of the Human Eye. Toronto: WB Saunders; 1971:638-677.
19. Matsuto T. Scanning electron microscopic studies on the normal and senile cataractous human lenses. Acta Soc Ophthalmol Jpn. 1973;77:155-174.
20. Tripathi RC, Tripathi BJ. Lens morphology, aging, and cataract. J Gerontol. 1983;38:258-270.
21. Kobayashi Y, Suzuki T. The aging lens: Ultrastructural changes in cataract. In: Bellows JG, ed. Cataract and Abnormalities of the Lens. New York: Grune & Stratton; 1975:313-343.
22. Vrensen G, Kappelhof J, Willekens B. Morphology of the aging human lens. Lens Eye Tox Res. 1990;7:1-30.
23. Kuszak JR, Deutsch TA, Brown HG. Anatomy of aged and senile cataractous lenses. In: Albert D, Jakobiec F, eds. Principles and Practices of Ophthalmology. Philadelphia: WB Saunders; 1992:564-574.
24. Costello MJ, Oliver TN, Cobo LM. Cellular architecture in age-related human nuclear cataracts. Invest Ophthalmol Vis Sci. 1992;33:3209-3227.
25. Kuszak JR. The development of lens sutures. Prog Retinal Eye Res. 1995;14:567-591.
26. Duke-Elder S, Cook C. System of Ophthalmology. Vol. III. Normal and Abnormal Development. St. Louis: CV Mosby; 1963:309-324.
27. Berliner ML. Biomicroscopy of the Eye: Slit Lamp Microscopy of the Living Eye. New York: Paul B Hoeber; 1949:948-1019.
28. Slamovits, TL. Basic and Clinical Science Course Section 11: Lens and Cataract. San Francisco: American Academy of Ophthalmology; 1995:27-30.
29. Al-Ghoul KJ, Costello MJ. Morphological changes in human nuclear cataracts of late-onset diabetics. Exp Eye Res. 1993;57:469-486.
30. Kuszak JR, Ennesser CA, Bertram BA, Imherr-McMannis S, Jones-Rufer LS, Weinstein RS. The contribution of cell-to-cell fusion to the ordered structure of the crystalline lens. Lens Eye Tox Res. 1989;6:639-673.
31. Rasband W. Image Version 1.21, User's Guide PB90-123308. Bethesda: National Institutes of Health; 1989.
32. Remington RD, Schork MA. Statistics With Applications to the Biological and Health Sciences. 2nd ed. Englewood Cliffs: Prentice-Hall; 1985:313-316.
33. Dickson DH, Crock GW. Interlocking patterns on primate lens fibers. Invest Ophthalmol. 1972;11:809-815.
34. Kuszak J, Alcala J, Maisel H. The surface morphology of embryonic and adult chick lens fiber cells. Am J Anat. 1980;159:395-410.
35. Vrensen G, Marle J, Veen H, Willekens B. Membrane architecture as a function of lens fibre maturation: A freeze fracture and scanning electron microscopic study in the human lens. Exp Eye Res. 1992;54:433-446.
36. Phelps Brown NA. The lens. In: Spalton DJ, Hitchings RA, Hunter PA, eds. Atlas of Clinical Ophthalmology. 2nd ed. London: Wolfe; 1994:11.2-11.26.
37. Fine H. Cortical cleaving hydrodissection. J Cataract Refract Surg. 1992;18:508-512.
38. Garland DL, Duglas-Tabor Y, Datiles MB, Zigler JS, Magno B. Analysis of human lens proteins during fiber cell maturation. ARVO Abstracts. Invest Ophthalmol Vis Sci. 1995;36:S822.
39. Kuszak JR, Bertram BA, Rae JL. The ordered structure of the crystalline lens. In: Hilfer SR, Shaffield JB, eds. Development of Order in the Visual System. New York: Springer-Verlag; 1986:35-60.
40. Pierscionek BK, Augusteyn RC. Growth related changes to functional parameters in the bovine lens. Biochim Biophys Acta. 1992;1116:283-290.
41. Tardieu A, Vérétout F, Krop B, Slingsby, C. Protein interactions in the calf eye lens: Interactions between beta-crystallins are repulsive whereas in gamma-crystallins they are attractive. Eur Biophys J. 1992;21:1-12.
42. Kenworthy AK, Magid AD, Oliver TN, McIntosh TJ. Colloid osmotic pressure of steer alpha and beta crystallins: Possible functional roles for lens crystallin distribution and structural diversity. Exp Eye Res. 1994;59:11-30.
43. Kuszak JR, Macsai MS, Bloom KJ, Rae JL, Weinstein RS. Cell-to-cell fusion of lens fiber cells in situ: Correlative light, scanning electron microscopic, and freeze-fracture studies. J Ultrastruct Res. 1985;93:144-160.
44. Hoenders HJ, Bloemendal H. Lens proteins and aging. J Gerontol. 1983;38:278-286.
45. Zigler JS. Lens proteins. In: Albert D, Jakobiec F, eds. Principles and Practices of Ophthalmology. Philadelphia: WB Saunders; 1994:97-113.
46. Thomson JA, Augusteyn RC. Ontogeny of human lens crystallins. Exp Eye Res. 1985;40:393-410.
47. Kuszak JR, Brown HG. Embryology and anatomy of the crystalline lens. In: Albert D, Jakobiec F, eds. Principles and Practices of Ophthalmology. Philadelphia: WB Saunders; 1994:82-96.
48. Dilley KJ, Bron AJ, Habgood JO. Anterior polar and posterior subcapsular cataract in a patient with retinitis pigmentosa: A light-microscopic and ultrastructural study. Exp Eye Res. 1976;22:155-167.
49. Fine BS, Yanoff M. The lens. In: Ocular Histology: A Text and Atlas. 2nd ed. New York: Harper & Row; 1979:147-159.
50. Kuszak JR, Macsai MS, Rae JL. Stereo scanning electron microscopy of the crystalline lens. Scanning Electron Microsc. 1983;3:1415-1426.
51. Jedziniak JA, Kinoshita JH, Yates EM, Hocker LO, Benedek GB. On the presence and mechanism of formation of heavy molecular weight aggregates in human normal and cataractous lenses. Exp Eye Res. 1973;15:185-192.
52. Benedek GB. Theory of transparency of the eye. Appl Opt. 1971;10:459-473.